List of bestselling drugs - AbsoluteAstronomy.com

The following is a list of the top 200 pharmaceutical products ranked by sales in U.S. dollars for 2006.

Rank 2006	Brand Name(s)	Generic Name	Sales 2006 (USD millions)	Change from 2005	Company(ies)	Disease/Medical Use	First Approval Date	Patent Expiration Date
1	Lipitor	Atorvastatin Atorvastatin Atorvastatin , sold by Pfizer under the trade name Lipitor, is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms...	14,385	7%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Cholesterol	Dec-1996	Nov-2011
2	Advair, Seretide	Fluticasone Fluticasone Fluticasone is a synthetic glucocorticoid.Both the furoate and propionate forms are used as topical anti-inflammatories:Fluticasone propionateFluticasone furoateTreatment of asthma - Fluticasone in combination with Salmeterol - "[]" - aerosol.... + Salmeterol Salmeterol Salmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease. It is currently available as a dry powder inhaler that releases a powdered form of the drug...	6,129	12%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Asthma	Aug-2000	Mar-2012
3	Plavix, Iscover	Clopidogrel Clopidogrel Clopidogrel is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. It is marketed by Bristol-Myers Squibb and Sanofi-Aventis under the trade name Plavix. The drug works by irreversibly...	6,057	-5%	Bristol-Myers Squibb Bristol-Myers Squibb Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation... /Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Thrombotic events	Nov-1997	Nov-2011
4	Nexium	Esomeprazole Esomeprazole Esomeprazole is a proton pump inhibitor developed and marketed by AstraZeneca which is used in the treatment of dyspepsia, peptic ulcer disease , gastroesophageal reflux disease and Zollinger-Ellison syndrome...	5,182	12%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Gastrointestinal disorders	Mar-2000	Sep-2007
5	Norvasc	Amlodipine Amlodipine Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina...	4,866	3%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Hypertension	Jul-1992	Jul-2006
6	Remicade	Infliximab Infliximab Infliximab is a monoclonal antibody against tumour necrosis factor alpha . It is used to treat autoimmune diseases. Remicade is marketed by Janssen Biotech, Inc...	4,428	23%	Johnson & Johnson Johnson & Johnson Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500.... , Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co... , Mitsubishi Tanabe Pharma	Crohn's disease, Rheumatoid arthritis	Aug-1998	n/a
7	Enbrel	Etanercept Etanercept Etanercept is a drug that treats autoimmune diseases by interfering with the tumor necrosis factor by acting as a TNF inhibitor. Pfizer describes in a SEC filing that the drug is used to treat rheumatoid, juvenile rheumatoid and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis...	4,379	20%	Amgen Amgen Amgen Inc. is an international biotechnology company headquartered in Thousand Oaks, California. Located in the Conejo Valley, Amgen is the world's largest independent biotech firm. The company employs approximately 17,000 staff members. Its products include Epogen, Aranesp, Enbrel, Kineret,...	Rheumatoid arthritis	Nov-1998	Oct-2012
8	Zyprexa	Olanzapine Olanzapine Olanzapine is an atypical antipsychotic, approved by the FDA for the treatment of schizophrenia and bipolar disorder...	4,364	4%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Schizophrenia, Bipolar Disorder	Sep-1996	Jun-2013
9	Diovan	Valsartan Valsartan Valsartan is an angiotensin II receptor antagonist , with particularly high affinity for the type I angiotensin receptor. By blocking the action of angiotensin, valsartan dilates blood vessels and reduces blood pressure...	4,223	15%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Hypertension	Dec-1996	Jul-2011
10	Risperdal	Risperidone Risperidone Risperidone is a second generation or atypical antipsychotic, sold under the trade name . It is used to treat schizophrenia , schizoaffective disorder, the mixed and manic states associated with bipolar disorder, and irritability in people with autism...	4,183	18%	Johnson & Johnson Johnson & Johnson Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....	Psychosis	Dec-1993	Dec-2007
11	Aranesp	Darbepoetin alfa Darbepoetin alfa Darbepoetin alfa is a synthetic form of erythropoietin. It stimulates erythropoiesis and is used to treat anemia, commonly associated with chronic renal failure and cancer chemotherapy...	4,121	26%	Amgen Amgen Amgen Inc. is an international biotechnology company headquartered in Thousand Oaks, California. Located in the Conejo Valley, Amgen is the world's largest independent biotech firm. The company employs approximately 17,000 staff members. Its products include Epogen, Aranesp, Enbrel, Kineret,...	Anemia	Jun-2001	Mon-20XX
12	Rituxan, MabThera	Rituximab Rituximab Rituximab, sold under the trade names Rituxan and MabThera, is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells...	3,861	16%	Roche, Genentech Genentech Genentech Inc., or Genetic Engineering Technology, Inc., is a biotechnology corporation, founded in 1976 by venture capitalist Robert A. Swanson and biochemist Dr. Herbert Boyer. Trailing the founding of Cetus by five years, it was an important step in the evolution of the biotechnology industry... , Biogen Idec Biogen Idec Biogen Idec, Inc. is a biotechnology company specializing in drugs for neurological disorders, autoimmune disorders and cancer. The company was formed in 2003 by the merger of Cambridge, Massachusetts-based Biogen Inc. and San Diego, California-based IDEC Pharmaceuticals... , Chugai Pharmaceutical	Non-Hodgkin’s lymphoma, Rheumatoid arthritis	Nov-1997	Mon-20XX
13	Effexor	Venlafaxine Venlafaxine Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. First introduced by Wyeth in 1993, now marketed by Pfizer, it is licensed for the treatment of major depressive disorder , as a treatment for generalized anxiety disorder, and comorbid indications in...	3,722	8%	Wyeth Wyeth Wyeth, formerly one of the companies owned by American Home Products Corporation , was a pharmaceutical company. The company was based in Madison, New Jersey, USA...	Depression, Anxiety disorders	Dec-1993	Dec-2007
14	Protonix, Pantozol, Pantoloc	Pantoprazole Pantoprazole Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion.-Use:...	3,621	4%	Wyeth Wyeth Wyeth, formerly one of the companies owned by American Home Products Corporation , was a pharmaceutical company. The company was based in Madison, New Jersey, USA... , Altana Altana The Altana AG is a German chemical company based in Wesel. Altana develops and produces products in the specialty chemicals business. The ALTANA Group, with headquarters in Wesel/Germany, sells 85% of its products overseas... , Solvay Solvay Solvay may refer to* Solvay , an international chemicals and plastics company* the Solvay process* Ernest Solvay, its inventor* Solvay Conference* the Solvay Business School* Solvay, New York* Solvay Hut, on the Matterhorn...	Gastrointestinal disorders	Feb-2000	Mon-20XX
15	Singulair	Montelukast Montelukast Montelukast is a leukotriene receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally...	3,579	20%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...	Asthma	Feb-1998	Feb-2012
16	Seroquel	Quetiapine Quetiapine Quetiapine , is an atypical antipsychotic approved for the treatment of schizophrenia, and bipolar disorder....	3,560	23%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Schizophrenia	Sep-1997	Sep-2011
17	Prevacid, Takepron	Lansoprazole Lansoprazole Lansoprazole is a proton-pump inhibitor which prevents the stomach from producing gastric acid. It is manufactured by a number of companies worldwide under several brand names . It was first approved by the U.S...	3,425	3%	TAP Pharmaceuticals TAP Pharmaceuticals TAP Pharmaceuticals was a Japanese pharmaceutical company.It was a joint venture between Abbott Laboratories and the Japanese Takeda Pharmaceutical Company, formed in 1977. The joint venture was dissolved in 2008 and most of the company merged with Takeda Pharmaceutical Co... , Takeda Pharmaceutical	Gastrointestinal disorders	May-1995	May-2009
18	Procrit, Eprex	Erythropoietin Erythropoietin Erythropoietin, or its alternatives erythropoetin or erthropoyetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production...	3,180	-4%	Johnson & Johnson Johnson & Johnson Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....	Anemia	Dec-1990	Mon-20XX
19	Cozaar, Hyzaar	Losartan Losartan Losartan is an angiotensin II receptor antagonist drug used mainly to treat high blood pressure . Losartan was the first angiotensin II receptor antagonist to be marketed. Losartan potassium is marketed by Merck & Co. Inc. under the trade name Cozaar...	3,163	4%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...	Hypertension	Apr-1995	Mon-20XX
20	Fosamax	Alendronate Alendronate Alendronic acid or alendronate sodium — sold as Fosamax by Merck — is a bisphosphonate drug used for osteoporosis and several other bone diseases. It is marketed alone as well as in combination with vitamin D . Merck's U.S...	3,134	-2%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...	Osteoporosis	Sep-1995	Mon-20XX
21	Herceptin	Trastuzumab Trastuzumab Trastuzumab is a monoclonal antibody that interferes with the HER2/neu receptor.The HER receptors are proteins that are embedded in the cell membrane and communicate molecular signals from outside the cell to inside the cell, and turn genes on and off...	3,134	83%	Roche, Genentech Genentech Genentech Inc., or Genetic Engineering Technology, Inc., is a biotechnology corporation, founded in 1976 by venture capitalist Robert A. Swanson and biochemist Dr. Herbert Boyer. Trailing the founding of Cetus by five years, it was an important step in the evolution of the biotechnology industry... , Chugai Pharmaceutical	Breast cancer	Sep-1998	Mon-20XX
