Encyclopedia
Gout is a form of arthritis caused by the accumulation of
uric acid crystals in joints. It is an intensely painful disease, which in most cases affects only one joint , most commonly the
big toe. The term “gout” comes from the
Latin word "gutta" meaning "a drop" from the belief that gout was caused by drops of morbid humors and may be related to the large lumps of urate deposits.
Signs and symptoms
The classic picture is of excruciating and sudden pain, swelling, redness, warmness and stiffness in the joint. Low-grade fever may also be present. The patient usually suffers from two sources of pain. The crystals inside the joint cause intense pain whenever the affected area is moved. The inflammation of the tissues around the joint also causes the skin to be swollen, tender and sore if it is even slightly touched. For example, a blanket draping over the affected area would cause extreme pain.
Gout usually attacks the
big toe , however it can also affect other joints such as the ankle, heel, instep, knee, wrist, elbow, fingers, and spine. In some cases the condition may appear in the joints of the small toes which have become immobile due to impact injury earlier in life, causing poor blood circulation that leads to gout.
Patients with longstanding hyperuricemia can have uric acid crystal deposits called
tophi in other tissues e.g. the helix of the ear. Uric acid stones can form as one kind of
kidney stone in some occasions.
Diagnosis
The diagnosis is generally made on a clinical basis, although tests are required to confirm the disease.
Hyperuricemia is a common feature; however, urate levels are not always raised.
Hyperuricemia is defined as a
plasma urate level greater than 420
µmol/L in males ; despite the above, high
uric acid level does not necessarily mean a person will develop gout. Additionally, urate falls to within the normal range in up to two-thirds of cases.
If gout is suspected, the serum urate should be repeated once the attack has subsided. Other blood tests commonly performed are
full blood count, electrolytes, renal function and
erythrocyte sedimentation rate . This serves mainly to exclude other causes of arthritis, most notably septic arthritis.
A definitive diagnosis of gout is from light microscopy of joint fluid aspirated from the joint to demonstrate intracellular monosodium urate crystals in synovial fluid polymorphonuclear leukocytes. The urate crystal is identified by strong negative bi-refringence under polarised microscopy, and their needle-like morphology. A trained observer does better in distinguishing them from other crystals.
Pathogenesis
Although the exact cause of gout is not known, it is thought to be linked to defects in
purine metabolism. Purine is an organic compound commonly found in the body and is metabolized by the body into uric acid. People with primary gout have either an increased production of uric acid or an impaired excretion of uric acid, or a combination of both.
There are also different racial propensities to develop gout. The prevalence of gout is high among the peoples of the Pacific Islands, and the Maori of New Zealand, but rare in the Australian aborigine despite the latter's higher mean concentration of serum uric acid.
Hyperuricemia is considered an aspect of the metabolic syndrome, although its prominence has been reduced in recent classifications. This explains the increased prevalence of gout among
obese individuals.
Many still believe that gout is caused by a combination of dietary factors and "laziness". In particular, many believe that gout develops following several years of excessive alcohol consumption combined with an ongoing lack of physical activity and a diet completely lacking in purine-neutralising foods, such as berries, as well as other specific fruit and vegetables . Others have refined this theory, saying that some are genetically predisposed to gout and some are not. As a result, people who are not predisposed can live over-indulgent lifestyles and not develop gout, while others who are predisposed can develop gout, despite being physically active and having a well-rounded diet. However, most in the "genetic predisposition" school of thought nonetheless believe that the condition is much more likely to develop in the predisposed if the other factors are present over several years .
Gout can also develop as co-morbidity of other diseases, including polycythaemia, leukaemia, intake of cytotoxics,
obesity,
diabetes, hypertension,
renal disorders, and hemolytic anemia. This form of gout is often called secondary gout. Diuretics have traditionally been blamed for precipitating attacks of gout, but a Dutch case-control study from 2006 appears to cast doubt on this.
Stages of gout
Gout has four distinct stages:
- asymptomatic,
- acute,
- intercritical,
- chronic.
In the first stage, plasma uric acid level increases, but there are no symptoms. The first attack of gout marks the second or acute stage. Mild attacks usually go away quickly, whereas severe attacks can last days or even weeks. After the initial attack, the person enters the intercritical stage or symptom-free interval that may last months or even years. Most gout patients have their second attack within 6 months to 2 years from their initial episode.
In the last or chronic stage, gout attacks become frequent and become polyarticular . Large tophi can also be found in many joints. In advanced cases of chronic gout,
kidney damage, hypertension and
kidney stones can also develop.
