Janssen Pharmaceutica is a
pharmaceutical companyThe pharmaceutical industry develops, produces, and markets drugs licensed for use as medications. Pharmaceutical companies can deal in generic and/or brand medications. They are subject to a variety of laws and regulations regarding the patenting, testing and marketing of drugs.-History:The...
based in
BeerseBeerse is a municipality located in the Belgian province of Antwerp. The municipality comprises the towns of Beerse proper and Vlimmeren. On January 1 2006 Beerse had a total population of 16,482. By the end of 2007, this number had risen to 16,757. The total area is 37.48 km² which gives a...
, in the
CampineThe Campine is a natural region situated chiefly in north-eastern Belgium which once consisted mainly of extensive moors, tracts of sandy heath, and wetlands...
region of the province of
AntwerpAntwerp is the northernmost province both of the Flemish Region, also called Flanders, and of Belgium. It borders on the Netherlands and the Belgian provinces of Limburg, Flemish Brabant and East Flanders. Its capital is Antwerp which comprises the Port of Antwerp...
,
BelgiumThe Kingdom of Belgium is a country in northwest Europe. It is a founding member of the European Union and hosts its headquarters, as well as those of other major international organizations, including NATO...
. The company was established in 1953 by
Dr. Paul JanssenPaul Adriaan Jan, Baron Janssen was the founder of Janssen Pharmaceutica, a pharmaceutical company with over 20,000 employees....
. It was created not as a subsidiary of a chemical factory but solely with the aim of conducting
pharmacologicalPharmacology is the study of drug action. More specifically, it is the study of the interactions that occur between a living organism and exogenous chemicals that alter normal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals...
research. The company's stated aim is the continuous development of better
drugA drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
s to improve the quality of life.
In 1961 Janssen Pharmaceutica was purchased by
Johnson & JohnsonJohnson & Johnson is a global American pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500...
corporation and is now part of the company's worldwide research and development centre, the
Johnson & Johnson Pharmaceutical Research and DevelopmentJohnson & Johnson Pharmaceutical Research and Development is a subsidiary of Johnson & Johnson that is responsible for discovering and developing pharmaceutical drugs...
(J&J PRD) which conducts research and development activities related to a wide range of human medical disorders, including
mental illnessA mental disorder or mental illness is a psychological or behavioral pattern that occurs in an individual and is thought to cause distress or disability that is not expected as part of normal development or culture. The recognition and understanding of mental disorders has changed over time and...
,
neurological disordersNeurology is a medical specialty dealing with disorders of the nervous system. Specifically, it deals with the diagnosis and treatment of all categories of disease involving the central, peripheral, and autonomic nervous systems, including their coverings, blood vessels, and all effector tissue,...
,
anaesthesiaAnesthesia, or anaesthesia , has traditionally meant the condition of having sensation blocked or temporarily taken away. This allows patients to undergo surgery and other procedures without the distress and pain they would otherwise experience...
and
analgesiaAn analgesic is any member of the diverse group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos...
,
gastrointestinalThe human gastrointestinal tract , digestive tract, guts or gut is the system of organs within humans that takes in food, digests it to extract energy and nutrients, and expels the remaining matter...
disorders, fungal infection,
allergiesAllergy is a disorder of the immune system often also referred to as atopy. Allergic reactions occur to normally harmless environmental substances known as allergens; these reactions are acquired, predictable, and rapid. Strictly, allergy is one of four forms of hypersensitivity and is called type...
and
cancerCancer is a class of diseases in which a group of cells display uncontrolled growth , invasion , and sometimes metastasis...
.
Janssen and Ortho-McNeil have been placed in the
Ortho-McNeil-JanssenOrtho-McNeil-Janssen Pharmaceuticals, Inc is a healthcare company of Johnson & Johnson composed of two divisions:* Ortho-McNeil, based in Raritan, NJ ; the division is focused on primary care....
group within
Johnson & JohnsonJohnson & Johnson is a global American pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500...
.
The early roots of what would become Janssen Pharmaceutica date back to 1933.
