Abbott Laboratories
Encyclopedia
Abbott Laboratories is an American-based global, diversified (multi-division) pharmaceutical
Pharmacology
Pharmacology is the branch of medicine and biology concerned with the study of drug action. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function...

s and health care
Health care
Health care is the diagnosis, treatment, and prevention of disease, illness, injury, and other physical and mental impairments in humans. Health care is delivered by practitioners in medicine, chiropractic, dentistry, nursing, pharmacy, allied health, and other care providers...

 products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois
North Chicago, Illinois
North Chicago is an outer suburb/exurb of the Chicago metropolitan area and is an incorporated city in Lake County, Illinois, United States. The population was 35,918 at the 2000 census....

. The company was founded by Chicago physician
Physician
A physician is a health care provider who practices the profession of medicine, which is concerned with promoting, maintaining or restoring human health through the study, diagnosis, and treatment of disease, injury and other physical and mental impairments...

, Dr. Wallace Calvin Abbott in 1888. In 2010, Abbott had over $35 billion in revenue.

In 1985, the company developed the first HIV
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...

 blood screening test. The company's drug portfolio includes HUMIRA
Adalimumab
Adalimumab is the third TNF inhibitor, after infliximab and etanercept, to be approved in the United States. Like infliximab and etanercept, adalimumab binds to TNFα, preventing it from activating TNF receptors; adalimumab was constructed from a fully human monoclonal antibody, while infliximab...

, a drug for rheumatoid arthritis
Rheumatoid arthritis
Rheumatoid arthritis is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium secondary to hyperplasia of synovial cells, excess synovial fluid, and the development...

, psoriatic arthritis
Psoriatic arthritis
Psoriatic arthritis is a type of inflammatory arthritis that, according to the National Psoriasis Foundation, will develop in up to 30 percent of people who have the chronic skin condition psoriasis...

, ankylosing spondylitis
Ankylosing spondylitis
Ankylosing spondylitis , previously known as Bekhterev's disease, Bekhterev syndrome, and Marie-Strümpell disease is a chronic inflammatory disease of the axial skeleton with variable involvement of peripheral joints and nonarticular structures...

, Crohn's disease
Crohn's disease
Crohn's disease, also known as regional enteritis, is a type of inflammatory bowel disease that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms...

, moderate to severe chronic psoriasis
Psoriasis
Psoriasis is an autoimmune disease that appears on the skin. It occurs when the immune system mistakes the skin cells as a pathogen, and sends out faulty signals that speed up the growth cycle of skin cells. Psoriasis is not contagious. However, psoriasis has been linked to an increased risk of...

 and juvenile idiopathic arthritis
Juvenile idiopathic arthritis
Juvenile idiopathic arthritis is the most common form of persistent arthritis in children. JIA is a subset of arthritis seen in childhood, which may be transient and...

; Norvir, a treatment for HIV; Depakote, an anticonvulsant
Anticonvulsant
The anticonvulsants are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and in the treatment of neuropathic pain. The goal of an...

 drug; and Synthroid, a synthetic thyroid hormone
Thyroid hormone
The thyroid hormones, thyroxine and triiodothyronine , are tyrosine-based hormones produced by the thyroid gland primarily responsible for regulation of metabolism. An important component in the synthesis of thyroid hormones is iodine. The major form of thyroid hormone in the blood is thyroxine ,...

. Abbott also has a broad range of medical devices, diagnostics and immunoassay
Immunoassay
An immunoassay is a biochemical test that measures the presence or concentration of a substance in solutions that frequently contain a complex mixture of substances. Analytes in biological liquids such as serum or urine are frequently assayed using immunoassay methods...

 products as well as nutritional products, including Ensure
Ensure
Ensure is the brand name of a family of liquid nutritional supplements manufactured by Abbott Laboratories.The beverages are meant to be administered orally, or through nasogastric tubes, directly to the recipient's stomach....

, a line of well known meal replacement shakes, and EAS, the largest producer of performance based nutritional supplements.

Abbott's in vitro diagnostics business is a world leader in immunoassays and blood screening. Abbott's broad range of medical tests and diagnostic instrument systems are used worldwide by hospitals, laboratories, blood banks, and physician offices to diagnose and monitor diseases such as HIV, hepatitis, cancer, heart failure and metabolic disorders, as well as assess other important indicators of general health. Abbott Point-of-Care manufactures diagnostic products for blood analysis to provide health care professionals critical diagnostics information accurately and immediately at the point of patient care. Abbott also provides point-of-care cardiac assays to the emergency room.