22	Lovenox, Clexane	Enoxaparin Enoxaparin Enoxaparin is a low molecular weight heparin marketed under the trade names Lovenox and Clexane, among others. It is an anticoagulant used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection...	3,059	14%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Deep-vein thrombosis	Mar-1993	Dec-2004
23	Avandia, Avandamet, Avandaryl	Rosiglitazone Rosiglitazone Rosiglitazone is an antidiabetic drug in the thiazolidinedione class of drugs. It works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin...	3,043	26%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Type 2 diabetes	May-1999	Sep-2011
24	Actos	Pioglitazone Pioglitazone Pioglitazone is a prescription drug of the class thiazolidinedione with hypoglycemic action.Pioglitazone is marketed as trademarks Actos in the USA, Canada, the UK and Germany, Glustin in Europe,"Glizone" and "Pioz" in India by Zydus CND and USV respectively and Zactos in Mexico by Takeda...	2,880	25%	Takeda Pharmaceutical, Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Type 2 diabetes	Jul-1999	May-2007
25	Zocor	Simvastatin Simvastatin Simvastatin is a hypolipidemic drug used to control elevated cholesterol, or hypercholesterolemia. Simvastatin is a member of the statin class of pharmaceuticals, is a synthetic derivate of a fermentation product of Aspergillus terreus.-Medical uses:The primary uses of simvastatin is for the...	2,803	-36%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...	Cholesterol	Dec-1991	Dec-2005
26	Copaxone	Glatiramer	2,757	19%	Teva Pharmaceutical Industries Teva Pharmaceutical Industries Teva Pharmaceutical Industries Ltd. , is an international pharmaceutical company headquartered in Petah Tikva, Israel. It specializes in generic and proprietary pharmaceuticals and active pharmaceutical ingredients... , Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Multiple sclerosis	Dec-1996	Mon-20XX
27	AcipHex, Pariet	Rabeprazole Rabeprazole Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It was developed by Eisai Co. and is marketed by Janssen-Cilag as rabeprazole sodium under the brand names AcipHex in the US and Pariet in Britain, Italy, Greece, Australia, Brazil, Canada, Japan, and Russia. It is sold as...	2,729	-4%	Eisai Eisai Myōan Eisai was a Japanese Buddhist priest, credited with bringing the Rinzai school of Zen Buddhism and green tea from China to Japan. He is often known simply as Eisai Zenji , literally "Zen master Eisai".... , Johnson & Johnson Johnson & Johnson Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....	Gastrointestinal disorders	Aug-1999	May-2013
28	Neulasta	Filgrastim Filgrastim Filgrastim is a granulocyte colony-stimulating factor analog used to stimulate the proliferation and differentiation of granulocytes. It is produced by recombinant DNA technology. The gene for human granulocyte colony-stimulating factor is inserted into the genetic material of Escherichia coli. ...	2,710	18%	Amgen Amgen Amgen Inc. is an international biotechnology company headquartered in Thousand Oaks, California. Located in the Conejo Valley, Amgen is the world's largest independent biotech firm. The company employs approximately 17,000 staff members. Its products include Epogen, Aranesp, Enbrel, Kineret,...	Neutropenia	Jan-2002	Mon-20XX
29	Lexapro, Cipralex	Escitalopram Escitalopram Escitalopram is an antidepressant of the selective serotonin reuptake inhibitor class. It is approved by the U.S...	2,696	16%	Forest Laboratories Forest Laboratories Forest Laboratories is a pharmaceutical company headquartered in New York City, USA. Its revenues for the year ended 31 March 2007 were US$3.4 billion. The company's research and development spending has grown rapidly in recent years, and as of 2007, approached almost a billion US dollars a year,... , H. Lundbeck	Depression, Anxiety disorders	Aug-2002	Sep-2011
30	Gleevec, Glivec	Imatinib Imatinib Imatinib is a drug used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec or Glivec as its mesylate salt, imatinib mesilate . It is used in treating chronic myelogenous leukemia , gastrointestinal stromal tumors and some other diseases...	2,554	18%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Leukemia	May-2001	Jan-2015
31	Ambien, Stilnox	Zolpidem Zolpidem Zolpidem is a prescription medication used for the short-term treatment of insomnia, as well as some brain disorders. It is a short-acting nonbenzodiazepine hypnotic of the imidazopyridine class that potentiates gamma-aminobutyric acid , an inhibitory neurotransmitter, by binding to GABAA...	2,545	33%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Insomnia	Dec-1992	Oct-2006
32	Aricept	Donepezil Donepezil Donepezil, marketed under the trade name Aricept by its developer Eisai and partner Pfizer, is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of mild to moderate Alzheimer's disease. Common side effects include...	2,519	24%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Alzheimer’s disease	Nov-1996	Nov-2010
33	Epogen	Erythropoietin Erythropoietin Erythropoietin, or its alternatives erythropoetin or erthropoyetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production...	2,511	2%	Amgen Amgen Amgen Inc. is an international biotechnology company headquartered in Thousand Oaks, California. Located in the Conejo Valley, Amgen is the world's largest independent biotech firm. The company employs approximately 17,000 staff members. Its products include Epogen, Aranesp, Enbrel, Kineret,...	Anemia	Jun-1989	Mon-20XX
34	Zyrtec, Cirrus	Cetirizine Cetirizine Cetirizine , a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.-Availability:...	2,377	9%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States... , UCB UCB (company) UCB is a multinational biopharmaceutical manufacturing company headquartered in Brussels, Belgium.- History :UCB was founded on 18 January 1928 by Emmanuel Janssen, a Belgian businessman... , Daiichi Sankyo	Allergic rhinitis	Dec-1995	Jun-2007
35	Avapro, Aprovel, Avalide	Irbesartan Irbesartan Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Irbesartan was developed by Sanofi Research...	2,372	13%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the... , Bristol-Myers Squibb Bristol-Myers Squibb Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...	Hypertension	Sep-1997	Sep-2011
36	Avastin	Bevacizumab Bevacizumab Bevacizumab is a drug that blocks angiogenesis, the growth of new blood vessels. It is commonly used to treat various cancers, including colorectal, lung, breast, kidney, and glioblastomas....	2,364	78%	Roche, Genentech Genentech Genentech Inc., or Genetic Engineering Technology, Inc., is a biotechnology corporation, founded in 1976 by venture capitalist Robert A. Swanson and biochemist Dr. Herbert Boyer. Trailing the founding of Cetus by five years, it was an important step in the evolution of the biotechnology industry...	Colorectal cancer	Feb-2004	Mon-20XX
37	Taxotere	Docetaxel	2,201	9%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Cancer	Oct-1995	May-2010
38	Eloxatin, Eloxatine	Oxaliplatin Oxaliplatin Oxaliplatin is a coordination complex that is used in cancer chemotherapy. These platinum-based drugs are usually classified as alkylating agents, although they are not actually alkylating groups ....	2,127	8%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Colorectal cancer	Aug-2002	Aug-2016
39	Zoloft	Sertraline Sertraline Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor class. It was introduced to the market by Pfizer in 1991. Sertraline is primarily used to treat major depression in adult outpatients as well as obsessive–compulsive, panic, and social anxiety disorders in...	2,110	-35%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Depression, Anxiety disorders	Dec-1991	Dec-2005
40	Tamiflu	Oseltamivir Oseltamivir Oseltamivir INN , an antiviral drug, slows the spread of influenza virus between cells in the body by stopping the virus from chemically cutting ties with its host cell; median time to symptom alleviation is reduced by 0.5–1 day. The drug is sold under the trade name Tamiflu, and is taken orally...	2,096	69%	Roche, Chugai Pharmaceutical, Hetero Drugs Hetero Drugs Hetero Drugs Limited is an Indian Pharmaceutical Company established in the year 1993. Hetero Drugs Limited founded by Dr. B. Partha Saradhi Reddy Phd., a scientist and expert in chemistry...	Influenza	Oct-1999	Mon-20XX
41	Lantus	Insulin analog Insulin analog An insulin analog is an altered form of insulin, different from any occurring in nature, but still available to the human body for performing the same action as human insulin in terms of glycemic control...	2,093	37%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Type 2 diabetes and type 1 diabetes	Apr-2000	Dec-2011
42	Crestor	Rosuvastatin Rosuvastatin Rosuvastatin is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. It was developed by Shionogi.-Medical uses:The primary uses of rosuvastatin is for the treatment of dyslipidemia...	2,049	61%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries... , Shionogi Shionogi is a Japanese pharmaceutical company best known for developing Crestor. Medical supply and brand name also uses Shionogi .Shionogi has business roots that date back to 1878, and was incorporated in 1919. Among the medicines produced are for hyperlipidaemia, antibiotics, and cancer medicines.In...	Cholesterol	Nov-2002	Jan-2016
43	Humira	Adalimumab Adalimumab Adalimumab is the third TNF inhibitor, after infliximab and etanercept, to be approved in the United States. Like infliximab and etanercept, adalimumab binds to TNFα, preventing it from activating TNF receptors; adalimumab was constructed from a fully human monoclonal antibody, while infliximab...	2,044	46%	Abbott Laboratories Abbott Laboratories Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr....	Rheumatoid arthritis	Dec-2002	Dec-2016
44	Celebrex	Celecoxib Celecoxib Celecoxib INN is a sulfa non-steroidal anti-inflammatory drug and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial...	2,039	18%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Osteoarthritis and rheumatoid arthritis	Dec-1998	Mon-20XX