Janssen Pharmaceutica is a
pharmaceutical companyThe pharmaceutical industry develops, produces, and markets drugs licensed for use as medications. Pharmaceutical companies can deal in generic and/or brand medications. They are subject to a variety of laws and regulations regarding the patenting, testing and marketing of drugs.-History:The...
based in
BeerseBeerse is a municipality located in the Belgian province of Antwerp. The municipality comprises the towns of Beerse proper and Vlimmeren. On January 1 2006 Beerse had a total population of 16,482. By the end of 2007, this number had risen to 16,757. The total area is 37.48 km² which gives a...
, in the
CampineThe Campine is a natural region situated chiefly in north-eastern Belgium which once consisted mainly of extensive moors, tracts of sandy heath, and wetlands...
region of the province of
AntwerpAntwerp is the northernmost province both of the Flemish Region, also called Flanders, and of Belgium. It borders on the Netherlands and the Belgian provinces of Limburg, Flemish Brabant and East Flanders. Its capital is Antwerp which comprises the Port of Antwerp...
,
BelgiumThe Kingdom of Belgium is a country in northwest Europe. It is a founding member of the European Union and hosts its headquarters, as well as those of other major international organizations, including NATO...
. The company was established in 1953 by
Dr. Paul JanssenPaul Adriaan Jan, Baron Janssen was the founder of Janssen Pharmaceutica, a pharmaceutical company with over 20,000 employees....
. It was created not as a subsidiary of a chemical factory but solely with the aim of conducting
pharmacologicalPharmacology is the study of drug action. More specifically, it is the study of the interactions that occur between a living organism and exogenous chemicals that alter normal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals...
research. The company's stated aim is the continuous development of better
drugA drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
s to improve the quality of life.
In 1961 Janssen Pharmaceutica was purchased by
Johnson & JohnsonJohnson & Johnson is a global American pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500...
corporation and is now part of the company's worldwide research and development centre, the
Johnson & Johnson Pharmaceutical Research and DevelopmentJohnson & Johnson Pharmaceutical Research and Development is a subsidiary of Johnson & Johnson that is responsible for discovering and developing pharmaceutical drugs...
(J&J PRD) which conducts research and development activities related to a wide range of human medical disorders, including
mental illnessA mental disorder or mental illness is a psychological or behavioral pattern that occurs in an individual and is thought to cause distress or disability that is not expected as part of normal development or culture. The recognition and understanding of mental disorders has changed over time and...
,
neurological disordersNeurology is a medical specialty dealing with disorders of the nervous system. Specifically, it deals with the diagnosis and treatment of all categories of disease involving the central, peripheral, and autonomic nervous systems, including their coverings, blood vessels, and all effector tissue,...
,
anaesthesiaAnesthesia, or anaesthesia , has traditionally meant the condition of having sensation blocked or temporarily taken away. This allows patients to undergo surgery and other procedures without the distress and pain they would otherwise experience...
and
analgesiaAn analgesic is any member of the diverse group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos...
,
gastrointestinalThe human gastrointestinal tract , digestive tract, guts or gut is the system of organs within humans that takes in food, digests it to extract energy and nutrients, and expels the remaining matter...
disorders, fungal infection,
allergiesAllergy is a disorder of the immune system often also referred to as atopy. Allergic reactions occur to normally harmless environmental substances known as allergens; these reactions are acquired, predictable, and rapid. Strictly, allergy is one of four forms of hypersensitivity and is called type...
and
cancerCancer is a class of diseases in which a group of cells display uncontrolled growth , invasion , and sometimes metastasis...
.
Janssen and Ortho-McNeil have been placed in the
Ortho-McNeil-JanssenOrtho-McNeil-Janssen Pharmaceuticals, Inc is a healthcare company of Johnson & Johnson composed of two divisions:* Ortho-McNeil, based in Raritan, NJ ; the division is focused on primary care....
group within
Johnson & JohnsonJohnson & Johnson is a global American pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500...
.