Organization

Abbott's core businesses focus on pharmaceuticals, medical devices and nutritional products, which have been supplemented through several notable acquisitions. The firm currently divides itself into several divisions:
  • Animal Health: anesthesia
    Anesthesia
    Anesthesia, or anaesthesia , traditionally meant the condition of having sensation blocked or temporarily taken away...

     for animals, Clinicare liquid animal diets and other veterinary products
  • Diabetes Care: Glucose monitoring devices
    Glucose meter
    A glucose meter is a medical device for determining the approximate concentration of glucose in the blood. It is a key element of home blood glucose monitoring by people with diabetes mellitus or hypoglycemia...

     and medicine
  • Diagnostics: Hematology
    Hematology
    Hematology, also spelled haematology , is the branch of biology physiology, internal medicine, pathology, clinical laboratory work, and pediatrics that is concerned with the study of blood, the blood-forming organs, and blood diseases...

    , immunodiagnostic, oncology
    Oncology
    Oncology is a branch of medicine that deals with cancer...

     and clinical chemistry (including the i-Stat)
  • Molecular: analysis of DNA, RNA, and proteins at the molecular level
  • Nutrition: baby nutrition
    Infant formula
    Infant formula is a manufactured food designed and marketed for feeding to babies and infants under 12 months of age, usually prepared for bottle-feeding or cup-feeding from powder or liquid . The U.S...

     (Similac
    Similac
    Similac is a brand of infant formula that was developed by Alfred Bosworth of Tufts University and marketed by Ross Laboratories....

    , Isomil, and Gain), adult health products (Ensure and ZonePerfect) and special dietary needs (Glucerna
    Glucerna
    Glucerna is the brand name of a family of snack bars and beverages manufacured by Abbott Laboratories. These food products are meant for people with diabetes and are promoted for their ability to satisfy hunger with minimum calories and without causing rapid increases in glucose concentration in...

    )
  • Vascular: stents, vessel closure devices, endovascular and coronary technologies


It has also divested itself of less profitable businesses through sales and spinoffs. In the 1970s, it acquired Ross Laboratories, making Ross a wholly owned subsidiary of Abbott. In 2001, Abbott acquired Knoll, the pharmaceutical division of BASF
BASF
BASF SE is the largest chemical company in the world and is headquartered in Germany. BASF originally stood for Badische Anilin- und Soda-Fabrik . Today, the four letters are a registered trademark and the company is listed on the Frankfurt Stock Exchange, London Stock Exchange, and Zurich Stock...

. In 2002, Abbott divested the Selsun Blue
Selsun Blue
Selsun Blue is an over-the-counter brand of dandruff shampoo now owned by Sanofi-Aventis. First made by Abbott Laboratories, the brand was bought in Chattem in 2002. Chattem was acquired by Sanofi-Aventis in 2010. Selsun Blue has been marketed as a more effective alternative to brand leader Head &...

 brand to Chattem
Chattem
Chattem is a Chattanooga, Tennessee, producer and marketer of over-the-counter healthcare products, toiletries, dietary supplements, topical analgesics, and medicated skin care products...

. Later in 2002, Abbott sold Clear Eyes and Murine to Prestige Brands
Prestige Brands
Prestige Brands, Inc. is a company that manufactures personal care and home cleaning products. It was formed by the merger of Medtech Products, Inc., Prestige Brands International, and The Spic and Span Company...

. In 2004, Abbott spun off its hospital products division into a new 14,000 employee company named Hospira
Hospira
Hospira, Inc. is a U.S.-based global pharmaceutical and medical device company with headquarters in Lake Forest, Illinois. It has approximately 14,000 employees. Hospira is the world's largest producer of generic injectable pharmaceuticals, manufacturing generic acute-care and oncology...