45	Topamax	Topiramate Topiramate Topiramate is an anticonvulsant drug. It was originally produced by Ortho-McNeil Neurologics and Noramco, Inc., both divisions of the Johnson & Johnson Corporation. This medication was discovered in 1979 by Bruce E. Maryanoff and Joseph F. Gardocki during their research work at McNeil...	2,027	21%	Johnson & Johnson Johnson & Johnson Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....	Seizures	Dec-1996	Sep-2008
46	Prevnar	vaccine Vaccine A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...	1,961	30%	Wyeth Wyeth Wyeth, formerly one of the companies owned by American Home Products Corporation , was a pharmaceutical company. The company was based in Madison, New Jersey, USA...	Pneumococcal disease	Feb-2000	Jan-2007
47	Vytorin	Ezetimibe Ezetimibe Ezetimibe is a drug that lowers cholesterol. It acts by decreasing cholesterol absorption in the intestine. It may be used alone , when other cholesterol-lowering medications are not tolerated, or together with statins when statins alone do not control cholesterol.Even though ezetimibe decreases... + Simvastatin Simvastatin Simvastatin is a hypolipidemic drug used to control elevated cholesterol, or hypercholesterolemia. Simvastatin is a member of the statin class of pharmaceuticals, is a synthetic derivate of a fermentation product of Aspergillus terreus.-Medical uses:The primary uses of simvastatin is for the...	1,955	90%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township... , Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...	Cholesterol	Jul-2004	Mon-20XX
48	Zetia	Ezetimibe Ezetimibe Ezetimibe is a drug that lowers cholesterol. It acts by decreasing cholesterol absorption in the intestine. It may be used alone , when other cholesterol-lowering medications are not tolerated, or together with statins when statins alone do not control cholesterol.Even though ezetimibe decreases...	1,929	38%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township... , Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...	Cholesterol	Oct-2002	Oct-2016
49	Wellbutrin	Bupropion Bupropion Bupropion is an atypical antidepressant and smoking cessation aid. The drug is a non-tricyclic antidepressant and differs from most commonly prescribed antidepressants such as SSRIs, as its primary pharmacological action is thought to be norepinephrine-dopamine reuptake inhibition...	1,926	26%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom... , Biovail Biovail Biovail Corporation was a Canadian pharmaceutical company, operating internationally in all aspects of pharmaceutical products. Its major production facility was located in Steinbach, Manitoba...	Depression, Seasonal affective disorder (SAD)	Aug-2003	May-1994
50	Abilify	Aripiprazole Aripiprazole Aripiprazole is an atypical antipsychotic and antidepressant used in the treatment of schizophrenia, bipolar disorder, and clinical depression...	1,900	1%	Otsuka Pharmaceutical, Bristol-Myers Squibb Bristol-Myers Squibb Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...	Psychosis, Depression	Nov-2002	Oct-2014
51	Lamictal	Lamotrigine Lamotrigine Lamotrigine, marketed in the US and most of Europe as Lamictal by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used as an adjunct in treating depression, though this is considered off-label usage...	1,843	19%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Seizures	Dec-1994	Jul-2008
52	Toprol, Seloken	Metoprolol Metoprolol Metoprolol is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension. The active substance metoprolol is employed either as metoprolol succinate or metoprolol tartrate...	1,795	3%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Hypertension	Jan-1992	Mon-20XX
53	NeoRecormon, Epogin	Erythropoietin Erythropoietin Erythropoietin, or its alternatives erythropoetin or erthropoyetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production...	1,777	-1%	Roche, Chugai Pharmaceutical	Anemia	Jul-1997	Mon-20XX
54	Atacand, Blopress	Candesartan Candesartan Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. The prodrug candesartan cilexetil is marketed by AstraZeneca and Takeda Pharmaceuticals, commonly under the trade names Blopress, Atacand, Amias, and Ratacand.-Clinical use:As all angiotensin II...	1,768	8%	Takeda Pharmaceutical, AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Hypertension	Oct-1997	Jul-2012
55	Spiriva	Tiotropium Tiotropium Tiotropium bromide is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease . Tiotropium bromide capsules for inhalation are co-promoted by Boehringer-Ingelheim and Pfizer under the trade name Spiriva...	1,735	45%	Boehringer Ingelheim	Chronic obstructive pulmonary disease	Apr-2002	Jan-2018
56	Avonex	Interferon beta-1a Interferon beta-1a Interferon beta-1a is a drug in the interferon family used to treat multiple sclerosis . It is produced by mammalian cells, while Interferon beta-1b is produced in modified E. coli. Interferons have been shown to produce about a 18–38% reduction in the rate of MS relapses, and to slow the...	1,707	11%	Biogen Idec Biogen Idec Biogen Idec, Inc. is a biotechnology company specializing in drugs for neurological disorders, autoimmune disorders and cancer. The company was formed in 2003 by the merger of Cambridge, Massachusetts-based Biogen Inc. and San Diego, California-based IDEC Pharmaceuticals...	Multiple sclerosis	May-1996	Mon-20XX
57	Viagra	Sildenafil Sildenafil Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension . It was originally developed by British scientists and then brought to market by the US-based pharmaceutical company Pfizer...	1,657	1%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Erectile dysfunction	Mar-1998	Mar-2012
58	Micardis	Telmisartan Telmisartan Telmisartan is an angiotensin II receptor antagonist used in the management of hypertension. It is marketed under the trade name Micardis , among others.-Administration:...	1,645	35%	Boehringer Ingelheim, Astellas Pharma Astellas Pharma is a Japanese pharmaceutical company, formed on 1 April 2005 from the merger of and .Astellas' franchise areas are urology, immunology , dermatology, cardiology, and infectious disease...	Hypertension	Nov-1998	Mon-20XX
59	Actonel	Risedronate Risedronate Risedronic acid or risedronate sodium is a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone. It is produced and marketed by Warner Chilcott, Sanofi-Aventis, and in Japan by Takeda under the trade names Actonel, Atelvia, and Benet...	1,619	-4%	Procter & Gamble Procter & Gamble Procter & Gamble is a Fortune 500 American multinational corporation headquartered in downtown Cincinnati, Ohio and manufactures a wide range of consumer goods.... , Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Osteoporosis	Mar-1998	Mon-20XX
60	Lupron, Leuplin	Leuprolide Leuprolide Leuprorelin or leuprolide acetate is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt - Mode of action:Leuprolide acts as an agonist at pituitary GnRH receptors...	1,579	1%	Takeda Pharmaceutical, TAP Pharmaceuticals TAP Pharmaceuticals TAP Pharmaceuticals was a Japanese pharmaceutical company.It was a joint venture between Abbott Laboratories and the Japanese Takeda Pharmaceutical Company, formed in 1977. The joint venture was dissolved in 2008 and most of the company merged with Takeda Pharmaceutical Co...	Prostate cancer	Jan-1989	Jan-1996
61	TriCor, Lipanthyl	Fenofibrate Fenofibrate Fenofibrate is a drug of the fibrate class. Fenofibrate was developed by Groupe Fournier SA, before it was acquired in 2005 by Solvay Pharmaceutical, a business unit owned by the Belgian corporation, Solvay S.A. In 2009 Solvay Pharmaceutical was acquired by Abbott Laboratories. It is mainly used to...	1,567	38%	Abbott Laboratories Abbott Laboratories Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr.... , Solvay Solvay Solvay may refer to* Solvay , an international chemicals and plastics company* the Solvay process* Ernest Solvay, its inventor* Solvay Conference* the Solvay Business School* Solvay, New York* Solvay Hut, on the Matterhorn...	Cholesterol	Feb-1998	Mon-20XX
62	Zofran	Ondansetron Ondansetron Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic , often following chemotherapy. Its effects are thought to be on both peripheral and central nerves...	1,567	3%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Nausea and vomiting	Dec-1992	Jan-2005
63	Valtrex	Valaciclovir	1,563	24%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Herpes	Jun-1995	Jun-2009
64	Levaquin, Floxin	Levofloxacin Levofloxacin Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class and is used to treat severe or life-threatening bacterial infections or bacterial infections that have failed to respond to other antibiotic classes. It is sold under various brand names, such as Levaquin and...	1,530	3%	Johnson & Johnson Johnson & Johnson Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....	Bacterial infections	Dec-1996	Dec-2010
65	Arimidex	Anastrozole Anastrozole Anastrozole is an aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer is increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor...	1,508	28%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Breast cancer	Dec-1995	Dec-2009
66	Prograf	Tacrolimus Tacrolimus Tacrolimus is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection...	1,499	20%	Astellas Pharma Astellas Pharma is a Japanese pharmaceutical company, formed on 1 April 2005 from the merger of and .Astellas' franchise areas are urology, immunology , dermatology, cardiology, and infectious disease...	Transplant rejection	Apr-1993	Apr-2008
67	CellCept	Mycophenolate mofetil Mycophenolate mofetil Mycophenolate mofetil is an immunosuppressant and prodrug of mycophenolic acid, used extensively in transplant medicine. It is a reversible inhibitor of inosine monophosphate dehydrogenase in purine biosynthesis, which is necessary for the growth of T cells and B cells...	1,470	8%	Roche, Chugai Pharmaceutical	Transplant rejection	May-1995	May-2009
