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Arthritis



 
 
Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a group of conditions involving damage to the joint
Joint

A joint is the location at which two or more bones make contact. They are constructed to allow movement and provide mechanical support, and are classified structurally and functionally....
s of the body. Arthritis is the leading cause of disability in people older than fifty-five years.

There are different forms of arthritis and each has a different cause. The most common form of arthritis, osteoarthritis
Osteoarthritis

Osteoarthritis , is a group of diseases and mechanical abnormalities entailing degradation of joints, including articular cartilage and the subchondral bone next to it....
 (degenerative joint disease) is a result of trauma to the joint, infection of the joint, or age.






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Encyclopedia


Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a group of conditions involving damage to the joint
Joint

A joint is the location at which two or more bones make contact. They are constructed to allow movement and provide mechanical support, and are classified structurally and functionally....
s of the body. Arthritis is the leading cause of disability in people older than fifty-five years.

There are different forms of arthritis and each has a different cause. The most common form of arthritis, osteoarthritis
Osteoarthritis

Osteoarthritis , is a group of diseases and mechanical abnormalities entailing degradation of joints, including articular cartilage and the subchondral bone next to it....
 (degenerative joint disease) is a result of trauma to the joint, infection of the joint, or age. Emerging evidence suggests that abnormal anatomy might contribute to the early development of osteoarthritis. Other arthritis forms are rheumatoid arthritis
Rheumatoid arthritis

Rheumatoid arthritis is a chronic, systemic disease inflammation that may affect many tissues and organs, but principally attacks the joints producing a inflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints....
 and psoriatic arthritis
Psoriatic arthritis

Psoriatic arthritis is a type of inflammatory arthritis that, according to the National Psoriasis Foundation, affects around 10-30% of people suffering from the chronic skin condition psoriasis....
, autoimmune diseases in which the body attacks itself. Septic arthritis
Septic arthritis

Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis....
 is caused by joint infection
Infection

An infection is the detrimental colonization of a host organism by a foreign species. In an infection, the infecting organism seeks to utilize the host resources to multiply ....
. Gouty arthritis
Gout

Gout is a crystal deposition disease hallmarked by elevated levels of uric acid in the Circulatory system. In this condition, crystals of monosodium urate or uric acid are deposited on the articular cartilage of joints, tendons and surrounding tissues....
 is caused by deposition of uric acid
Uric acid

Uric acid is an organic compound of carbon, nitrogen, oxygen and hydrogen with the formula C5H4N4O3....
 crystals in the joint, causing inflammation. There is also an uncommon form of gout caused by the formation of rhomboid crystals of calcium pyrophosphate. This gout is known as pseudogout
Calcium pyrophosphate deposition disease

Calcium pyrophosphate dihydrate disease is a rheumatology disorder with varied clinical manifestations due to precipitation of calcium pyrophosphate dihydrate crystals in the connective tissues....
.

History and physical examination


All arthritides feature pain
Pain

Pain, in the sense of physical pain, is a typical sensory experience that may be described as the unpleasant awareness of a noxious stimulus or bodily harm....
. Pain patterns may differ depending on the arthritides and the location. Rheumatoid arthritis is generally worse in the morning and associated with stiffness; in the early stages, patients often have no symptoms after a morning shower. In the aged and children, pain might not be the main presenting feature; the aged patient simply moves less, the infantile patient refuses to use the affected limb.

Elements of the history of the disorder guide diagnosis. Important features are speed and time of onset, pattern of joint involvement, symmetry of symptoms, early morning stiffness, tenderness, gelling or locking with inactivity, aggravating and relieving factors, and other systemic symptoms. Physical examination may confirm the diagnosis, or may indicate systemic disease. Radiographs are often used to follow progression or assess severity in a more quantitative manner.