, and acquired TheraSense, a diabetes care company, which it merged with its MediSense division to become Abbott Diabetes Care. In 2006, Abbott assisted Boston Scientific
Boston Scientific
The Boston Scientific Corporation , is a worldwide developer, manufacturer and marketer of medical devices whose products are used in a range of interventional medical specialties, including interventional cardiology, peripheral interventions, neuromodulation, neurovascular intervention,...

 in its purchase of Guidant
Guidant
Guidant Corporation, part of Boston Scientific and Abbott Labs, designs and manufactures artificial pacemakers, implantable defibrillators, stents, and other cardiovascular medical products. Their company headquarters is located in Indianapolis, Indiana. Their main competitors are Medtronic, St...

 Corporation. As part of the agreement, Abbott purchased the vascular device division of Guidant. In 2007, Ross was renamed Abbott Nutrition.

In January 2007, Abbott Laboratories agreed to sell its in vitro diagnostics and Point-of-Care diagnostics divisions to General Electric
General Electric
General Electric Company , or GE, is an American multinational conglomerate corporation incorporated in Schenectady, New York and headquartered in Fairfield, Connecticut, United States...

 for more than $8 billion. These units were slated to be integrated into the GE Healthcare
GE Healthcare
GE Healthcare is a division of GE Technology Infrastructure, which is itself a division of General Electric . It employs more than 46,000 people worldwide and is headquartered in Little Chalfont, Buckinghamshire, United Kingdom. GE Healthcare is the first GE business segment to be headquartered...

 business unit. The transaction was approved by the Boards of Directors of Abbott and GE and was targeted to close in the first half of 2007. However, on July 11, 2007, Abbott announced that it had terminated its agreement with GE because both parties could not agree on terms of the deal.

On September 8, 2007, Abbott completed the sale of the UK manufacturing plant at Queenborough
Queenborough
Queenborough is a small town on the Isle of Sheppey in the Swale borough of Kent in South East England.Queenborough is two miles south of Sheerness. It grew as a port near the Thames Estuary at the westward entrance to The Swale where it joins the River Medway...

 to Aesica Pharmaceuticals, a Private equity-owned UK manufacturer. No announcements have been made restricting the movement of staff to Abbott unlike other sell outs. On February 26, 2009, Abbott completed its acquisition of Advanced Medical Optics
Advanced Medical Optics
Abbott Medical Optics Inc. earlier known as Advanced Medical Optics, Inc. is a global medical supply company. Products in the ophthalmic surgical line include intraocular lenses, laser vision correction systems, phacoemulsification systems, viscoelastics, microkeratomes and related products used...

 based in Santa Ana, California
Santa Ana, California
Santa Ana is the county seat and second most populous city in Orange County, California, and with a population of 324,528 at the 2010 census, Santa Ana is the 57th-most populous city in the United States....

. The acquisition gives Abbott a Vision Eye Care division. In February 2010 Abbott completed its $6.2 billion (EUR 4.5 billion) acquisition of Solvay Pharmaceuticals. This provided Abbott with a large and complementary portfolio of pharmaceutical products and also expanding its presence in key emerging markets.

On March 22, 2010, Abbott completed its acquisition of a Hollywood, Florida
Hollywood, Florida
-Demographics:As of 2000, there were 59,673 households out of which 24.9% had children under the age of 18 living with them, 41.5% were married couples living together, 11.9% had a female householder with no husband present, and 42.2% were non-families. 34.4% of all households were made up of...

-based LIMS company STARLIMS
Starlims
STARLIMS, an Abbott Company, develops and sells web-based commercial off-the-shelf Laboratory Information Management Systems ; Software solutions which manage the collection, processing, storage, retrieval and analysis of information generated in laboratories.- Corporate history :STARLIMS's initial...

. Under the terms of the deal, Abbott Laboratories acquired the company for $14 per share in an all-cash transaction valued at $123 million. On April 21, 2010, Abbott has completed its acquisition of Facet Biotech Corporation, strengthening its pharmaceutical pipeline in immunology and oncology. On May 20, 2010, Abbott Laboratories said it will buy Piramal Healthcare Ltd.'s Healthcare Solutions unit for $3.72 billion to become the biggest drug company in India.

In October 2011, the company agreed to pay at least $1.3 billion for illegally marketing its Depakote epilepsy drug to the U.S. government and 24 states.

Pharmaceuticals

  • Advicor (niacin/lovastatin
    Niacin/lovastatin
    Niacin/lovastatin is a drug combination used for the treatment of dyslipidemia. It is a combination of niacin and the statin drug lovastatin...

