List of fictional diseases
Encyclopedia
This article is a list of fiction
Fiction
Fiction is the form of any narrative or informative work that deals, in part or in whole, with information or events that are not factual, but rather, imaginary—that is, invented by the author. Although fiction describes a major branch of literary work, it may also refer to theatrical,...

al disease
Disease
A disease is an abnormal condition affecting the body of an organism. It is often construed to be a medical condition associated with specific symptoms and signs. It may be caused by external factors, such as infectious disease, or it may be caused by internal dysfunctions, such as autoimmune...

s
— nonexistent, named medical conditions which appear in fiction where they have a major plot or thematic importance. They may be fictional psychological disorders, magical
Magic (paranormal)
Magic is the claimed art of manipulating aspects of reality either by supernatural means or through knowledge of occult laws unknown to science. It is in contrast to science, in that science does not accept anything not subject to either direct or indirect observation, and subject to logical...

, from mythological
Mythology
The term mythology can refer either to the study of myths, or to a body or collection of myths. As examples, comparative mythology is the study of connections between myths from different cultures, whereas Greek mythology is the body of myths from ancient Greece...

 or fantasy
Fantasy
Fantasy is a genre of fiction that commonly uses magic and other supernatural phenomena as a primary element of plot, theme, or setting. Many works within the genre take place in imaginary worlds where magic is common...

 settings, have evolved naturally
Evolution
Evolution is any change across successive generations in the heritable characteristics of biological populations. Evolutionary processes give rise to diversity at every level of biological organisation, including species, individual organisms and molecules such as DNA and proteins.Life on Earth...

, been engineered
Genetic engineering
Genetic engineering, also called genetic modification, is the direct human manipulation of an organism's genome using modern DNA technology. It involves the introduction of foreign DNA or synthetic genes into the organism of interest...

 artificially (most often created as biological weapons), or be any illness that came forth from the (ab)use of technology
Technology
Technology is the making, usage, and knowledge of tools, machines, techniques, crafts, systems or methods of organization in order to solve a problem or perform a specific function. It can also refer to the collection of such tools, machinery, and procedures. The word technology comes ;...

.
Items in this list are followed by a brief description of symptoms and other details.

In literature

Name Source Symptoms
Andromeda Strain also known as La Linea Verde de Muerte; The Green Line of Death. Andromeda StrainThe Andromeda Strain
The Andromeda Strain
The Andromeda Strain , by Michael Crichton, is a techno-thriller novel documenting the efforts of a team of scientists investigating a deadly extraterrestrial microorganism that rapidly and fatally clots human blood, while in other people inducing insanity...


by Michael Crichton
Michael Crichton
John Michael Crichton , best known as Michael Crichton, was an American best-selling author, producer, director, and screenwriter, best known for his work in the science fiction, medical fiction, and thriller genres. His books have sold over 200 million copies worldwide, and many have been adapted...

A deadly, green, crystal
Crystal
A crystal or crystalline solid is a solid material whose constituent atoms, molecules, or ions are arranged in an orderly repeating pattern extending in all three spatial dimensions. The scientific study of crystals and crystal formation is known as crystallography...

line, extraterrestrial
Astrobiology
Astrobiology is the study of the origin, evolution, distribution, and future of life in the universe. This interdisciplinary field encompasses the search for habitable environments in our Solar System and habitable planets outside our Solar System, the search for evidence of prebiotic chemistry,...

 agent of indeterminate origin. It erodes the vessel walls of the circulatory system
Circulatory system
The circulatory system is an organ system that passes nutrients , gases, hormones, blood cells, etc...

, causing death by either triggering the body's coagulation
Coagulation
Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...

 response (resulting in the entire system clotting in a few seconds), or by cerebral
Human brain
The human brain has the same general structure as the brains of other mammals, but is over three times larger than the brain of a typical mammal with an equivalent body size. Estimates for the number of neurons in the human brain range from 80 to 120 billion...

 hematoma
Hematoma
A hematoma, or haematoma, is a localized collection of blood outside the blood vessels, usually in liquid form within the tissue. This distinguishes it from an ecchymosis, which is the spread of blood under the skin in a thin layer, commonly called a bruise...

s (accompanied by dementia
Dementia
Dementia is a serious loss of cognitive ability in a previously unimpaired person, beyond what might be expected from normal aging...

) if clotting is prevented. It evolves at a rapid rate, is spread by airborne transmission
Transmission (medicine)
In medicine and biology, transmission is the passing of a communicable disease from an infected host individual or group to a conspecific individual or group, regardless of whether the other individual was previously infected...

, and is extremely contagious
Infectious disease
Infectious diseases, also known as communicable diseases, contagious diseases or transmissible diseases comprise clinically evident illness resulting from the infection, presence and growth of pathogenic biological agents in an individual host organism...

.
Anton's Key Ender's Shadow
Ender's Shadow
Ender's Shadow is a parallel science fiction novel by the American author Orson Scott Card, taking place at the same time as the novel Ender's Game and depicting the same events from the point of view of Bean, a supporting character in the original novel. It was originally to be titled Urchin, but...


by Orson Scott Card
Orson Scott Card
Orson Scott Card is an American author, critic, public speaker, essayist, columnist, and political activist. He writes in several genres, but is primarily known for his science fiction. His novel Ender's Game and its sequel Speaker for the Dead both won Hugo and Nebula Awards, making Card the...

Genetic condition that causes the afflicted's brain to never stop growing; however, neither does the rest of his/her body, thus assuring that by the mid 20s the spine or heart will give out from extreme gigantism.
Arcan virus Arcan-Virus
by Andreas D. Hesse
Everyone on earth must get a weekly dose of the antiviral drug Carviron to keep from dying.
Atlantis Complex Artemis Fowl: The Atlantis Complex
Artemis Fowl: The Atlantis Complex
Artemis Fowl: The Atlantis Complex is the seventh book in the Artemis Fowl series...


by Eoin Colfer
Eoin Colfer
Eoin Colfer is an Irish author. He is most famous as the author of the Artemis Fowl series, but he has also written other successful books. His novels have been compared to the works of J. K. Rowling...

A psychosis common in guilt ridden fairies, but is contracted by Artemis by his dabbling in fairy magic. The symptoms include obsessive compulsive behavior, paranoia, multiple personality disorder, and in his case professing his love to Holly Short
Holly Short
Holly Short is a fictional character and a LEPrecon Captain in the Artemis Fowl book series by Eoin Colfer.-Character outline:Holly Short is a talkative and sarcastic elf with an auburn crew cut and hazel eyes, as well as the pointy ears and nut-brown skin typical of her species...

.
Bloodfire Blood Nation
Blood Nation
Blood Nation is a four-issue comic book mini-series by Platinum Studios. -Plot:In the future, the world is reeling from an outbreak of vampirism...

A virus that gestated in wolves two thousand years ago. The first to be infected was Genghis Khan
Genghis Khan
Genghis Khan , born Temujin and occasionally known by his temple name Taizu , was the founder and Great Khan of the Mongol Empire, which became the largest contiguous empire in history after his death....

. It causes the symptoms usually associated with vampirism, photosensitivity
Photosensitivity
Photosensitivity is the amount to which an object reacts upon receiving photons, especially visible light.- Human medicine :Sensitivity of the skin to a light source can take various forms. People with particular skin types are more sensitive to sunburn...

 and invincibility. The entire nation of Russia is infected, except for a few feral
Feral
A feral organism is one that has changed from being domesticated to being wild or untamed. In the case of plants it is a movement from cultivated to uncultivated or controlled to volunteer. The introduction of feral animals or plants to their non-native regions, like any introduced species, may...

 children. The virus can cause extreme mutation
Mutation
In molecular biology and genetics, mutations are changes in a genomic sequence: the DNA sequence of a cell's genome or the DNA or RNA sequence of a virus. They can be defined as sudden and spontaneous changes in the cell. Mutations are caused by radiation, viruses, transposons and mutagenic...

, for example the snake's tail present in the Khan's head scientist.
Captain Trips StandThe Stand
The Stand
The Stand is a post-apocalyptic horror/fantasy novel by American author Stephen King. It demonstrates the scenario in his earlier short story, Night Surf...


by Stephen King
Stephen King
Stephen Edwin King is an American author of contemporary horror, suspense, science fiction and fantasy fiction. His books have sold more than 350 million copies and have been adapted into a number of feature films, television movies and comic books...

A deadly, flu
Influenza
Influenza, commonly referred to as the flu, is an infectious disease caused by RNA viruses of the family Orthomyxoviridae , that affects birds and mammals...

-based virus. Created as a biological weapon codenamed Blue. Causes a lethally high fever and is highly contagious. It is deadly because as the body fights off the disease, it mutates into different strains of influenza, making immunity
Immunity (medical)
Immunity is a biological term that describes a state of having sufficient biological defenses to avoid infection, disease, or other unwanted biological invasion. Immunity involves both specific and non-specific components. The non-specific components act either as barriers or as eliminators of wide...

 next to impossible. Also called "Superflu", "tube neck", and "project blue".
Clone-Killing Nanovirus Star Wars Republic Commando: Hard Contact
Star Wars Republic Commando: Hard Contact
Republic Commando: Hard Contact is the tie-in novel to the video game Republic Commando, written by Karen Traviss.-Plot:The story begins during the Battle of Geonosis with Clone Commando Darman and his team assaulting a Separatist position. However, the entire squad is massacred in the attack, with...


by Karen Traviss
Karen Traviss
Karen Traviss is a science fiction author, and full-time novelist from Wiltshire, England. Originally from the Portsmouth area, Traviss worked as both a journalist and defence correspondent before turning her attention to writing fiction. She also served in both the Territorial Army and the Royal...

A nanovirus developed by the Confederacy of Independent Systems designed specifically to kill the clone
Cloning
Cloning in biology is the process of producing similar populations of genetically identical individuals that occurs in nature when organisms such as bacteria, insects or plants reproduce asexually. Cloning in biotechnology refers to processes used to create copies of DNA fragments , cells , or...

s of Jango Fett. Its creator, Ovolot Qail Uthan, is captured by Republic Commandos before her research is complete, however. In later books in the series, it is revealed (though not to any of the main characters, but to the reader through both Palpatine's and Dr. Uthan's private journals), Chancellor Palpatine secretly chooses not to completely destroy all evidence or research of the virus, but rather opts to hold onto it as a back-up plan, should the clone army ever be turned against him.
Brainpox "Cobra" The Cobra Event
The Cobra Event
The Cobra Event is a 1998 thriller novel by Richard Preston describing a terror attempt on the United States by a lone man, the creator of a virus, called "Cobra", that mixes the incurable common cold with one of the world's most deadly diseases, smallpox...

A genetically-engineered recombinant virus
Recombinant virus
A recombinant virus is a virus produced by recombining pieces of DNA using recombinant DNA technology. This may be used to produce viral vaccines or gene therapy vectors....

 made from the nuclear polyhedrosis virus
Nuclear Polyhedrosis Virus
The nuclear polyhedrosis virus which belongs to the sub group Baculoviruses is a virus affecting insects, predominantly moths and butterflies. It has been used as a pesticide for crops infested by insects susceptible to contraction...

, the rhinovirus
Rhinovirus
Human rhinoviruses are the most common viral infective agents in humans and are the predominant cause of the common cold. Rhinovirus infection proliferates in temperatures between 33–35 °C , and this may be why it occurs primarily in the nose...

, and smallpox
Smallpox
Smallpox was an infectious disease unique to humans, caused by either of two virus variants, Variola major and Variola minor. The disease is also known by the Latin names Variola or Variola vera, which is a derivative of the Latin varius, meaning "spotted", or varus, meaning "pimple"...

. It causes nightmares, fever, chills, runny nose, encephalitis (brain swelling), and herpes-like boils in the mouth and genitals, followed by a short period of aggression and autocannibalism preceding death. Used as a bioterror weapon.
Cibiscosis http://www.shelfari.com/glossary/Cibiscosis The Windup Girl
The Windup Girl
The Windup Girl is a biopunk science fiction novel written by Paolo Bacigalupi and published in September 2009. It was named as the ninth best fiction book of 2009 by TIME magazine, and as the best science fiction book of the year in the Reference and User Services Association's 2010 Reading List...

A genetically-engineered disease spread via South East Asian fruit crops that causes a lethal lung condition with Tuberculosis
Tuberculosis
Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...

-like symptoms. Used as competitive weapons by biotech companies undermining polities not buying genetically engineered seeds.
Cooties
Cooties
Cooties is in American childlore, a kind of STD usually found on the male penis infectious disease found only in boys. The term may have originated with references to lice, fleas, and other parasites. A child is said to "catch" cooties through any form of bodily contact, proximity, or touching of...

Various A term used by children in the USA, with varied meaning. "Cooties" generally refers to an invisible germ or bug, transferred by skin to skin contact, usually with a member of the opposite sex.
Collins' Syndrome The Legend of Deathwalker
The Legend of Deathwalker
The Legend of Deathwalker is an heroic fantasy novel written by British author David Gemmell, it was first published in 1996 and was reprinted in 1999. The book follows on from the novel The First Chronicles of Druss the Legend and was the 7th book to be released in the Drenai Series...

 by David Gemmell
David Gemmell
David Andrew Gemmell was a bestselling British author of heroic fantasy. A former journalist and newspaper editor, Gemmell had his first work of fiction published in 1984. He went on to write over thirty novels. Best known for his debut, Legend, Gemmell's works display violence, yet also explore...

A mutating disease that often starts with pain and sensitivity in the victims nipples, then forms a temporary tumor in the brain as it feeds upon the genetic material of the brain cells, sapping away the victims critical thinking skills and intelligence, once it reaches its critical density, the tumor disbands into the bloodstream, the virus going into a form of hibernation, leaving its victim in a state of near absolute uselessness. Once the virus detects that it has entered a new host due to differences in protein markers of the victims cells, the process begins again.
Descolada Speaker for the Dead
Speaker for the Dead
Speaker for the Dead is a science fiction novel by Orson Scott Card and an indirect sequel to the novel Ender's Game. This book takes place around the year 5270, some 3,000 years after the events in Ender's Game...


by Orson Scott Card
Orson Scott Card
Orson Scott Card is an American author, critic, public speaker, essayist, columnist, and political activist. He writes in several genres, but is primarily known for his science fiction. His novel Ender's Game and its sequel Speaker for the Dead both won Hugo and Nebula Awards, making Card the...

A quasi-conscious self-modifying organism capable of infecting any form of life. "Descolada" is also the Portuguese word for "unglued". In the context of the book, this refers to the Descolada virus's effects: it breaks the link of the DNA double helix (ungluing it) and induces mutations.
Diseasemaker's Croup Fragile Things
Fragile Things
Fragile Things: Short Fictions and Wonders is a collection of short stories and poetry by English author, Neil Gaiman. It was published in the US and UK in 2006 by HarperCollins and Headline Review....

 by Neil Gaiman
Neil Gaiman
Neil Richard Gaiman born 10 November 1960)is an English author of short fiction, novels, comic books, graphic novels, audio theatre and films. His notable works include the comic book series The Sandman and novels Stardust, American Gods, Coraline, and The Graveyard Book...

A disorder 'afflicting those who habitually and pathologically catalogue and construct diseases.' It is characterized by increasingly nonsensical speech and writing patterns and an obsessive insistence on trying to repeat previous statements out of context.
Fire-Us (Sounds like "Virus") Fire-Us series A viral infection that infects extremely fast and only infects those that produce sex hormones (i.e. those after puberty and women before menopause) or are taking medicine that include similar hormones. It was released by the President of the United States of America to start the world over, killing almost all adults within 2 weeks. As a result, children were left to fend for themselves, most of whom failed. Once all the targets of the virus were gone, it died out.
The Flare The Maze Runner Series by James Dashner
James Dashner
James Dashner is an American author of children's fantasy series and adult books, including The 13th Reality series and the Jimmy Fincher Saga. His novel The Journal of Curious Letters was chosen for a 2008 Borders Original Voices pick...

A disease erupting after The Scorch on Earth that Eats away at people's minds slowly making them crazed. Those infected seem normal and become mad in slow stages. Once past the Gone, death is certain, and death is inevitable for all infected by the Flare. The gone is the point where the infected is completely insane and will even eat people.
Foul-Drought Heir of Mistmantle by M. I. McAllisterThe Heir of Mistmantle
by M. I. McAllister
M. I. McAllister
Margaret I. McAllister is an English author of children's books, born in 1956. She grew up on the north-east coast of England. Her first book, A Friend for Rachel was published by the Oxford University Press in 1997...

Disease caused from drinking poisoned water. Animals who have it will have pain, blurry sight and some will eventually die.
Dryditch Fever Salamandastron
Salamandastron
Salamandastron is a fantasy novel by Brian Jacques, published in 1992. It is the fifth book in the Redwall series.-Plot introduction:Ferahgo the Assassin, a terrible weasel warlord, and his son Klitch lead their army of Corpsemakers to Salamandastron, to take over from the Badger Lord, Urthstripe...


by Brian Jacques
Brian Jacques
James Brian Jacques was an English author best known for his Redwall series of novels and Castaways of the Flying Dutchman series. He also completed two collections of short stories entitled The Ribbajack & Other Curious Yarns and Seven Strange and Ghostly Tales.-Biography:Brian Jacques was born...

A deadly disease causing weakness, hot flashes, chills, and dizziness. The victim is usually bedridden until eventual death. The only known cure are Flowers of Icetor boiled in spring water.
Gray DeathThe Gray Death Gail Carson Levine
Gail Carson Levine
Gail Carson Levine is an American author of young adult books. Her first novel, Ella Enchanted, received a Newbery Honor in 1998.-Early life:...

's The Two Princesses of Bamarre
The Two Princesses of Bamarre
The Two Princesses of Bamarre is a 2001 novel by Gail Carson Levine, the author of Ella Enchanted and several other books. The story revolves around the lives of two sisters who are very close, but as different as night and day. Adelina , the younger and fearful sister, is frightened by many...

Disease created from the noxious gas from the defeated dragon Yune's stomach. It comes on with no warning and is not contagious. There are three stages of the disease. The first stage is the weakness, and it can last anywhere from a week to six months. The second stage is the sleeping, and it always lasts nine days. The last stage is fever, and it always lasts three days. At the end of the fever stage, the victim will die. The only cure is water sent down from the fairies' Mount Ziriat. The cure will only be discovered when cowards find courage and rain falls over all Bamarre.
DX The Lost World
by Michael Crichton
Michael Crichton
John Michael Crichton , best known as Michael Crichton, was an American best-selling author, producer, director, and screenwriter, best known for his work in the science fiction, medical fiction, and thriller genres. His books have sold over 200 million copies worldwide, and many have been adapted...

An unknown prion
Prion
A prion is an infectious agent composed of protein in a misfolded form. This is in contrast to all other known infectious agents which must contain nucleic acids . The word prion, coined in 1982 by Stanley B. Prusiner, is a portmanteau derived from the words protein and infection...

 dubbed "DX" by scientists on Isla Sorna. It is similar to mad cow disease and was the result of feeding ground-up sheep to carnivorous dinosaurs. DX increased the mortality rate of newborn dinosaurs and is eventually fatal to adult dinosaurs. In order to combat DX, InGen scientists released animals into the wild of Isla Sorna. The prion initially infected carnivorous dinosaurs such as velociraptor
Velociraptor
Velociraptor is a genus of dromaeosaurid theropod dinosaur that existed approximately 75 to 71 million years ago during the later part of the Cretaceous Period. Two species are currently recognized, although others have been assigned in the past. The type species is V. mongoliensis; fossils...

s and procompsognathus
Procompsognathus
Procompsognathus is a genus of small theropod dinosaur that lived during the late Triassic period , about 210 million years ago. Procompsognathus was named by Eberhard Fraas in 1913. He named the type species, P...

, which would then spread the disease to herbivores such as apatosaurus
Apatosaurus
Apatosaurus , also known by the popular but scientifically deprecated synonym Brontosaurus, is a genus of sauropod dinosaur that lived from about 154 to 150 million years ago, during the Jurassic Period . It was one of the largest land animals that ever existed, with an average length of and a...

, and the apatosaur carcasses would be eaten by compys, which would then spread the disease to other carcasses, and the cycle would repeat. Ian Malcolm said at the end of the novel that, because of the imbalance of carnivores and herbivores due to DX, the dinosaurs were doomed to die out.
Ebola Gulf A DC Comics
DC Comics
DC Comics, Inc. is one of the largest and most successful companies operating in the market for American comic books and related media. It is the publishing unit of DC Entertainment a company of Warner Bros. Entertainment, which itself is owned by Time Warner...

