Etodolac

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Etodolac

Etodolac is a non-steroidal anti-inflammatory drug

Non-steroidal anti-inflammatory drug

Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs or NAIDs, are Medications with analgesic, antipyretic and, in higher doses, with anti-inflammatory effects ....
(NSAID) - of the arylalkanoic acids

Non-steroidal anti-inflammatory drug

Pain

Pain, in the sense of physical pain, is a typical sensory experience that may be described as the unpleasant awareness of a noxious stimulus or bodily harm....
and inflammation

Inflammation

Inflammation is the complex biological response of Blood vessel tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue....
in the body .

It is an inhibitor of cyclooxygenase

Cyclooxygenase

Cyclooxygenase is an enzyme that is responsible for formation of important biological mediators called prostanoids . Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain; this is the method of action of non-steroidal anti-inflammatory drugs, such as the well-known aspirin and ibuprofen....
.
Indications
Etodolac is licensed for the treatment

Therapy

This is a list of types of therapy.* Adventure therapy* Animal-assisted therapy* Aromatherapy* Art therapy* Authentic Movement* Behavioral therapy...
of inflammation

Inflammation

Osteoarthritis

Osteoarthritis , is a group of diseases and mechanical abnormalities entailing degradation of joints, including articular cartilage and the subchondral bone next to it....
and rheumatoid arthritis

Rheumatoid arthritis

Rheumatoid arthritis is a chronic, systemic disease inflammation that may affect many tissues and organs, but principally attacks the joints producing a inflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints....
.

lass="link1" onMouseover='showByLink("m4357770",this)' onMouseout='hide("m4357770")'href="http://www.absoluteastronomy.com/topics/Sustained_release">Sustained release

Sustained release

Time Release Technology also known as Sustained-release , extended-release , time-release or timed-release, controlled-release , or continuous-release pills are tablets or capsule s formulated to solvation slowly and release a drug over time....
dosing is 600mg once-a-day .

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Encyclopedia

Etodolac is a non-steroidal anti-inflammatory drug

Non-steroidal anti-inflammatory drug

Pain

Pain, in the sense of physical pain, is a typical sensory experience that may be described as the unpleasant awareness of a noxious stimulus or bodily harm....
and inflammation

Inflammation

Cyclooxygenase

Preparations

Etodolac is manufacturered by Shire under the tradename Lodine SR and by Meda Pharmacuticals under the name Eccoxolac . Non-proprietry etodolac is also available

Indications

Etodolac is licensed for the treatment

Therapy

This is a list of types of therapy.* Adventure therapy* Animal-assisted therapy* Aromatherapy* Art therapy* Authentic Movement* Behavioral therapy...
of inflammation

Inflammation

Osteoarthritis

Rheumatoid arthritis

Dosing

Sustained release

Interactions

Etodolac should be avoided by patients with a history of asthma

Asthma

Asthma is a common chronic obstructive pulmonary disease, in which the Lung constrict, become inflammation, and are lined with excessive amounts of thickened mucus, often in response to one or more triggers....
attacks, hives

Urticaria

Urticaria are a kind of skin rash notable for dark red, raised, itchy bumps. Hives are frequently caused by allergic reactions, however there are many non-allergic causes....
, or other allergic reactions

Allergy

Allergy is a Disorder of the immune system often also referred to as atopy. Allergic reactions occur to Natural environmental substances known as allergens; these reactions are Acquired disorder, predictable and rapid....
to aspirin

Aspirin

Aspirin , also known as acetylsalicylic acid , is a salicylate medication, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication....
or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer

Peptic ulcer

A peptic ulcer, also known as ulcus pepticum, PUD or peptic ulcer disease, is an ulcer of an area of the gastrointestinal tract that is usually acidic and thus extremely painful....
disease or poor kidney function

Renal physiology

Renal physiology is the study of the physiology of the kidney. This encompasses all functions of the kidney, including reabsorption of glucose, amino acids, and other small molecules; regulation of sodium, potassium, and other electrolytes; regulation of fluid balance and blood pressure; maintenance of acid-base balance; and the production...
, since this medication can aggravate both conditions. Etodolac is generally used with caution in patients taking blood thinning medications (anticoagulant

Anticoagulant

An anticoagulant is a substance that prevents blood coagulation; that is, it stops blood from clotting. A group of pharmaceuticals called anticoagulants can be used in vivo as a medication for thrombosis disorders....
s), such as warfarin

Warfarin

Warfarin is an anticoagulant. It was initially marketed as a pesticide against rats and mice, and is still popular for this purpose, although more potent poisons such as brodifacoum have since been developed....
(Coumadin), because of increased risk of bleeding