History
The early roots of what would become Janssen Pharmaceutica date back to 1933. In 1933 Dr.
Constant JanssenDr. Jan Constant Janssen , was a Belgian physician and businessman. He was the third child of Adriaan Victor Janssen and Anna Catharina Eelen . He went to highschool in Hoogstraten and studied medicine at the Catholic University of Leuven and the University of Ghent...
, the father of Paul Janssen, acquires the right to distribute the pharmaceutical products of
RichterGedeon Richter Ltd. , the largest pharmaceutical factory in Hungary, was established by Mr. Gedeon Richter, a pharmacist in 1901. Mr. Richter is not only the founder of the company, but the establishment of his firm also marked the beginning of the development of the Hungarian pharmaceutical industry...
, a
HungarianHungary , in English officially the Republic of Hungary , is a landlocked country in the Carpathian Basin of Central Europe, bordered by Austria, Slovakia, Ukraine, Romania, Serbia, Croatia, and Slovenia. Its capital is Budapest. Hungary is a member of OECD, NATO, EU, V4 and is a Schengen state...
pharmaceutical company, for Belgium, the Netherlands and
Belgian CongoThe Belgian Congo was the formal title of present-day Democratic Republic of the Congo between King Leopold II's formal relinquishment of personal control over the state to Belgium on 15 November 1908, and the dawn of Congolese independence on 30 June 1960.-Background: 1884-1908:Until the later...
. On 23 October 1934, he founded the
N.V. Produkten Richter in
TurnhoutTurnhout is a Belgian municipality located in the Flemish province of Antwerp. The city is also known as the Capital of the Campine. The municipality comprises only the city of Turnhout proper. On January 1 2006 Turnhout had a total population of 39,791...
. In 1937 Constant Janssen acquired an old factory building in the
Statiestraat 78 in
TurnhoutTurnhout is a Belgian municipality located in the Flemish province of Antwerp. The city is also known as the Capital of the Campine. The municipality comprises only the city of Turnhout proper. On January 1 2006 Turnhout had a total population of 39,791...
for his growing company, which he expanded during
World War IIWorld War II, or the Second World War , was a global military conflict which involved a majority of the world's nations, including all great powers, organized into two opposing military alliances: the Allies and the Axis...
into a four-storey building. Still a student, Paul Janssen helps on the development of Perdolan. After the war, the name for the company products was changed in
Eupharma, although the company name
Richter would remain until 1956.
Dr. Paul Janssen founded his own research laboratory in 1953 on the third floor of the building in the
Statiestraat, still within the
Richter-Eurpharma company of his father. In 1955, he and his team developed their first drug: Neomeritine (
ambucetamideAmbucetamide is an antispasmodic found to be particularly effective for the relief of menstrual pain. It was discovered in 1953 by Paul Janssen.-References:...
), an antispasmodic found to be particularly effective for the relief of menstrual pain. On 5 April 1956, the name of the company was changed in
NV Laboratoria Pharmaceutica Dr. C. Janssen (named after Dr. Constant Janssen). On 27 April 1957, the company opened a new research facility in Beerse, but the move to Beerse would not be completed until 1971-1972. On 2 May 1958, the research department in Beerse became a separate legal entity, the
N.V. Research Laboratorium Dr. C. Janssen.
On 24 October 1961, the company was acquired by the American corporation
Johnson & JohnsonJohnson & Johnson is a global American pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500...
. The negotiations with Johnson & Johnson were led by
Frans Van den BerghBaron Frans Van den Bergh was a Belgian business man, who founded the cigar factory Alto in Turnhout, Belgium and who would become one of the leading managers of Janssen Pharmaceutica. In addition to his success with Alto, he was by the marriage of his daughter Lea related to Margriet...
, head of the Board of Directors. In 1964, on 10 February, the name was changed to
Janssen Pharmaceutica N.V. and the seat of the company in Turnhout was also transferred to Beerse. The company was led by Paul Janssen,
Bob StouthuysenBaron Robert "Bob" Stouthuysen is a Belgian businessman. He is honorary president of the Vlaams Economisch Verbond and of Janssen Pharmaceutica. He lives in Kasterlee in the Campine region of Flanders.-Education:...
and Frans Van Den Bergh. When, in 1971-1972 the pharmaceutical production also came to Beerse, the move from Turnhout was completed.
