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Constipation



 
 
Constipation, costiveness, or irregularity, is a condition of the digestive system in which a person (or animal) experiences hard feces
Feces

Feces, faeces, or f?ces is a waste product from an animal's gastrointestinal tract expelled through the anus during defecation....
 that are difficult to expel. This usually happens because the colon absorbs too much water from the food. If the food moves through the gastro-intestinal tract too slowly, the colon may absorb too much water, resulting in feces that are dry and hard.






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Constipation, costiveness, or irregularity, is a condition of the digestive system in which a person (or animal) experiences hard feces
Feces

Feces, faeces, or f?ces is a waste product from an animal's gastrointestinal tract expelled through the anus during defecation....
 that are difficult to expel. This usually happens because the colon absorbs too much water from the food. If the food moves through the gastro-intestinal tract too slowly, the colon may absorb too much water, resulting in feces that are dry and hard. Defecation
Defecation

Defecation is the final act of digestion by which organisms eliminate solid, semisolid or liquid waste material from the digestive tract via the anus....
 may be extremely painful, and in severe cases (fecal impaction
Fecal impaction

A fecal impaction is a solid, immobile bulk of Human feces that can develop in the rectum as a result of chronic constipation....
) lead to symptoms of bowel obstruction
Bowel obstruction

Bowel obstruction is a mechanical or functional obstruction of the intestines, preventing the normal transit of the products of digestion. It can occur at any level distal to the duodenum of the small intestine and is a medical emergency....
. The term obstipation is used for severe constipation that prevents passage of both stools and gas. Causes of constipation may be diet
Diet (nutrition)

In nutrition, the diet is the sum of food consumed by a person or other organism. Dietary habits are the habitual decisions an individual or culture makes when choosing what foods to eat....
ary, hormonal
Hormone

Hormones are chemicals released by cells that affect cells in other parts of the body. Only a small amount of hormone is required to alter cell metabolism....
, anatomical, a side effect of medication
Medication

A pharmaceutical drug, also referred to as medicine or medicament, can be loosely defined as any substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease....
s (e.g. some opiates), or an illness or disorder. Treatments consist of changes in dietary and exercise habits, the use of laxatives, and other medical interventions depending on the underlying cause.

Signs and symptoms

Bristol Stool Chart
In common constipation, the stool is hard, difficult, and painful to pass.Usually, there is an infrequent urge to void. Straining to pass stool may cause hemorrhoid
Hemorrhoid

Hemorrhoids , haemorrhoids , emerods, or piles are swelling and inflammation of veins in the rectum and anus. The anatomical term "hemorrhoids" technically refers to "'Cushions of tissue filled with blood vessels at the junction of the rectum and the anus." However, the term is popularly used to refer to varicosities of the...
s. In later stages of constipation, the abdomen may become distended and diffusely tender and cramp
Cramp

For the heraldic device, see cramp ; for the band, see The CrampsCramps, , are very unpleasant, often painful, sensations caused by contraction or over shortening of muscles....
, occasionally with enhanced bowel sounds
Borborygmus

Borborygmus also known as stomach growling, or rumbling, is the rumbling sound produced by the movement of flatulence through the intestines of animals, including humans....
.

The definition of constipation includes the following:
  • infrequent bowel movements (typically three times or fewer per week)
  • difficulty during defecation (straining during more than 25% of bowel movements or a subjective sensation of hard stools), or
  • the sensation of incomplete bowel evacuation.


Severe cases ("fecal impaction") may feature symptoms of bowel obstruction (vomiting
Vomiting

Vomiting is the forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Undesired vomiting may result from many causes, ranging from gastritis or poisoning to brain tumors, or elevated intracranial pressure....
, very tender abdomen) and "paradoxical diarrhea", where soft stool from the small intestine bypasses the impacted matter in the colon
Colon (anatomy)

The colon is the last portion of the digestive system in most vertebrates; it extracts water and salt from feces before they are defecation from the body....
.

Diagnosis

The diagnosis is essentially made from the patient's description of the symptoms. Bowel movements that are difficult to pass, very firm, or made up of small rabbit-like pellets qualify as constipation, even if they occur every day. Other symptoms related to constipation can include bloating, distension, abdominal pain, or a sense of incomplete emptying.