Extra-articular features of joint disease
cutaneous nodules
cutaneous vasculitic lesions
lymphadenopathy
Lymphadenopathy

Lymphadenopathy is a term meaning "disease of the lymph nodes." It is, however, almost synonymously used with "swollen/enlarged lymph nodes".When the infection is of the lymph nodes themselves, it is called lymphadenitis, but when the infection is of the lymph channels, it is called lymphangitis....
oedema
ocular inflammation
urethritis
Urethritis

Urethritis is inflammation of the urethra. The main symptom is dysuria, which is painful or difficult urination....
tenosynovitis
Tenosynovitis

Tenosynovitis is the inflammation of the fluid-filled sheath that surrounds a tendon. Symptoms of tenosynovitis include pain, swelling, and difficulty moving the particular joint where the inflammation occurs....
 (tendon sheath effusions)
bursitis
Bursitis

Bursitis is the inflammation of one or more Bursa of synovial fluid in the body. The bursae rest at the points where internal functionaries, such as muscles and tendons, slide across bone....
 (swollen bursa)
diarrhea
Diarrhea

In medicine, diarrhea, also spelled diarrhoea , is characterized by frequent loose or liquid bowel movements. The spelling of "diarrhea" is an appropriation of the Greek "diarrhoia" meaning "a flowing through." ....
orogenital ulceration


Blood test
Blood test

A blood test is a medical laboratory analysis performed on a blood sample that is usually extracted from a vein in the arm using a hypodermic needle, or via fingerprick....
s and X-ray
X-ray

X-radiation is a form of electromagnetic radiation. X-rays have a wavelength in the range of 10 to 0.01 nanometers, corresponding to frequency in the range 30 Hertz to 30 Hertz and energies in the range 120 Electron volt to 120 keV....
s of the affected joints often are performed to make the diagnosis. Screening blood tests are indicated if certain arthritides are suspected. These might include: rheumatoid factor
Rheumatoid factor

Rheumatoid factor is an autoantibody most relevant in rheumatoid arthritis. It is an antibody against the Fc portion of IgG, which is itself an antibody....
, antinuclear factor (ANF), extractable nuclear antigen, and specific antibodies.

Types of arthritis

Primary forms of arthritis:
  • Osteoarthritis
    Osteoarthritis

    Osteoarthritis , is a group of diseases and mechanical abnormalities entailing degradation of joints, including articular cartilage and the subchondral bone next to it....
  • Rheumatoid arthritis
    Rheumatoid arthritis

    Rheumatoid arthritis is a chronic, systemic disease inflammation that may affect many tissues and organs, but principally attacks the joints producing a inflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints....
  • Septic arthritis
    Septic arthritis

    Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis....
  • Gout
    Gout

    Gout is a crystal deposition disease hallmarked by elevated levels of uric acid in the Circulatory system. In this condition, crystals of monosodium urate or uric acid are deposited on the articular cartilage of joints, tendons and surrounding tissues....
     and pseudogout
    Calcium pyrophosphate deposition disease

    Calcium pyrophosphate dihydrate disease is a rheumatology disorder with varied clinical manifestations due to precipitation of calcium pyrophosphate dihydrate crystals in the connective tissues....
  • Juvenile idiopathic arthritis
    Juvenile idiopathic arthritis

    Juvenile idiopathic arthritis is the most common form of persistent arthritis in children. JIA is a subset of arthritis seen in childhood, which may be transient and self-limited or chronic....
  • Still's disease
    Still's disease

    Still's disease can refer to:* Juvenile idiopathic arthritis* Adult-onset Still's diseasees:Enfermedad de Stillru:??????? ??????sv:Stills sjukdom...
  • Ankylosing spondylitis
    Ankylosing spondylitis

    Ankylosing spondylitis It is a member of the group of the spondyloarthropathy with a strong genetic predisposition. Complete fusion results in a complete rigidity of the spine, a condition known as bamboo spine....