68	Xalatan, Xalacom	Latanoprost Latanoprost Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension by reducing intraocular pressure...	1,453	6%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Intraocular pressure	Jun-1996	Jul-2006
69	Rebif	Interferon beta-1a Interferon beta-1a Interferon beta-1a is a drug in the interferon family used to treat multiple sclerosis . It is produced by mammalian cells, while Interferon beta-1b is produced in modified E. coli. Interferons have been shown to produce about a 18–38% reduction in the rate of MS relapses, and to slow the...	1,452	14%	Serono Serono Serono is a biotechnology company headquartered in Geneva, Switzerland. The company was founded as the Serono Pharmacolodgical Institute by Cesare Serono in 1906 in Italy. A key step in its development was the discovery of a method of extracting urinary gonadotropins by Dr Piero Donini allowing...	Multiple sclerosis	Feb-1998	Mon-20XX
70	Coreg	Carvedilol Carvedilol Carvedilol is a non-selective beta blocker/alpha-1 blocker indicated in the treatment of mild to moderate congestive heart failure . It is marketed under various trade names including Carvil , Coreg , Dilatrend , Eucardic , and Carloc as a generic drug ., and as a...	1,441	38%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Hypertension	Sep-1995	Mar-2007
71	Gemzar	Gemcitabine	1,408	5%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Cancer	May-1996	May-2010
72	Prilosec, Losec	Omeprazole Omeprazole Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease , gastroesophageal reflux disease , laryngopharyngeal reflux and Zollinger–Ellison syndrome...	1,371	-17%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Gastrointestinal disorders	Sep-1989	Apr-2001
73	Benicar, Olmetec	Olmesartan Olmesartan Olmesartan medoxomil is an angiotensin II receptor antagonist used to treat high blood pressure.-Indications:...	1,370	73%	Daiichi Sankyo, Forest Laboratories Forest Laboratories Forest Laboratories is a pharmaceutical company headquartered in New York City, USA. Its revenues for the year ended 31 March 2007 were US$3.4 billion. The company's research and development spending has grown rapidly in recent years, and as of 2007, approached almost a billion US dollars a year,...	Hypertension	Apr-2002	Apr-2016
74	Lotrel	Amlodipine Amlodipine Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina... + Benazepril Benazepril Benazepril, brand name Lotensin, is a medication used to treat high blood pressure , congestive heart failure, and chronic renal failure...	1,352	26%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Hypertension	Jun-1999	Mon-20XX
75	Cymbalta	Duloxetine Duloxetine Duloxetine is a serotonin-norepinephrine reuptake inhibitor manufactured and marketed by Eli Lilly. It is effective for major depressive disorder and has been shown to be as effective as venlafaxine for generalized anxiety disorder...	1,316	94%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Depression, Anxiety disorders	Aug-2004	Jun-2013
76	Imitrex, Imigran	Sumatriptan Sumatriptan Sumatriptan is a triptan sulfa drug containing a sulfonamide group. It is used for the treatment of migraine headaches. Sumatriptan is produced and marketed by various drug manufacturers with many different trade names such as Sumatriptan, Imitrex, Imigran, Imigran recovery.-Approval and...	1,315	4%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Migraine	Dec-1992	Dec-2006
77	Depakote	Valproate semisodium Valproate semisodium Valproate semisodium or divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the United Kingdom, Canada, and United States for the treatment of the manic episodes of bipolar disorder...	1,308	19%	Abbott Laboratories Abbott Laboratories Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr....	Seizures	Mar-1983	Mon-20XX
78	Humalog	Insulin analog Insulin analog An insulin analog is an altered form of insulin, different from any occurring in nature, but still available to the human body for performing the same action as human insulin in terms of glycemic control...	1,300	8%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Diabetes	Apr-1996	Mon-20XX
79	Duragesic	Fentanyl	1,295	-18%	Johnson & Johnson Johnson & Johnson Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....	Pain	Aug-1990	Mon-20XX
80	Pulmicort	Budesonide Budesonide Budesonide is a glucocorticoid steroid for the treatment of asthma and non-infectious rhinitis , and for treatment and prevention of nasal polyposis...	1,292	11%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Asthma	Jun-1997	Mon-20XX
81	Zometa	Zoledronate Zoledronate Zoledronic acid or zoledronate is a bisphosphonate. Zometa is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer, as well as for treating osteoporosis...	1,283	5%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Hypercalcemia	Aug-2000	Mon-20XX
82	Betaseron, Betaferon	Interferon beta-1b Interferon beta-1b Interferon beta-1b is a drug in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis . It is approved for use after the first MS event...	1,245	14%	Schering AG	Multiple sclerosis	Jul-1993	Mon-20XX
83	Delix, Tritace	Ramipril Ramipril Ramipril is an angiotensin-converting enzyme inhibitor, used to treat high blood pressure and congestive heart failure.-Mechanism of action:ACE inhibitors lower the...	1,227	-3%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Hypertension	Jul-2000	Mon-20XX
84	Flovent, Flixotide	Fluticasone Fluticasone Fluticasone is a synthetic glucocorticoid.Both the furoate and propionate forms are used as topical anti-inflammatories:Fluticasone propionateFluticasone furoateTreatment of asthma - Fluticasone in combination with Salmeterol - "[]" - aerosol....	1,219	5%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Asthma	Mar-1996	Mon-20XX
85	Neupogen	Filgrastim Filgrastim Filgrastim is a granulocyte colony-stimulating factor analog used to stimulate the proliferation and differentiation of granulocytes. It is produced by recombinant DNA technology. The gene for human granulocyte colony-stimulating factor is inserted into the genetic material of Escherichia coli. ...	1,213	0%	Amgen Amgen Amgen Inc. is an international biotechnology company headquartered in Thousand Oaks, California. Located in the Conejo Valley, Amgen is the world's largest independent biotech firm. The company employs approximately 17,000 staff members. Its products include Epogen, Aranesp, Enbrel, Kineret,...	Neutropenia	Feb-1991	Mon-20XX
86	Casodex	Bicalutamide Bicalutamide Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancer and hirsutism...	1,206	7%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Prostate cancer	Oct-1995	Mon-20XX
87	Pravachol	Pravastatin Pravastatin Pravastatin is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Initially known as CS-514, it was originally identified in a bacterium called Nocardia autotrophica by researchers of the Sankyo Pharma Inc....	1,197	-47%	Bristol-Myers Squibb Bristol-Myers Squibb Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...	Cholesterol	Oct-1991	Mon-20XX
88	Truvada	Tenofovir + Emtricitabine Emtricitabine Emtricitabine , with trade name Emtriva , is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children....	1,194	110%	Gilead Sciences Gilead Sciences Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes therapeutics. For many years since the company was founded, the company concentrated primarily on antiviral drugs to treat patients infected with HIV, hepatitis B or influenza. In 2006, Gilead acquired two...	HIV infection	Aug-2004	Mon-20XX
89	Symbicort	Budesonide Budesonide Budesonide is a glucocorticoid steroid for the treatment of asthma and non-infectious rhinitis , and for treatment and prevention of nasal polyposis... + Formoterol Formoterol Formoterol or eformoterol is a long-acting β2-agonist used in the management of asthma and/or chronic obstructive pulmonary disease...	1,184	18%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Asthma	Aug-2000	Mon-20XX
90	Pegasys	Pegylated interferon alfa-2a	1,171	5%	Roche, Chugai Pharmaceutical	Hepatitis C	Jun-2002	Mon-20XX
91	Evista	Raloxifene Raloxifene Raloxifene is an oral selective estrogen receptor modulator that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast...	1,159	4%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States... , Chugai Pharmaceutical	Osteoporosis	Dec-1997	Mon-20XX
92	Flomax	Tamsulosin Tamsulosin Tamsulosin is an α1a-selective alpha blocker used in the symptomatic treatment of benign prostatic hyperplasia . Tamsulosin was developed by Yamanouchi Pharmaceuticals and is marketed by various companies under licence, including Boehringer-Ingelheim and CSL...	1,158	28%	Boehringer Ingelheim	Benign prostatic hypertrophy	Oct-1997	Mon-20XX
93	Lyrica	Pregabalin Pregabalin Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. It has also been found effective for generalized anxiety disorder and is approved for this use in the European Union. It was designed...	1,156	297%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Neuropathic pain	Jul-2004	Mon-20XX
94	Paxil, Seroxat	Paroxetine Paroxetine Paroxetine is an SSRI antidepressant. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, now GlaxoSmithKline...	1,147	3%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Depression, Anxiety disorders	Dec-1992	Mon-20XX
95	Kaletra	Lopinavir Lopinavir Lopinavir is an antiretroviral of the protease inhibitor class. It is used as a fixed-dose combination with another protease inhibitor, ritonavir, under the trade names Kaletra and Aluvia ....	1,135	13%	Abbott Laboratories Abbott Laboratories Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr....	HIV infection	Mar-2001	Mon-20XX