Bleeding

Bleeding, technically known as hemorrhaging or haemorrhaging is the loss of blood from the circulatory system. Bleeding can occur internally, where blood leaks from blood vessels inside the body or externally, either through a natural opening such as the vagina, Mouth , nose, or anus, or through a break in the skin....
. Patients taking lithium

Lithium

Lithium is a chemical element with the symbol Li and atomic number 3. It is a soft alkali metal with a silver-white color. Under standard conditions for temperature and pressure, it is the lightest metal and the least dense solid element....
can develop toxic blood lithium levels. Patients also taking ciclosporin

Ciclosporin

Ciclosporin , cyclosporine or cyclosporin , is an immunosuppressant medication widely used in Allograft organ transplant to reduce the activity of the patient's immune system and so the risk of organ Transplant rejection....
(Sandimmune) can develop kidney toxicity. Use in children has not been adequately studied. Etodolac is not habit-forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Etodolac is best discontinued at least four days in advance of the procedure.

Persons who have more than 3 alcoholic beverages per day are at increased risk of developing stomach ulcers when taking etodolac or other NSAIDs.

Pregnancy

Etodolac is generally avoided during pregnancy

Pregnancy

Pregnancy is the carrying of one or more offspring, known as a fetus or embryo, inside the uterus of a female. In a pregnancy, there can be multiple gestations, as in the case of twins or Multiple birth....
.

Nursing mothers

Etodolac is generally avoided in nursing mothers.

Side Effects

Etodolac may cause side effects

Side Effects

Side Effects is an anthology of 17 comical short stories written by Woody Allen between 1975 and 1980, all but one of which were previously published in, variously, The New Republic, The New York Times, The New Yorker, and The Kenyon Review....
, or Adverse drug reaction

Adverse drug reaction

An adverse drug reaction or adverse drug event is an expression that describes the unwanted, negative consequences associated with the use of given medications....
. Tell your doctor if any of these symptom

Symptom

A symptom is a departure from normal function or feeling which is noticed by a patient, indicating the presence of disease or abnormality. A symptom is subjective, observed by the patient, and not measured....
s are severe or do not go away:

constipation

Constipation

Constipation, costiveness, or irregularity, is a condition of the digestive system in which a person experiences hard feces that are difficult to expel....
, diarrhea

Diarrhea

In medicine, diarrhea, also spelled diarrhoea , is characterized by frequent loose or liquid bowel movements. The spelling of "diarrhea" is an appropriation of the Greek "diarrhoia" meaning "a flowing through." ....
, gas

Flatulence

Flatulence is the production of a mixture of gases in the gastrointestinal tract of mammals or other animals that are byproducts of the digestion process....
or bloating

Bloating

Bloating is any abnormal general swelling, or increase in diameter of the abdomen area. As a symptom, the patient feels a full and tight abdomen, which may cause abdominal pain sometimes accompanied by borborygmus....
, vomiting

Vomiting

Vomiting is the forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Undesired vomiting may result from many causes, ranging from gastritis or poisoning to brain tumors, or elevated intracranial pressure....
, headache

Headache

In medicine a headache or wiktionary:cephalalgia is a symptom of a number of different conditions of the head and sometimes neck. Some of the causes are benign while others are medical emergencies....
, dizziness

Dizziness

Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance....
, ringing in the ears

Tinnitus

Tinnitus is the perception of sound within the human ear in the absence of corresponding external sound.Tinnitus can be perceived in one or both ears or in the head....
, runny nose

Rhinorrhea

Rhinorrhea, commonly known as a runny nose, consists of an unusually significant amount of nasal discharge. It is a symptom of the common cold and of allergies ....
, sore throat

Pharyngitis

Pharyngitis is an inflammation of the throat or pharynx. In most cases it is painful, and thus is often referred to as a sore throat. Inflammation of the tonsils and/or larynx occur simultaneously, which can make eating difficult or painful....
, blurred vision

Blurred vision

Blurred vision is an ocular symptom....
.

Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more etodolac until you speak to your doctor:

unexplained weight gain

Weight gain

Weight gain is an increase in body weight. This can be either an increase in muscle mass, fat deposits, or excess fluids such as water....
, swelling

Swelling (medical)

In medicine, swelling is the enlargement of organs caused by accumulation of excess fluid in Tissue , called edema.It can occur throughout the body , or a specific part or organ can be affected ....
of the eye

Eye

Eyes are Organ that detect light, and send signals along the optic nerve to the visual system and other areas of the brain. Complex optical systems with resolving power have come in ten fundamentally different forms, and 96% of animal species possess a complex optical system....
s, face

Face

The term face refers to the central sense organ complex, for those animals that have one, normally on the ventral surface of the head and can depending on the definition in the human case, include the hair, forehead, eyebrow, eyes, nose, ears, cheeks, mouth, lips, philtrum, tooth, skin, and chin....
, lip