    )
  • Azmacort (triamcinolone
    Triamcinolone
    Triamcinolone is a long-acting synthetic corticosteroid given orally, by injection, inhalation, or as a topical ointment or cream....

    )
  • Biaxin/Klacid (clarithromycin
    Clarithromycin
    Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia , skin and skin structure infections...

    )
  • Depacon (valproic acid
    Valproic acid
    Valproic acid is a chemical compound that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, major depression. It is also used to treat migraine headaches and schizophrenia...

    )
  • Depakote (valproate semisodium
    Valproate semisodium
    Valproate semisodium or divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the United Kingdom, Canada, and United States for the treatment of the manic episodes of bipolar disorder...

    )
  • Desoxyn (medical methamphetamine
    Methamphetamine
    Methamphetamine is a psychostimulant of the phenethylamine and amphetamine class of psychoactive drugs...

    )
  • Dilaudid (hydromorphone
    Hydromorphone
    Hydromorphone, a more common synonym for dihydromorphinone, commonly a hydrochloride is a very potent centrally-acting analgesic drug of the opioid class. It is a derivative of morphine, to be specific, a hydrogenated ketone thereof and, therefore, a semi-synthetic drug...

    )
  • Gengraf (ciclosporin
    Ciclosporin
    Ciclosporin , cyclosporine , cyclosporin , or cyclosporin A is an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the immune system, and therefore the risk of organ rejection...

    )
  • Gopten/Mavik (trandolapril
    Trandolapril
    Trandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions.It is marketed by Abbott Laboratories with the brand name Mavik.- Pharmacology :...

    )
  • Humira (adalimumab
    Adalimumab
    Adalimumab is the third TNF inhibitor, after infliximab and etanercept, to be approved in the United States. Like infliximab and etanercept, adalimumab binds to TNFα, preventing it from activating TNF receptors; adalimumab was constructed from a fully human monoclonal antibody, while infliximab...

    )
  • Hytrin (terazosin
    Terazosin
    Terazosin is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate...

    )
  • Isoptin (verapamil
    Verapamil
    Verapamil is an L-type calcium channel blocker of the phenylalkylamine class. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most recently, cluster headaches. It is also an effective preventive medication for migraine...

    )
  • Kaletra (lopinavir
    Lopinavir
    Lopinavir is an antiretroviral of the protease inhibitor class. It is used as a fixed-dose combination with another protease inhibitor, ritonavir, under the trade names Kaletra and Aluvia ....

    /ritonavir
    Ritonavir
    Ritonavir, with trade name Norvir , is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS....

    )
  • Meridia/Reductil (sibutramine
    Sibutramine
    Sibutramine is an oral anorexiant. Until 2010 it was marketed and prescribed as an adjunct in the treatment of exogenous obesity along with diet and exercise...

    )
  • Niaspan (niacin
    Niacin
    "Niacin" redirects here. For the neo-fusion band, see Niacin .Niacin is an organic compound with the formula and, depending on the definition used, one of the forty to eighty essential human nutrients.Niacin is one of five vitamins associated with a pandemic deficiency disease: niacin deficiency...

    )
  • Norvir (ritonavir
    Ritonavir
    Ritonavir, with trade name Norvir , is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS....

    )
  • Omnicef (cefdinir
    Cefdinir
    Cefdinir is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S...

    )
  • Synthroid (levothyroxine
    Levothyroxine
    Levothyroxine, also L-thyroxine, synthetic T4, or 3,5,3',5'-tetraiodo-L-thyronine, is a synthetic form of thyroxine , used as a hormone replacement for patients with thyroid problems. The natural hormone is chemically in the chiral L-form, as is the pharmaceutical agent...

    )
  • Simcor (niacin/simvastatin
    Niacin/simvastatin
    Niacin/simvastatin is a combination drug consisting of an extended release form of the vitamin niacin and the statin drug simvastatin. It is used for the treatment of dyslipidemia. It was approved by the FDA on February 15, 2008....

    )
  • Simdax (levosimendan
    Levosimendan
    Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. It is marketed under the trade name Simdax .-Mode of action:...

    )
  • Tarka (trandolapril
    Trandolapril
    Trandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions.It is marketed by Abbott Laboratories with the brand name Mavik.- Pharmacology :...