96	Detrol	Tolterodine Tolterodine Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence.It is marketed by Pfizer in Canada and the United States by its brand name Detrol. In Egypt it is also found under the trade names Tolterodine by Sabaa and Incont L.A...	1,100	11%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Overactive bladder	Mar-1998	Mon-20XX
97	Harnal	Tamsulosin Tamsulosin Tamsulosin is an α1a-selective alpha blocker used in the symptomatic treatment of benign prostatic hyperplasia . Tamsulosin was developed by Yamanouchi Pharmaceuticals and is marketed by various companies under licence, including Boehringer-Ingelheim and CSL...	1,085	-8%	Astellas Pharma Astellas Pharma is a Japanese pharmaceutical company, formed on 1 April 2005 from the merger of and .Astellas' franchise areas are urology, immunology , dermatology, cardiology, and infectious disease...	Benign prostatic hypertrophy	Jul-1992	Mon-20XX
98	Erbitux	Cetuximab Cetuximab Cetuximab is a chimeric monoclonal antibody, an epidermal growth factor receptor inhibitor, given by intravenous infusion for treatment of metastatic colorectal cancer and head and neck cancer.- Distribution :Cetuximab is manufactured and distributed in North America by ImClone and Bristol-Myers...	1,075	56%	Bristol-Myers Squibb Bristol-Myers Squibb Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation... , Merck KGaA Merck KGaA Merck KGaA is a German chemical and pharmaceutical company. Merck, also known as “German Merck” and “Merck Darmstadt”, was founded in Darmstadt, Germany, in 1668, making it the world's oldest operating chemical and pharmaceutical company. The company was privately owned until going public in 1995...	Colorectal cancer	Feb-2004	Mon-20XX
99	Synagis	Palivizumab Palivizumab Palivizumab is a monoclonal antibody produced by recombinant DNA technology. It is used in the prevention of respiratory syncytial virus infections...	1,065	-9%	MedImmune MedImmune MedImmune, LLC, headquartered in Gaithersburg, Maryland, became a wholly owned subsidiary of AstraZeneca in 2007. Since being acquired, MedImmune has remained a Maryland-based biotechnology development enterprise...	Respiratory syncytial virus	Jun-1998	Mon-20XX
100	Augmentin	Co-amoxiclav Co-amoxiclav Amoxicillin/clavulanic acid or co-amoxiclav is a combination antibiotic consisting of amoxicillin trihydrate, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor...	1,055	-13%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Bacterial infections	Aug-1984	Mon-20XX
101	Premarin, Prempro, Premphase	Estrogen Estrogen Estrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal...	1,051	16%	Wyeth Wyeth Wyeth, formerly one of the companies owned by American Home Products Corporation , was a pharmaceutical company. The company was based in Madison, New Jersey, USA...	Menopausal symptoms	Nov-1995	Mon-20XX
102	Ortho contraceptives	Estrogen Estrogen Estrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal... + Progesterone Progesterone Progesterone also known as P4 is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species...	1,016	-11%	Johnson & Johnson Johnson & Johnson Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....	Contraception	Apr-1984	Mon-20XX
103	Zoladex	Goserelin Goserelin Goserelin acetate is an injectable gonadotropin releasing hormone superagonist , also known as a luteinizing hormone releasing hormone agonist. Structurally, it is a decapeptide...	1,008	0%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Prostate cancer	Dec-1989	Mon-20XX
104	Cerezyme	Imiglucerase Imiglucerase Imiglucerase is a medication used in the treatment of Gaucher's disease.It is a recombinant DNA-produced analogue of human β-glucocerebrosidase....	1,007	8%	Genzyme Genzyme Genzyme Corporation is a fully owned subsidiary of Sanofi-Aventis. Before its acquisition, Genzyme was an American biotechnology company based in Cambridge, Massachusetts. In 2010, Genzyme was the world’s third-largest biotechnology company, employing more than 11,000 people around the world...	Gaucher disease	Apr-1991	Mon-20XX
105	Cravit	Levofloxacin Levofloxacin Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class and is used to treat severe or life-threatening bacterial infections or bacterial infections that have failed to respond to other antibiotic classes. It is sold under various brand names, such as Levaquin and...	1,002	2%	Daiichi Sankyo, Santen Pharmaceutical	Bacterial infections	Jun-1993	Mon-20XX
106	Yasmin	Drospirenone Drospirenone Drospirenone is an anti-androgenic synthetic progestin that is typically used in birth control. There have been concerns raised regarding its safety and is thus not recommended as a first line agent.- Medical uses :...	998	36%	Schering AG	Prevention of pregnancy	Aug-2000	Mon-20XX
107	Kogenate	Recombinant factor VIII	989	19%	Bayer Bayer Bayer AG is a chemical and pharmaceutical company founded in Barmen , Germany in 1863. It is headquartered in Leverkusen, North Rhine-Westphalia, Germany and well known for its original brand of aspirin.-History:...	Hemophilia	Feb-1993	Mon-20XX
108	Botox	Botulin toxin	982	18%	Allergan Allergan Allergan, Inc., is a global specialty pharmaceutical company. Their product ranges include ophthalmic pharmaceuticals, dermatology products, and neurological products.-Profile:...	Cervical dystonia	Dec-1989	Mon-20XX
109	Lamisil	Terbinafine Terbinafine Terbinafine hydrochloride is a...	978	-14%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Fungal infections	Dec-1992	Mon-20XX
110	Combivir	Lamivudine Lamivudine Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor .It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir, and Epivir-HBV.Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV... + Zidovudine Zidovudine Zidovudine or azidothymidine is a nucleoside analog reverse-transcriptase inhibitor , a type of antiretroviral drug used for the treatment of HIV/AIDS. It is an analog of thymidine....	977	-8%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	HIV infection	Sep-1997	Mon-20XX
111	Zosyn, Tazocin	Piperacillin Piperacillin Piperacillin is an extended spectrum beta-lactam antibiotic of the ureidopenicillin class.It is normally used together with a beta-lactamase inhibitor such as tazobactam. The combination drug piperacillin/tazobactam is commercially available as e.g. Tazocin, Zosyn, Brodactam, Piptaz and as Trezora...	972	9%	Wyeth Wyeth Wyeth, formerly one of the companies owned by American Home Products Corporation , was a pharmaceutical company. The company was based in Madison, New Jersey, USA...	Bacterial infections	Oct-1993	Mon-20XX
112	Cialis	Tadalafil Tadalafil Tadalafil is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension...	971	30%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States... , Lilly Icos	Erectile dysfunction	Nov-2002	Mon-20XX
113	Keppra	Levetiracetam	956	36%	UCB UCB (company) UCB is a multinational biopharmaceutical manufacturing company headquartered in Brussels, Belgium.- History :UCB was founded on 18 January 1928 by Emmanuel Janssen, a Belgian businessman...	Seizures	Nov-1999	Mon-20XX
114	NovoSeven	Factor VII Factor VII Factor VII is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. A recombinant form of human factor VIIa has U.S. Food and Drug Administration approval for uncontrolled bleeding in hemophilia patients...	948	11%	Novo Nordisk Novo Nordisk Novo Nordisk manufactures and markets pharmaceutical products and services. Created in 1989 through a merger of two Danish companies dating back to the 1920s, it has become one of the world's leading companies in diabetes care, where Novo Nordisk pursues research into pulmonary delivery systems;...	Bleeding due to hemophilia	Feb-1996	Mon-20XX
115	Infanrix, Pediarix	vaccine Vaccine A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...	945	21%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Diphtheria, tetanus, and pertussis	Jan-1996	Mon-20XX
116	Nasonex	Mometasone	944	28%	Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...	Allergic rhinitis	Oct-1997	Mon-20XX
117	Reyataz	Atazanavir Atazanavir Atazanavir, marketed under the trade name Reyataz by Bristol Myers, is an antiretroviral drug of the protease inhibitor class...	931	34%	Bristol-Myers Squibb Bristol-Myers Squibb Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...	HIV infection	Jan-2003	Mon-20XX
118	Concerta	Methylphenidate Methylphenidate Methylphenidate is a psychostimulant drug approved for treatment of attention-deficit hyperactivity disorder, postural orthostatic tachycardia syndrome and narcolepsy. It may also be prescribed for off-label use in treatment-resistant cases of lethargy, depression, neural insult and obesity...	930	20%	Johnson & Johnson Johnson & Johnson Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....	Attention-deficit hyperactivity disorder	Aug-2000	Mon-20XX
119	Humulin	Recombinant human insulin	925	-8%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Diabetes	Oct-1982	Mon-20XX
120	Neoral, Sandimmun	Ciclosporin Ciclosporin Ciclosporin , cyclosporine , cyclosporin , or cyclosporin A is an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the immune system, and therefore the risk of organ rejection...	918	-4%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Transplant rejection	Jul-1995	Mon-20XX
121	Sandostatin	Somatostatin Somatostatin Somatostatin is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G-protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.Somatostatin...	915	2%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Acromegaly	Oct-1988	Mon-20XX
122	Camptosar	Irinotecan Irinotecan Irinotecan is a drug used for the treatment of cancer.Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin....	903	-1%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Colorectal cancer	Jun-1996	Mon-20XX
123	Engerix-B, Havrix, Twinrix	vaccine Vaccine A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...	886	10%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Hepatitis	Aug-1989	Mon-20XX