Inquiring about dietary habits may reveal a low intake of dietary fiber or inadequate amounts of fluids. Constipation as a result of poor ambulation or immobility should be considered in the elderly. Constipation may arise as a side effect
Adverse effect (medicine)

In medicine, an adverse effect is a harmful and undesired effect resulting from a medication or other intervention such as chemotherapy or surgery....
 of medications, including antidepressants, which can suppress acetylcholine
Acetylcholine

The chemical compound acetylcholine is a neurotransmitter in both the peripheral nervous system and central nervous system in many organisms including homo sapiens....
 and opiates, which can slow the movement of food through the intestines. Rarely, other symptoms suggestive of hypothyroidism
Hypothyroidism

Hypothyroidism is the disease state in humans and in animals caused by insufficient production of thyroid hormone by the thyroid gland. Cretinism is a form of hypothyroidism found in infants....
 may be elicited.

During physical examination
Physical examination

File:Reeve 978.jpgPhysical examination or clinical examination is the process by which a health care provider investigates the body of a patient for sign of disease....
, scybala (manually palpable lumps of stool) may be detected on palpation of the abdomen. Rectal examination
Rectal examination

A rectal examination or rectal exam is an internal examination of the rectum such as by a physician or other healthcare professional.The digital rectal examination is a relatively simple procedure....
 gives an impression of the anal sphincter tone and whether the lower rectum contains any feces or not; if so, then suppositories or enemas may be considered. Otherwise, oral medication may be required. Rectal examination also gives information on the consistency of the stool, presence of hemorrhoids, admixture of blood and whether any tumors or abnormalities are present.

X-ray
X-ray

X-radiation is a form of electromagnetic radiation. X-rays have a wavelength in the range of 10 to 0.01 nanometers, corresponding to frequency in the range 30 Hertz to 30 Hertz and energies in the range 120 Electron volt to 120 keV....
s of the abdomen, generally only performed on hospitalized patients or if bowel obstruction is suspected, may reveal impacted fecal matter in the colon, and confirm or rule out other causes of similar symptoms.

Chronic constipation (symptoms present for more than 3 months at least 3 days per month) associated with abdominal discomfort is often diagnosed as irritable bowel syndrome
Irritable bowel syndrome

Irritable bowel syndrome , also called spastic colon, is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any organic cause....
 (IBS) when no obvious cause is found. Physicians caring for patients with chronic constipation are advised to rule out obvious causes through normal testing.

Colonic propagating pressure wave sequences (PSs) are responsible for discrete movements of content and are vital for normal defaecation. Deficiencies in PS frequency, amplitude and extent of propagation are all implicated in severe defecatory dysfunction. Mechanisms that can normalise these aberrant motor patterns may help rectify the problem. Recently the novel therapy of sacral nerve stimulation (SNS) has been utilized for the treatment of severe constipation.

Causes

The main causes of constipation include:
  • Hardening of the feces
    • Insufficient intake of dietary fiber
      Dietary fiber

      Dietary fiber, sometimes called "roughage", is the indigestible portion of plant foods that pushes food through the digestive system, absorbing water and easing defecation....
    • Dehydration
      Dehydration

      Dehydration is the removal of water from an object. In Physiology terms, it entails a relative deficiency of water molecules in relation to other dissolved solutes....
       from any cause or inadequate fluid intake
    • Medication, e.g. diuretic
      Diuretic

      A diuretic is any drug that elevates the rate of urination and thus provides a means of forced diuresis. There are several categories of diuretics....
      s and those containing iron
      Iron

      Iron is a chemical element with the symbol Fe and atomic number 26. Iron is a Group 8 element and period 4 element. Iron is lustrous and silvery in color....
      , calcium
      Calcium

      Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft grey alkaline earth metal, and is the fifth most abundant element by mass in the earth's Crust ....
      , aluminum
  • Paralysis or slowed transit, where peristaltic action is diminished or absent, so that feces are not moved along
    • Hypothyroidism
      Hypothyroidism

      Hypothyroidism is the disease state in humans and in animals caused by insufficient production of thyroid hormone by the thyroid gland. Cretinism is a form of hypothyroidism found in infants....
       (underactive thyroid gland)
    • Hypokalemia
      Hypokalemia

      Hypokalemia refers to the condition in which the concentration of potassium in the blood is low. The prefix hypo- means low . Kal refers to kalium, the Neo-Latin for potassium, and -emia means "in the blood."...
    • Injured anal sphincter (patulous anus
      Anus

      The anus is an opening at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as coprolite ; food material after all the nutrients have b...
      )
    • Medications, such as loperamide
      Loperamide

      Loperamide, a synthetic piperidine derivative, is a medication effective against diarrhea resulting from gastroenteritis or inflammatory bowel disease....
      , opioid
      Opioid

      An opioid is a chemical substance that has a morphine-like action in the body. The main use is for analgesia. These agents work by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract....
      s (e.g. codeine
      Codeine