Secondary to other diseases:
  • Lupus erythematosus
    Lupus erythematosus

    Lupus erythematosus is a connective tissue disease....
  • Henoch-Schönlein purpura
    Henoch-Schönlein purpura

    Henoch-Sch?nlein purpura, also known as allergic purpura or anaphylactoid purpura and commonly abbreviated to HSP, is a systemic vasculitis characterized by deposition of immune complexes containing the antibody IgA in the skin and kidney....
  • Psoriatic arthritis
    Psoriatic arthritis

    Psoriatic arthritis is a type of inflammatory arthritis that, according to the National Psoriasis Foundation, affects around 10-30% of people suffering from the chronic skin condition psoriasis....
  • Reactive arthritis
    Reactive arthritis

    Reactive arthritis is an autoimmune condition that develops in response to an infection in another part of the body. Coming into contact with bacteria and developing an infection can trigger reactive arthritis....
  • Haemochromatosis
    Haemochromatosis

    Haemochromatosis, also spelled hemochromatosis , also called hereditary haemochromatosis, siderophilia and bronze diabetes, is a hereditary disease characterized by excessive absorption of Human iron metabolism resulting in a pathological increase in total body iron stores....
  • Hepatitis
    Hepatitis

    Hepatitis implies injury to the liver characterized by the presence of inflammatory cell s in the Tissue of the organ. The name is from ancient Greek hepar , the root being hepat- , meaning liver, and suffix -itis, meaning "inflammation" ....
  • Wegener's granulomatosis
    Wegener's granulomatosis

    Wegener's granulomatosis is a form of vasculitis that affects the lungs, kidneys and other organs. Due to its end-organ damage, it can be a serious disease that requires long-term immune suppression....
     (and many other vasculitis
    Vasculitis

    Vasculitis refers to a heterogeneous group of disorders that are characterized by inflammatory destruction of blood vessels.Both arteries and veins are affected....
     syndromes)
  • Lyme disease
    Lyme disease

    Lyme disease, or borreliosis, is an emerging infectious disease caused by at least three species of bacteria belonging to the genus Borrelia....
  • Familial Mediterranean fever
    Familial Mediterranean fever

    Familial Mediterranean Fever is a genetic disorder inflammation disorder that affects groups of people originating from around the Mediterranean Sea ....
  • Hyperimmunoglobulinemia D with recurrent fever
  • TNF receptor associated periodic syndrome
    TNF receptor associated periodic syndrome

    TNF receptor associated periodic syndrome is a periodic fever syndrome associated with mutations in a Receptor for the molecule Tumor necrosis factors that is inheritable in an autosomal dominant manner....
  • Inflammatory bowel disease
    Inflammatory bowel disease

    In medicine, inflammatory bowel disease is a group of inflammation conditions of the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis.....
     (Including Crohn's Disease
    Crohn's disease

    Crohn's disease is an inflammatory disease which may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms....
     and Ulcerative Colitis
    Ulcerative colitis

    Ulcerative colitis is a form of inflammatory bowel disease . Ulcerative colitis is a form of colitis, a disease of the intestine, specifically the large intestine or colon , that includes characteristic Peptic ulcer, or open sores, in the colon....
    )


Diseases that can mimic arthritis include:
  • Hypertrophic osteoarthropathy
    Clubbing

    In medicine, clubbing, finger clubbing, or digital clubbing is a deformity of the fingers and Nail s that is associated with a number of diseases, mostly of the heart disease and lung disease....
  • Multiple myeloma
    Multiple myeloma

    Multiple myeloma is a cancer of plasma cells. These immune system cells are formed in bone marrow, are numerous in lymphatics and produce antibody....
  • Osteoporosis
    Osteoporosis

    Osteoporosis is a disease of bone that leads to an increased risk of bone fracture. In osteoporosis the bone mineral density is reduced, bone microarchitecture is disrupted, and the amount and variety of collagen proteins in bone is altered....
  • Fifth disease
    Fifth disease

    Erythema infectiosum or fifth disease is one of several possible manifestations of infection by erythrovirus previously called parvovirus B19....
     (parvovirus
    Parvovirus

    Parvovirus, commonly truncated to parvo, is a genus of the Parvoviridae family linear, non-segmented single stranded DNA viruses with an average genome size of 5 base pair....
     infection)