124	Allegra, Telfast	Fexofenadine Fexofenadine Fexofenadine is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms...	864	-49%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Allergic rhinitis	Jul-1996	Mon-20XX
125	Adderall	Amphetamine Amphetamine Amphetamine or amfetamine is a psychostimulant drug of the phenethylamine class which produces increased wakefulness and focus in association with decreased fatigue and appetite.Brand names of medications that contain, or metabolize into, amphetamine include Adderall, Dexedrine, Dextrostat,...	864	18%	Shire Pharmaceuticals	Attention-deficit hyperactivity disorder	Oct-2001	Mon-20XX
126	Combivent	Ipratropium Ipratropium Ipratropium bromide is an anticholinergic drug used for the treatment of chronic obstructive pulmonary disease and acute asthma. It blocks the muscarinic acetylcholine receptors in the smooth muscles of the bronchi in the lungs, opening the bronchi... + Salbutamol Salbutamol Salbutamol or albuterol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease. It is marketed as Ventolin among other brand names....	843	20%	Boehringer Ingelheim	Chronic obstructive pulmonary disease	Oct-1996	Mon-20XX
127	Peg-Intron	Pegylated interferon alfa-2b	837	11%	Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...	Hepatitis C	May-2000	Mon-20XX
128	Adalat	Nifedipine Nifedipine Nifedipine is a dihydropyridine calcium channel blocker...	825	0%	Bayer Bayer Bayer AG is a chemical and pharmaceutical company founded in Barmen , Germany in 1863. It is headquartered in Leverkusen, North Rhine-Westphalia, Germany and well known for its original brand of aspirin.-History:...	Hypertension	Nov-1985	Mon-20XX
129	Avelox, Avalox	Moxifloxacin Moxifloxacin Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent developed by Bayer AG . It is marketed worldwide under the brand names Avelox, Avalox, and Avelon for oral treatment. In most countries, the drug is also available in parenteral form for intravenous infusion...	822	17%	Bayer Bayer Bayer AG is a chemical and pharmaceutical company founded in Barmen , Germany in 1863. It is headquartered in Leverkusen, North Rhine-Westphalia, Germany and well known for its original brand of aspirin.-History:... , Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co... , Shionogi Shionogi is a Japanese pharmaceutical company best known for developing Crestor. Medical supply and brand name also uses Shionogi .Shionogi has business roots that date back to 1878, and was incorporated in 1919. Among the medicines produced are for hyperlipidaemia, antibiotics, and cancer medicines.In...	Bacterial infections	Dec-1999	Mon-20XX
130	Mobic	Meloxicam Meloxicam Meloxicam is a nonsteroidal anti-inflammatory drug with analgesic and fever reducer effects. It is a derivative of oxicam, closely related to piroxicam, and falls in the enolic acid group of NSAIDs...	818	-66%	Boehringer Ingelheim, Daiichi Sankyo	Osteoarthritis and rheumatoid arthritis	Feb-1996	Mon-20XX
131	Biaxin	Clarithromycin Clarithromycin Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia , skin and skin structure infections...	816	-23%	Abbott Laboratories Abbott Laboratories Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr....	Bacterial infections	Oct-1991	Mon-20XX
132	Mevalotin	Pravastatin Pravastatin Pravastatin is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Initially known as CS-514, it was originally identified in a bacterium called Nocardia autotrophica by researchers of the Sankyo Pharma Inc....	799	-35%	Daiichi Sankyo	Cholesterol	Jun-1909	Mon-20XX
133	Ultane, Sevorane	Sevoflurane Sevoflurane Sevoflurane , also called fluoromethyl hexafluoroisopropyl ether, is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology...	799	-9%	Abbott Laboratories Abbott Laboratories Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr....	Anesthesia	Jun-1995	Mon-20XX
134	Genotropin	Somatropin	795	-2%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Growth failure	Aug-1995	Mon-20XX
135	Sustiva	Efavirenz Efavirenz Efavirenz is a non-nucleoside reverse transcriptase inhibitor and is used as part of highly active antiretroviral therapy for the treatment of a human immunodeficiency virus type 1....	791	16%	Bristol-Myers Squibb Bristol-Myers Squibb Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...	HIV infection	Sep-1998	Mon-20XX
136	Zyvox	Linezolid Linezolid Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics...	782	27%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Bacterial infections	Apr-2000	Mon-20XX
137	Xeloda	Capecitabine	775	22%	Roche, Chugai Pharmaceutical	Cancer	Jun-1909	Mon-20XX
138	Geodon, Zeldox	Ziprasidone Ziprasidone Ziprasidone was the fifth atypical antipsychotic to gain FDA approval . In the United States, Ziprasidone is Food and Drug Administration approved for the treatment of schizophrenia, and the intramuscular injection form of ziprasidone is approved for acute agitation in schizophrenic patients...	758	29%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Schizophrenia	Feb-2001	Mon-20XX
139	Cipro, Ciprobay	Ciprofloxacin Ciprofloxacin Ciprofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class.It is a second-generation fluoroquinolone antibacterial. It kills bacteria by interfering with the enzymes that cause DNA to rewind after being copied, which stops synthesis of DNA and of...	755	-6%	Bayer Bayer Bayer AG is a chemical and pharmaceutical company founded in Barmen , Germany in 1863. It is headquartered in Leverkusen, North Rhine-Westphalia, Germany and well known for its original brand of aspirin.-History:... , Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...	Bacterial infections	Oct-1987	Mon-20XX
140	Provigil	Modafinil Modafinil Modafinil is an analeptic drug manufactured by Cephalon, and is approved by the U.S. Food and Drug Administration for the treatment of narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea...	735	43%	Cephalon Cephalon Cephalon, Inc. is a U.S. biopharmaceutical company co-founded in 1987 by Dr. Frank Baldino, Jr., a pharmacologist and former scientist with the DuPont Company, who served as the company's chairman and chief executive officer until his death in December 2010...	Sleepiness	Dec-1998	Mon-20XX
141	Lescol	Fluvastatin Fluvastatin Fluvastatin is a member of the drug class of statins, used to treat hypercholesterolemia and to prevent cardiovascular disease....	725	-5%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Cholesterol	Dec-1993	Mon-20XX
142	Clarinex, Aerius	Desloratadine Desloratadine Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn, Claramax, Clarinex, Larinex, Aerius, Dazit, Azomyr and Delot...	722	12%	Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...	Allergic rhinitis	Dec-2001	Mon-20XX
143	Femara	Letrozole Letrozole Letrozole is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme...	722	35%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry... , Chugai Pharmaceutical	Breast cancer	Jul-1997	Mon-20XX
144	Trileptal	Oxcarbazepine Oxcarbazepine Oxcarbazepine is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. It is also used to treat anxiety and mood disorders, and benign motor tics...	721	17%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Seizures	Nov-1999	Mon-20XX
145	Tracleer	Bosentan Bosentan Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary artery hypertension . It is licensed in the United States, the European Union and other countries by Actelion Pharmaceuticals for the management of PAH under the trade name Tracleer.-Mechanism of action:Bosentan is...	717	42%	Actelion Actelion Actelion was founded in December 1997 and is headquartered in Allschwil near Basel . Its CEO and co-founder is cardiologist Jean-Paul Clozel. Actelion scientists were among the first to work in the field of endothelian receptor antagonists...	Pulmonary arterial hypertension	Nov-2001	Mon-20XX
146	Primaxin	Imipenem Imipenem Imipenem is an intravenous β-lactam antibiotic developed in 1980. It has an extremely broad spectrum of activity.Imipenem belongs to the subgroup of carbapenems. It is derived from a compound called thienamycin, which is produced by the bacterium Streptomyces cattleya... + Cilastatin Cilastatin Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.Dehydropeptidase is found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong...	705	-5%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...	Bacterial infections	Nov-1985	Mon-20XX
147	Temodar	Temozolomide Temozolomide Temozolomide Temozolomide Temozolomide (brand names Temodar and Temodal is an oral alkylating agent which can be used for the treatment of Grade IV astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme as well as melanoma, a form of skin cancer...	703	20%	Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...	Anaplastic astrocytoma	Aug-1999	Mon-20XX
148	Trusopt, Cosopt	Dorzolamide Dorzolamide Dorzolamide is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. This drug, developed by Merck, was the first drug in human therapy which resulted from structure-based drug design...	697	13%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...	Intraocular pressure	Dec-1994	Mon-20XX
149	Voltaren	Diclofenac Diclofenac Diclofenac is a non-steroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions....	690	0%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Osteoarthritis and rheumatoid arthritis	Jul-1998	Mon-20XX
150	Viread	Tenofovir	689	-12%	Gilead Sciences Gilead Sciences Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes therapeutics. For many years since the company was founded, the company concentrated primarily on antiviral drugs to treat patients infected with HIV, hepatitis B or influenza. In 2006, Gilead acquired two...	HIV infection	Oct-2001	Mon-20XX
151	Sifrol	Pramipexole Pramipexole Pramipexole is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease and restless legs syndrome...	673	23%	Boehringer Ingelheim	Parkinson’s disease	Oct-1997	Mon-20XX