      Codeine or methylmorphine is an opiate used for its analgesic, Cough medicine and Antidiarrhoeal properties. It is by far the most widely used opiate in the world and probably the most commonly used drug overall according to numerous reports over the years by organizations such as the World Health Organization and its League of Nations...
       & morphine
      Morphine

      Morphine is a highly potent opiate analgesic Medication, is the principal active agent in opium, and is considered to be the prototypical opioid....
      ) and certain tricyclic antidepressant
      Tricyclic antidepressant

      Tricyclic antidepressants are a class of antidepressant Medications first used in the 1950s. They are named after the drugs' molecular structure, which contains three rings of atoms ....
      s
    • Severe illness due to other causes
    • Acute porphyria
      Porphyria

      Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway . They are broadly classified as acute porphyrias and cutaneous porphyrias, based on the site of the overproduction and accumulation of the porphyrins ....
       (a rare inherited condition)
    • Lead poisoning
      Lead poisoning

      Lead poisoning is a medical condition caused by increased levels of the metal lead in the blood. Lead may cause irreversible neurological damage as well as renal disease, cardiovascular effects, and human reproduction toxicity....
  • Dyschezia (usually the result of suppressing defecation)
  • Constriction, where part of the intestine
    Intestine

    In anatomy, the intestine is the segment of the Gastrointestinal tract extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine....
     or rectum
    Rectum

    The rectum is the final straight portion of the large intestine in some mammals, and the Gastrointestinal tract in others, terminating in the anus....
     is narrowed or blocked, not allowing feces to pass
    • Stenosis
      Stenosis

      A stenosis is an abnormal narrowing in a blood vessel or other tubular Organ or structure.It is also sometimes called a "stricture" .The term "coarctation" is synonymous, but is commonly used only in the context of aortic coarctation....
       (Strictures)
    • Diverticula
    • Tumor
      Tumor

      A tumor or tumour is the name for a swelling or lesion formed by an abnormal growth of cells . Tumor is not synonymous with cancer. A tumor can be Benign neoplasm, Carcinoma in situ or malignant, whereas cancer is by definition malignant....
      s, either of the bowel or surrounding tissues
  • Obstructed defecation, due to:
    • Mechanical causes from morphological abnormalities of the anorectum including megarectum
      Megarectum

      Megarectum is a large rectum as a result of underlying nerve supply abnormalities or muscle dysfunction, which remains after disimpaction of the rectum....
      , rectal prolapse
      Rectal prolapse

      Rectal prolapse normally describes a medical condition wherein the walls of the rectum protrude through the anus and hence become visible outside the body....
      , rectocele
      Rectocele

      A rectocele results from a tear in the rectovaginal septum . Rectal tissue bulges through this tear, into the vagina, as a hernia. There are two main causes of this tear: childbirth and hysterectomy....
      , and enterocele
    • Functional causes from neurological disorders and dysfunction of the pelvic floor muscles or anorectal muscles, including anismus
      Anismus

      Anismus is a malfunction of the external anal sphincter and puborectalis muscle during defecation. Normal defecation involves relaxation of both of these muscles....
      , descending perineum syndrome, and Hirschsprung's disease
      Hirschsprung's disease

      Hirschsprung's disease, or congenital aganglionic megacolon, involves an enlargement of the colon , caused by bowel obstruction resulting from an ganglion section of bowel that starts at the anus and progresses upwards....
    • Retained foreign body
      Foreign body

      In physiology, a foreign body is any object originating outside the body. In machinery, it can mean any unwanted intruding object....
       or a bezoar
      Bezoar

      A bezoar is a mass found trapped in the gastrointestinal system , though they can occur in other locations.There are several varieties of bezoar, some of which have inorganic constituents and others organic compound....
  • Psychosomatic constipation, based on anxiety or unfamiliarity with surroundings.
    • Functional constipation
      Functional constipation

      Functional constipation is constipation that does not have a physical or physiology cause. It may have a neurology, psychology or psychosomatic cause....
    • Constipation-predominant irritable bowel syndrome
      Irritable bowel syndrome

      Irritable bowel syndrome , also called spastic colon, is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any organic cause....
      , characterized by a combination of constipation and abdominal discomfort and/or pain
  • Smoking cessation
    Smoking cessation

    Smoking cessation is the action leading towards the discontinuation of the consumption of a smoked substance, keenly tobacco, however it may encompass cannabis smoking and other substances as well....
     (nicotine
    Nicotine

    Nicotine is an alkaloid found in the nightshade family of plants which constitutes approximately 0.6?3.0% of dry weight of tobacco, with biosynthesis taking place in the roots, and accumulating in the leaves....
     has a laxative
    Laxative