Also known as "the Clench", due to the victims clenching their stomachs, Ebola Gulf is an evolved form of the ebola virus
Ebola
Ebola virus disease is the name for the human disease which may be caused by any of the four known ebolaviruses. These four viruses are: Bundibugyo virus , Ebola virus , Sudan virus , and Taï Forest virus...

 created by the terrorist mastermind Ra's Al Ghul
Ra's al Ghul
Ra's al Ghul is a DC Comics supervillain and is one of Batman's greatest enemies. His name in Arabic has been translated in the comics as "The Demon's Head" and references the name of the star Algol. Created by writer Dennis O'Neil and artist Neal Adams, he was introduced in Batman #232's...

 after he consulted the Wheel of Plagues.
Herod's Flu (SHEVA) Darwin's Radio
Darwin's Radio
Darwin's Radio is a 1999 science fiction novel by Greg Bear. It won the Nebula Award in 2000 for Best Novel and the 2000 Endeavour Award. It was also nominated for the Hugo Award, Locus and Campbell Awards the same year....

 by Greg Bear
Greg Bear
Gregory Dale Bear is an American science fiction and mainstream author. His work has covered themes of galactic conflict , artificial universes , consciousness and cultural practices , and accelerated evolution...

A contagious, sexually-transmitted human endogenous retrovirus (HERV) that causes flu-like symptoms and ultimately causes miscarriage of pregnancies. Though treated as a public health crisis by the Centers for Disease Control and Prevention
CDC
-Government:* Caisse des dépôts et consignations, a French government-controlled financial institution* California Department of Corrections, the US state of California's prison system...

 and World Health Organization
Who
Who may refer to:* Who , an English-language pronoun* who , a Unix command* Who?, one of the Five Ws in journalism- Art and entertainment :* Who? , a 1958 novel by Algis Budrys...

, the virus is later revealed to be a mechanism which causes rapid speciation
Speciation
Speciation is the evolutionary process by which new biological species arise. The biologist Orator F. Cook seems to have been the first to coin the term 'speciation' for the splitting of lineages or 'cladogenesis,' as opposed to 'anagenesis' or 'phyletic evolution' occurring within lineages...

 and accelerates evolution
Evolution
Evolution is any change across successive generations in the heritable characteristics of biological populations. Evolutionary processes give rise to diversity at every level of biological organisation, including species, individual organisms and molecules such as DNA and proteins.Life on Earth...

.
Hags Disease Cowboy Feng's Space Bar and Grille by Steven Brust
Steven Brust
Steven Karl Zoltán Brust is an American fantasy and science fiction author of Hungarian descent. He was a member of the writers' group The Scribblies, which included Emma Bull, Pamela Dean, Will Shetterly, Nate Bucklin, Kara Dalkey, and Patricia Wrede; he also belongs to the Pre-Joycean...

An incurable, virulently contagious disease, its symptoms only vaguely described in the novel, but which seems to end in victims melting or flattening (as is evident in comparisons of Hags victims with flounder). In the novel, the disease spread throughout human settled space, becoming a background to all events (particularly those in the novel).
Great Plague The Lord of the Rings
The Lord of the Rings
The Lord of the Rings is a high fantasy epic written by English philologist and University of Oxford professor J. R. R. Tolkien. The story began as a sequel to Tolkien's earlier, less complex children's fantasy novel The Hobbit , but eventually developed into a much larger work. It was written in...

by J.R.R. Tolkien
A mysterious disease which swept down through every single kingdom of Middle-earth
Middle-earth
Middle-earth is the fictional setting of the majority of author J. R. R. Tolkien's fantasy writings. The Hobbit and The Lord of the Rings take place entirely in Middle-earth, as does much of The Silmarillion and Unfinished Tales....

 during the mid 1600s of the Third Age of the Sun. The Plague's origins are unknown except it was possibly contracted from the Corsairs who attacked Gondor
Gondor
Gondor is a fictional kingdom in J. R. R. Tolkien's writings, described as the greatest realm of Men in the west of Middle-earth by the end of the Third Age. The third volume of The Lord of the Rings, The Return of the King, is concerned with the events in Gondor during the War of the Ring and with...

 in Third Age 1634, two years before the Plague occurred. The Plague was 90% fatal for nearly all inhabitants of Middle-earth, especially in Gondor and the North
Arnor
Arnor is a fictional kingdom in J. R. R. Tolkien's writings. Arnor, or the Northern Kingdom, was a kingdom of the Dúnedain in the land of Eriador in Middle-earth. The name probably means "Land of the King", from Sindarin Ara- + dor...

.
I-Pollen Degenerative Disorder DC Comics
DC Comics
DC Comics, Inc. is one of the largest and most successful companies operating in the market for American comic books and related media. It is the publishing unit of DC Entertainment a company of Warner Bros. Entertainment, which itself is owned by Time Warner...


Transmetropolitan
Transmetropolitan
Transmetropolitan is a cyberpunk comic book series written by Warren Ellis with art by Darick Robertson and published by DC Comics. The series was originally part of the short-lived DC Comics imprint Helix, but upon the end of the book's first year the series was moved to the Vertigo imprint as DC...

The hero Spider Jerusalem has I-Pollen Degenerative Disorder, a disease he gained as a result of coming into contact with Information-Pollen, pollen used to transmit information. In 98% of the cases, the disease will cause the victim to lose all motor and cognative skills. It is comparable to Alzheimer's and Parkinson's disease.
Jason Strain Friday the 13th: The Jason Strain
by Christa Faust
Christa Faust
Christa Faust is an American author who writes original novels, as well as novelizations and media tie-ins. Faust won the 2009 Crimespree Award for Money Shot.-Novels:*Control Freak...

A virus created when an artificial virus was exposed to undead killer Jason Voorhees
Jason Voorhees
Jason Voorhees is a fictional character from the Friday the 13th series of slasher films. He first appeared in Friday the 13th , as the son of camp cook-turned-murderer, Mrs. Voorhees, in which he was portrayed by Ari Lehman. Created by Victor Miller, with contributions by Ron Kurz, Sean S...

, it was originally meant to be a cure-all and age retarding
Geriatrics
Geriatrics is a sub-specialty of internal medicine and family medicine that focuses on health care of elderly people. It aims to promote health by preventing and treating diseases and disabilities in older adults. There is no set age at which patients may be under the care of a geriatrician, or...

 super drug. Those infected by the virus gain some select powers of Jason Voorhees, including superhuman strength
Superhuman strength
Superhuman strength, also called superstrength, super-strength, or super strength, is an ability commonly employed in fiction. It is the ability for a character to be stronger than humanly possible...

 and the inability to feel pain
Pain
Pain is an unpleasant sensation often caused by intense or damaging stimuli such as stubbing a toe, burning a finger, putting iodine on a cut, and bumping the "funny bone."...

, but intelligence
Intelligence
Intelligence has been defined in different ways, including the abilities for abstract thought, understanding, communication, reasoning, learning, planning, emotional intelligence and problem solving....

 is severely reduced. Those infected with the virus can only be killed via decapitation
Decapitation
Decapitation is the separation of the head from the body. Beheading typically refers to the act of intentional decapitation, e.g., as a means of murder or execution; it may be accomplished, for example, with an axe, sword, knife, wire, or by other more sophisticated means such as a guillotine...

. A cure for the virus is developed and released into the air and the original carrier, Jason (who was not affected by the airborne cure due to unique physiology) is rid of it when a heavy dosage of the cure is injected directly into his brain.
Life-Eater Virus Warhammer 40,000
Warhammer 40,000
Warhammer 40,000 is a tabletop miniature wargame produced by Games Workshop, set in a dystopian science fantasy universe. Warhammer 40,000 was created by Rick Priestley in 1987 as the futuristic companion to Warhammer Fantasy Battle, sharing many game mechanics...

novels
The Life-eater virus is a form of necrotizing fasciitis
Necrotizing fasciitis
Necrotizing fasciitis , commonly known as flesh-eating disease or Flesh-eating bacteria syndrome, is a rare infection of the deeper layers of skin and subcutaneous tissues, easily spreading across the fascial plane within the subcutaneous tissue.Necrotizing fasciitis is a quickly progressing and...

 that causes all biological matter to break down into its component parts, releasing toxic, flammable gas that can be ignited with a single explosion. The virus eats itself when there is nothing else to attack. It is quite effective against Tyrranids. In the short-story anthology Planetkill, an updated strain goes after the soul
Soul
A soul in certain spiritual, philosophical, and psychological traditions is the incorporeal essence of a person or living thing or object. Many philosophical and spiritual systems teach that humans have souls, and others teach that all living things and even inanimate objects have souls. The...

, turning the population into zombies, created by a Techpriest inhabited by a daemonic Unclean One.
Krytos virus Star Wars Expanded Universe"Star Wars Expanded Universe
Star Wars Expanded Universe
The Star Wars Expanded Universe encompasses all of the officially licensed, fictional background of the Star Wars universe, outside of the six feature films produced by George Lucas. The expanded universe includes books, comic books, video games, spin-off films like Star Wars: The Clone Wars,...

"
The Krytos virus was a deadly and highly contagious virus that only attacked non-human species. It could spread via a number of avenues, including by water supplies
Waterborne diseases
Waterborne diseases are caused by pathogenic microorganisms which are directly transmitted when contaminated fresh water is consumed. Contaminated fresh water, used in the preparation of food, can be the source of foodborne disease through consumption of the same microorganisms...

 and by air. The virus often killed its host in less than two weeks, resulting in a painful death.
Red DeathThe Red Death
The Red Death
The Red Death were a death metal band from Bath, New York.-History:Formed in 2002 after the demise of Another Day Forgotten by singer Paul Hamblin, guitarist Josh Williammee, and drummer Graham Mitchell, the original lineup was rounded out by guitarist Brian VanGelder and bassist Karl Janovec...

Masque of the Red Death by Edgar Allan Poe"The Masque of the Red Death
The Masque of the Red Death
"The Masque of the Red Death", originally published as "The Mask of the Red Death" , is a short story by Edgar Allan Poe. The story follows Prince Prospero's attempts to avoid a dangerous plague known as the Red Death by hiding in his abbey. He, along with many other wealthy nobles, has a...

"
by Edgar Allan Poe
Edgar Allan Poe
Edgar Allan Poe was an American author, poet, editor and literary critic, considered part of the American Romantic Movement. Best known for his tales of mystery and the macabre, Poe was one of the earliest American practitioners of the short story and is considered the inventor of the detective...

Victims bleed from their pores
Sebaceous gland
The sebaceous glands are microscopic glands in the skin that secrete an oily/waxy matter, called sebum, to lubricate and waterproof the skin and hair of mammals...

 before eventually dying. See also: Scarlet Plague.
RipleyThe Ripley Dreamcatcher
Dreamcatcher (novel)
Dreamcatcher is a horror novel written by Stephen King. It was adapted into a 2003 movie of the same name. The book, written longhand, was the author's tool for recuperation from a 1999 car accident, and was completed in half a year...


by Stephen King
Stephen King
Stephen Edwin King is an American author of contemporary horror, suspense, science fiction and fantasy fiction. His books have sold more than 350 million copies and have been adapted into a number of feature films, television movies and comic books...

An alien parasitoid
Parasitoid
A parasitoid is an organism that spends a significant portion of its life history attached to or within a single host organism in a relationship that is in essence parasitic; unlike a true parasite, however, it ultimately sterilises or kills, and sometimes consumes, the host...

 macrovirus. The adult aliens resemble deformed potato beings with legs, while the younger aliens — nicknamed "shit-weasels" because they can be created in a host organism's
Host (biology)
In biology, a host is an organism that harbors a parasite, or a mutual or commensal symbiont, typically providing nourishment and shelter. In botany, a host plant is one that supplies food resources and substrate for certain insects or other fauna...

 stomach and escape by eating their host's body between the stomach
Stomach
The stomach is a muscular, hollow, dilated part of the alimentary canal which functions as an important organ of the digestive tract in some animals, including vertebrates, echinoderms, insects , and molluscs. It is involved in the second phase of digestion, following mastication .The stomach is...

 and anus
Anus
The anus is an opening at the opposite end of an animal's digestive tract from the mouth. Its function is to control the expulsion of feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest,...

 — are legless, smaller versions of the adult alien. Both adult and young aliens have a mouth consisting of a slit on the underside of the head that goes down the length of the worm. The lips separate to reveal hundreds of teeth that can bite through steel.
McLendon's Syndrom McLendon's Syndrome by Robert A. Frezza Described as a "slow bacillus" like leprosy, McLendon's Syndrome is a fictional condition the symptoms of which resemble vampirism: sensitivity to sunlight, extreme food allergies (in the novel, an affected character reports that some of McLendon's subjects were only able to ingest blood), increased strength. Like leprosy, it is transmitted through extended contact with an infected individual or individuals (in the novel, it is established that transmission can also occur through sex). Emphasis by affected characters is on the disease's inconvenient side effects, and it is described as being a highly idiosyncratic illness, with a broad range of symptoms manifesting variously in its victims.
Mycetic Spores Warhammer 40,000
Warhammer 40,000
Warhammer 40,000 is a tabletop miniature wargame produced by Games Workshop, set in a dystopian science fantasy universe. Warhammer 40,000 was created by Rick Priestley in 1987 as the futuristic companion to Warhammer Fantasy Battle, sharing many game mechanics...

novels
Tyranid organisms that infect and break down aerobic organism
Aerobic organism
An aerobic organism or aerobe is an organism that can survive and grow in an oxygenated environment.Faculitative anaerobes grow and survive in an oxygenated environment and so do aerotolerant anaerobes.-Glucose:...

s (creatures that survive in oxygenated environments) into raw biomatter for collection by Ripper swarms and subsequent digestion and manipulation. There are larger strains, such as Spore Mines, which are filled with acid, smaller Mycetic Spores, or bone shrapnel, and even ones developed into drop-pods. Apparently named for the real-life fungal infection mycetoma
Eumycetoma
Eumycetoma is a chronic, specific, granulomatous, fungal disease. It mainly affects the foot; and Mycetoma pedis is also known as Madura foot. This infection is endemic in Africa, India, and Central and South America.-Causes and presentation:...

, which causes a rash and pustules.
Neurodermatitis Dark Benediction (1951)
by Walter Miller Jr.
Walter M. Miller, Jr.
Walter Michael Miller, Jr. was an American science fiction author. Today he is primarily known for A Canticle for Leibowitz, the only novel he published in his lifetime. Prior to its publication he was a prolific writer of short stories.- Biography :Miller was born in New Smyrna Beach, Florida...

A pathogen
Pathogen
A pathogen gignomai "I give birth to") or infectious agent — colloquially, a germ — is a microbe or microorganism such as a virus, bacterium, prion, or fungus that causes disease in its animal or plant host...

 causing rapid nervous system evolution and development of new sensory organs, which causes synesthetic psychosis in unprepared hosts. Sent to Earth by an alien race living in symbiosis with it, in the hopes of furthering other races' advance. Designed for controlled delivery, it is turned into a plague by a curious retriever's cutting the vessel with an hacksaw.
Scarlet Plague Scarlet Plague by Jack LondonThe Scarlet Plague
The Scarlet Plague
The Scarlet Plague is a post-apocalyptic fiction novel written by Jack London and originally published in London Magazine in 1912.The story takes place in 2073, sixty years after an uncontrollable epidemic, the Red Death, has depopulated the planet...


by Jack London
Jack London
John Griffith "Jack" London was an American author, journalist, and social activist. He was a pioneer in the then-burgeoning world of commercial magazine fiction and was one of the first fiction writers to obtain worldwide celebrity and a large fortune from his fiction alone...

This 1912 novella, also known as the Scarlet Death, is a work of post-apocalyptic fiction
Apocalyptic and post-apocalyptic fiction
Apocalyptic fiction is a sub-genre of science fiction that is concerned with the end of civilization due to a potentially existential catastrophe such as nuclear warfare, pandemic, extraterrestrial attack, impact event, cybernetic revolt, technological singularity, dysgenics, supernatural...

 treating the world after civilization has been destroyed by this fictional disease.
Shiva Rainbow Six
Rainbow Six
Tom Clancy's Rainbow Six is a media franchise created by American author Tom Clancy about a fictional international counter-terrorist unit called "Rainbow." The franchise began with Clancy's novel Rainbow Six, which was adapted into a successful series of tactical first-person shooter video games.-...


by Tom Clancy
Tom Clancy
Thomas Leo "Tom" Clancy, Jr. is an American author, best known for his technically detailed espionage, military science, and techno thriller storylines set during and in the aftermath of the Cold War, along with video games on which he did not work, but which bear his name for licensing and...

A artificial virus created by the means of biotechnology and based upon the Ebola
Ebola
Ebola virus disease is the name for the human disease which may be caused by any of the four known ebolaviruses. These four viruses are: Bundibugyo virus , Ebola virus , Sudan virus , and Taï Forest virus...

 agent to help the aim of a group of eco-terrorists in annihilating mankind.
Snow Crash Snow Crash
Snow Crash
Snow Crash is Neal Stephenson's third novel, published in 1992. Like many of Stephenson's other novels it covers history, linguistics, anthropology, archaeology, religion, computer science, politics, cryptography, memetics, and philosophy....


by Neal Stephenson
Neal Stephenson
Neal Town Stephenson is an American writer known for his works of speculative fiction.Difficult to categorize, his novels have been variously referred to as science fiction, historical fiction, cyberpunk, and postcyberpunk...

A dangerous drug which is both a computer virus
Computer virus
A computer virus is a computer program that can replicate itself and spread from one computer to another. The term "virus" is also commonly but erroneously used to refer to other types of malware, including but not limited to adware and spyware programs that do not have the reproductive ability...

 capable of infecting the brains of unwary hackers in the Metaverse and a mind-altering virus distributed by a network of Pentecostal churches
Pentecostalism
Pentecostalism is a diverse and complex movement within Christianity that places special emphasis on a direct personal experience of God through the baptism in the Holy Spirit, has an eschatological focus, and is an experiential religion. The term Pentecostal is derived from Pentecost, the Greek...

 via its infrastructure and belief system. Both forms cause glossolalia
Glossolalia
Glossolalia or speaking in tongues is the fluid vocalizing of speech-like syllables, often as part of religious practice. The significance of glossolalia has varied with time and place, with some considering it a part of a sacred language...

, and the computer virus form appears as a snowy pattern of pixels.
Solanum (also styled as "African Rabies" early in the outbreak) The Zombie Survival Guide
The Zombie Survival Guide
The Zombie Survival Guide, written by American author Max Brooks and published in 2003, is a survival manual dealing with the fictional potentiality of a zombie attack. It contains detailed plans for the average citizen to survive zombie uprisings of varying intensity and reach, and describes...


by Max Brooks
Max Brooks
Maximillian Michael "Max" Brooks is an American author and screenwriter, with a particular interest in zombies. Brooks is also a television and voice-over actor.- Early life and education :...

/World War Z: An Oral History of the Zombie War by Max Brooks
A virus that creates zombies by transforming the brain, then reanimating the infected. Bodily functions vary in how they are affected by the virus; some function in their original or modified state, while others remain dormant. The infected brain's oxygen-independence is a notable feature, allowing the animated dead to persist underwater for long periods. Reanimation occurs solely in humans; animals simply die from infection. Ingesting contaminated flesh is permanently fatal. The disease is contracted by direct contact with infected individuals/bodies. Upon infection, the victim succumbs to bouts of high fevers, hallucinations, headaches, and vomiting spasms, before being officially declared dead a few hours later as the virus replicates through the brain. Approximately twenty-two hours later, the victim's corpse reanimates as a zombie.
Spattergroit Harry Potter and the Order of the Phoenix
Harry Potter and the Order of the Phoenix
Harry Potter and the Order of the Phoenix is the fifth in the Harry Potter series written by J. K. Rowling, and was published on 21 June 2003 by Bloomsbury in the United Kingdom, Scholastic in the United States, and Raincoast in Canada...

 and Harry Potter and the Deathly Hallows
A disease that covers the victim in purple pustules and renders them unable to speak. It may be a type of fungus, as Ron Weasley
Ron Weasley
Ronald Bilius "Ron" Weasley is a fictional character and one of the three protagonists in the Harry Potter book series written by J. K. Rowling. His first appearance was in the first book of the series, Harry Potter and the Philosopher's Stone as the best friend of Harry Potter and Hermione Granger...

 says that the effect of being unable to speak occurs “once the fungus has spread to your uvula”. The only known cure, according to the portrait of a Healer in St. Mungo's Hospital for Magical Maladies and Injuries, is to bind the liver
Liver
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion...

 of a toad
Toad
A toad is any of a number of species of amphibians in the order Anura characterized by dry, leathery skin , short legs, and snoat-like parotoid glands...

 around the victim's throat and stand nude in a barrel of eel
Eel
Eels are an order of fish, which consists of four suborders, 20 families, 111 genera and approximately 800 species. Most eels are predators...