152	Namenda	Memantine	660	30%	Forest Laboratories Forest Laboratories Forest Laboratories is a pharmaceutical company headquartered in New York City, USA. Its revenues for the year ended 31 March 2007 were US$3.4 billion. The company's research and development spending has grown rapidly in recent years, and as of 2007, approached almost a billion US dollars a year,...	Alzheimer disease	Oct-2003	Mon-20XX
153	Altace	Ramipril Ramipril Ramipril is an angiotensin-converting enzyme inhibitor, used to treat high blood pressure and congestive heart failure.-Mechanism of action:ACE inhibitors lower the...	653	18%	King Pharmaceuticals King Pharmaceuticals King Pharmaceuticals , was the world's 39th largest pharmaceutical company, based in Bristol, Tennessee. However, on October 12, 2010, King was acquired by Pfizer for $14.25 per share. King produced a wide range of pharmaceuticals, including Altace for heart attack prevention, Levoxyl for...	Cardiovascular events	Jan-1991	Mon-20XX
154	Byetta	Exenatide Exenatide Exenatide is a medication approved in April 2005 for the treatment of diabetes mellitus type 2. It belongs to the group of incretin mimetics and is manufactured by Amylin Pharmaceuticals and Eli Lilly and Company....	649	464%	Amylin Pharmaceuticals Amylin Pharmaceuticals Amylin Pharmaceuticals is a biopharmaceutical company based in San Diego, CA, that was founded in 1987. The company is engaged in the discovery, development and commercialization of drug candidates for the treatment of diabetes, obesity and other diseases. Currently, Amylin produces two drugs,... , Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Type 2 diabetes	Apr-2005	Mon-20XX
155	Tarceva	Erlotinib Erlotinib Erlotinib hydrochloride is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor . It is marketed in the United States by Genentech and OSI...	649	110%	Roche, Genentech Genentech Genentech Inc., or Genetic Engineering Technology, Inc., is a biotechnology corporation, founded in 1976 by venture capitalist Robert A. Swanson and biochemist Dr. Herbert Boyer. Trailing the founding of Cetus by five years, it was an important step in the evolution of the biotechnology industry...	Non-small cell lung cancer	Nov-2004	Mon-20XX
156	Zithromax, Zmax	Azithromycin Azithromycin Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics...	638	-68%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Bacterial infections	Nov-1991	Mon-20XX
157	Omnicef	Cefdinir Cefdinir Cefdinir is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S...	637	29%	Abbott Laboratories Abbott Laboratories Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr....	Bacterial infections	Dec-1997	Mon-20XX
158	Proscar	Finasteride Finasteride Finasteride is a synthetic antiandrogen that inhibits type II 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone...	619	-16%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...	Benign prostatic hypertrophy	Jun-1992	Mon-20XX
159	Alimta	Pemetrexed Pemetrexed Pemetrexed is a chemotherapy drug manufactured and marketed by Eli Lilly and Company. Its indications are the treatment of Pleural Mesothelioma as well as non-small cell lung cancer.-History:...	612	32%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Non-small cell lung cancer	Feb-2004	Mon-20XX
160	Merrem	Meropenem Meropenem Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem. Meropenem was originally developed by Sumitomo Pharmaceuticals...	604	20%	AstraZeneca AstraZeneca AstraZeneca plc is a global pharmaceutical and biologics company headquartered in London, United Kingdom. It is the world's seventh-largest pharmaceutical company measured by revenues and has operations in over 100 countries...	Bacterial infections	Jun-1996	Mon-20XX
161	Forteo	Teriparatide Teriparatide Teriparatide is a recombinant form of parathyroid hormone, used in the treatment of some forms of osteoporosis. It is manufactured and marketed by Eli Lilly and Company.-Administration:...	594	53%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Osteoporosis	Nov-2002	Mon-20XX
162	Strattera	Atomoxetine	579	5%	Eli Lilly and Company Eli Lilly and Company Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...	Attention-deficit hyperactivity disorder	Nov-2002	Mon-20XX
163	Actiq	Fentanyl	578	40%	Cephalon Cephalon Cephalon, Inc. is a U.S. biopharmaceutical company co-founded in 1987 by Dr. Frank Baldino, Jr., a pharmacologist and former scientist with the DuPont Company, who served as the company's chairman and chief executive officer until his death in December 2010...	Cancer pain	Nov-1998	Mon-20XX
164	Flonase, Flixonase	Fluticasone Fluticasone Fluticasone is a synthetic glucocorticoid.Both the furoate and propionate forms are used as topical anti-inflammatories:Fluticasone propionateFluticasone furoateTreatment of asthma - Fluticasone in combination with Salmeterol - "[]" - aerosol....	575	-52%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Allergic rhinitis	Oct-1994	Mon-20XX
165	Amaryl	Glimepiride Glimepiride Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic drug. It is marketed as Amaryl by Sanofi-Aventis and GLIMY by Dr.Reddy's Labs...	567	-33%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Type 2 diabetes	Nov-1995	Mon-20XX
166	Lidoderm	Lidocaine Lidocaine Lidocaine , Xylocaine, or lignocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.- History :Lidocaine, the first amino...	567	35%	Endo Pharmaceuticals Endo Pharmaceuticals Endo Pharmaceuticals Inc. is an American pharmaceutical company. It was created as a result of a management buyout from DuPont Merck in 1997. Three DuPont Merck executives Endo Pharmaceuticals Inc. is an American pharmaceutical company. It was created as a result of a management buyout from...	Pain	Mar-1999	Mon-20XX
167	Lunesta	Eszopiclone Eszopiclone Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic used as a treatment for insomnia. Eszopiclone is the active dextrorotatory stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrolones.Eszopiclone is a short acting...	567	72%	Sepracor Sepracor Sepracor, Inc. is a pharmaceutical company founded in 1984 by Tim Barberich. It was originally located in Princeton, New Jersey and then re-located to Marlborough, Massachusetts. On October 12, 2010, the company changed its name to Sunovion.-Company history:The company's initial focus was on the...	Insomnia	Dec-2004	Mon-20XX
168	Boniva, Bonviva	Ibandronate	565	454%	Roche, GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Osteoporosis	Mar-2005	Mon-20XX
169	Taxol	Paclitaxel Paclitaxel Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a U.S. National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol...	563	-25%	Bristol-Myers Squibb Bristol-Myers Squibb Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...	Cancer	Dec-1992	Mon-20XX
170	Zelnorm, Zelmac	Tegaserod Tegaserod Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the name Zelnorm for the management of irritable bowel syndrome and constipation. Approved by the FDA in 2002, it was subsequently removed from the market in 2007 due to FDA concerns about possible adverse cardiovascular effects...	561	34%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Irritable bowel syndrome	Mar-2002	Mon-20XX
171	Renagel	Sevelamer Sevelamer Sevelamer is a phosphate binding drug used to prevent hyperphosphatemia in patients with chronic renal failure. When taken with meals, it binds to dietary phosphate and prevents its absorption...	559	23%	Genzyme Genzyme Genzyme Corporation is a fully owned subsidiary of Sanofi-Aventis. Before its acquisition, Genzyme was an American biotechnology company based in Cambridge, Massachusetts. In 2010, Genzyme was the world’s third-largest biotechnology company, employing more than 11,000 people around the world... , Roche, Chugai Pharmaceutical	Hyperphosphatemia	Oct-1998	Mon-20XX
172	Norditropin	Human growth hormone	557	19%	Novo Nordisk Novo Nordisk Novo Nordisk manufactures and markets pharmaceutical products and services. Created in 1989 through a merger of two Danish companies dating back to the 1920s, it has become one of the world's leading companies in diabetes care, where Novo Nordisk pursues research into pulmonary delivery systems;...	Growth hormone deficiency	Jun-1909	Mon-20XX
173	Xopenex	Levalbuterol Levalbuterol Levosalbutamol or levalbuterol , trade name Xopenex, is the R-enantiomer of the short-acting β2-adrenergic receptor agonist salbutamol. It is marketed by Cipla as Levolin, & by axa named Axazest.-Uses:...	555	29%	Sepracor Sepracor Sepracor, Inc. is a pharmaceutical company founded in 1984 by Tim Barberich. It was originally located in Princeton, New Jersey and then re-located to Marlborough, Massachusetts. On October 12, 2010, the company changed its name to Sunovion.-Company history:The company's initial focus was on the...	Bronchospasm	Mar-1999	Mon-20XX
174	Xenical	Orlistat Orlistat Orlistat , also known as tetrahydrolipstatin, is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake...	553	9%	Roche	Obesity	Jul-1998	Mon-20XX
175	Vasotec, Vaseretic	Enalapril Enalapril Enalapril is an angiotensin converting enzyme inhibitor used in the treatment of hypertension and some types of chronic heart failure. ACE raises blood pressure by constricting blood vessels. ACE inhibitors like enalapril prevent this effect. Enalapril has been shown to lower the death rate in...	547	-12%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...	Hypertension	Dec-1985	Mon-20XX
176	Serevent	Salmeterol Salmeterol Salmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease. It is currently available as a dry powder inhaler that releases a powdered form of the drug...	538	-10%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Asthma	Feb-1994	Mon-20XX
177	Cardura	Doxazosin Doxazosin Doxazosin mesylate, a quinazoline compound sold by Pfizer under the brand names Cardura and Carduran, is an α1a-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia ....	538	-8%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Hypertension	Nov-1990	Mon-20XX