    Laxatives are foods, compounds, or drugs taken to induce bowel movements or to loosen the stool, most often taken to treat constipation. Certain stimulant, lubricant, and saline laxatives are used to evacuate the Colon for rectum and bowel examinations, and may be supplemented by enemas in that circumstance....
     effect)
  • Abdominal surgery, other types of surgery, childbirth
  • Severe dehydration


Treatment

In people without medical problems, the main intervention is to increase the intake of fluids (preferably water
Water

Water is a common chemical substance that is essential for the survival of all known forms of life. In typical usage, water refers only to its liquid form or States of matter, but the substance also has a solid state, ice, and a gaseous state, water vapor or steam....
) and dietary fiber
Dietary fiber

Dietary fiber, sometimes called "roughage", is the indigestible portion of plant foods that pushes food through the digestive system, absorbing water and easing defecation....
. The latter may be achieved by consuming more vegetable
Vegetable

The term "vegetable" generally means the Eating parts of plants. The definition of the word is traditional rather than scientific, however, and therefore the usage of the word is somewhat arbitrary and subjective, as it is determined by individual cultural customs of food selection and food preparation....
s and fruit
Fruit

The term fruit has different meanings dependent on context, and the term is not synonymous in food preparation and biology. In botany, which is the scientific study of plants, fruits are the ripened Ovary of flowering plants....
 and whole meal
Whole grain

Whole grains are cereal that contain bran and cereal germ as well as the endosperm, in contrast to refined grains, which retain only the endosperm....
 bread
Bread

Bread is a staple food prepared by baking a dough of flour and water. It may be leavened or unleavened. Edible salt, fat and a leavening agent such as yeast are common ingredients, though bread may contain a range of other ingredients: milk, Egg , sugar, spice, fruit , vegetables , Nut or seeds ....
, and pulses such as baked beans and chick peas and by adding linseeds to one's diet. The routine non-medical use of laxatives is to be discouraged as this may result in bowel action becoming dependent upon their use. Enemas can be used to provide a form of mechanical stimulation. However, enemas are generally useful only for stool in the rectum, not in the intestinal tract.

Lactulose
Lactulose

Lactulose is a synthetic sugar used in the treatment of constipation and hepatic encephalopathy, a complication of liver disease. It is a disaccharide formed from one molecule each of the simple sugars fructose and galactose....
, a nonabsorbable synthetic sugar that keeps sodium and water inside the intestinal lumen, relieves constipation. It can be used for months together. Among the other safe remedies, fiber supplements, lactitiol, sorbitol, milk of magnesia, lubricants etc. may be of value. Electrolyte imbalance e.g. Hyponatremia
Hyponatremia

Hyponatremia is an electrolyte disturbance in which the sodium concentration in the blood plasma is too low .Severe or rapidly progressing hyponatremia can result in swelling of the brain , and the symptoms of hyponatremia are mainly neurology....
 may occur in some cases especially in diabetics.

In alternative and traditional medicine, colonic irrigation, enemas, exercise, diet, and herbs are used to treat constipation. The mechanism of the herbal, enema, and colonic irrigation treatments often includes the breakdown of impacted and hardened fecal matter.

Laxatives

Laxative
Laxative

Laxatives are foods, compounds, or drugs taken to induce bowel movements or to loosen the stool, most often taken to treat constipation. Certain stimulant, lubricant, and saline laxatives are used to evacuate the Colon for rectum and bowel examinations, and may be supplemented by enemas in that circumstance....
s may be necessary in people in whom dietary intervention is not effective or is inappropriate. Most laxatives can be safely used long-term, although some are associated with cramping and bloatedness and can cause the phenomenon of melanosis coli
Melanosis coli

Melanosis coli is a disorder of pigmentation of the wall of the Colon , identified at the time of colonoscopy. It is benign, and has no significant correlation with disease....
.

Physical intervention

Constipation that resists all the above measures requires physical intervention. Manual dissimpaction (the physical removal of impacted stool) is done for those patients who have lost control of their bowels secondary to spinal injuries. Manual dissimpaction is also used by physicians and nurses to relieve rectal impactions. Finally, manual dissimpaction can occasionally be done under sedation
Sedation

Sedation is a medical procedure involving the administration of sedative drugs, generally to facilitate a medical procedure with local anaesthesia....
 or a general anesthetic—this avoids pain and loosens the anal sphincter.