's eyes under a full moon. The portrait said that he believed Ron had this disease, due to the "unsightly blemishes
Freckle
For other uses of the word, see Freckles .Freckles are clusters of concentrated melanin which are most often visible on people with a fair complexion. A freckle is also called an "ephelis". Freckles do not have an increased number of melanin producing cells...

" on his face. Ron would later use this disease in Harry Potter and the Deathly Hallows as an excuse as to why he was unable to return to Hogwarts
Hogwarts
Hogwarts School of Witchcraft and Wizardry or simply Hogwarts is the primary setting for the first six books of the Harry Potter series by J. K. Rowling, with each book lasting the equivalent of one school year. It is a fictional boarding school of magic for witches and wizards between the ages of...

, when in actuality he and his friends were out searching for Lord Voldemort
Lord Voldemort
Lord Voldemort is the main antagonist of the Harry Potter series written by British author J. K. Rowling. Voldemort first appeared in Harry Potter and the Philosopher's Stone, which was released in 1997...

's Horcruxes.
Stone Sickness The Edge Chronicles
The Edge Chronicles
The Edge Chronicles is a young-adult fantasy novel series by Paul Stewart and Chris Riddell. It consists of three trilogies, plus three additional books, and others . Originally published in the United Kingdom, this series has since been published in the United States, Canada and Australia. To...

by Paul Stewart
Paul Stewart (writer)
Paul Stewart is a writer of children's books, best known for the bestselling The Edge Chronicles, the Free Lance novels and the Far Flung Adventures series which are written in collaboration with the illustrator Chris Riddell...

 and Chris Riddell
Chris Riddell
Chris Riddell is a British illustrator and occasional writer of children's literature, and a political cartoonist for The Observer. He has won the Kate Greenaway Medal twice and the Nestlé Smarties Book Prize seven times....

Not a human disease, but one which affects humans and other inhabitants of the Edge by attacking the rocks of the flight ships which is the primary means of transport and communication on the Edge. As the flight ships are carried aloft by the rocks, this puts an end to business and trade, resulting in a brief societal collapse followed by a gradual rebuilding of society when the Edge's inhabitants become accustomed to life with Stone-sickness. Symptoms of infected flight rocks include a brief scar, followed by an open wound and a gaping hole as the rock dissolves. Eventually the sky ship drops clean out of the sky. Many theories abound on the origin of Stone-sickness. Some people blame the gods. Others blame the Mother Storm, the mysterious meteorlogical creator of the Edge. Some say that the sky pirate captain Cloud Wolf who perished in the Mother Storm somehow infected her and the Stone-sickness is a result of his pestilence. It is only at the end of the series that it is revealed the Gloamglozer created the disease and it had been incubating inside the Stone Gardens ever since he fled the city of Sanctaphrax almost a century before the sickness.
"T4 Angel Virus" Hollows (series) by Kim Harrison
Kim Harrison
Kim Harrison is a nom de plume of American author Dawn Cook. Under the name of Harrison, she is best known for her Rachel Morgan urban fantasy series set in an alternate history where a worldwide pandemic caused by genetically modified tomatoes led to the death of a large portion of the world's...

The result of genetic engineering, the T4 Angel Virus was spread by infected tomatoes. It wiped out a large percentage of humanity, along with the elves and several other species which had been secretly coexisting. Other species unaffected by the virus, such as witches, vampires, and werewolves, soon equaled humanity's depleted numbers and began living openly. Tomatoes are still feared and shunned by humans throughout the series.
"Teen Plague" Black Hole
Black Hole (comics)
Black Hole was a twelve-issue comic book limited series written and illustrated by Charles Burns and published first by Kitchen Sink Press and then Fantagraphics...

by Charles Burns
Charles Burns (cartoonist)
Charles Burns is an American cartoonist, illustrator and film director.-Life:Burns is renowned for his meticulous, high-contrast and creepy artwork and stories. He lives in Philadelphia with his wife, painter Susan Moore, and their two daughters Ava and Rae-Rae.His father was an oceanographer for...

Also known as the "bug." It is a mutagenic STD which causes grotesque mutations, such as extra body parts, to grow all over the body. Seems to affect only teenagers.
The Pulse Cell
Cell (novel)
Cell is an apocalyptic horror novel published by American author Stephen King in 2006. The story follows a New England artist struggling to reunite with his young son after a mysterious signal broadcast over the global cell phone network turns the majority of his fellow humans into mindless vicious...

by Stephen King
Stephen King
Stephen Edwin King is an American author of contemporary horror, suspense, science fiction and fantasy fiction. His books have sold more than 350 million copies and have been adapted into a number of feature films, television movies and comic books...

A powerful virus which lies dormant inside mobile phones and which requires a powerful signal to set off. The exact unleashers are unknown, but are implied to be a terrorist group due to numerous theories in the novel. The virus is implied to have been released just after September 11th, and lain dormant in cell phones ever since. Once the right signal is transmitted and leaked into incoming phone calls, the caller's brain cells immediately disintegrate and they are unable to recognize friend from foe; they are even unable to recognize other people infected with the virus. Inevitably, the infected callers become psychotic and start killing each other, the chaos of which lasts approximately two days before the infected callers have become "stable" enough to cooperate and recognize each other.
V-CIDS ImmortalsThe Immortals
The Immortals (novel)
The Immortals by Tracy Hickman is a science fiction novel originally published in hardcover by Roc. The novel describes a future America in which a virus similar to AIDS has panicked the U.S. government into setting up internment camps to contain the sufferers...

An AIDS
AIDS
Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the human immunodeficiency virus...

-like virus.
Vampiris I Am Legend
by Richard Matheson
Richard Matheson
Richard Burton Matheson is an American author and screenwriter, primarily in the fantasy, horror, and science fiction genres. He is perhaps best known as the author of What Dreams May Come, Bid Time Return, A Stir of Echoes, The Incredible Shrinking Man, and I Am Legend, all of which have been...

A bacillus
Bacillus
Bacillus is a genus of Gram-positive, rod-shaped bacteria and a member of the division Firmicutes. Bacillus species can be obligate aerobes or facultative anaerobes, and test positive for the enzyme catalase. Ubiquitous in nature, Bacillus includes both free-living and pathogenic species...

 (rod-shaped) bacterium that causes photosensitivity, hysterical blindness near mirrors, overdevelopment of canine teeth, and production of a bulletproof adhesive. Victims feed on blood. While in the body, it is anaerobic, and causes the victim to exhibit zombie-like behavior. Outside the body, it sporulates into dust. If an infected person is cut deep enough, the bacteria turns them into powder. Can be treated, but not cured, with a pill containing a fusion inhibitor and dehydrated blood.
Venus Particle Tyrannosaur Canyon
Tyrannosaur Canyon
Tyrannosaur Canyon is a 2005 novel by Douglas Preston. The story revolves around the search for a mysterious item buried in the New Mexico desert.-Plot summary:The novel opens with a lunar find by the Apollo 17 astronauts, which is suppressed....

An extraterrestrial infectious particle found in a lunar rock sample and within a fantastically well-preserved tyrannosaur fossil in the New Mexico desert. It is later revealed that the organism came to Earth via the Chicxulub
Chicxulub Crater
The Chicxulub crater is an ancient impact crater buried underneath the Yucatán Peninsula in Mexico. Its center is located near the town of Chicxulub, after which the crater is named...

 asteroid which wiped out the dinosaurs. The particle, which was named for its resemblance to the symbol of Venus
Venus
Venus is the second planet from the Sun, orbiting it every 224.7 Earth days. The planet is named after Venus, the Roman goddess of love and beauty. After the Moon, it is the brightest natural object in the night sky, reaching an apparent magnitude of −4.6, bright enough to cast shadows...

 and femininity, causes rapid mitosis
Mitosis
Mitosis is the process by which a eukaryotic cell separates the chromosomes in its cell nucleus into two identical sets, in two separate nuclei. It is generally followed immediately by cytokinesis, which divides the nuclei, cytoplasm, organelles and cell membrane into two cells containing roughly...

 and apparent cellular differentiation
Cellular differentiation
In developmental biology, cellular differentiation is the process by which a less specialized cell becomes a more specialized cell type. Differentiation occurs numerous times during the development of a multicellular organism as the organism changes from a simple zygote to a complex system of...

 in its host.
(unknown) The Walking Dead
The Walking Dead
The Walking Dead is a monthly black-and-white US comic book series published by Image Comics beginning in 2003. The comic was created by writer Robert Kirkman and artist Tony Moore, who was replaced by Charlie Adlard from issue #7 onward, although Moore continued to do the covers through issue...

An unnamed disease of unknown origin. When a human is infected by it, the disease will infect all cells, eventually resulting in the clinical death
Clinical death
Clinical death is the medical term for cessation of blood circulation and breathing, the two necessary criteria to sustain life. It occurs when the heart stops beating in a regular rhythm, a condition called cardiac arrest. The term is also sometimes used in resuscitation research.Stopped blood...

 of the host. The symptoms that occur before the victim's clinical death, include fever
Fever
Fever is a common medical sign characterized by an elevation of temperature above the normal range of due to an increase in the body temperature regulatory set-point. This increase in set-point triggers increased muscle tone and shivering.As a person's temperature increases, there is, in...

, headache
Headache
A headache or cephalalgia is pain anywhere in the region of the head or neck. It can be a symptom of a number of different conditions of the head and neck. The brain tissue itself is not sensitive to pain because it lacks pain receptors. Rather, the pain is caused by disturbance of the...

, fatigue, confusion
ConFusion
ConFusion is an annual science fiction convention organized by the Stilyagi Air Corps and its parent organization, the Ann Arbor Science Fiction Association. Commonly, it is held the third weekend of January. It is the oldest science fiction convention in Michigan, a regional, general SF con...

, hallucinations and paralysis
Paralysis
Paralysis is loss of muscle function for one or more muscles. Paralysis can be accompanied by a loss of feeling in the affected area if there is sensory damage as well as motor. A study conducted by the Christopher & Dana Reeve Foundation, suggests that about 1 in 50 people have been diagnosed...

. The disease has a very short incubation period
Incubation period
Incubation period is the time elapsed between exposure to a pathogenic organism, a chemical or radiation, and when symptoms and signs are first apparent...

 of around 16 hours. Approximately 12 hours after the victim's clinical death, the host will be revitalized and will wake up exhibiting zombie
Zombie
Zombie is a term used to denote an animated corpse brought back to life by mystical means such as witchcraft. The term is often figuratively applied to describe a hypnotized person bereft of consciousness and self-awareness, yet ambulant and able to respond to surrounding stimuli...

-like behavior. However the disease will only activate one brain function: the brain-stem, where feeding is controlled. The host becomes a violent mindless cannibal, and can infect other people by biting. The disease leads to society's collapse and results in a world stricken by a zombie apocalypse
Zombie apocalypse
A zombie apocalypse is a particular scenario of apocalyptic literature that customarily has a science fiction/horror rationale. In a zombie apocalypse, a widespread rise of zombies hostile to human life engages in a general assault on civilization....

.
White Blindness Blindness
Blindness (novel)
Blindness is a novel by Portuguese author José Saramago. It was originally published in Portuguese and then translated into English. It is one of his most famous novels, along with The Gospel According to Jesus Christ and Baltasar and Blimunda....


by José Saramago
José Saramago
José de Sousa Saramago, GColSE was a Nobel-laureate Portuguese novelist, poet, playwright and journalist. His works, some of which can be seen as allegories, commonly present subversive perspectives on historic events, emphasizing the human factor. Harold Bloom has described Saramago as "a...

A mysterious epidemic
Epidemic
In epidemiology, an epidemic , occurs when new cases of a certain disease, in a given human population, and during a given period, substantially exceed what is expected based on recent experience...

 of sudden blindness
Blindness
Blindness is the condition of lacking visual perception due to physiological or neurological factors.Various scales have been developed to describe the extent of vision loss and define blindness...

 affecting virtually all humanity, leading to society's collapse. So-called because victims see nothing but a white glare. Not to be confused with the White Blindness in Watership Down
Watership Down
Watership Down is a classic heroic fantasy novel, written by English author Richard Adams, about a small group of rabbits. Although the animals in the story live in their natural environment, they are anthropomorphised, possessing their own culture, language , proverbs, poetry, and mythology...

which is a name the rabbits use for the real illness Myxomatosis
Myxomatosis
Myxomatosis is a disease that affects rabbits and is caused by the Myxoma virus. It was first observed in Uruguay in laboratory rabbits in the late 19th century. It was introduced into Australia in 1950 in an attempt to control the rabbit population...

 which affects rabbits causing blindness and death.
Plague of Insomnia One Hundred Years of Solitude
One Hundred Years of Solitude
One Hundred Years of Solitude , by Gabriel García Márquez, is a novel which tells the multi-generational story of the Buendía family, whose patriarch, José Arcadio Buendía, founds the town of Macondo, the metaphoric Colombia...


by Gabriel García Márquez
Gabriel García Márquez
Gabriel José de la Concordia García Márquez is a Colombian novelist, short-story writer, screenwriter and journalist, known affectionately as Gabo throughout Latin America. He is considered one of the most significant authors of the 20th century. He was awarded the Nobel Prize in Literature in...

An epidemic brought into the Buendía household and the town of Macondo by Rebeca; the adopted daughter of José Arcadio Buendía and Úrsula Iguarán. This plague, originally coming from the northern Indian kingdoms in La Guajira (Colombia), is identified by the symptoms of wide-open, glowing eyes like those of a cat, and the impossibility of sleeping
Insomnia
Insomnia is most often defined by an individual's report of sleeping difficulties. While the term is sometimes used in sleep literature to describe a disorder demonstrated by polysomnographic evidence of disturbed sleep, insomnia is often defined as a positive response to either of two questions:...

. Those infected (in the novel consisting of the entire town of Macondo) feel no tiredness or sleepiness whatsoever and hence can work all day and night. However, as time advances, those infected begin to lose all their memories
Amnesia
Amnesia is a condition in which one's memory is lost. The causes of amnesia have traditionally been divided into categories. Memory appears to be stored in several parts of the limbic system of the brain, and any condition that interferes with the function of this system can cause amnesia...

 and knowledge of the world; ultimately leaving them in a state in which they have forgotten the names and uses of all things and their own identities. The plague is generally seen as one of the most prominent demonstrations of magical realism in García Márquez's literary works.
White Disease White Disease by Karel ČapekThe White Disease
The White Disease
The White Disease is a play written by Czech novelist Karel Čapek in 1937. Written at a time of increasing threat from Nazi Germany to Czechoslovakia, it portrays a human response to a tense, prewar situation in an unnamed country that greatly resembles Germany with one extra, somewhat absurd...


by Karel Čapek
Karel Capek
Karel Čapek was Czech writer of the 20th century.-Biography:Born in 1890 in the Bohemian mountain village of Malé Svatoňovice to an overbearing, emotional mother and a distant yet adored father, Čapek was the youngest of three siblings...

An incurable mysterious form of leprosy
Leprosy
Leprosy or Hansen's disease is a chronic disease caused by the bacteria Mycobacterium leprae and Mycobacterium lepromatosis. Named after physician Gerhard Armauer Hansen, leprosy is primarily a granulomatous disease of the peripheral nerves and mucosa of the upper respiratory tract; skin lesions...

, killing people older than 30.
White Plague White Plague by Frank HerbertThe White Plague
The White Plague
The White Plague is a science fiction novel by Frank Herbert.-Plot:When an IRA bomb goes off, the wife and children of molecular biologist John Roe O'Neill are killed on May 20, 1996. Driven halfway insane by loss, his mind fragments into several personalities that carry out his plan for him. He...


by Frank Herbert
Frank Herbert
Franklin Patrick Herbert, Jr. was a critically acclaimed and commercially successful American science fiction author. Although a short story author, he is best known for his novels, most notably Dune and its five sequels...

A genetically engineered virus that kills only women. Released only on Irish
Irish people
The Irish people are an ethnic group who originate in Ireland, an island in northwestern Europe. Ireland has been populated for around 9,000 years , with the Irish people's earliest ancestors recorded having legends of being descended from groups such as the Nemedians, Fomorians, Fir Bolg, Tuatha...

, English
English people
The English are a nation and ethnic group native to England, who speak English. The English identity is of early mediaeval origin, when they were known in Old English as the Anglecynn. England is now a country of the United Kingdom, and the majority of English people in England are British Citizens...

, and Libya
Libya
Libya is an African country in the Maghreb region of North Africa bordered by the Mediterranean Sea to the north, Egypt to the east, Sudan to the southeast, Chad and Niger to the south, and Algeria and Tunisia to the west....

n populace.
Legacy Virus
Legacy Virus
In the fictional Marvel Universe, the Legacy Virus was a devastating plague that ripped through the mutant population, killing hundreds and mutating so that it affected baseline humans as well....

Marvel Multiverse A disease that targets only mutants
Mutant (Marvel Comics)
In comic books published by Marvel Comics, a mutant is an organism who possesses a genetic trait called an X-gene that allows the mutant to naturally develop superhuman powers and abilities...

, causing genetic and biological degradation and eventual death; shortly before death, the virus' effects will cause a violent, uncontrolled flare-up of the victim's superhuman abilities
Superpower (ability)
Superpower is a popular culture term for a fictional superhuman ability. When a character possesses multiple such abilities, the terms super powers or simply powers are used...

.

In film

Name Source Symptoms
Brain Cloud Joe Versus the Volcano
Joe Versus the Volcano
Joe Versus the Volcano is a 1990 comedy film written and directed by John Patrick Shanley and starring Tom Hanks and—in three roles—Meg Ryan. The film is writer Shanley's directorial debut and the first of three films pairing Hanks and Ryan....

The brain cloud has no symptoms—apart from quickly and painlessly killing in about six months.
ComaThe Coma
The Coma
The Coma, is novel by Alex Garland, illustrated by his father, Nicholas Garland. It explores the boundary between the conscious and subconscious mind. The Coma was published in 2004, eight years after Garland's first novel, The Beach....

PlagueClive Barker
Clive Barker
Clive Barker is an English author, film director and visual artist best known for his work in both fantasy and horror fiction. Barker came to prominence in the mid-1980s with a series of short stories which established him as a leading young horror writer...

's The Plague
The Plague (film)
The Plague is a 2006 horror film directed by Hal Masonberg and written by Masonberg and Teal Minton; it was also co-produced by Clive Barker.-Plot:...

Affects all children. Induces a 10 year coma, after which the children simultaneously wake up and desire to kill all adults.
Carnosaur virus Carnosaur
Carnosaur (film)
Carnosaur is a 1993 horror film starring Diane Ladd as a mad scientist who plans to recreate dinosaurs and destroy humanity. The film is loosely based on a the novel Carnosaur by John Brosnan that was released in 1984, but the two have little in common...

A genetically engineered virus created by Dr. Jane Tiptree. Infects fertile women of child-bearing age (including Dr. Tiptree herself), making them pregnant with a dinosaur. Rather than being born, upon maturation the dinosaurs tear their way out of the womb, killing the woman in the process.
La Muerte Roja
(Red Death)
Osmosis Jones
Osmosis Jones
Osmosis Jones is a 2001 live-action/animated comedy film directed by Tom Sito and Piet Kroon for the animated segments and the Farrelly brothers for the live-action segments...

'
A virus that damages the hypothalamus gland
Hypothalamus
The Hypothalamus is a portion of the brain that contains a number of small nuclei with a variety of functions...

, causing the victim's body temperature to skyrocket to deadly levels. Also damages cells upon contact.
Fever"The Fever" Cabin Fever Cabin fever 2:Spring fever Necrotizing fasciitis
Necrotizing fasciitis
Necrotizing fasciitis , commonly known as flesh-eating disease or Flesh-eating bacteria syndrome, is a rare infection of the deeper layers of skin and subcutaneous tissues, easily spreading across the fascial plane within the subcutaneous tissue.Necrotizing fasciitis is a quickly progressing and...

 which causes massive hemorrhaging and tissue necrosis. The first symptom of the disease is usually a painful rash, which develops into a scabby or weeping wound. In later stages, tissues become soft and slough away. The initial rash stage can be exacerbated by harsh physical trauma, as was seen when one afflicted woman discovered hand-shaped rashes on her body, where she had recently been tightly held during a passionate sexual encounter
One Night Stand
One Night Stand is an HBO stand-up series that first aired on February 15, 1989. The half-hour series aired weekly and featured stand-up comedy specials from some of the top performing comedians. The series originally comprised 55 specials over the course of its four years on HBO...