Treatment
Attacks
Acutely, first line treatment should be pain relief. Once the diagnosis has been confirmed, the drugs of choice are
indometacin, other nonsteroidal anti-inflammatory drugs , or intra-articular glucocorticoids, administered via a joint injection.
Colchicine was previously the drug of choice in acute attacks of gout. It impairs the motility of granulocytes and can prevent the inflammatory phenomena that initiate an attack of gout. Colchicine should be taken within the first 12 hours of the attack and usually relieves the pain within 48 hours. Its main side-effects can complicate its use. NSAIDs are the preferred form of analgesia for patients with gout.
Before medical help is available, some over the counter medication can provide temporary relief to the pain and swelling. NSAIDs such as
ibuprofen can reduce the pain and inflammation slightly, although
aspirin should not be used as it can worsen the condition. Preparation H
hemorrhoidal ointment can be applied to the swollen skin to reduce the swelling temporarily. Professional medical care is needed for long term management of gout.
Prevention
Long term treatment is antihyperuricemic therapy.
Dietary change can make a contribution to lowering the plasma urate level if a diet low in purines is maintained, because the body metabolizes purines into uric acid. Avoiding alcohol, high-purine foods, such as meat, fish, dry beans , mushrooms, spinach, asparagus, and cauliflower, as well as consuming purine-neutralizing foods, such as fresh fruits and most fresh vegetables, diluted celery juice, distilled water, and B-complex and C vitamins can help.
A strong natural cure is a berry extract supplement consisting of bilberry, blueberry or cherry extracts. The anthocyanides which give the berries their blue and purple hues, after entering the body, turn into powerful anti-inflammatories. These might be an especially preferable option to transplant patients, who frequently suffer gout due to increased toxicity and strain on the kidneys due to their immunosuppressant medication.
The mainstay of this approach, however, is the drug
allopurinol, a
xanthine oxidase inhibitor, which directly reduces the production of uric acid. However, allopurinol treatment should not be initiated during an attack of gout, as it can then worsen the attack. If a patient is on allopurinol during an attack, it should be continued.
The decision to use allopurinol is often a lifelong one. Patients have been known to relapse into acute arthritic gout when they stop taking their allopurinol, as the changing of their serum urate levels alone seems to cause crystal precipitation.
Allopurinol and uricosuric agents are contraindicated in patients with kidney stones and other renal conditions.
Additional measures
- Febuxostat - a novel non-purine inhibitor of xanthine oxidase seems to be an alternative that is superior to allopurinol.
- Probenecid, a uricosuric drug that promotes the excretion of uric acid in urine, is also commonly prescribed - often in conjunction with colchicine. Interestingly, the drug fenofibrate also exerts beneficial uricosuric effect.
- As arterial hypertension quite often coexists with gout, treating it with losartan, an AT receptor antagonist, might have an additional beneficial effect on uric acid plasma levels. This way losartan can offset the negative side-effect of thiazides on uric acid metabolism in patients with gout.
- It is suspected that in many cases gout may be secondary to untreated sleep apnea, when oxygen-starved cells break down and release purines as a by-product. Treatment for apnea can be effective in lessening incidence of acute gout attacks.
- A study in 2004 suggests that animal flesh sources of purine, such as beef and seafood, greatly increase the risk of developing gout. However, high-purine vegetable sources did not. Low fat dairy products such as skim milk significantly reduced the chances of gout. The study followed over 40 thousand men over a period of years, in which 1300 cases of gout were reported.
Surgery
For
extreme cases of gout, surgery may be necessary to remove large tophi and correct joint deformity.
Diet
The following suggestions do not meet with universal approval among medical practitioners.
Low
purine diet:
- To lower uric acid:
- cherries have been shown to reduce uric acid
- strawberries or blueberries are also reputed to be beneficial
- celery extracts is believed by many to reduce uric acid levels .
- limit food high in protein such as meat, fish, poultry, or tofu to 8 ounces a day. Avoid entirely during a flare up.
- Food to avoid:
- foods high in purines
- sweetbreads, kidneys, liver, brains, or other offal meats
- sardines
- anchovies
- scallops, prawns, and crabs
- alcohol. Some claim that this applies especially to beer, on the basis that brewer's yeasts are very rich in purine. In view of the fact that most modern commercial beer contains trace amounts of yeast, this claim requires substantiation. Others claim that red wine is particularly bad for gout, though again it is difficult to find an explanation. Alcohol may also reduce the rate of uric acid excretion.