    /verapamil
    Verapamil
    Verapamil is an L-type calcium channel blocker of the phenylalkylamine class. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most recently, cluster headaches. It is also an effective preventive medication for migraine...

    )
  • Tricor (fenofibrate
    Fenofibrate
    Fenofibrate is a drug of the fibrate class. Fenofibrate was developed by Groupe Fournier SA, before it was acquired in 2005 by Solvay Pharmaceutical, a business unit owned by the Belgian corporation, Solvay S.A. In 2009 Solvay Pharmaceutical was acquired by Abbott Laboratories. It is mainly used to...

    )
  • Trilipix (fenofibric acid)
  • Ultane (sevoflurane
    Sevoflurane
    Sevoflurane , also called fluoromethyl hexafluoroisopropyl ether, is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology...

    )
  • Valcote
  • Vicodin
    Vicodin
    Hydrocodone/paracetamol is a combination of two analgesic products hydrocodone and paracetamol used to relieve moderate to severe pain...

     (hydrocodone
    Hydrocodone
    Hydrocodone or dihydrocodeinone is a semi-synthetic opioid derived from either of two naturally occurring opiates: codeine and thebaine. It is an orally active narcotic analgesic and antitussive...

    /paracetemol)
  • Zemplar (paricalcitol
    Paricalcitol
    Paricalcitol is a drug used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure...

    )

Diabetes Care

  • FreeStyle Freedom Blood Glucose Monitor
  • FreeStyle Lite Blood Glucose Monitor
  • FreeStyle MINI Blood Glucose Monitor
  • FreeStyle Navigator Continuous Blood Glucose Monitor
  • G2 Sensor Card Blood Glucose Monitor
  • Medisense Optium Blood Glucose Monitor
  • Optium Xceed Blood Glucose and Ketone Monitor
  • Precision Pcx HCP Blood Glucose Monitor
  • Precision QID Blood Glucose Monitor
  • Xceed Pro HCP Blood Glucose and Ketone Monitor

Diagnostics

  • Abbott Aeroset
  • Abbott Architect
  • Abbott AxSYM
    Abbott Axsym
    The Abbott AxSYM is an immunochemical automated analyzer made by Abbott Laboratories. It is used for serology tests and therapeutic drug monitoring, and uses antibodies to alter the deflection of polarized light...

  • Abbott CELL-DYN (Complete blood count
    Complete blood count
    A complete blood count , also known as full blood count or full blood exam or blood panel, is a test panel requested by a doctor or other medical professional that gives information about the cells in a patient's blood...

     analyzer)
  • Abbott i-STAT system
  • Abbott m2000sp and m2000rt
  • Abbott PRISM

History

In 1888 at the age of 30, Dr. Wallace C. Abbott, an 1885 graduate of the University of Michigan
University of Michigan
The University of Michigan is a public research university located in Ann Arbor, Michigan in the United States. It is the state's oldest university and the flagship campus of the University of Michigan...

, founded the Abbott Alkaloidal Company. At the time he was a practicing physician and owned a drug store. His innovation was the use of the active part of a medicinal plant
Herbalism
Herbalism is a traditional medicinal or folk medicine practice based on the use of plants and plant extracts. Herbalism is also known as botanical medicine, medical herbalism, herbal medicine, herbology, herblore, and phytotherapy...

, generally an alkaloid
Alkaloid
Alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids...

 (morphine
Morphine
Morphine is a potent opiate analgesic medication and is considered to be the prototypical opioid. It was first isolated in 1804 by Friedrich Sertürner, first distributed by same in 1817, and first commercially sold by Merck in 1827, which at the time was a single small chemists' shop. It was more...

, quinine
Quinine
Quinine is a natural white crystalline alkaloid having antipyretic , antimalarial, analgesic , anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine which, unlike quinine, is an anti-arrhythmic...

, strychnine
Strychnine
Strychnine is a highly toxic , colorless crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine causes muscular convulsions and eventually death through asphyxia or sheer exhaustion...

, and codeine
Codeine
Codeine or 3-methylmorphine is an opiate used for its analgesic, antitussive, and antidiarrheal properties...

), which he formed into tiny pills which he called “dosimetric granules.” This was successful since it allowed more consistent and effective dosages for patients.

External links

The source of this article is wikipedia, the free encyclopedia.  The text of this article is licensed under the GFDL.
 
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