. The disease is transmitted when an infected creatures' blood is exposed to a victim's bloodstream (bare skin contact with infectious blood is implied to not result in infection). It can also be contracted through unprotected sexual activity and by drinking contaminated water
Waterborne diseases
Waterborne diseases are caused by pathogenic microorganisms which are directly transmitted when contaminated fresh water is consumed. Contaminated fresh water, used in the preparation of food, can be the source of foodborne disease through consumption of the same microorganisms...

. The disease spreads cross-species and was initially discovered in a dead dog. Where the dog contracted the disease is unknown.
Geostigma Final Fantasy VII: Advent Children
Final Fantasy VII: Advent Children
is a 2005 Japanese computer-animated science fiction film directed by Tetsuya Nomura, co-directed by Takeshi Nozue, and produced by Yoshinori Kitase and Shinji Hashimoto. It was written by Kazushige Nojima and the music was composed by Nobuo Uematsu...

A disease caused by Jenova's presence in the Lifestream as it rose to destroy Meteor in the ending of Final Fantasy VII
Final Fantasy VII
is a role-playing video game developed by Square and published by Sony Computer Entertainment as the seventh installment in the Final Fantasy series. It was originally released in 1997 for the Sony PlayStation and was re-released in 1998 for Microsoft Windows-based personal computers and in 2009...

. Decreases the efficiency of the body's immune system
Immune system
An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumor cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own...

-like inner Lifestream current. Also causes exhaustion and black sores appearing on the skin. Mostly affects children due to their weaker constitutions. Healed by Aerith Gainsborough
Aerith Gainsborough
— spelled Aeris Gainsborough in the English releases of Final Fantasy VII and Final Fantasy Tactics — is a player character in Square's console role-playing game Final Fantasy VII...

's Great Gospel healing rain. "The Stigma. It's a symptom of alien matter infesting the body. The body tries to eliminate it, and overcompensates. Inside our bodies is a current like the Lifestream. That current is what fights off any malevolent intruders." - Vincent Valentine
Vincent Valentine
is an optional player character in Square Enix's console role-playing game Final Fantasy VII. Designed by Tetsuya Nomura, he also appears in various titles from the Compilation of Final Fantasy VII, a series of prequels of and sequels of Final Fantasy VII, and is the protagonist in the third-person...

Goldfield Syndrome 50 First Dates
50 First Dates
50 First Dates is a 2004 American romantic comedy film directed by Peter Segal and written by George Wing. The film stars Adam Sandler as a woman-chasing veterinarian and Drew Barrymore as an amnesiac, along with Rob Schneider, Sean Astin, Lusia Strus, Blake Clark, and Dan Aykroyd.Most of the film...

A form of anterograde amnesia
Anterograde amnesia
Anterograde amnesia is a loss of the ability to create new memories after the event that caused the amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact. This is in contrast to retrograde amnesia, where memories...

 in which the sufferer begins each day with no memory of the events of the previous day. The person believes every day to be same day on which they acquired the condition.
Hemoglophagia (HGV) Ultraviolet
Ultraviolet (film)
Ultraviolet is a 2006 American science fiction action film written and directed by Kurt Wimmer and produced by Screen Gems. It stars Milla Jovovich as Violet Song and Cameron Bright as Six. It was released in North America on March 3, 2006...

Disease responsible for turning many humans into vampire
Vampire
Vampires are mythological or folkloric beings who subsist by feeding on the life essence of living creatures, regardless of whether they are undead or a living person...

-like creatures. Contrary to most vampiral diseases, hemoglophagia drastically shortens the lifespan of an infected individual to little over a decade.
The Host's Disease The Host
The Host (film)
The Host is a 2006 South Korean monster film, which also contains elements of comedy and drama films. The film was directed by Bong Joon-ho, who co-wrote the screenplay, along with Baek Chul-hyun....

The unnamed disease carried by the giant monster terrorizing South Korea
South Korea
The Republic of Korea , , is a sovereign state in East Asia, located on the southern portion of the Korean Peninsula. It is neighbored by the People's Republic of China to the west, Japan to the east, North Korea to the north, and the East China Sea and Republic of China to the south...

. In actuality, there was no virus; the government claimed the monster was spreading a disease just to save face.
Infertility epidemic Children of Men
Children of Men
Children of Men is a 2006 science fiction film loosely adapted from P. D. James's 1992 novel The Children of Men, directed by Alfonso Cuarón. In 2027, two decades of human infertility have left society on the brink of collapse. Illegal immigrants seek sanctuary in England, where the last...

A mysterious epidemic has led to worldwide infertility
Infertility
Infertility primarily refers to the biological inability of a person to contribute to conception. Infertility may also refer to the state of a woman who is unable to carry a pregnancy to full term...

 in women. The human race has lost the ability to reproduce.
Krippin Virus (KV) I Am Legend
I Am Legend (film)
I Am Legend is a 2007 post-apocalyptic science fiction film directed by Francis Lawrence and starring Will Smith. It is the third feature film adaptation of Richard Matheson's 1954 novel of the same name, following 1964's The Last Man on Earth and 1971's The Omega Man. Smith plays virologist Robert...

A genetically re-engineered measles
Measles
Measles, also known as rubeola or morbilli, is an infection of the respiratory system caused by a virus, specifically a paramyxovirus of the genus Morbillivirus. Morbilliviruses, like other paramyxoviruses, are enveloped, single-stranded, negative-sense RNA viruses...

 virus originally created as a "miracle cure" for cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...

, but mutated into a lethal, highly-pathogenic strain. KV has a 90% mortality rate; less than 1% of humans are immune. Two transmission vectors for the pathogen are inhalation and infected blood, with two corresponding immunity profiles. Infected humans who did not die began exhibiting early symptoms of rabies
Rabies
Rabies is a viral disease that causes acute encephalitis in warm-blooded animals. It is zoonotic , most commonly by a bite from an infected animal. For a human, rabies is almost invariably fatal if post-exposure prophylaxis is not administered prior to the onset of severe symptoms...

 and degenerated into a state driven by rage. A major symptom is that the adrenal gland
Adrenal gland
In mammals, the adrenal glands are endocrine glands that sit atop the kidneys; in humans, the right suprarenal gland is triangular shaped, while the left suprarenal gland is semilunar shaped...

s are "permanently open", giving victims increased strength, speed and agility but also a faster metabolism
Metabolism
Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...

. This results in increased body temperature, heart rate
Heart rate
Heart rate is the number of heartbeats per unit of time, typically expressed as beats per minute . Heart rate can vary as the body's need to absorb oxygen and excrete carbon dioxide changes, such as during exercise or sleep....

, and breathing speed, making those infected hyperventilate constantly. Pupils became permanently dilated and skin became hypersensitive to UV radiation, forcing infected hosts into a nocturnal life cycle. Loss of body hair is another symptom. Non-humans such as rats
RATS
RATS may refer to:* RATS , Regression Analysis of Time Series, a statistical package* Rough Auditing Tool for Security, a computer program...

 and dogs are also susceptible to KV. They are sensitive to blood. These infected are similar to vampire
Vampire
Vampires are mythological or folkloric beings who subsist by feeding on the life essence of living creatures, regardless of whether they are undead or a living person...

s.
Lampington's Disease Last Holiday In the original 1950 film
Last Holiday (1950 film)
Last Holiday is a 1950 British film featuring Alec Guinness in his sixth starring role. The low-key, dark comedy was written by J. B. Priestley and directed by Henry Cass, featuring irony and wit often associated with Priestley....

, the disease seems to have been a tumor in the abdomen (the patient's x-ray is used to indicate something "between the stomach and the small intestine," although a shot of the pelvis is actually being shown). Here, it is an untreatable, terminal condition which is nearly pain-free, but which leads to coma and death within a couple of weeks to a couple of months at the most. It is explained as a recently discovered condition, described by and named for Sir Trevor Lampington, a character who also appears in the plot. In the 2006 remake, the disease has morphed into a neurological disease causing multiple brain tumor
Brain tumor
A brain tumor is an intracranial solid neoplasm, a tumor within the brain or the central spinal canal.Brain tumors include all tumors inside the cranium or in the central spinal canal...

s, rapidly progressing to death within a few weeks if not treated with an exorbitantly expensive operation.
MacGregor's Disease Batman & Robin A four stages disease that Mr. Freeze
Mr. Freeze
Mr. Freeze, real name Dr. Victor Fries , is a DC Comics supervillain, an enemy of Batman. Created by Bob Kane, he first appeared in Batman #121 ....

's wife, Nora
Nora Fries
Nora Fries is a fictional character from DC Comics and a supervillainess enemy of Batman known as Lazara. She is the wife of villain Mr. Freeze, and is introduced in Batman: The Animated Series.-History on Batman: The Animated Series:...

, was suffering from and placed in cryogenic stasis
Cryopreservation
Cryopreservation is a process where cells or whole tissues are preserved by cooling to low sub-zero temperatures, such as 77 K or −196 °C . At these low temperatures, any biological activity, including the biochemical reactions that would lead to cell death, is effectively stopped...

 for. The film also revealed that Batman
Batman
Batman is a fictional character created by the artist Bob Kane and writer Bill Finger. A comic book superhero, Batman first appeared in Detective Comics #27 , and since then has appeared primarily in publications by DC Comics...

's butler, Alfred Pennyworth
Alfred Pennyworth
Alfred Pennyworth is a fictional character that appears throughout the DC Comics franchise. The character first appears in Batman #16 , and was created by writer Bob Kane and artist Jerry Robinson. Alfred serves as Batman’s tireless butler, assistant, confidant, and surrogate father figure...

, was also suffering from Stage-1 MacGregor's. Mr. Freeze successfully created the antidote for Stage-1 of the disease, and gave some of it to Batman as an apology for thinking that Batman killed Nora (which was actually a lie fabricated by Poison Ivy).
Mad Zombie Disease Zombieland (film)
Zombieland
Zombieland is a 2009 American zombie comedy film directed by Ruben Fleischer from a screenplay written by Rhett Reese and Paul Wernick. The film stars Woody Harrelson, Jesse Eisenberg, Emma Stone, and Abigail Breslin as survivors of a zombie apocalypse...

The disease which caused people, upon receiving a bite from one of the infected, to become zombies. The disease is a mutation of Mad Cow Disease, which became Mad Human Disease and then mutated to form Mad Zombie Disease.
Malignalitaloptereosis The Sword in
the Stone
The Sword in the Stone (film)
The Sword in the Stone is a 1963 American animated fantasy comedy film produced by Walt Disney and originally released to theaters on December 25, 1963...

A rare disease which causes the victim to break out in spots, followed by hot and cold flashes, then violent sneezing. During the wizard's duel, Merlin had transformed himself into the germ that caused this disease and infected Madam Mim with it.
Motaba Outbreak
Outbreak (film)
Outbreak is a 1995 American disaster film starring Dustin Hoffman, Rene Russo, Morgan Freeman, and Kevin Spacey. The film was directed by Wolfgang Petersen. In addition, Outbreak features Cuba Gooding, Jr., Donald Sutherland, and Patrick Dempsey....

A deadly, virulent Ebola
Ebola
Ebola virus disease is the name for the human disease which may be caused by any of the four known ebolaviruses. These four viruses are: Bundibugyo virus , Ebola virus , Sudan virus , and Taï Forest virus...

-like virus
Virus
A virus is a small infectious agent that can replicate only inside the living cells of organisms. Viruses infect all types of organisms, from animals and plants to bacteria and archaea...

 from the jungles of Zaire.
Patriot The Patriot
The Patriot (1998 film)
The Patriot is a 1998 action film loosely based on the novel, The Last Canadian by William C. Heine. The film stars Steven Seagal, Gallard Sartain, L.Q. Jones, Whitney Yellow Robe, and Camilla Belle. It was directed by Dean Semler, written by M. Sussman, and produced by Patrick Choi, Nile Niami,...

 (1998)
A highly contagious airborne virus which has been stolen from a government biological warfare
Biological warfare
Biological warfare is the use of biological toxins or infectious agents such as bacteria, viruses, and fungi with intent to kill or incapacitate humans, animals or plants as an act of war...

 laboratory. Its early symptoms include a rash, and it is quickly fatal. It is not clear in the film whether the virus was supposed to have been harvested from the wild (such as Ebola
Ebola
Ebola virus disease is the name for the human disease which may be caused by any of the four known ebolaviruses. These four viruses are: Bundibugyo virus , Ebola virus , Sudan virus , and Taï Forest virus...

) and then grown as a weapon, or whether the laboratory first engineered it in some way. In the film, the leader of a local militia has obtained both the virus and what he believes to be a vaccine
Vaccine
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...

 for it, and decides to start an epidemic with the virus, believing that he will be safe because he has taken the vaccine. A local doctor of Indian (Native American) ancestry fights to find a cure for it.
Nerve Attenuation Syndrome (NAS) Johnny Mnemonic
Johnny Mnemonic (film)
Johnny Mnemonic is a 1995 cyberpunk film, loosely based on the short story "Johnny Mnemonic" by William Gibson. The title character, a man with a cybernetic brain implant designed to store information, is played by Keanu Reeves. The film portrays Gibson's dystopian view of the future with the world...

Causes uncontrollable seizure
Seizure
An epileptic seizure, occasionally referred to as a fit, is defined as a transient symptom of "abnormal excessive or synchronous neuronal activity in the brain". The outward effect can be as dramatic as a wild thrashing movement or as mild as a brief loss of awareness...

s at complete random. It is apparently caused by the overload of electronic interference present in the film.
Rage (Human Cortico-Deficiency Virus) 28 Days Later
28 Days Later
28 Days Later is an acclaimed 2002 British horror film directed by Danny Boyle. The screenplay was written by Alex Garland, and the film stars Cillian Murphy, Naomie Harris, Brendan Gleeson, Megan Burns, and Christopher Eccleston...


28 Weeks Later
28 Weeks Later
28 Weeks Later is a 2007 British/Spanish film sequel to the 2002 post-apocalyptic horror film 28 Days Later. 28 Weeks Later was directed by Juan Carlos Fresnadillo and released in the United Kingdom and United States on 11 May 2007...

Rage causes extreme aggression
Aggression
In psychology, as well as other social and behavioral sciences, aggression refers to behavior between members of the same species that is intended to cause humiliation, pain, or harm. Ferguson and Beaver defined aggressive behavior as "Behavior which is intended to increase the social dominance of...

 in a victim ten to thirty seconds after being Infected with the disease. The disease is easily transmissible through any bodily fluid, except apparently semen. Because of this extreme contagiousness
Infectious disease
Infectious diseases, also known as communicable diseases, contagious diseases or transmissible diseases comprise clinically evident illness resulting from the infection, presence and growth of pathogenic biological agents in an individual host organism...

 and very short incubation time
Incubation period
Incubation period is the time elapsed between exposure to a pathogenic organism, a chemical or radiation, and when symptoms and signs are first apparent...

, a crowd of hundreds could be infected by one single individual in a manner of minutes. A graphic novel
28 Days Later: The Aftermath
28 Days Later: The Aftermath is a graphic novel, as a continuation of the hit film 28 Days Later, written by Steve Niles and distributed by Fox Atomic Comics. It was released on April 3, 2007....

 based on the films purports that Rage is a recombinant strain
Recombinant virus
A recombinant virus is a virus produced by recombining pieces of DNA using recombinant DNA technology. This may be used to produce viral vaccines or gene therapy vectors....

 of Ebola, though its symptoms are similar to that of rabies. Animal testing was being performed on the disease but one animal was released by activists unaware of the virus. The infection
Infection
An infection is the colonization of a host organism by parasite species. Infecting parasites seek to use the host's resources to reproduce, often resulting in disease...

 soon spread to eliminate the entire population of Britain save a few lucky individuals who managed to survive. Infected organisms die out in a few months, succumbing to starvation
Starvation
Starvation is a severe deficiency in caloric energy, nutrient and vitamin intake. It is the most extreme form of malnutrition. In humans, prolonged starvation can cause permanent organ damage and eventually, death...

, since they do not actually eat their victims. They also seem to drool blood constantly.
Reaper Doomsday
Doomsday (film)
Doomsday is a 2008 British science fiction film written and directed by Neil Marshall. The film takes place in the future. Scotland has been quarantined because of a deadly virus. When the virus is found in London, political leaders send a team led by Major Eden Sinclair to Scotland to find a...

Reaper causes effects similar to black plague. It appears in Scotland in the year 2008 and kills most of the inhabitants. Scotland is put under quarantine. Some decades later, Reaper reappears in London. A cure is found several days later, but it is unknown whether or not it will be given to the population.
Satan Bug The Satan Bug (1965)
The Satan Bug
The Satan Bug is a science fiction film directed by John Sturges that stars George Maharis and Anne Francis. It was loosely adapted from Alistair MacLean's 1962 novel of the same name...

A biological warfare agent that could kill all life on Earth in a matter of months is stolen from a government lab. Why was it stolen, and can it be recovered before it is too late?
Say the Opposite of What You Mean Disease Ace Ventura: Pet Detective
Ace Ventura: Pet Detective
Ace Ventura: Pet Detective is a 1994 American comedy film directed by Tom Shadyac and starring Jim Carrey. It co-stars Courteney Cox, Tone Loc, Sean Young and former Miami Dolphins quarterback Dan Marino....

A disease which causes the speaker to say the opposite of the correct answer to a question posed by another party. This disease was thought up on the spot by Ace after he realizes that the people in the bar think poorly of Ray Finkle.
"Stick It To the Man-Neosis" School of Rock
School of Rock
School of Rock, also called The School of Rock, is a 2003 American musical comedy film directed by Richard Linklater, written by Mike White, and starring Jack Black...

Not actually a real disease, but one invented by Dewey to allow his class of budding rockstars into the Battle of the Bands. Dewey's urges to allow the children into the gig was backed up by a very loose explanation that the kids suffered from a "very rare disease" - Stick It To the Man-Neosis, which he had previously told his class they had to "Stick it to the Man" if they wanted to succeed in life, which is namely rebelling against adult oppression.
Venomous Venomous A contagious virus originating in genetically altered poisonous snakes, and spread by contact with infected people.
SP-43
SP-43
SP-43 is a state highway in the state of São Paulo in Brazil....

Derailed (2002)
Derailed (2002 film)
Derailed is a 2002 action movie directed by Bob Misiorowski and starring Jean-Claude Van Damme and Tomas Arana.- Plot:NATO operative Jacques Kristoff is summoned into action—on his birthday, no less—to track down Galina Konstantin , who has stolen an extremely valuable and dangerous top-secret...

SP-43 is a modified form of smallpox
Smallpox
Smallpox was an infectious disease unique to humans, caused by either of two virus variants, Variola major and Variola minor. The disease is also known by the Latin names Variola or Variola vera, which is a derivative of the Latin varius, meaning "spotted", or varus, meaning "pimple"...

 (variola) that has an extremely short incubation period. Its development is part of the back story, which is not completely clear, but given the fact that it appears to have been stolen in Slovakia and is being transported to Munich by a NATO agent, it appears to have been developed by the Czechoslovak
Czechoslovakia
Czechoslovakia or Czecho-Slovakia was a sovereign state in Central Europe which existed from October 1918, when it declared its independence from the Austro-Hungarian Empire, until 1992...

 government or some other Eastern Block country during the Cold War.
Space Dementia Armageddon A disease whose symptoms include extreme recklessness (in space) and unlike actual dementia the ability to reference old movies at choice moments. Steve Buscemi's charater Rockhound suffered this disease on the asteroid as proclaimed William Fitchner's character Col. Willie Sharp.
Space Rabies Howard the Duck
Howard the Duck (film)
Howard the Duck is a 1986 American science fiction comedy film directed by Willard Huyck and produced by George Lucas. It is loosely based on the Marvel comic book of the same name, created by Steve Gerber and quoting scripts by Bill Mantlo, the film focuses on Howard, an alien from a planet...

Disease Howard claims to have in order to intimidate would-be attackers and make an escape. He claims it causes "agonizing death in fifteen seconds".
St. Mary's V for Vendetta
V for Vendetta (film)
V for Vendetta is a 2005 dystopian thriller film directed by James McTeigue and produced by Joel Silver and the Wachowski brothers, who also wrote the screenplay. It is an adaptation of the V for Vendetta comic book by Alan Moore and David Lloyd...

A biological weapon engineered and released by the Norsefire party as a means of clandestinely gaining control over their own country.
Synaptic/Neural Overstimulation Syndrome Repo! The Genetic Opera
Repo! The Genetic Opera
Repo! The Genetic Opera is a 2008 horror-rock opera musical film directed by Darren Lynn Bousman. The film is based on a play written and composed by Darren Smith and Terrance Zdunich....