Many of the products are widely available over-the-counter
Over-the-counter drug

Over-the-counter drugs are medications that may be sold to a customer without a medical prescription. The term "over-the-counter" is somewhat counter-intuitive, since these items can often be found on the shelves of stores and bought like any other packaged product in some countries in contrast to prescription drug which are more likely to l...
. Enema
Enema

An enema is the procedure of introducing liquids into the rectum and Colon via the anus. Enemas can be carried out for medical reasons as a remedy for encopresis, as part of alternative health therapies, as punishment, and also for eroticism purposes, particularly to prepare for anal sex, and as part of BDSM activities....
s (clysters) are a remedy occasionally used for hospitalized patients in whom the constipation has proven to be severe, dangerous in other ways, or resistant to laxatives. Sorbitol
Sorbitol

Sorbitol, also known as glucitol, is a sugar alcohol that the body metabolises slowly. It is obtained by Redox of glucose changing the aldehyde group to an additional hydroxyl group....
, glycerin and arachis oil suppositories
Suppository

A suppository is a drug delivery system that is inserted either into the rectum , vagina or urethra where it dissolves.They are used to deliver both systemically-acting and locally-acting medications....
 can be used. Severe cases may require phosphate
Phosphate

A phosphate, an inorganic chemical, is a Salt of phosphoric acid. Inorganic phosphates are mining to obtain phosphorus for use in agriculture and industry....
 solutions introduced as enemas.

Pediatrics

Lactulose
Lactulose

Lactulose is a synthetic sugar used in the treatment of constipation and hepatic encephalopathy, a complication of liver disease. It is a disaccharide formed from one molecule each of the simple sugars fructose and galactose....
 has been compared to PEG (Polyethylene Glycol) in children. They had similar side effects but PEG was more effective at treating constipation. Osmotic laxatives are recommended over stimulant laxatives.

Prevention

Constipation is usually easier to prevent than to treat. The relief of constipation with osmotic agents, i.e. lactulose, polyethylene glycol
Polyethylene glycol

Poly , also known as poly or polyoxyethylene , is the most commercially important type of Ether. PEG, PEO or POE refers to an oligomer or polymer of ethylene oxide....
 (PEG), or magnesium salts, should immediately be followed with prevention using increased fiber (fruits, vegetables, and grains) and a nightly decreasing dose of osmotic laxative. With continuing narcotic use, for instance, nightly doses of osmotic agents can be given indefinitely (without harm) to cause a daily bowel movement.

Recent controlled studies have questioned the role of physical exercise in the prevention and management of chronic constipation, while exercise is often recommended by published materials on the subject.

In various conditions (such as the use of codeine
Codeine

Codeine or methylmorphine is an opiate used for its analgesic, Cough medicine and Antidiarrhoeal properties. It is by far the most widely used opiate in the world and probably the most commonly used drug overall according to numerous reports over the years by organizations such as the World Health Organization and its League of Nations...
 or morphine
Morphine

Morphine is a highly potent opiate analgesic Medication, is the principal active agent in opium, and is considered to be the prototypical opioid....
), combinations of hydrating (e.g. lactulose
Lactulose

Lactulose is a synthetic sugar used in the treatment of constipation and hepatic encephalopathy, a complication of liver disease. It is a disaccharide formed from one molecule each of the simple sugars fructose and galactose....
 or glycols), bulk-forming (e.g. psyllium
Psyllium

Psyllium or Ispaghula is the common name used for several members of the plant genus Plantago whose seeds are used commercially for the production of mucilage....
) and stimulant agents may be necessary to prevent constipation.

Epidemiology

Depending on the definition employed, constipation occurs in 2% of the population; it is more common in women, the elderly and children.

In animals

Hibernating
Hibernation

Hibernation is a state of inactivity and Metabolism depression in animals, characterized by lower body temperature, slower breathing, and lower metabolic rate....
 animals can experience tappens that are usually expelled in the spring. For example, bears eat many foods that create a "rectal plug" before hibernation.

Canines
Canidae

Canidae is the family of the dogs; a member of this family is called a canid. They include wolf, foxes, coyotes, and jackals. The Canidae family is divided into the "true dogs" of the tribe Canini and the "foxes" of the tribe Vulpini....
 may also experience constipation, which they usually attempt to rectify by ingesting grass and other plant materials.

See also

  • Defecation
    Defecation

    Defecation is the final act of digestion by which organisms eliminate solid, semisolid or liquid waste material from the digestive tract via the anus....
  • Diarrhea
    Diarrhea

    In medicine, diarrhea, also spelled diarrhoea , is characterized by frequent loose or liquid bowel movements. The spelling of "diarrhea" is an appropriation of the Greek "diarrhoia" meaning "a flowing through." ....
  • Feces
    Feces

    Feces, faeces, or f?ces is a waste product from an animal's gastrointestinal tract expelled through the anus during defecation....


External links

  • - the World Gastroenterology Organisation (WGO)