Treatment

Treatment options vary depending on the type of arthritis and include physical
Physical therapy

Physical therapy is a health care profession which provides services to individuals and populations to develop, maintain and restore maximum movement and functional ability throughout life....
 and occupational therapy
Occupational therapy

File:Occupational therapy psychiatric hospital.jpgOccupational Therapy, often abbreviated as "OT", incorporates meaningful and purposeful occupation to enable people with limitations or impairments to participate in everyday life....
, lifestyle changes (including exercise and weight control), medications and dietary supplements (symptomatic or targeted at the disease process causing the arthritis). Arthroplasty
Arthroplasty

Arthroplasty is an operative procedure of Podiatric surgery performed, in which the arthritic or dysfunctional joint surface is replaced with something better or by remodeling or realigning the joint by osteotomy or some other procedure....
 (joint replacement surgery) may be required in eroding forms of arthritis.

In general, studies have shown that physical exercising of the affected joint can have noticeable improvement in terms of long-term pain relief. Furthermore, exercising of the arthritic joint is encouraged to maintain the health of the particular joint and the overall body of the person.

History

While evidence of primary ankle (kaki) osteoarthritis has been discovered in dinosaurs, the first known traces of human arthritis date back as far as 4500 BC. It was noted in skeletal remains of Native Americans
Native Americans in the United States

Native Americans in the United States are the Indigenous peoples of the Americas from the regions of North America now encompassed by the continental United States United States, including parts of Alaska and the island state of Hawaii....
 found in Tennessee
Tennessee

Tennessee is a U.S. state located in the Southern United States United States. In 1796, it became the sixteenth state to join the United States....
 and parts of what is now Olathe, Kansas
Kansas

The State of Kansas is a Midwestern U.S. state in the Central United States of the United States of America, an area often referred to as the United States "Heartland"....
. Evidence of arthritis has been found throughout history, from Ötzi
Ötzi the Iceman

?tzi the Iceman , and Similaun Man are modern names of a well-preserved natural mummy of a man from about 34th century BC . The mummy was found in 1991 in the Schnalstal glacier in the ?tztal Alps, near Hauslabjoch on the border between Austria and Italy....
, a mummy
Mummy

A mummy is a corpse whose skin and organs have been preserved by either intentional or incidental exposure to chemicals, extreme coldness, very high humidity, or lack of air when bodies are submerged in bogs....
 (circa 3000 BC) found along the border of modern Italy
Italy

Italy , officially the Italian Republic , is a country located on the Italian Peninsula in Southern Europe and on the two largest islands in the Mediterranean Sea, Sicily and Sardinia....
 and Austria
Austria

Austria , officially the Republic of Austria , is a landlocked country in Central Europe. It borders both Germany and the Czech Republic to the north, Slovakia and Hungary to the east, Slovenia and Italy to the south, and Switzerland and Liechtenstein to the west....
, to the Egyptian mummies circa 2590 BC .

In 1715 William Musgrave
William Musgrave

William Musgrave , physician and antiquary. He was educated at Winchester College and New College, Oxford, where he was a fellow from 1677 to 1692....
 published the second edition of his most important medical work De arthritide symptomatica which concerned arthritis and its effects.

See also

  • Arthritis Care
    Arthritis Care

    Arthritis Care is the UK's largest Charitable organization dedicated to supporting people with arthritis . It is a user led organisation which means people with arthritis are at the heart of its work ? they form its membership, are involved in its activities and are well represented on its staff and board of trustees....
     (charity in the UK)
  • Osteoimmunology
    Osteoimmunology

    Osteoimmunology is the study of the interface between the skeleton and the immune system, comprising the ?osteo-immune system?. It is also the study of shared components and mechanisms between the two systems in vertebrates, including ligands, receptors, signaling molecules and transcription factors....


External links

  • - US professional society of rheumatologists
  • - US national not-for-profit organization for arthritis
  • - UK charity that exists to support people with arthritis