A disease of unknown origin that killed roughly ten million people at the beginning of the 21st century in the Repo!-verse. It creates massive organ failure
Multiple organ dysfunction syndrome
Multiple organ dysfunction syndrome ', previously known as multiple organ failure or multisystem organ failure , is altered organ function in an acutely ill patient requiring medical intervention to achieve homeostasis...

 and apparently has no cure.
Synaptic Seepage Johnny Mnemonic
Johnny Mnemonic (film)
Johnny Mnemonic is a 1995 cyberpunk film, loosely based on the short story "Johnny Mnemonic" by William Gibson. The title character, a man with a cybernetic brain implant designed to store information, is played by Keanu Reeves. The film portrays Gibson's dystopian view of the future with the world...

Caused by downloading too much information into the brain. Causes cerebral hemorrhage and data corruption. It kills in approximately three days, and causes intermittent seizures.
T-Virus Resident Evil movies An artificial virus created by Umbrella. When a human is infected by it, the virus will destroy all cells, killing the host. Among two and four hours, all cells will be revitalized. But the virus will only activate one brain function: the hypothalamus
Hypothalamus
The Hypothalamus is a portion of the brain that contains a number of small nuclei with a variety of functions...

, where feeding is controlled. The host becomes a violent mindless cannibal, and can infect other people by biting. Because of this effect, the virus was called the "cannibal disease".
Trixie The Crazies, The Crazies
The Crazies (2010 film)
The Crazies is a 2010 American horror film directed by Breck Eisner. Written by Scott Kosar and Ray Wright, the film is a remake of the 1973 film of the same name by George A. Romero, who is also the executive producer and co-writer of the remake....

 (remake)
A highly contagious "Rhabdoviridae
Rhabdoviridae
Rhabdoviruses are viruses belonging to the family Rhabdoviridae, which is in the order Mononegavirales. The name is derived from the Greek rhabdos meaning rod referring to the shape of the viral particles. Rhabdoviruses infect a broad range of hosts throughout the animal and plant kingdoms...

 prototype" biological weapon. Causes those exposed to it to become homicidal.
Unknown Daybreakers
Daybreakers
Daybreakers is a 2009 science-fiction horror film written and directed by Australian filmmakers Michael and Peter Spierig. The film takes place in 2019, where a plague has turned most of the planet's human population into vampires. A vampiric corporation sets out to capture and farm the remaining...

A mysterious plaque spreading like an epidemic, transforms the majority of the world's human population into vampires.
Thing cells ThingThe Thing Triangle-pyramid viruses that makes up Thing monsters. If it enters another animal, it fuses with every cell of the host, possessing the host entirely. Each infected cell becomes an individual life form with its own desire to survive. An infected cell will seek out other cells to infect with its virus, and will work together with other infected cells to imitate other life forms. Because infected cells can rapidly duplicate and shapeshift, and because dislocated pieces of an infected host will shapeshift and become separate entities, infected hosts can only be killed if every individual cell is destroyed. Finally, hosts retain their knowledge and memories, allowing the virus to perfectly imitate any person and remain undetected. The only effective way of killing the Thing monsters is through incineration, for instance with a flamethrower.
Pandorum (Orbital Dysfunctional Syndrome) Pandorum
Pandorum
Pandorum is a 2009 German-British science fiction thriller film written by Travis Milloy, directed by Christian Alvart and produced by Paul W.S. Anderson. The film stars Dennis Quaid and Ben Foster. Filming began in Berlin in August 2008. Pandorum was released on September 25, 2009 in the United...

Psychological disorder stemming from excessive amounts of time spent conscious during space travel. The ailment takes full-blown effect when the victim is faced with unpleasant or painful truths. It starts with minor twitches, then auditory and visual hallucination
Hallucination
A hallucination, in the broadest sense of the word, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid,...

s before becoming a severe psychotic episode. The most famous example is the first recorded case: a spaceship technician murdered his superiors before launching all 5000 cryosleep pods into space to their death, vertigo
Vertigo
Vertigo is a form of dizziness.Vertigo may also refer to:* Vertigo , a 1958 film by Alfred Hitchcock**Vertigo , its soundtrack** Vertigo effect, or Dolly zoom, a special effect in film, named after the movie...

 is a sub-branch of this fictional disease.
(unknown) Transporter 2
Transporter 2
Transporter 2 is a 2005 action film directed by Louis Leterrier and produced by Luc Besson. It is the sequel to The Transporter . It is itself followed by Transporter 3 ....

Created by scientists working for an assassin named Gianni, this unnamed virus kills everyone it infects within 48 hours. Whoever the infected person breathes on contracts the virus, and whoever they breathes on contracts it, etc. The Colombian drug cartel hires Gianni and his minions to use the virus to assassinate Jefferson Billings, the director of the National Drug Control Policy and all of the attendees of a major anti-drug conference. An antidote was also created, just in case, but was retrieved by the Billing Family's personal driver, Frank Martin
Frank Martin (character)
The Transporter is a French film series, comprising three films released between 2002 and 2008. The protagonist and reluctant hero is Frank Martin, portrayed by Jason Statham. Martin is portrayed as a professional freelance courier driver for hire. Statham is himself an accomplished martial artist,...

.
(unknown) What's So Bad About Feeling Good?
What's so bad about feeling good?
What's So Bad About Feeling Good? is the title of a 1968 comedy film, starring George Peppard, Mary Tyler Moore, Jeanne Arnold, Dom DeLuise and Gillian Spencer....

A highly-contagious virus, carried over from South America via a Toucan
Toucan
Toucans are members of the family Ramphastidae of near passerine birds from the Neotropics. The family is most closely related to the American barbets. They are brightly marked and have large, often colorful bills. The family includes five genera and about forty different species...

, causes intense feelings of giddiness, happiness and kindness in those affected.
(unknown, called "Conversationalism" by the film's director) Pontypool
Pontypool (film)
Pontypool is a 2009 Canadian horror film directed by Bruce McDonald and adapted by Tony Burgess from Burgess' novel Pontypool Changes Everything.- Plot :...

A contagious disease spread through use of the English language
English language
English is a West Germanic language that arose in the Anglo-Saxon kingdoms of England and spread into what was to become south-east Scotland under the influence of the Anglian medieval kingdom of Northumbria...

 (origin is unknown). The disease initially presents with the repeating of a word or short phrase (usually a term of endearment like "sweetheart"), followed by severe aphasia and confusion, and finally causing a psychotic belief that the only way to solve their problem is to chew out the mouths of other people. By deliberately mismatching words with their meanings, a cure was found. Unfortunately, before the cure could be spread to the public, the town was wiped out by the army in an attempt to stop the spread of the disease.
(unknown) Children of Men
Children of Men
Children of Men is a 2006 science fiction film loosely adapted from P. D. James's 1992 novel The Children of Men, directed by Alfonso Cuarón. In 2027, two decades of human infertility have left society on the brink of collapse. Illegal immigrants seek sanctuary in England, where the last...

In 2027, two decades of worldwide human infertility have left society on the brink of collapse.


On television

Name Source Symptoms
Amoria Phlebitis The Simpsons
Bart Gets an F
"Bart Gets an F" is the first episode of The Simpsons second season. It originally aired on the Fox network in the United States on October 11, 1990. In the episode, Bart fails four consecutive history exams and the school psychiatrist recommends that Bart repeat the fourth grade...

Amoria phlebitis is characterized by sharp, stabbing pains in the stomach, a shooting pain in the arm and temporary loss of vision.
Cordilla Virus 24
24 (TV series)
24 is an American television series produced for the Fox Network and syndicated worldwide, starring Kiefer Sutherland as Counter Terrorist Unit agent Jack Bauer. Each 24-episode season covers 24 hours in the life of Bauer, using the real time method of narration...

The Cordilla virus was a type 3 immuno-pulmonary virus that is similar to the Hantavirus. The incubation period of the virus was initially 14 hours but decreased significantly as a result of a weaponized variant added. The symptoms of the virus were nose-bleeds, hemorrhaging, skin abscesses and eventually death.
Bendii Syndrome Star Trek
Star Trek
Star Trek is an American science fiction entertainment franchise created by Gene Roddenberry. The core of Star Trek is its six television series: The Original Series, The Animated Series, The Next Generation, Deep Space Nine, Voyager, and Enterprise...

: Memory Alpha
A degenerative neurological illness affecting a minority of elderly Vulcans. Initially it is characterized by wasting, weakness, fatigue, fever, and a gradual but accelerating loss of emotional control, with victims exhibiting sudden bursts of emotion. Diagnosis is made by culturing tissue samples taken from the patient's metathalamus. There is no known treatment, but the disease is the focus of ongoing medical research.
A dangerous side effect of Bendii Syndrome is that the loss of emotional control can be telepathically projected to others. Vulcans are able to resist the emotional projections, but if the afflicted person is in the presence of non-Vulcans the emotions can cause outbreaks of violence. An attending Vulcan telepath can keep these projections under control, but when the sufferer is particularly stressed, the side effect can overwhelm such efforts.."
Bliss Virus Doctor Who
Doctor Who
Doctor Who is a British science fiction television programme produced by the BBC. The programme depicts the adventures of a time-travelling humanoid alien known as the Doctor who explores the universe in a sentient time machine called the TARDIS that flies through time and space, whose exterior...

: Gridlock
Gridlock (Doctor Who)
"Gridlock" is the third episode from the third series of the revived British science fiction television series Doctor Who which aired on 14 April 2007. The Doctor returns to a much grittier New Earth with Martha Jones and meets the Face of Boe one final time. But as New New York becomes a deadly...

Appeared around five billion years into the future on New Earth. It began when New Earthlings developed a new mood-drug called Bliss. The world became addicted to it and, in Novice Hame's words, "A virus mutated inside the compound and became airborne. Everything died. Even the virus in the end. It killed the world in seven minutes flat."
Blue Shadow Virus Star Wars: The Clone Wars
Star Wars: The Clone Wars (2008 TV series)
-Production:At April 2005's Star Wars Celebration III, Lucas stated that "we are working on a 3-D continuation of the pilot series that was on the Cartoon Network; we probably won't start that project for another year." In July 2005, pre-production had begun on the series, according to Steve...

A lethal virus capable of killing a planet's entire population. Eradicated prior to the Clone Wars, it was recreated by the insane Separatist scientist Dr. Nuvo Vindi as a weapon against the Republic. Can only be cured with the root of the reeksa plant. Symptoms include muscular weakness, cough, and fainting, and if not cured in time, the victim will die. In its original liquid-bound form, it could kill a life-form almost instantly.
Bone-itis Futurama
Futurama
Futurama is an American animated science fiction sitcom created by Matt Groening and developed by Groening and David X. Cohen for the Fox Broadcasting Company. The series follows the adventures of a late 20th-century New York City pizza delivery boy, Philip J...

In the Future Stock
Future Stock
"Future Stock" is the 21st episode in the third production season of Futurama. The episode first aired on March 31, 2002 as the ninth episode in the fourth broadcast season.-Plot:...

episode, "80's Guy" suffers from bone-itis and cryogenically freezes himself in order to sustain him until a cure is found. Upon waking up, however, he neglects to get it cured, and dies suddenly as his bones contort horrifically. Not to be confused with osteitis
Osteitis
Osteitis is a general term for inflammation of bone. More specifically, it can refer to one of the following conditions:* Alveolar osteitis or "dry socket"* Condensing osteitis * Osteitis deformans...

.
Bonerplasia Saturday Night Live
Saturday Night Live
Saturday Night Live is a live American late-night television sketch comedy and variety show developed by Lorne Michaels and Dick Ebersol. The show premiered on NBC on October 11, 1975, under the original title of NBC's Saturday Night.The show's sketches often parody contemporary American culture...

In the October 4, 2008
Saturday Night Live (Season 34)
The thirty-fourth season of the variety series Saturday Night Live began airing in 2008 and concluded in 2009 on NBC. This season of Saturday Night Live consisted of 22 episodes, in an attempt to compensate for episodes lost during the 2007–2008 Writers Guild of America strike...

 episode, Bonerplasia is a fictional condition which is allegedly a kind of chronic priapism
Priapism
Priapism is a potentially harmful and painful medical condition in which the erect penis or clitoris does not return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours. There are two types of priapism: low-flow and high-flow. Low-flow...

. A man (played by Jason Sudeikis
Jason Sudeikis
Daniel Jason Sudeikis is an American actor and comedian currently starring as a cast member on Saturday Night Live.-Early life:Sudeikis was born Daniel Jason Sudeikis in Fairfax, Virginia, the son of Kathryn , a travel agent who was president of the American Society of Travel Agents, and Dan...

) used it as a fake explanation for why he constantly got erections around a woman, Amber (played by Anne Hathaway
Anne Hathaway (actress)
Anne Jacqueline Hathaway is an American actress. After several stage roles, she appeared in the 1999 television series Get Real. She played Mia Thermopolis in The Princess Diaries...

), he was secretly attracted to though claiming to be gay
Gay
Gay is a word that refers to a homosexual person, especially a homosexual male. For homosexual women the specific term is "lesbian"....

. However, she honestly believed him, because she "read the Bonerplasia article on Wikipedia", only for the man to then reveal "I actually wrote that article".
Bowden's Malady Firefly
Firefly (TV series)
Firefly is an American space western television series created by writer and director Joss Whedon, under his Mutant Enemy Productions label. Whedon served as executive producer, along with Tim Minear....

A degenerative disease that affects the bone and muscle, the only known treatment being a drug called Pescaline D. The disease is considered a "quirk" of planetary terraforming – the result of underground air mixing up with a mine's ore processors.
Cutie Pox My Little Pony: Friendship is Magic
My Little Pony: Friendship is Magic
My Little Pony: Friendship Is Magic is an animated television series that premiered on October 10, 2010 on the United States cable network The Hub, and is based on Hasbro's My Little Pony line of toys and animated works. The series is produced by Hasbro Studios and DHX Media Vancouver...

A magic-borne disease that affects the ponies of Equestria, causing them to sprout Cutie Marks all over their body and uncontrollably act out the talents that they represent. It disappears on its own, but can be quickly cured by consuming a flower sprouted from the Seeds of Truth. Apple Bloom accidentally infected herself with Cutie Pox when she used a magic plant called Heart's Desire to create a potion that would give her a Cutie Mark; she confessed to stealing the Heart's Desire from Zecora in order to sprout the Seeds of Truth and gain the cure.
Closed Shell Syndrome Ghost in the Shell: Stand Alone Complex
Ghost in the Shell: Stand Alone Complex
is an anime television series produced by Production I.G and based on Masamune Shirow's manga Ghost in the Shell. It was written and directed by Kenji Kamiyama, with original character design by Hajime Shimomura and a soundtrack by Yoko Kanno...

A type of autism
Autism
Autism is a disorder of neural development characterized by impaired social interaction and communication, and by restricted and repetitive behavior. These signs all begin before a child is three years old. Autism affects information processing in the brain by altering how nerve cells and their...

 caused by cyberbrain implants
Microchip implant (human)
A human microchip implant is an integrated circuit device or RFID transponder encased in silicate glass and implanted in the body of a human being...

.
Cyberbrain Sclerosis Ghost in the Shell: Stand Alone Complex
Ghost in the Shell: Stand Alone Complex
is an anime television series produced by Production I.G and based on Masamune Shirow's manga Ghost in the Shell. It was written and directed by Kenji Kamiyama, with original character design by Hajime Shimomura and a soundtrack by Yoko Kanno...

Cyberbrain implant malady resembling multiple sclerosis
Multiple sclerosis
Multiple sclerosis is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms...

, eventually fatal.
Croatoan virus Supernatural
Supernatural (TV series)
Supernatural is an American supernatural and horror television series created by Eric Kripke, which debuted on September 13, 2005 on The WB, and is now part of The CW's lineup. Starring Jared Padalecki as Sam Winchester and Jensen Ackles as Dean Winchester, the series follows the brothers as they...

A virus that is Demonic in origin. It creates an unnatural murderous rage in infected people.
Dave's Syndrome Black Books
Black Books
Black Books is a British sitcom television series created by Dylan Moran and Graham Linehan and produced by Nira Park, first broadcast on Channel 4 from 2000 to 2004...

A condition which is known to affect Manny, it is triggered by being exposed to a temperature of at least 88°F
Fahrenheit
Fahrenheit is the temperature scale proposed in 1724 by, and named after, the German physicist Daniel Gabriel Fahrenheit . Within this scale, the freezing of water into ice is defined at 32 degrees, while the boiling point of water is defined to be 212 degrees...

 (31°C
Celsius
Celsius is a scale and unit of measurement for temperature. It is named after the Swedish astronomer Anders Celsius , who developed a similar temperature scale two years before his death...

). While the exact effects of the disease are not described, a scene at the end of the episode shows the results — Manny is driven to madness and totally ransacks the area outside the shop, before using a hot water bottle as a loincloth, grabbing a flaming torch and painting "EAT ME" on his stomach, whilst jumping on the roof of an abandoned car. Bernard dismisses it as "attention-seeking rubbish" throughout the episode.
Deep Space Disorder Planetes
Planetes
is a Japanese hard science fiction manga by Makoto Yukimura. It was adapted as a 26-episode television anime by Sunrise, which was broadcast on NHK from October 2003 through April 2004...

A condition which is known to affect Hachirota "Hachimaki" Hoshino after an accident in lunar orbit, on the dark side of the moon, during a solar storm which left him isolated in complete darkness. He is retrieved with negligible physical effects, but is diagnosed with Deep Space Disorder, a mental disorder that can cripple an EVA astronaut with severe hallucinations.
Dermatemeculitis Drake & Josh
Drake & Josh
Drake & Josh is an American sitcom that premiered on the Nickelodeon television network on January 11, 2004, which follows the lives of two stepbrothers. It stars Drake Bell and Josh Peck as stepbrothers Drake Parker and Josh Nichols, respectively. Both actors had played roles in The Amanda Show,...

A skin disease that causes the hands and feet of the body to turn a sickly green color. This can usually only be cured by a series of painful injections
Injection (medicine)
An injection is an infusion method of putting fluid into the body, usually with a hollow needle and a syringe which is pierced through the skin to a sufficient depth for the material to be forced into the body...

. A rumored alternate cure is to soak the hands and feet in buckets of a substance called zypholic acid, which can be found in lizard urine
Urine
Urine is a typically sterile liquid by-product of the body that is secreted by the kidneys through a process called urination and excreted through the urethra. Cellular metabolism generates numerous by-products, many rich in nitrogen, that require elimination from the bloodstream...

. The hands and feet must be soaked for no less than 45 minutes. Megan tricks Drake into thinking he has this disease because he ate a cookie that was hers, and later states, "You know, there's another cure: Next time, don't eat my big cookie."
Desperation Disease Eureka 7 A disease that strikes randomly and has no known vector of contagion. Individuals gradually become detached from the world until they are completely catatonic. The name of the disease does not come from the victims' state, who seem to be communing with something metaphysical
Metaphysics
Metaphysics is a branch of philosophy concerned with explaining the fundamental nature of being and the world, although the term is not easily defined. Traditionally, metaphysics attempts to answer two basic questions in the broadest possible terms:...

, but rather, from their families who despair of trying to wake them.
Dark Gundam Cells Mobile Fighter G Gundam
Mobile Fighter G Gundam
Mobile Fighter G Gundam, known in Japan as , is a Japanese animated television series directed by Yasuhiro Imagawa . Created to commemorate the 15th anniversary of the franchise in 1994, it is the first of the Gundam series to be set in an alternate continuity from the original "Universal Century"...

Nanomachines from the Devil Gundam (Dark Gundam in North American dub) infect living organisms and undergo mitosis, allowing the Devil Gundam to control the victim. The victim will gain super-strength and self-recovery abilities and if inside a Mobile Fighter, will spread the cells to the Mobile Fighter and give it the abilities of the Devil Gundam, often mutating the Mobile Fighter into a stronger robot. If the cells have not reached the brain, the victim can be cured.
Drafa Plague Babylon 5
Babylon 5
Babylon 5 is an American science fiction television series created, produced and largely written by J. Michael Straczynski. The show centers on a space station named Babylon 5: a focal point for politics, diplomacy, and conflict during the years 2257–2262...

Neutralizes chemicals in the synaptic gap
Synapse
In the nervous system, a synapse is a structure that permits a neuron to pass an electrical or chemical signal to another cell...