- meat extracts, consommés, and gravies
- diet sodas
- To avoid dehydration:
- Drink plenty of liquids, especially water, to dilute and assist excretion of urates;
- Use sparingly diuretic foods or medicines like aspirin, vitamin C, tea and alcohol.
- Folklore has it that Joe-Pye weed flushes uric acid quickly, but continued use can damage the liver or kidneys
- Another folk remedy is the use of oenomel, a drink with honey and unfermented grape juice.
- Moderate intake of purine-rich vegetables is not associated with increased gout.ggestions for pain relief
Improved blood circulation in the immediate area of an affected immobile joint can be encouraged with a warm bath. This assists in the relief of swelling and reduction in uric acid crystallization. Ensure area is dry before putting on clothes. Common wisdom in treating regular swelling and inflamation is to use an ice pack. However, since the uric acid crystalization is accelerated by low temperature, the use of an ice pack would worsen the condition. One has to do the opposite by treating gout with warmth.
Additional observations
Due to swelling around affected joint for prolonged periods, shedding of skin may occur. This is particularly evident when small toes are affected and may promote fungal infection in the web region if dampness occurs. Treat in a similar fashion to Athlete's foot.
History
Gout was traditionally viewed as a disease of the decadent and indolent, because the foods which contribute to its development were only available in quantity to the wealthy. The stereotypical victim was a lazy, obese middle-aged man who habitually overindulged in rich foods and alcohol, with port consumption often cited as a specific cause. This stereotype is especially evident when Gout is referred to as "The Disease of Kings".
Perhaps due to the traditional relationship between wealth and literacy, gout is one of the most commonly-reported maladies in history.
The Roman gladiatorial surgeon Galen described gout as a discharge of the four humors of the body in unbalanced amounts into the joints. The Latin term for a drop, as a drop of discharge, is gutta -- the term gout descends from this word.
Famous people who had gout
Gout in fiction
- In an episode of King of the Hill is a satirical American [i] animated television series [i] created by ...
, Bobby Hill develops gout in the big toe as a result of eating chopped liver on a daily basis. - In an episode of Lost In Space is a science fiction [i] TV series [i] produced between 1965 [i] and 1968 [i] by telev ...
, Will Robinson encounters Hamish Rhu-Glamis, a Scotsman executed in 1497, but who was suffering gout at the time of his death. Will's mother Maureen attempts to treat the gout when Hamish is made living again by passage through a space warp. - In George Eliot's Middlemarch, Tertius Lydgate publishes a book on gout.
- In an episode of Everybody Hates Chris is an American [i] sitcom [i] on The CW Television Network [i]...
, Chris's father has gout in the episode "Everybody Hates The Gout." - In Archie Comics, the school principal Mr. Weatherbee was a long time sufferer of gout.
- In an episode of Keeping Up Appearances was a British sitcom [i], which ran on BBC1 [i] from 1990 [i] to 1995 [i].
...
, Richard has a fungus infection on his feet, but Hyacinth prefers to tell everyone it's gout because it "afflicts those who over-indulge on finer living".
- In the movie Captain Blood , Dr. Peter Blood , a physician convicted of treason for treating a rebel against the crown and thus sentenced to a life of slavery in Port Royal, Jamaica, tends to Governor Steed's gouty foot.
- Jiggs, the beleaguered husband of Maggie, in George McManus' long defunct comic strip 'Bringing Up Father'. Maggie loved the opera; Jiggs detested it. Compromises were rare. Despite her warnings "portly" top-hatted Jiggs ate large amounts of wonderfully rich food, especially corned beef and cabbage, bringing on very painful attacks of gout in the foot.
- Matthew Bramble, an invalid gentleman in Tobia Smollett's c. 1750 novel 'Humphry Clinker', suffers from a number of ailments, including gout. He reluctantly takes the waters of Bath to attempt a cure.
- In Jane Austen's last novel, Persuasion, the amiable character, Admiral Croft, arrives at Bath with orders "to walk to keep off the gout."
- In the Epic Fantasy series "A Song of Ice and Fire", Prince Doran suffers from a chronic case of gout.
- In the classic comic strip Katzenjammer Kids, the lazy and overweight Captain spends much of his time having things dropped upon his gout-ridden foot by the mischievous protagonists.
See also
- Pseudogout is a very similar disease, but caused by deposition of calcium pyrophosphate, not uric acid.
References
Footnotes
External links
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