Lip

Lips are a visible body part at the mouth of humans and many animals. Lips are soft, movable, and serve as the opening for food intake, as an erogenous organ used in kissing and other acts of intimacy, as a tactile sensory organ, and in the articulation of speech....
s, tongue

Tongue

The tongue is skeletal muscle on the floor of the mouth that manipulates food for chewing . It is the primary organ of taste. Much of the upper surface of the tongue is covered in papillae and taste buds....
, throat

Throat

In anatomy, the throat is the anterior part of the neck, in front of the vertebrae. It consists of the pharynx and larynx. An important feature of the throat is the epiglottis, a flap which separates the esophagus from the vertebrate trachea and prevents inhalation of food or drink....
, hand

Hand

The hands are the two intricate, prehensile, multi-fingered body parts normally located at the end of each arm of a human or other primate. They are the chief organs for physically manipulating the environment, using anywhere from the roughest motor skills to the finest , and since the fingertips contain some of the densest areas of nerve e...
s, feet

Foot

The foot is an anatomical structure found in many animals. It is the terminal portion of a limb which bears weight and allows locomotion. In many animals with feet, the foot is a separate organ at the terminal part of the leg made up of one or more segments or bones, generally including claws or nails....
, ankle

Ankle

In human anatomy, the ankle joint is formed where the foot and the human leg meet. The ankle, or talocrural joint, is a synovial hinge joint that connects the distal ends of the tibia and fibula in the lower limb with the proximal end of the talus bone in the foot....
s, or lower leg

Human leg

In common usage, the human leg is the lower limb of the human body, extending from the knee to the ankle, and excluding the thigh,The largest bone in the human body, the femur, is in the leg ....
s, fever

Fever

Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is most accurately characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1?2 ?C ....
or chills

Rigor (medicine)

Rigor is a tremor occurring during a high fever. It occurs because cytokine and prostaglandins are released as part of an immune response and increase the set point for body temperature in the hypothalamus....
, blister

Blister

A blister is a small pocket of fluid within the upper layers of the skin, typically caused by forceful rubbing , burning, freezing, chemical exposure or infection....
s, rash

Rash

A rash is a change of the skin which affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin....
, itch

Itch

Itch is an unpleasant sensation that evokes the desire or reflex to scratch. Itch has resisted many attempts to classify it as any one type of sensory experience....
ing, hives, hoarseness

Dysphonia

Dysphonia is the medical term for hoarseness or other phonation disorders. It is considered much less severe than aphonia. Recently, medical science has studied the effects of osculation and the human saliva on hoarseness....
, difficulty breathing or swallowing

Swallowing

"Gulp" redirects here. For other uses, see Gulp .Swallowing, known scientifically as deglutition, is the process in the human or animal body that makes something pass from the mouth, to the pharynx, into the esophagus, with the shutting of the epiglottis....
, yellowing of the skin or eyes, excessive tiredness, unusual bleeding

Bleeding

Bruise

A bruise, also called a contusion, is an injury to biological tissue in which the capillary are damaged, allowing blood to seep into the surrounding tissue....
, lack of energy, loss of appetite

Anorexia (symptom)

Anorexia is the decreased sensation of appetite. While the term in non-scientific publications is often used interchangeably with anorexia nervosa, many possible causes exist for a decreased appetite, some of which may be harmless, while others indicate a serious clinical condition, or pose a significant risk....
, pain in the upper right part of the stomach

Stomach

In most mammals, the stomach is a hollow muscular organ of the gastrointestinal tract involved in the second phase of digestion, following mastication....
, flu

Influenza

Influenza, commonly known as the flu, is an infectious disease that affects birds and mammals caused by RNA viruses of the biological family Orthomyxoviridae ....
-like symptoms, pale skin, fast heartbeat

Cardiac cycle

Cardiac cycle is the term referring to all or any of the events related to the flow of blood that occur from the beginning of one heartbeat to the beginning of the next....
, cloudy, discolored, or bloody urine

Hematuria

In medicine, hematuria, or haematuria, is the presence of red blood cells in the urine. It can be a sign that there is a kidney stone or a tumor in the ureter, urinary bladder, prostate, or urethra....
, difficult or painful urination

Urination

Urination, also known as micturition, voiding, and, more rarely, emiction, is the process of disposing urine from the urinary bladder through the urethra to the outside of the body....
, back pain

Back pain

Back pain is pain felt in the Human back that usually originates from the muscles, nerves, bones, joints or other structures in the Vertebral column....
.

Etodolac may cause other side effects.

Etodolac

Preparations

Indications

Dosing

Interactions

Pregnancy

Nursing mothers

Side Effects

External links