, thus inhibiting nerve signals
Action potential
In physiology, an action potential is a short-lasting event in which the electrical membrane potential of a cell rapidly rises and falls, following a consistent trajectory. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and...

 from the brain to the rest of the body. Without clear direction from the brain as a result of the signals being blocked, the organs lose their ability to function correctly. For those that can be affected, the disease is 100% contagious, and if left untreated 100% terminal.
Ecola Spaceballs: The Animated Series
Spaceballs: The Animated Series
Spaceballs: The Animated Series, also known as Spaceballs: The Series, is an animated television series that premiered in 2008 on G4 and Canada's Super Channel, and is loosely based on the parody science fiction film Spaceballs...

A barf-borne disease made from E. coli
Escherichia coli
Escherichia coli is a Gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms . Most E. coli strains are harmless, but some serotypes can cause serious food poisoning in humans, and are occasionally responsible for product recalls...

 and Ebola
Ebola
Ebola virus disease is the name for the human disease which may be caused by any of the four known ebolaviruses. These four viruses are: Bundibugyo virus , Ebola virus , Sudan virus , and Taï Forest virus...

Electrogonnorhea Futurama
Futurama
Futurama is an American animated science fiction sitcom created by Matt Groening and developed by Groening and David X. Cohen for the Fox Broadcasting Company. The series follows the adventures of a late 20th-century New York City pizza delivery boy, Philip J...

An STD
Sexually transmitted disease
Sexually transmitted disease , also known as a sexually transmitted infection or venereal disease , is an illness that has a significant probability of transmission between humans by means of human sexual behavior, including vaginal intercourse, oral sex, and anal sex...

 humans can contract from robots. Called the "Noisy Killer".
Electric flu Pokémon
Pokémon (anime)
, abbreviated from , is a children's TV anime series, which has since been adapted for the North and South American, Australian and European television markets...

A condition when an electric Pokémon builds up too much electricity in its body or makes contact with an electromagnetic field
Electromagnetic field
An electromagnetic field is a physical field produced by moving electrically charged objects. It affects the behavior of charged objects in the vicinity of the field. The electromagnetic field extends indefinitely throughout space and describes the electromagnetic interaction...

. Characterized by sparks coming from the Pokémon's cheeks, a red face and uncontrolled bursts of electricity. Curable by having the Pokémon expunge the excess electricity.
Entitilitus Mr. Show
Mr. Show
Mr. Show with Bob and David is an American sketch comedy series featuring former Saturday Night Live writer/actor Bob Odenkirk and stand up comedian/actor David Cross...

Nobody knows what entitilitus is, but entitilitus kills.
Epideme
Epideme
"Epideme" is the seventh episode of science fiction comedy series Red Dwarf VII and the 43rd in the series run. It was first broadcast on the British television channel BBC2 on 28 February 1997. Written by Paul Alexander & Doug Naylor and directed by Ed Bye...

Red Dwarf
Red Dwarf
Red Dwarf is a British comedy franchise which primarily comprises eight series of a television science fiction sitcom that aired on BBC Two between 1988 and 1999 and Dave from 2009–present. It gained cult following. It was created by Rob Grant and Doug Naylor, who also wrote the first six series...

An intelligent virus, originally created as a smoking cure but long since mutated.
European flu Survivors (2008 TV series)
Survivors (2008 TV Series)
Survivors is a British science fiction television series produced by the BBC. It depicts the lives of a group of people who survived a virulent strain of heretofore unknown influenza which has wiped out most of the human race...

A strain of flu based on the real Spanish flu
Spanish flu
The 1918 flu pandemic was an influenza pandemic, and the first of the two pandemics involving H1N1 influenza virus . It was an unusually severe and deadly pandemic that spread across the world. Historical and epidemiological data are inadequate to identify the geographic origin...

 but killing 99.9% of mankind.
Fossil Disease Fullmetal Alchemist
Fullmetal Alchemist
, is a Japanese manga series written and illustrated by Hiromu Arakawa. The world of Fullmetal Alchemist is styled after the European Industrial Revolution...

A disease that makes the body turn into stone or dry up suddenly. The person dies like a withering flower. It is incurable with traditional medicine, and has only been 'cured' (temporarily offset) by Lujon with a fake Philosophers Stone by decomposing and reconstructing the diseased flesh.
Genie Flu Genie in the House
Genie In The House
Genie in the House is a British situation comedy broadcast on Nickelodeon about a widowed father with two teenage daughters who find a dusty old golden lamp while exploring the loft of their new home. A quick rub of the lamp releases Adil, a trainee genie from Balamkadaar who has been confined to...

A disease of Genies which causes them to change colours, become invisible and have squeaky voices.
Geodermic granititis Look Around You
Look Around You
Look Around You is a British television comedy series devised and written by Robert Popper and Peter Serafinowicz, and, in the first series, narrated by Nigel Lambert...

A disease that attacks the central nervous system, fooling it into calcifying the bodily tissue, eventually turning the victim into what is, essentially, a pile of rocks. More commonly known as cobbles.
Groat's Disease Curb your Enthusiasm
Curb Your Enthusiasm
Curb Your Enthusiasm is an American comedy television series produced and broadcast by HBO, which premiered on October 15, 2000. As of 2011, it has completed 80 episodes over eight seasons. The series was created by Seinfeld co-creator Larry David, who stars as a fictionalized version of himself...

A neurological disorder presumed to have a high mortality rate through a slow, painful process. It is characterized by hyperactivity, "like having 5 cups of coffee". It was named after the doctor who discovered it. Larry David, who writes the show, came up with the name of the disease when he thought baseball player Dick Groat's name sounded like the name of a disease.
Hades Covert One: The Hades Factor
Covert One: The Hades Factor
Covert One: The Hades Factor is a made-for-TV thriller filmed in Toronto that first aired in 2006...

A blood-borne/air-born virus that causes sever internal hemorrhaging and bleeding from every orifice. Incubation period of 12 – 24 hrs. Kills within another 24 hours.
Hate Plague Transformers Bacteria
Bacteria
Bacteria are a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals...

l spore
Spore
In biology, a spore is a reproductive structure that is adapted for dispersal and surviving for extended periods of time in unfavorable conditions. Spores form part of the life cycles of many bacteria, plants, algae, fungi and some protozoa. According to scientist Dr...

 of unknown origin transmitted by touch. Induces extreme paranoia
Paranoia
Paranoia [] is a thought process believed to be heavily influenced by anxiety or fear, often to the point of irrationality and delusion. Paranoid thinking typically includes persecutory beliefs, or beliefs of conspiracy concerning a perceived threat towards oneself...

 and aggression
Aggression
In psychology, as well as other social and behavioral sciences, aggression refers to behavior between members of the same species that is intended to cause humiliation, pain, or harm. Ferguson and Beaver defined aggressive behavior as "Behavior which is intended to increase the social dominance of...

 in the infected, causing them to strike out against anyone or anything in an increasingly maddening desire to destroy. Symptoms include a deep reddish glow emanating from the infected. The only curative is intense logic and wisdom, which presumably counters the extreme irrationality the disease causes in its victims. First appearing during the Autobot-Decepticon wars (which necessitated the second resurrection of Optimus Prime), a relatively milder strain is seen again during the events of Beast Machines; Megatron triggers a pre-planted virus in Silverbolt, infecting him and the rest of the Maximals. The strain is cured, again, by intense logic and wisdom.
Heart virus Dragon Ball Z Is a virus that affects one's heart, Goku acquired this virus from a unknown location and had to be bedridden for days. In an alternate time line Goku dies from this virus leaving the rest of Earth's special forces to be killed by androids 17 and 18, who were activated six months after Goku's death. Bulma creates a cure for this virus so that Trunks can take it back in time to save Goku and stop the androids.
Hinamizawa Syndrome When They Cry/When The Cicadas Cry/Higurashi no Naku Koro ni A mental disease similar to schizophrenia
Schizophrenia
Schizophrenia is a mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social...

. It is often referred to as "The Curse of Oyashiro" by the townspeople who have no knowledge of the disease and instead relate it to a supposed curse on the town by its guardian god, Oyashiro. It causes paranoia
Paranoia
Paranoia [] is a thought process believed to be heavily influenced by anxiety or fear, often to the point of irrationality and delusion. Paranoid thinking typically includes persecutory beliefs, or beliefs of conspiracy concerning a perceived threat towards oneself...

-inducing hallucinations which progressively grow more threatening as the victim becomes more paranoid. In the case of the character Keiichi Maebara, it caused his friends' humored laughter to seem maniacal, and their tone of voice more threatening and sinister than it was. Eventually, he hallucinated a marker held by Mion Sonozaki to be a syringe, having heard that a murderer in the town was on drugs. This caused him to kill Mion, as well as Rena Ryuuguu, with a baseball bat. In most cases, the end result of the disease involves suicide
Suicide
Suicide is the act of intentionally causing one's own death. Suicide is often committed out of despair or attributed to some underlying mental disorder, such as depression, bipolar disorder, schizophrenia, alcoholism, or drug abuse...

, which Keiichi did by clawing his throat out. Rena also once attempted suicide from the syndrome by cutting her wrist with a knife. It is revealed later in the series that Hanyuu, the incarnation of Oyashiro, was responsible for some of the paranoia, mostly that one is being watched or followed. However, the disease was still mostly psychological.
Holovirus Red Dwarf:
Red Dwarf
Red Dwarf is a British comedy franchise which primarily comprises eight series of a television science fiction sitcom that aired on BBC Two between 1988 and 1999 and Dave from 2009–present. It gained cult following. It was created by Rob Grant and Doug Naylor, who also wrote the first six series...

Quarantine
Discovered, contracted and possibly created by viral researcher Hildeguard Lanstrom, this nasty condition can only be passed between holograms. It can be transmitted across radio-waves and drains the victim's life-force while endowing them with powers such as telepathy, telekinesis and hex-vision. The sufferer tends to go insane long before his or her demise.
Suggested treatment: A remote link to the hologram disk projection system, a detachable power transfer adapter capable of holding spikes of up to five million volts, and a B47/7RF resistor. Plus confiscation of equally deranged penguin glove-puppet
Irumodic Syndrome Star Trek The Next Generation
Star Trek: The Next Generation
Star Trek: The Next Generation is an American science fiction television series created by Gene Roddenberry as part of the Star Trek franchise. Roddenberry, Rick Berman, and Michael Piller served as executive producers at different times throughout the production...

A neurological disease caused by a defect
Congenital disorder
A congenital disorder, or congenital disease, is a condition existing at birth and often before birth, or that develops during the first month of life , regardless of causation...

 in the brain
Human brain
The human brain has the same general structure as the brains of other mammals, but is over three times larger than the brain of a typical mammal with an equivalent body size. Estimates for the number of neurons in the human brain range from 80 to 120 billion...

's parietal lobe
Parietal lobe
The parietal lobe is a part of the Brain positioned above the occipital lobe and behind the frontal lobe.The parietal lobe integrates sensory information from different modalities, particularly determining spatial sense and navigation. For example, it comprises somatosensory cortex and the...

. It can take years for the illness to actually develop. In one potential alternate reality
Parallel universe (fiction)
A parallel universe or alternative reality is a hypothetical self-contained separate reality coexisting with one's own. A specific group of parallel universes is called a "multiverse", although this term can also be used to describe the possible parallel universes that constitute reality...

, Jean-Luc Picard
Jean-Luc Picard
Captain Jean-Luc Picard is a Star Trek character portrayed by Patrick Stewart. He appears in the television series Star Trek: The Next Generation and the feature films Star Trek Generations, Star Trek: First Contact, Star Trek: Insurrection, and Star Trek Nemesis...

 had this defect and developed the syndrome over a 25-year period.
Imminent Death Syndrome Mr. Show
Mr. Show
Mr. Show with Bob and David is an American sketch comedy series featuring former Saturday Night Live writer/actor Bob Odenkirk and stand up comedian/actor David Cross...

A terminal disease in which the effected individual may experience death at any given time, usually within 80-100 years.
Lackadaisy-Cathro Disease Ed, Edd n Eddy
Ed, Edd n Eddy
Ed, Edd n Eddy is an original animated television series created by Danny Antonucci and produced by Canadian-based a.k.a. Cartoon. It premiered on Cartoon Network on January 4, 1999. Ed, Edd n Eddy was one of Cartoon Network's longest running and most successful franchises and the longest-running...

Main symptoms include "rationalising of mundane circumstances, habitual cleanliness and an abnormal fixation to head wear. Other symptoms include mumbled words and "weakness in the lower extremities
Leg
Łęg may refer to the following places in Poland:*A former name for the town of Ełk *Part of the Czyżyny district of Kraków*Łęg, Pleszew County in Greater Poland Voivodeship...

". This was shown in an Ed, Edd n Eddy episode "A Case of Ed."
Lazar's Disease Doctor Who
Doctor Who
Doctor Who is a British science fiction television programme produced by the BBC. The programme depicts the adventures of a time-travelling humanoid alien known as the Doctor who explores the universe in a sentient time machine called the TARDIS that flies through time and space, whose exterior...

: Terminus
Terminus (Doctor Who)
Terminus is a serial in the British science fiction television series Doctor Who, which was originally broadcast in four twice-weekly parts from 15 to 23 February 1983...

A leprosy-like disease, the only cure is a dose of radiation.
Lurgy (The Dreaded Lurgi) Goon ShowThe Goon Show
The Goon Show
The Goon Show was a British radio comedy programme, originally produced and broadcast by the BBC Home Service from 1951 to 1960, with occasional repeats on the BBC Light Programme...

A disease that causes anyone who catches it to say nothing but 'Eeee-yakkaboo!'.
Macrovirus Star Trek: Voyager
Star Trek: Voyager
Star Trek: Voyager is a science fiction television series set in the Star Trek universe. Set in the 24th century from the year 2371 through 2378, the series follows the adventures of the Starfleet vessel USS Voyager, which becomes stranded in the Delta Quadrant 70,000 light-years from Earth while...

An airborne pathogen-by-proxy that infects endothermic
Endothermic
In thermodynamics, the word endothermic describes a process or reaction in which the system absorbs energy from the surroundings in the form of heat. Its etymology stems from the prefix endo- and the Greek word thermasi,...

 humanoids with a virus, causing the host to get lethargic and churn out more macroviruses until he/she/it wastes away and dies. When some of the bugs invaded Voyager
USS Voyager (Star Trek)
The fictional Intrepid-class starship USS Voyager is the primary setting of the science fiction television series Star Trek: Voyager. It is commanded by Captain Kathryn Janeway....

, the EMH
Doctor (Star Trek)
The Doctor, an Emergency Medical Hologram Mark I , is a fictional character from the television series Star Trek: Voyager, played by actor Robert Picardo...

 was able to synthesize a cure.
Mad Snail Disease SpongeBob SquarePants
SpongeBob SquarePants
SpongeBob SquarePants is an American animated television series, created by marine biologist and animator Stephen Hillenburg. Much of the series centers on the exploits and adventures of the title character and his various friends in the underwater city of "Bikini Bottom"...

A disease that spread by infected snail bite. In the first stage of the disease, after being bitten, toxins enter the body through the vibradious, moving through the host until the host's body is taken over. Symptoms include:messy pants, severely untrimmed toenails, ticklish ribcage, and loss of balance. After final stage, the host becomes a zombie. In the episode, Gary bites Sqwidward and most of the citizens of Bikini Bottom. They think they were zombies and chased SpongeBob until Dr. Gil Gilliams, SDE, SE (Snail Disease Expert and Snail Expert) informs them that "Mad Snail Disease" is nothing more than an urban legend.
Mad Cow Disease/Mad Zombie Disease The Simpsons
The Simpsons
The Simpsons is an American animated sitcom created by Matt Groening for the Fox Broadcasting Company. The series is a satirical parody of a middle class American lifestyle epitomized by its family of the same name, which consists of Homer, Marge, Bart, Lisa and Maggie...

Similar to the virus shown on Zombieland
Zombieland
Zombieland is a 2009 American zombie comedy film directed by Ruben Fleischer from a screenplay written by Rhett Reese and Paul Wernick. The film stars Woody Harrelson, Jesse Eisenberg, Emma Stone, and Abigail Breslin as survivors of a zombie apocalypse...

this plague is non-canonical in The Simpsons universe but nonetheless appears in Treehouse of Horror XX
Treehouse of Horror XX
"Treehouse of Horror XX" is the fourth episode of The Simpsons twenty-first season. The episode first aired on October 18, 2009 on Fox. This is the twentieth "Treehouse of Horror" installment, containing three self-contained stories: In "Dial 'M' for Murder or Press '#' to Return to Main Menu,"...

. Like in Zombieland it was transmitted through cows. In this segment, Krusty develops a new burger from cannibalistic cows
Meat and bone meal
Meat and bone meal is a product of the rendering industry. It is typically about 48 - 52% protein, 33-...

 and the effects of this mutate into a virus which turns the victim into a zombie in a matter of seconds. Symptoms include drooling saliva at the mouth, blackened bags under the eyes, and extremely pale skin and psychotic behaviour. The virus can be transmitted through biting. The only known cure is Bart Simpson
Bart Simpson
Bartholomew JoJo "Bart" Simpson is a fictional main character in the animated television series The Simpsons and part of the Simpson family. He is voiced by actress Nancy Cartwright and first appeared on television in The Tracey Ullman Show short "Good Night" on April 19, 1987...

 as he ate one of the infected burgers but was immune.
Monkeynucleosis Hey Arnold!
Hey Arnold!
Hey Arnold! is an American animated television series created by Craig Bartlett for Nickelodeon. The show's premise focuses on a fourth grader named Arnold who lives with his grandparents. Episodes center on his experiences navigating big city life while dealing with the problems he and his friends...

A disease that is caused if a person is touched by a monkey. Helga thinks she had this disease when a monkey trainer's monkey kissed her on the arm. It seems that the disease leads to death (Or, as said, "Expiration") There are four symptoms: 1) puffy rash where infected, 2) sweaty palms, 3) loss of appetite, and 4) irritability. On the show, monkeynucleosis is said to have been long debunked by modern science.
Monoorangeosis Wizards of Waverly Place
Wizards of Waverly Place
Wizards of Waverly Place is a Disney Channel Original Series that premiered on October 12, 2007. It won "Outstanding Children's Program" at the 61st Primetime Emmy Awards in 2009...

A disease that seemingly does not allow one to experience the color orange in any of the five senses. It is mentioned by Max (Who obviously made it up) in the episode Art Teacher
Moon Fever H2O, Just add Water A Mermaid disease that affects them when they see a full moon. This illness makes them catatonic and draws them to water like a magnet.
Motaba The Pretender
The Pretender (TV series)
The Pretender is an American television series that aired on NBC from 1996 to 2000. The series starred Michael T. Weiss as Jarod, a genius and former child prodigy with "the ability to become anyone he wants to be," i.e., to flawlessly impersonate anyone in virtually any line of work...

The A Virus among us episode borrows from the Outbreak
Outbreak (film)
Outbreak is a 1995 American disaster film starring Dustin Hoffman, Rene Russo, Morgan Freeman, and Kevin Spacey. The film was directed by Wolfgang Petersen. In addition, Outbreak features Cuba Gooding, Jr., Donald Sutherland, and Patrick Dempsey....

 film its center plot disease.
Pentapox Avatar: The Last Airbender
Avatar: The Last Airbender
Avatar: The Last Airbender is an American animated television series that aired for three seasons on Nickelodeon from 2005 to 2008. The series was created and produced by Michael Dante DiMartino and Bryan Konietzko, who served as executive producers along with Aaron Ehasz...

A made-up disease. "Symptoms" include purple spots on the skin (actually sucker marks left by a Purple Pentapus). The inhabitants of Omashu pretended to be infected with Pentapox in order to escape the Fire Nation-occupied city.
Petrifold Regression Doctor Who
Doctor Who
Doctor Who is a British science fiction television programme produced by the BBC. The programme depicts the adventures of a time-travelling humanoid alien known as the Doctor who explores the universe in a sentient time machine called the TARDIS that flies through time and space, whose exterior...

: New Earth
A condition that causes the sufferer to turn to stone (similar to petrification). Unknown origins.
PhageThe Phage
Vidiian
The Vidiians are a fictional race in the science fiction television series Star Trek: Voyager, located in the Delta Quadrant. The Vidiians suffer from a necrotizing plague called "the Phage"...

Star Trek: Voyager
Star Trek: Voyager
Star Trek: Voyager is a science fiction television series set in the Star Trek universe. Set in the 24th century from the year 2371 through 2378, the series follows the adventures of the Starfleet vessel USS Voyager, which becomes stranded in the Delta Quadrant 70,000 light-years from Earth while...

A necrotizing plague that affects members of the Vidiian species. Organ transplants are required for survival. Klingon DNA seems to be highly resistant to the phage. It was cured by the Think Tank.
Proxyglossariasis Duckman
Duckman
Duckman: Private Dick/Family Man is an American animated sitcom that aired from 1994–1997, created by Everett Peck and developed by Peck. The sitcom is based on characters created by Peck in his Dark Horse comic...

