Osmosis Jones
Overview
 
Osmosis Jones is a 2001 live-action/animated
Live-action/animated film
A live-action/animated film is a motion picture that features a combination of real actors or elements: live-action and animated elements, typically interacting.-History:...

 comedy film directed by Tom Sito
Tom Sito
Tom Sito is a well-known American animator, animation historian and teacher. He has been called a "key figure in the Disney Renaissance", and one of the One Hundred Most Important People in Animation.-Education:...

 and Piet Kroon for the animated segments and the Farrelly brothers
Farrelly brothers
Peter John Farrelly and Robert Leo "Bobby" Farrelly, Jr. , professionally known as the Farrelly Brothers are screenwriters and directors of ten comedy films, including There's Something About Mary; Dumb and Dumber; Kingpin; Hall Pass; Me, Myself & Irene; Shallow Hal; Stuck on You; Osmosis Jones;...

 for the live-action segments. Unusual in this genre, the live-action characters never meet the animated characters.

The film is set in a fictionalized version of the human body, where micro-organisms or any being based in organisms, are anthropomorphic
Anthropomorphism
Anthropomorphism is any attribution of human characteristics to animals, non-living things, phenomena, material states, objects or abstract concepts, such as organizations, governments, spirits or deities. The term was coined in the mid 1700s...

. The film centers on Frank Detorre (Bill Murray
Bill Murray
William James "Bill" Murray is an American actor and comedian. He first gained national exposure on Saturday Night Live in which he earned an Emmy Award and later went on to star in a number of critically and commercially successful comedic films, including Caddyshack , Ghostbusters , and...

), a slovenly zookeeper
Zookeeper
A zookeeper is a worker in a zoo, responsible for the feeding and daily care of the animals. As part of their routine, they clean the exhibits and report health problems...

.
Quotations

Yo, you see this badge? You see this gun? You see this gooey white saccus membranous 'round my personhood? Well, you dealin' with a white blood cell here! I should be out in the veins, fightin' disease, not in the mouth on tartar control.

Osmosis Jones to dispatch. We got multiple germs - I repeat, multiple germs - comin' down the windpipe, and if these bad boys hit the blood stream, we're gonna be illin'. I'm talkin' nose-drippin', chicken soup-drinkin', rectal thermometer-stickin' illin'!

[The Chief asks Jones where he was in their conversation] Uh, you were just talking about promoting me to head of brain security.

[Thrax demands to know who the undercover Jones really is] Uh, "Bad Booty-Shaken Pickanosis", yeah, that's who I am.

[Drix shoves his gun arm into the flu shot's mouth and Osmosis gets an idea] Uh-oh, you done done it now, Chill. This guy's a psycho cop. You had your chance to spill it, but it's too late. This guy just got off the thorazine, and now he's Cuckoo for Cocoa Puffs! He's going El Pollo Loco on your crazy behind!

Funny. He dosn't look fluish.

[first line] Special Agent Drixo-Benzo-Medapedramine. [changes tone of voice to more commercial-friendly] Drixnol! The brand that eases your coughs and sneezes!

[first line] Careful, I'm contagious.

Think I'll turn up the heat in here!

Ebola? Let me tell you something about Ebola, baby. Ebola is a case of DANDRUFF compared to me!

 
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