178	Synthroid	Levothyroxine Levothyroxine Levothyroxine, also L-thyroxine, synthetic T4, or 3,5,3',5'-tetraiodo-L-thyronine, is a synthetic form of thyroxine , used as a hormone replacement for patients with thyroid problems. The natural hormone is chemically in the chiral L-form, as is the pharmaceutical agent...	534	-4%	Abbott Laboratories Abbott Laboratories Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr....	Hypothyroidism	May-1909	Mon-20XX
179	Gonal-f	Follitropin alfa	533	-3%	Serono Serono Serono is a biotechnology company headquartered in Geneva, Switzerland. The company was founded as the Serono Pharmacolodgical Institute by Cesare Serono in 1906 in Italy. A key step in its development was the discovery of a method of extracting urinary gonadotropins by Dr Piero Donini allowing...	Infertility	Oct-1995	Mon-20XX
180	Pepcid, Gaster	Famotidine Famotidine Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and it is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease . It is commonly marketed by Johnson & Johnson/Merck under the trade names Pepcidine and Pepcid and by...	532	-10%	Astellas Pharma Astellas Pharma is a Japanese pharmaceutical company, formed on 1 April 2005 from the merger of and .Astellas' franchise areas are urology, immunology , dermatology, cardiology, and infectious disease...	Gastrointestinal disorders	Jun-1909	Mon-20XX
181	Cancidas	Caspofungin Caspofungin Caspofungin is an antifungal drug, the first of a new class termed the echinocandins from Merck & Co., Inc. It shows activity against infections with Aspergillus and Candida, and works by inhibiting the enzyme β-D-Glucan synthase and thereby disturbing the integrity of the fungal cell wall...	530	-7%	Merck & Co. Merck & Co. Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...	Fungal infections	Jan-2001	Mon-20XX
182	Exelon	Rivastigmine Rivastigmine Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parkinson's disease. The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, which...	525	12%	Novartis Novartis Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...	Alzheimer’s disease	May-1998	Mon-20XX
183	Vfend	Voriconazole Voriconazole Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immunocompromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections.-Invasive...	515	30%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Fungal infections	Mar-2002	Mon-20XX
184	Amlodin	Amlodipine Amlodipine Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina...	506	4%	Dainippon Sumitomo	Hypertension, angina pectoris	n/a	Mon-20XX
185	Niaspan	Niacin Niacin "Niacin" redirects here. For the neo-fusion band, see Niacin .Niacin is an organic compound with the formula and, depending on the definition used, one of the forty to eighty essential human nutrients.Niacin is one of five vitamins associated with a pandemic deficiency disease: niacin deficiency...	498	13%	Kos Pharmaceuticals	Cholesterol	Jul-1997	Mon-20XX
186	Neurontin	Gabapentin Gabapentin Gabapentin is a pharmaceutical drug, specifically a GABA analogue. It was originally developed for the treatment of epilepsy, and currently is also used to relieve neuropathic pain...	496	-22%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Seizures	Dec-1993	Mon-20XX
187	Trizivir	Abacavir Abacavir Abacavir is a nucleoside analog reverse transcriptase inhibitor used to treat HIV and AIDS. It is available under the trade name Ziagen and in the combination formulations Trizivir and Kivexa/Epzicom... + Lamivudine Lamivudine Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor .It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir, and Epivir-HBV.Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV... + Zidovudine Zidovudine Zidovudine or azidothymidine is a nucleoside analog reverse-transcriptase inhibitor , a type of antiretroviral drug used for the treatment of HIV/AIDS. It is an analog of thymidine....	496	-10%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	HIV infection	Nov-2000	Mon-20XX
188	Requip	Ropinirole Ropinirole Ropinirole is a non-ergoline dopamine agonist. It is manufactured by GlaxoSmithKline , Cipla and Sun Pharmaceutical. It is used in the treatment of Parkinson's disease...	496	74%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Parkinson disease	Sep-1997	Mon-20XX
189	Follistim, Puregon	Follitropin beta	482	8%	Akzo Nobel Akzo Nobel Akzo Nobel N.V., trading as AkzoNobel, is a Dutch multinational, active in the fields of decorative paints, performance coatings and specialty chemicals. Headquartered in Amsterdam, the company has activities in more than 80 countries, and employs approximately 55,000 people. Sales in 2010 were EUR...	Infertility	Sep-1997	Mon-20XX
190	Basen	Voglibose Voglibose Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. Voglibose delays the absorption of glucose thereby reduces the risk of macrovascular complications...	476	-13%	Takeda Pharmaceutical	Hyperglycemia	Jun-1909	Mon-20XX
191	Levitra	Vardenafil Vardenafil Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction that is sold under the trade names Levitra and Staxyn.-History:...	474	19%	Bayer Bayer Bayer AG is a chemical and pharmaceutical company founded in Barmen , Germany in 1863. It is headquartered in Leverkusen, North Rhine-Westphalia, Germany and well known for its original brand of aspirin.-History:... , GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Erectile dysfunction	Mar-2003	Mon-20XX
192	Glucophage	Metformin Metformin Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function. Its use in gestational diabetes has been limited by safety concerns...	459	-16%	Merck KGaA Merck KGaA Merck KGaA is a German chemical and pharmaceutical company. Merck, also known as “German Merck” and “Merck Darmstadt”, was founded in Darmstadt, Germany, in 1668, making it the world's oldest operating chemical and pharmaceutical company. The company was privately owned until going public in 1995... , Bristol-Myers Squibb Bristol-Myers Squibb Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...	Type 2 diabetes	Dec-1994	Mon-20XX
193	Concor	Bisoprolol Bisoprolol Bisoprolol is a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases. More specifically, it is a selective type β1 adrenergic receptor blocker. The FDA approved Duramed Pharmaceutical's application for Zebeta Oral Tablets as a new molecular...	455	4%	Merck KGaA Merck KGaA Merck KGaA is a German chemical and pharmaceutical company. Merck, also known as “German Merck” and “Merck Darmstadt”, was founded in Darmstadt, Germany, in 1668, making it the world's oldest operating chemical and pharmaceutical company. The company was privately owned until going public in 1995...	Hypertension	Jul-1992	Mon-20XX
194	Epzicom, Kixeva	Abacavir Abacavir Abacavir is a nucleoside analog reverse transcriptase inhibitor used to treat HIV and AIDS. It is available under the trade name Ziagen and in the combination formulations Trizivir and Kivexa/Epzicom... + Lamivudine Lamivudine Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor .It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir, and Epivir-HBV.Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV...	446	107%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	HIV infection	Aug-2004	Mon-20XX
195	Xatral	Alfuzosin Alfuzosin Alfuzosin is an α1 receptor antagonist used to treat benign prostatic hyperplasia . It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate....	443	8%	Sanofi-Aventis Sanofi-Aventis Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...	Benign prostatic hypertrophy	Jan-2000	Mon-20XX
196	Diflucan	Fluconazole Fluconazole Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. In a bulk powder form, it appears as a white crystalline powder, and it is very slightly soluble in water and soluble in alcohol. It is commonly marketed under the trade...	435	-13%	Pfizer Pfizer Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...	Fungal infections	Jan-1990	Mon-20XX
197	Thalomid	Thalidomide Thalidomide Thalidomide was introduced as a sedative drug in the late 1950s that was typically used to cure morning sickness. In 1961, it was withdrawn due to teratogenicity and neuropathy. There is now a growing clinical interest in thalidomide, and it is introduced as an immunomodulatory agent used...	433	12%	Celgene Celgene Celgene Corporation is a manufacturer of drug therapies for cancer and inflammatory disorders. It is incorporated in Delaware and headquartered in Summit, New Jersey...	Erythema nodosum leprosum	Jul-1998	Mon-20XX
198	Zantac	Ranitidine Ranitidine Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in treatment of peptic ulcer disease and gastroesophageal reflux disease . Ranitidine is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions...	429	-18%	GlaxoSmithKline GlaxoSmithKline GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...	Gastrointestinal disorders	Jun-1983	Mon-20XX
199	Xolair	Omalizumab Omalizumab Omalizumab is a humanized antibody drug approved for patients with moderate-to-severe or severe allergic asthma, which is caused by hypersensitivity reactions to certain harmless environmental substances...	429	32%	Roche, Genentech Genentech Genentech Inc., or Genetic Engineering Technology, Inc., is a biotechnology corporation, founded in 1976 by venture capitalist Robert A. Swanson and biochemist Dr. Herbert Boyer. Trailing the founding of Cetus by five years, it was an important step in the evolution of the biotechnology industry...	Asthma	Jun-2003	Mon-20XX
200	Claritin	Loratadine Loratadine Loratadine is a second-generation H1 histamine antagonist drug used to treat allergies. Structurally, it is closely related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine. It is marketed by Schering-Plough under several trade names...	418	-5%	Schering-Plough Schering-Plough Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co... , Shionogi & Co.	Allergic rhinitis	Apr-1993	Mon-20XX

Source: MedAdNews 200 - World's Best-Selling Medicines, MedAdNews, July 2007

See also