A condition which causes someone, while speaking, to occasionally use the next word in the dictionary instead of the one they wanted. Appeared in the episode "Research and Destroy".
(Unknown) Star Trek
Star Trek
Star Trek is an American science fiction entertainment franchise created by Gene Roddenberry. The core of Star Trek is its six television series: The Original Series, The Animated Series, The Next Generation, Deep Space Nine, Voyager, and Enterprise...

:
"The Naked Time", Star Trek: The Next Generation
Star Trek: The Next Generation
Star Trek: The Next Generation is an American science fiction television series created by Gene Roddenberry as part of the Star Trek franchise. Roddenberry, Rick Berman, and Michael Piller served as executive producers at different times throughout the production...

:
"The Naked Now"
A mutated form of water from the planet Psi 2000 that spreads by perspiration (or small cuts in the skin) and causes its victims to act in a way similar to being drunk. However, the effects do not wear off and eventually will cause victims to make dangerous decisions. Dr. Leonard McCoy isolated an antidote, and once it was administered, patients had to be forced to use will power to combat the symptoms.
Re-vitiligo
Vitiligo
Vitiligo is a condition that causes depigmentation of sections of skin. It occurs when melanocytes, the cells responsible for skin pigmentation, die or are unable to function. The cause of vitiligo is unknown, but research suggests that it may arise from autoimmune, genetic, oxidative stress,...

BoondocksThe Boondocks
The Boondocks (TV series)
The Boondocks is an American animated series created by Aaron McGruder on Cartoon Network's late night programing block, Adult Swim, based on McGruder's comic strip of the same name...

A disease that turns a white person's skin black over time. Uncle Ruckus
Uncle Ruckus
Uncle Ruckus, also known as Rev. Uncle Ruckus and Rev. Fr. Uncle Ruckus, as well as Uncle Rukus while serving at Robert Freeman's Soul Food restaurant "The Itis" , is a fictional character from the Boondocks comic strip and animated television series The Boondocks...

 claims to have it, though every flashback
Flashback (narrative)
Flashback is an interjected scene that takes the narrative back in time from the current point the story has reached. Flashbacks are often used to recount events that happened before the story’s primary sequence of events or to fill in crucial backstory...

 in which he appears, features him as black as he is in 2005–2008. He regards Michael Jackson
Michael Jackson
Michael Joseph Jackson was an American recording artist, entertainer, and businessman. Referred to as the King of Pop, or by his initials MJ, Jackson is recognized as the most successful entertainer of all time by Guinness World Records...

 as a "lucky bastard," as his skin turned from black to white.
Rigellian Fever Star Trek
Star Trek
Star Trek is an American science fiction entertainment franchise created by Gene Roddenberry. The core of Star Trek is its six television series: The Original Series, The Animated Series, The Next Generation, Deep Space Nine, Voyager, and Enterprise...

:
"Requiem for Methuselah"
A disease originating from the Rigel system, the only known cure for which is the rare mineral ryetalyn.
Shanti Virus Heroes
Heroes (TV series)
Heroes is an American science fiction television drama series created by Tim Kring that appeared on NBC for four seasons from September 25, 2006 through February 8, 2010. The series tells the stories of ordinary people who discover superhuman abilities, and how these abilities take effect in the...

A virus that only affects individuals with superhuman abilities or powers, deactivating those powers and slowly killing the infected. At least one strain exists which affects humans without superhuman powers, which is simply lethal and was shown to have killed 93% of the world population in a possible future.
Spectrox Toxaemia Doctor Who
Doctor Who
Doctor Who is a British science fiction television programme produced by the BBC. The programme depicts the adventures of a time-travelling humanoid alien known as the Doctor who explores the universe in a sentient time machine called the TARDIS that flies through time and space, whose exterior...

: The Caves of Androzani
The Caves of Androzani
The Caves of Androzani is a serial in the British science fiction television series Doctor Who, which was first broadcast in four twice-weekly parts from 8–16 March 1984. It was Peter Davison's last regular appearance as the Doctor, and marks the first appearance of Colin Baker in the role...

A fatal condition caused by touching the raw form of Spectrox, a residue from the saliva of bats found on the planet Androzani Minor, that contained a chemical similar to nitrogen mustard
Nitrogen mustard
The nitrogen mustards are cytotoxic chemotherapy agents similar to mustard gas. Although their common use is medicinal, in principle these compounds can also be deployed as chemical warfare agents. Nitrogen mustards are nonspecific DNA alkylating agents. Nitrogen mustard gas was stockpiled by...

. The lifespan of the sufferer is then reduced to between two and three days; symptoms include a rash and/or cramp, followed by spasms, paralysis and finally Thermal Death Point. The only known cure was the milk of the Queen Bats.
SuddsThe Sudds SpongeBob SquarePants
SpongeBob SquarePants
SpongeBob SquarePants is an American animated television series, created by marine biologist and animator Stephen Hillenburg. Much of the series centers on the exploits and adventures of the title character and his various friends in the underwater city of "Bikini Bottom"...

The sudds is an illness that only sponges can catch, which makes them sneeze out bubbles constantly. It is essentially a common cold
Common cold
The common cold is a viral infectious disease of the upper respiratory system, caused primarily by rhinoviruses and coronaviruses. Common symptoms include a cough, sore throat, runny nose, and fever...

. The sudds can be cured by washing the sponge and using it to clean various things, as shown in the episode "The Sudds."
Super Diarrhea American Dad!
American Dad!
American Dad! is an American animated television series created by Seth MacFarlane and owned by Underdog Productions and Fuzzy Door Productions. It is produced in association with 20th Century Fox Television...

Francine experienced this disease while on a good-will mission to India.
Torsonic Polarity Syndrome (TPS) South Park
South Park
South Park is an American animated television series created by Trey Parker and Matt Stone for the Comedy Central television network. Intended for mature audiences, the show has become famous for its crude language, surreal, satirical, and dark humor that lampoons a wide range of topics...

A genetic condition which causes humans to be born with a set of buttocks over their facial organs. TPS is seen in South Park Ep.510 How To Eat With Your Butt
How to Eat with Your Butt
"How to Eat with Your Butt" is the tenth episode of the fifth season of the animated television series South Park, and the 75th episode of the series overall...

. Over 11 people worldwide are affected.
Tree-Rush One Piece
One Piece
is a Japanese shōnen manga series written and illustrated by Eiichiro Oda. It has been serialized in Weekly Shōnen Jump since August 4, 1997; the individual chapters are being published in tankōbon volumes by Shueisha, with the first released on December 24, 1997, and the 64th volume released as...

A virus which had almost destroyed the Shandian Tribe 400 years ago. The disease causes black spots to appear all over the victims body and eventually results in death. The disease was cured by Montblanc Norland by using a substance known as Connie from the Kona Tree.
(unknown) The Tribe Unknown virus that has killed all the adults, leaving only children and teenagers alive.
Uromysotysis Poisoning Seinfeld
Seinfeld
Seinfeld is an American television sitcom that originally aired on NBC from July 5, 1989, to May 14, 1998, lasting nine seasons, and is now in syndication. It was created by Larry David and Jerry Seinfeld, the latter starring as a fictionalized version of himself...

Poisoning that kills the infected person if they are unable to urinate.
Count-Choculitis, Hot Dog Fingers, and Spontaneous Dentohydroplosion The Office (USA) When asked for diseases that should be covered under the new healthcare these are some of the responses.

In video games

Name Source Symptoms
The Affliction Guild Wars
Guild Wars
Guild Wars is an episodic series of online 3D fantasy role-playing games developed by ArenaNet and published by NCsoft. Although often defined as an MMORPG the developers define it as a CORPG due to significant differences from the MMORPG genre. It provides two main modes of gameplay—a cooperative...

Also referred to as 'The Canthan Plague'. A disease that spread in Cantha, causing victims to become hulking, aggressive, pained creatures known as 'the afflicted'. It was seen to affect humans, cattle, and various animals in a menagerie. The sufferers were initially believed to be contagious, but this was later found out to be false.
Ancient virus Resident Evil series A rare viral strain found in queen ant genes. It was discovered by Alexia Ashford, while she was studying ants. When combined with Mother Virus (or Progenitor Virus) it creates the powerful T-Veronica virus. Probably the control power of it is due the Ancient virus.
Angel Toxicosis Tales of Symphonia
Tales of Symphonia
is a video game first released for the Nintendo GameCube and later for the PlayStation 2 in Japan. It debuted in Japan on August 29, 2003, selling 953,000 copies, in Canada and the United States on July 13, 2004, and in Europe on November 19, 2004. The game received a Japanese-only PlayStation 2...

A disease that cannot be transmitted, and affects only those with an unmounted Cruxis Crystal. Causes victim to eventually lose ability to taste, sleep, cry, feel pain, and talk. Also increases the victim's hearing, strength and sight abilities, as well as eliminating the need to eat and sleep. In early beginnings it allows the victim to gain crystal-like wings and fly until the disease is destroyed. The final stage of this diseases causes the victim to give up his/her heart and memory, and ultimately their life. The disease lasts for an unknown time, those afflicted are slowly "given" the symptoms via blessings of a person with a mounted Cruxis Crystal. A major example is Collette, one of the 8 protagonists of the game.
Anthrax Beta/Gamma Command & Conquer: Generals and Zero Hour Biowarfare agents concocted by the GLA. Unlike normal Anthrax, these agents kill in seconds, not days, and are powerful enough to corrode metal and ceramic armor.
Apathy Syndrome Persona-Trinity Soul, Persona 3
Persona 3
Shin Megami Tensei: Persona 3, originally released in Japan as simply , is the fourth video game in the Shin Megami Tensei: Persona series of console role-playing games developed by Atlus, which is part of the larger Megami Tensei series of video games...

 (video game)-
Technically not a real disease, Apathy Syndrome is caused when a human's soul is "destroyed" by a Shadow. The affected person becomes unresponsive and "apathetic" to everything around them like the name suggests.
BLACKLIGHT Virus Prototype (video game)
Prototype (video game)
Prototype is an open world action video game developed by Radical Entertainment and published by Activision. The game was released in North America on June 9, 2009, and in southwestern parts of North America as well as Oceania on June 10, and was released in Europe on June 12.The game is set in New...

The Virus is a small infection agent that can replicate only inside the living cell of other organisms. It is the driving force behind the story plot that turns the humans into zombies, spawns Hunters and creates the vegetation. The Supreme Hunter is created when Alex injects Elizabeth Greene with a catalyst that eradicates the BLACKLIGHT virus, this back fires and the serum is rejected and rapidly multiplies into the Supreme Hunter. The BLACKLIGHT virus is made to re-write D.N.A. in living organisms by combining genetic traits, this causes Alex's powers in the game. The BLACKLIGHT virus originates from the REDLIGHT virus and multiple toxins (both harmless and fatal) have been produced from the BLACKLIGHT virus.
Blorbs Mario & Luigi: Bowser's Inside Story A disease caught by Toad's after ingesting "Blorb Mushrooms".
Chimera Virus Resistance: Fall of Man
Resistance: Fall of Man
Resistance: Fall of Man is a first-person shooter video game for the PlayStation 3. It was developed by Insomniac Games and published by Sony Computer Entertainment. The game is set in an alternate history 1951, and follows Sgt...

It mutates the infected into the enemies of the series.
Corprus The Elder Scrolls III: Morrowind
The Elder Scrolls III: Morrowind
The Elder Scrolls III: Morrowind, often simply referred to as Morrowind, is a single-player computer role-playing game developed by Bethesda Game Studios, and published by Bethesda Softworks and Ubisoft. It is the third installment in The Elder Scrolls series of games, following The Elder Scrolls...

Corprus causes incredible mutations in humanoids, but it is an almost non-communicable disease. People infected with blight are often sent to a special institution called the Corprusarium, which was made for researching corprus. Corprus is caused by the volcanic ash that emanates from Red Mountain, but, as a positive side effect, grants 100% disease immunity. The only known antidote is proven to destroy corprus, but ends up killing the victim as well. However, the player is able to take the antidote without any adverse effects, presumably because he is the reincarnation of the demi-god Nerevar.
Corrupted Blood
Corrupted Blood
The Corrupted Blood incident is a video game glitch and virtual plague that occurred on September 13, 2005 in the MMORPG World of Warcraft...

World of Warcraft
World of Warcraft
World of Warcraft is a massively multiplayer online role-playing game by Blizzard Entertainment. It is the fourth released game set in the fantasy Warcraft universe, which was first introduced by Warcraft: Orcs & Humans in 1994...

Initially contracted from fighting Hakkar, the God of Blood, in the dungeon of Zul'Gurub. Highly infectious, with an incubation period
Incubation period
Incubation period is the time elapsed between exposure to a pathogenic organism, a chemical or radiation, and when symptoms and signs are first apparent...

 of 2 seconds and can infect any person in the immediate area. Referred to players as "the Plague", "Hakkar's SARS" or "WoW AIDS
AIDS
Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the human immunodeficiency virus...

" for a major outbreak of the virtual plague in the game due to a design oversight.
Creeping Derangea Advance Wars: Days of Ruin
Advance Wars: Days of Ruin
Advance Wars: Days of Ruin is a turn-based tactics video game for the Nintendo DS handheld game console...

An artificial virus that is revealed to be a failed Bio-Weapon created by Dr. Caulder to test the extent of IDS technology. Due to its inherent flaw of photophobia, creeping derangea is only able to thrive when the sun was effectively blocked out by the vast amounts of dust that were kicked up into the troposphere and stratosphere by the apocalyptic meteor impact events. The Virus is initially only able to infect those under the age of 20 but a new strain is somehow introduced that can infect older hosts over time. Symptoms include headaches, paranoia, and a black diamond on the skin called "the mark". It causes flowers to grow inside a person and break out of the skin. A beautiful, albeit excruciatingly painful, way to die. Its scientific name is Endoflorescens terribilis. It is also known as The Creeper and the Green Thumb.
Diathronitis Larn Afflicts daughter of player character; serves as primary motivation for gameplay.
Doll Syndrome hack GU.hack//G.U. A mysterious medical condition in which a person falls into a completely unresponsive state. Doll Syndrome is in fact a physical side effect to an infection by AIDA. Salvador Aihara tries to do an undercover investigation regarding Doll Syndrome in especially young children for his show "Online Jack".
Flood Parasite Halo
Halo (series)
Halo is a multi-million dollar science fiction video game franchise created by Bungie and now managed by 343 Industries and owned by Microsoft Studios. The series centers on an interstellar war between humanity and a theocratic alliance of aliens known as the Covenant...

The Flood Parasite is depicted in the Halo franchise as a Parasite that mutates infected hosts into creatures similar to zombies. Depending on the size or condition of the Host's body, the Parasite mutates the hapless host into various specialized physical forms.
Forced Evolutionary Virus Fallout Originally known as the Pan-Immunity Viron Project, FEV, along with radiation, is responsible for many mutations in the wastelands. The most visible of these are the super mutants, former humans granted incredible strength and endurance as result of being infected. Exposure to the virus is also known to be fatal in many cases. FEV serves as a major plot element in Fallout, Fallout 2 and Fallout 3.
FoxDie Metal Gear Solid
Metal Gear Solid
is a videogame by Hideo Kojima. The game was developed by Konami Computer Entertainment Japan and first published by Konami in 1998 for the PlayStation video game console. It is the sequel to Kojimas early MSX2 computer games Metal Gear and Metal Gear 2: Solid Snake...

FoxDie is a virus responsible for killing people with certain genetic markers via cardiac arrest. FoxDie is given to protagonist Solid Snake by Dr. Naomi Hunter, only it is engineered to go off at an indeterminate time. FoxDie was also the cause of death of Liquid Snake, Decoy Octopus (impersonating DARPA chief Donald Anderson), and the ArmsTech President.
G-Virus Resident Evil 2
Resident Evil 2
Resident Evil 2, known as in Japan, is a survival horror video game originally released for the PlayStation in 1998. Developed by Capcom as the second installment in the Resident Evil series, its story takes place two months after the events of the first game, Resident Evil...

A mutagenic pathogen which causes the host to become a big, constantly evolving, practically unstoppable killing machine, with exceedingly high attack power and immense vitality, in addition to the ability to regenerate
Regeneration (biology)
In biology, regeneration is the process of renewal, restoration, and growth that makes genomes, cells, organs, organisms, and ecosystems resilient to natural fluctuations or events that cause disturbance or damage. Every species is capable of regeneration, from bacteria to humans. At its most...

 and mutate so quickly the carrier virtually loses its mortality. The purified virus can be injected directly into the host, or a mutated host can implant a small larva
Larva
A larva is a distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle...

e, called a G-embryo into another host. The latter mode of transmission is most successful when the host and the new victim are genetically similar. The virus would later merge with the T-Virus, creating an extremely dangerous, electromagnetic
Electromagnetism
Electromagnetism is one of the four fundamental interactions in nature. The other three are the strong interaction, the weak interaction and gravitation...

-capable variant called T/G Virus
Gangliated Utrophin Immuno Latency Toxin (GUILT) Trauma Center: Under the Knife
Trauma Center: Under the Knife
Trauma Center: Under the Knife, known in Japan as , is a surgical simulation game developed and published by Atlus for the Nintendo DS and is the first entry in the Trauma Center series...

A series of eight parasitic pathogens created by the medical-terrorist group Delphi. Despite its ingame introduction as a toxin, GUILT is referred as a "moving tumor", but behaves more like a parasite. During ingame sequences where the player operates on patients, GUILT diseases are normally shown as a pseudo-sentient core that attacks the patient from within, using lacerations, tumors and other ailments. Individual strains are named after Greek days of the week (Kyriaki, Deftera, Triti, Tetarti, Pempti, Paraskevi, Savato), the only exception being the eighth strain, called "Bliss". Neo-GUILT strains, which were developed independently from the original GUILT project, introduce four more strains (Nous, Bythos, Sige, Aletheia). Some GUILT survivors were also inflicted with a variation of the disease, dubbed the PGS (Post-GUILT syndrome).
Gray Death Deus Ex
Deus Ex
Deus Ex is an action role-playing game developed by Ion Storm Inc. and published by Eidos Interactive in 2000, which combines gameplay elements of first-person shooters with those of role-playing video games...

A global plague
Pandemic
A pandemic is an epidemic of infectious disease that is spreading through human populations across a large region; for instance multiple continents, or even worldwide. A widespread endemic disease that is stable in terms of how many people are getting sick from it is not a pandemic...

 engineered using nanotechnology
Nanotechnology
Nanotechnology is the study of manipulating matter on an atomic and molecular scale. Generally, nanotechnology deals with developing materials, devices, or other structures possessing at least one dimension sized from 1 to 100 nanometres...

 within a Universal Constructor by Majestic-12, the Gray Death virus is actually a hybrid (cyborg
Cyborg
A cyborg is a being with both biological and artificial parts. The term was coined in 1960 when Manfred Clynes and Nathan S. Kline used it in an article about the advantages of self-regulating human-machine systems in outer space. D. S...

anic) disease of biological and mechanical structures. It is based on the adverse and ultimately lethal effects of nanotechnology on an unmodified human body. Named the Gray Death because of the gray patches of discolored scar tissue
Scar
Scars are areas of fibrous tissue that replace normal skin after injury. A scar results from the biological process of wound repair in the skin and other tissues of the body. Thus, scarring is a natural part of the healing process. With the exception of very minor lesions, every wound results in...

 that cover its victims' skins, if and when the disease is cured. Symptoms include the aforementioned discoloration of the skin, cough
Cough
A cough is a sudden and often repetitively occurring reflex which helps to clear the large breathing passages from secretions, irritants, foreign particles and microbes...

ing, physical pain
Pain
Pain is an unpleasant sensation often caused by intense or damaging stimuli such as stubbing a toe, burning a finger, putting iodine on a cut, and bumping the "funny bone."...

 and death.
Hyper-evolutionary virus StarCraft
StarCraft
StarCraft is a military science fiction real-time strategy video game developed by Blizzard Entertainment. The first game of the StarCraft series was released for Microsoft Windows on 31 March 1998. With more than 11 million copies sold worldwide as of February 2009, it is one of the best-selling...

The Hyper-evolutionary virus is a retrovirus
Retrovirus
A retrovirus is an RNA virus that is duplicated in a host cell using the reverse transcriptase enzyme to produce DNA from its RNA genome. The DNA is then incorporated into the host's genome by an integrase enzyme. The virus thereafter replicates as part of the host cell's DNA...

 produced by Zerg Queens. It is used to mutate "lesser" creatures into zerg warrior breeds. Only a small percent of humanity is fully compatible, who retain personality, intelligence, and psionics. Others mutate into living bombs, utterly dominated by the Overmind. It has a re-animation side-effect. It is transmissible through fluid transfer only, much like Solanum
Solanum
Solanum, the nightshades, horsenettles and relatives, is a large and diverse genus of annual and perennial plants. They grow as forbs, vines, subshrubs, shrubs, and small trees, and often have attractive fruit and flowers. Many formerly independent genera like Lycopersicon or Cyphomandra are...

.
Incuritis Apollo Justice: Ace Attorney A rare, but lethal disease, curable only through the use of a medicine made from the Borginian Cocoon. The cure is very difficult to make, and if made incorrectly, it is a deadly poison, and thus the exportation of such a cocoon is illegal. The Chief Justice's son is afflicted with the disease.
Kepral's Syndrome Mass Effect 2
Mass Effect 2
Mass Effect 2 is an action role-playing game developed by BioWare and published by Electronic Arts for Microsoft Windows, Xbox 360 and PlayStation 3. The game was released for Microsoft Windows and Xbox 360 on January 26, 2010 and for PlayStation 3 on January 18, 2011...

The leading cause of death for drell on their planet Kahje is Kepral's Syndrome, caused by cumulative long-term exposure to a humid climate. This syndrome erodes the ability of drell lungs to take in oxygen, and eventually spreads out to other organs. It is noncommunicable, and there is currently no known cure, though leading hanar scientific authorities are working on creating a genetic adaptation.
Khyme Syndrome Star Trek: The Next Generation — The Transinium Challenge No details are given aside from the fact Beverly Crusher
Beverly Crusher
Commander Beverly Crusher, M.D. , played by actress Gates McFadden, is a fictional character on the television series Star Trek: The Next Generation and its subsequent spinoff films...

 won a Nobel Prize
Nobel Prize
The Nobel Prizes are annual international awards bestowed by Scandinavian committees in recognition of cultural and scientific advances. The will of the Swedish chemist Alfred Nobel, the inventor of dynamite, established the prizes in 1895...

 for her work on this disease.
Las Plagas Resident Evil 4
Resident Evil 4
Resident Evil 4, known in Japan as , is a survival horror third-person shooter video game developed by Capcom Production Studio 4 and published by multiple publishers, including Capcom, Ubisoft, Nintendo Australia, Red Ant Enterprises and THQ Asia Pacific...

A parasitic
Parasitism
Parasitism is a type of symbiotic relationship between organisms of different species where one organism, the parasite, benefits at the expense of the other, the host. Traditionally parasite referred to organisms with lifestages that needed more than one host . These are now called macroparasites...

, organism which can infect a variety of hosts
Host (biology)
In biology, a host is an organism that harbors a parasite, or a mutual or commensal symbiont, typically providing nourishment and shelter. In botany, a host plant is one that supplies food resources and substrate for certain insects or other fauna...

, including humans. It has the ability to control its host's behavior, inducing a hive-like mentality
Group mind (science fiction)
A group mind, hive mind or group ego in science fiction is a single consciousness occupying many bodies. Its use in literature goes back at least as far as Olaf Stapledon's science fiction novel Last and First Men ....

 among the infected and extreme hostility towards uninfected individuals. The infected retain most of the characteristics of humans such as fine motor skill
Motor skill
A motor skill is a learned sequence of movements that combine to produce a smooth, efficient action in order to master a particular task. The development of motor skill occurs in the motor cortex, the region of the cerebral cortex that controls voluntary muscle groups.- Development of motor skills...

s as seen through their use of simple weapons such as scythe
Scythe
A scythe is an agricultural hand tool for mowing grass, or reaping crops. It was largely replaced by horse-drawn and then tractor machinery, but is still used in some areas of Europe and Asia. The Grim Reaper is often depicted carrying or wielding a scythe...

s and axe
Axe
The axe, or ax, is an implement that has been used for millennia to shape, split and cut wood; to harvest timber; as a weapon; and as a ceremonial or heraldic symbol...

s, and more complicated weapons such as chainsaws and chainguns. They are seen to obey "Queen" parasites, much like ants.
M2448 virus (The Freak Virus) Crackdown 2
Crackdown 2
Crackdown 2 is a sandbox-style third-person shooter video game developed by Ruffian Games and published by Microsoft Game Studios. It was released on Xbox 360 in July 2010 and is a direct sequel to the 2007 video game Crackdown.-Gameplay:...

The virus called M2448 was created by Catalina Thorne, the leader of Cell, during her time as a medical student working for the Agency. She conducted secret experiments of the virus but was discovered by the Agency and was kicked off the Agency-sponsored medical programme. She was enraged by this and wanted revenge on the Agency because it apparently ruined her life. To get her revenge she offered free vaccinations to the people of Unity Heights (formely "The Corridor"), she was actually vaccinating her victims with the M2448 Virus which tuned them into Freaks. The virus spread across Unity Heights very quickly and soon made its way into the two other boroughs of Pacific City.
NE-Alpha Parasite Resident Evil The NE-Alpha Parasite has an immunity to the T-virus, and is used to protect the higher brain functions of B.O.W.'s.
Porphyric Hemophilia Elder Scrolls III: Morrowind, Elder Scrolls IV: OblivionThe Elder Scrolls IV: Oblivion
The Elder Scrolls IV: Oblivion
The Elder Scrolls IV: Oblivion is a single-player action role-playing video game developed by Bethesda Game Studios and published by Bethesda Softworks and the Take-Two Interactive subsidiary 2K Games...

Causes vampirism after an incubation period
Incubation period
Incubation period is the time elapsed between exposure to a pathogenic organism, a chemical or radiation, and when symptoms and signs are first apparent...

 of three days. If the player is infected, they can go through a quest to cure the disease, however it is not necessary to be cured to complete the quest.
Pox of LeChuck Tales of Monkey Island
Tales of Monkey Island
Tales of Monkey Island is a 2009 graphic adventure video game developed by Telltale Games and LucasArts. It is the fifth game in the Monkey Island series, released nearly a decade after the previous installment, Escape from Monkey Island. Developed for Windows and the Wii console, the game was...

The Pox of LeChuck (also named LeChucken Pox in the final episode) is a plague apparent in Tales of Monkey Island that swept across the Caribbean when Guybrush stabbed LeChuck
LeChuck
LeChuck is a fictional character in the Monkey Island series of graphic adventure games. Created by Ron Gilbert for LucasArts, LeChuck was introduced in The Secret of Monkey Island and is the chief antagonist of the series. Gilbert drew on aspects of the characters in the 1988 novel On Stranger...

 with an enchanted voodoo sword at the Rock of Gelato. This caused LeChuck
LeChuck
LeChuck is a fictional character in the Monkey Island series of graphic adventure games. Created by Ron Gilbert for LucasArts, LeChuck was introduced in The Secret of Monkey Island and is the chief antagonist of the series. Gilbert drew on aspects of the characters in the 1988 novel On Stranger...

 to be stripped of his voodoo powers, releasing a pandemic that transformed many pirates into green-skinned, foul-mouthed monsters. It also spread to Guybrush's hand, giving it a life of its own (even after being cut off by Morgan LeFlay), as well as infecting his wife, Elaine Marley
Elaine Marley
Elaine Marley–Threepwood is a fictional character in the Monkey Island series of graphic adventure video games. Created by Ron Gilbert for LucasArts, the character first appears in The Secret of Monkey Island and is one of the core characters in the franchise...

. The only known cure is La Esponja Grande, which Guybrush embarks on a quest to find after speaking with the Voodoo Lady.
Progenitor Virus Resident Evil In the back-story
Back-story
A back-story, background story, or backstory is the literary device of a narrative chronologically earlier than, and related to, a narrative of primary interest. Generally, it is the history of characters or other elements that underlie the situation existing at the main narrative's start...

 of the series, the Progenitor virus is the primary virus created by the Umbrella Corporation, a mutagen based on ebola
Ebola
Ebola virus disease is the name for the human disease which may be caused by any of the four known ebolaviruses. These four viruses are: Bundibugyo virus , Ebola virus , Sudan virus , and Taï Forest virus...

. Successor viruses include the T-Virus, the G-Virus, and T-Veronica Virus.
Phazon Madness Metroid Prime
Metroid Prime
Metroid Prime is a video game developed by Retro Studios and Nintendo for the Nintendo GameCube, released in North America on November 17, 2002...

A virus transmitted by being in close proximity to Phazon. The victim's mind is warped so they can no longer tell friend from foe, and exist only to destroy. Phazon Madness is extremely contagious, and it later develops into Phazon Fever, wherein the victim gains an obsessive compulsive disorder regarding Phazon. Infected victims can utilize Phazon as a weapon and normally can only be killed by Phazon itself.
Pokérus Pokémon
Pokémon
is a media franchise published and owned by the video game company Nintendo and created by Satoshi Tajiri in 1996. Originally released as a pair of interlinkable Game Boy role-playing video games developed by Game Freak, Pokémon has since become the second most successful and lucrative video...

A virus that afflicts Pokémon. Though it is incurable, it has no negative effects, and is in fact helpful. Pokémon afflicted gain double effort values in battle. The Pokémon retains this ability even after its contagious period of 48 hours has passed. Transmission is by proximity in a party, and the 48 hour "clock" is stopped by placing the Pokémon into a PC.
Rust Lung Gears of War 2
Gears of War 2
Gears of War 2 is a third-person shooter video game developed by Epic Games with lead design by Cliff Bleszinski, and published by Microsoft Game Studios for the Xbox 360. It is the second installment of the Gears of War series. The game was officially released in North America, Europe and...

When the Lightmass bomb that killed the multitude of Locust monsters in the first game
Gears of War
Gears of War is a military science fiction third-person shooter video game developed by Epic Games and published by Microsoft Game Studios...

 vaporized the liquid element "Imulsion", the gas seeped into the atmosphere of planet Sera, resulting in 'Rust Lung', a disease that spreads quickly and deadly.
Scurge Scurge: Hive
Scurge: Hive
Scurge: Hive is an action-adventure video game by Orbital Media released for the Game Boy Advance and Nintendo DS in 2006. The game follows the protagonist Jenosa Arma, a female bounty hunter tasked with hunting a parasitic lifeform called the "Scurge" an alien entity capable of rapidly adapting...

A parasite that can infect biological, technological, or coherent energy systems. It takes about one minute to overwhelm the special filters designed to ward off its infection.
Green Flu (Previously Unknown) Left 4 Dead
Left 4 Dead
Left 4 Dead is a cooperative first-person shooter video game. It was developed by Turtle Rock Studios, which was purchased by Valve Corporation during development. The game uses Valve's proprietary Source engine, and is available for Microsoft Windows, Xbox 360 and Mac OS X...


Left 4 Dead 2
Left 4 Dead 2
Left 4 Dead 2 is a cooperative first-person shooter video game. It is the sequel to Valve Corporation's award-winning Left 4 Dead. The game launched on November 17, 2009, for Microsoft Windows and Xbox 360 in the United States and November 20 in Europe; in 2010, Left 4 Dead 2 was made available to...

The Green Flu,commonly referred to simply as The Infection, has caused most humans who come in contact with it to change into homicidal, zombie-like beings. Anyone can catch it, but there are few out there who show no symptoms of the virus. They can, however, spread it to whoever comes in contact with them. These carriers seldom realize they are spreading the virus, leaving a path of destruction in their wake.
Terminal Tourette
Tourette
Tourette can refer to:*Tourette syndrome, a neurological condition**Georges Gilles de la Tourette, a French physician who described the syndrome*"tourette's", a song by Nirvana on their 1993 album In Utero...

's
Sam and Max Beyond Time and Space A terminal version of Turette Syndrome; Timmy Two-Teeth, appearing in Ice Station Santa
Ice Station Santa
"Ice Station Santa" is the first episode of Sam & Max Season Two created by Telltale Games and published by GameTap. The episode's title is a play on the movie/book title "Ice Station Zebra", a story set in the cold war period.- Synopsis & Plot :...

 & What's New, Beelzebub?
What's New, Beelzebub?
"What's New, Beelzebub?" is the season finale of Sam & Max Season Two created by Telltale Games and published by GameTap. It was released on April 11, 2008.-Short plot synopsis:...

, has it. It causes him to oversay things getting bleeped out.
The Plague Mass Effect 2
Mass Effect 2
Mass Effect 2 is an action role-playing game developed by BioWare and published by Electronic Arts for Microsoft Windows, Xbox 360 and PlayStation 3. The game was released for Microsoft Windows and Xbox 360 on January 26, 2010 and for PlayStation 3 on January 18, 2011...

The Plague is a nasty virus possibly created by the Collectors which infects all species except Humans and Vorcha. It causes horrible sores, a bad cough and coughing up blood. It was being spread through the ventilation system by the Vorcha under orders of the Collectors but was stopped by Shepard.
The Plague of Undeath Warcraft III The Plague is responsible for the entire Undead race. It can re-animate dead creatures with a reasonable degree of sentience, and keeps the undead creature together even after its flesh has rotted away completely, similar to Necromantic sorcery. However, the creature is usually dominated by the undead command structure, but they can escape from the tyranny of undeath. It also causes the soil beneath and around Undead structures to change into a substance known as Blight, which is poisonus to most plants.
Rosalia Virus Trauma Team
Trauma Team
Trauma Team, known in Japan as is a video game for the Wii console. The game is part of the Trauma Center series by Atlus. The game was released on May 18, 2010 in North America....

A variation of viral hemorrhagic fever, capable of killing patients in days. The virus was originally found in the blood of Rosalia Rosselini by Cumberland College professor Albert Sartre. Sartre and his son attempted to use the virus to cure all disease, but instead found that it could not be used for positive means. An outbreak of the virus occurred, resulting in the Cumberland College Incident, where Sartre and Rosalia escaped to Mexico, and his son lost all memory of the incident, but was arrested and sentenced to 250 years of imprisonment under the ID "CR-S01". However, Sartre was inflicted with the virus, causing him to fall to insanity, killing Rosalia. Rosalia's blood splattered onto nearby flowers, which monarch butterflies fed upon, acting as vectors that caused a second outbreak. A variation of the Rosalia virus was encountered once, when one of the Rosalia patients, Naomi Kimishima, also had a pre-existing incurable genetic disease (thought to be related to GUILT). Interactions between the genetic disease and Rosalia gave birth to a "Twisted Rosalia" strain, which only one case was known to be documented.
Stigma Trauma Center: New Blood
Trauma Center: New Blood
is the third game of the Trauma Center surgery simulation video game series, for the Wii. New Blood is a new installment with features not seen in the previous title, including cardiopulmonary resuscitation, a cooperative mode, online leaderboards, full voice-over dialogue and a 16:9 widescreen...

A virus accidentally created by Markus Vaughn and Lloyd Wilkens. It later is used as a bioterror weapon by the group Parnassus. It comes in six strains, named after body parts it resmbles or attacks (Cheir, Soma, Ops, Onyx, Brachion, Cardia).
T-Virus Resident Evil A virus that causes dementia
Dementia
Dementia is a serious loss of cognitive ability in a previously unimpaired person, beyond what might be expected from normal aging...

 and cellular necrosis
Necrosis
Necrosis is the premature death of cells in living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular death...

. It can easily mutate into other strains, some of which have mutagenic effects on the host. In insects or amphibians, the resulting mutation often involves increased aggressiveness
Aggression
In psychology, as well as other social and behavioral sciences, aggression refers to behavior between members of the same species that is intended to cause humiliation, pain, or harm. Ferguson and Beaver defined aggressive behavior as "Behavior which is intended to increase the social dominance of...

, increased size, and (almost always) the development of poisonous traits. In mammals, the results include aggressiveness, physiological changes of varying degrees, and an extremely increased evolutionary rate. Variants include the NE-T virus
Nemesis (Resident Evil)
Nemesis, also called the Pursuer or , is a fictional character in Capcom's Resident Evil franchise. It first appears in Resident Evil 3: Nemesis, before later emerging in other titles and cameo roles. It is also featured on various merchandise and in the 2004 film Resident Evil: Apocalypse...

, T-G Virus, the T-JCCC203 (used for pharmaceutical, but killed two people) and many other variants.
Technocyte Virus Dark Sector
Dark Sector
Dark Sector is a third-person shooter video game for the Xbox 360, PlayStation 3 and Microsoft Windows developed by Digital Extremes. The game was released on March 25, 2008, in North America, March 27, 2008, in Japan and April 4, 2008, in Europe....

The metabolism of victims are increased and the surface of their skin hardens and forms a metallic exterior. The infection continues to mutate the host, driving them insane from the intense pain. The infected then become wildly aggressive and unpredictable, attacking anyone that is not infected on sight. The disease can be spread by physical contact and can affect animals as well as humans.
Tiberium poisoning Command & Conquer
Command & Conquer
Command & Conquer, abbreviated to C&C and also known as Tiberian Dawn, is a 1995 real-time strategy computer game developed by Westwood Studios for MS-DOS and published by Virgin Interactive. It was the first of twelve games to date to be released under the Command & Conquer label, including a...

Tiberium crystals start to grow on a person's skin. These skin crystals eventually force their way through the persons vital organs, killing them. If the infestation is in a certain proportion, the victim mutates into a living bag of rotten skin and organs, called a visceroid.
Uroboros Resident Evil 5
Resident Evil 5
Resident Evil 5, known in Japan as , is a survival horror third-person shooter video game developed and published by Capcom. The game is the seventh installment in the Resident Evil survival horror series, and was released on March 5, 2009 in Japan and on March 13, 2009 in North America and Europe...

An advanced strain of the Progenitor virus, the Uroboros virus was created by Albert Wesker, with inadvertent help from Jill Valentine. Exposure to Uroboros can lead to one of two things – forced evolution via DNA integration, leading to extremly heightened abilities, or rejection via the virus, leading to the parasitic nature taking over and forming a mass of black, leech-like pustules, which can grow in size if exposed to more organic matters. The only individual known to survive the process was Albert Wesker, which was more than likely due to the fact of his previous exposure to the T-virus. Other beings that took positive mutations from the Uroboros virus include the Reapers; cockroaches exposed accidentally to the virus, who then in turn grew largely in size, gained armour-like carapaces and scythe-like appendages, explaining the name.
Wailing Death Neverwinter Nights
Neverwinter Nights
Neverwinter Nights , produced by BioWare and published by Infogrames , is a third-person perspective computer role-playing game that is based on third edition Dungeons & Dragons and Forgotten Realms rules. It was originally to be published by Interplay Entertainment, but the publisher's financial...

A bubonic-like plague that infects almost the entire city of Neverwinter. Thought to be just a natural plague, it is later discovered that it was magically created and unleashed upon the city.
(unknown) Madworld
MadWorld
is a video game developed by Platinum Games and published by Sega. It was released for the Wii on March 10, 2009 in North America, on March 20 in Europe, March 26 in Australia, and February 10 in Japan...

A disease created by the Organizers to force innocent people to compete in the bloodsport Deathwatch for an antidote.
X-2 Virus BattleTanx
BattleTanx
BattleTanx is an action game for the Nintendo 64, produced by 3DO. The game is followed by a sequel titled BattleTanx: Global Assault.-Plot:...

, BattleTanx: Global Assault
BattleTanx: Global Assault
BattleTanx: Global Assault is a multi-player video game for the Nintendo 64 and PlayStation in which players control futuristic tanks. It is a sequel to the popular N64 game BattleTanx, which utilized the same method of game play. New features were added, such as the ability to utilize special...

An extremely deadly virus released in 2001 and further researched in 2006 that killed 99.9% of the world's human female population that did not possess a special psychic ability known as 'The Edge'. Those that were spared were treated with the utmost respect, authority, and loyalty, thereby earning their title of 'Queenlord'.
Twin Fever Metroid Prime
Metroid Prime
Metroid Prime is a video game developed by Retro Studios and Nintendo for the Nintendo GameCube, released in North America on November 17, 2002...

A Virus native to Twin Tabula causing double vision. When the twin sight fades, the victim is near death.
Marker: DNA sequence Dead Space
Dead space
In physiology, dead space is air that is inhaled by the body in breathing, but does not take part in gas exchange. Not all the air in each breath is able to be used for the exchange of oxygen and carbon dioxide. About a third of every resting breath has no change in O2 and CO2 levels...

After the human colony, on planet Aegis discover an alien Marker, that contained complex and powerful DNA sequence, that enabled dead cells to revive. Unfortunately, one of the scientists working on this DNA sequence, dropped the dish containing these engineered cells. The cells, eventually infected one scientists, which then lead to altered mutations of the human body.
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