Janssen Pharmaceutica expanded worldwide; in 1990, it had already 3000 employees in
BelgiumThe Kingdom of Belgium is a country in northwest Europe. It is a founding member of the European Union and hosts its headquarters, as well as those of other major international organizations, including NATO...
, further expanding up to 4600 in 2004. In 2004 there worked about 28000 people for Janssen Pharmaceutica worldwide.
Janssen Pharmaceutica from the beginning emphasized as its core activity research for the development of new drugs. The research department which was established in Beerse in 1957, developed into a large research campus. In 1987, the Janssen Research Foundation (JRF) was founded which performs research into new drugs, also in other laboratories around the globe. Janssen Pharmaceutica became the Flemish company with the largest budget for research and development. Beside the headquarters in Beerse with its research departments, pharmaceutical production and the administrative departments, Janssen Pharmaceutica in Belgium still has offices in
Berchem-Demography:Berchem's total surface is over 1,500 acres, and it is inhabited by more than 40,000 citizens.-Political structure:After the decentralization of Antwerp in 2000, Berchem became a semi-independent district with its own legislative body, the so-called Districtsraad , and its own executive...
(
Janssen-CilagJanssen-Cilag is a subsidiary of the Johnson & Johnson pharmaceutical company. The company was founded in the early 1990s by a merger between Janssen Pharmaceutica and Cilag....
), a chemical factory in
GeelGeel is a municipality located in the Belgian province of Antwerp. The municipality acquired the status of a city rather recently ....
, and Janssen Biotech in Olen.
The Chemical Production plant in Geel, makes the
active ingredientAn active ingredient , is the substance in a drug or a pesticide that is pesticidal or pharmaceutically active. Terms in similar use include: active pharmaceutical ingredient and bulk active in medicine, or in pesticide formulations active substance may be used. Some medications and pesticide...
s for the company’s medicines. In 1975, the first plant of a new chemical factory
Plant I was established in Geel,
Plant II was opened in 1977,
Plant III in 1984, and Plant IV in 1995. In 1999 the remaining chemical poduction in Beerse would be transferred to Geel. About 80% of its active components are manufactured here. The site in Geel also manufactures about two-thirds of the worldwide chemical production of the pharmaceutical sector of
Johnson & JohnsonJohnson & Johnson is a global American pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500...
. In 1995, the Center for Molecular Design (CMD) was founded by Paul Janssen and
Paul LewiPaul J. Lewi is a Belgian scientist, who elaborated Spectral Map Analysis in 1975 and was one of the cofounders of chemometrics in 1983.- Biography :...
.
In 1999, clinical research and non-clinical development become a global organization within Johnson & Johnson. In 2001, part of the research activities was transferred to the
United StatesThe United States of America is a federal constitutional republic comprising fifty states and a federal district...
with the reorganization of research activities in the Johnson & Johnson Pharmaceutical Research Development
(JJPRD) organization. The research activities of the Janssen Research Foundation
(JRF) and the R.W. Johnson Pharmaceutical Research Institute
(PRI) (United StatesThe United States of America is a federal constitutional republic comprising fifty states and a federal district...
) were merged into the new global research organization. A new building for pharmaceutical development is completed in Beerse in 2001. In 2002, a new logistics and informatics centre is opened at a new site, Beerse 2
. In 2003 two new research buildings are constructed, the Discovery Research Center
(DRC), and the Drug Safety Evaluation Center
(DSEC). On 27 October 2004, the Dr. Paul Janssen Research Center, for discovery research, was inaugurated.
The success of Janssen Pharmaceutica is commonly attributed to the vision of its founder, who himself was a brilliant scientist, but was also surrounded by talented and motivated employees, both scientifically and commercially. Dr. Paul Janssen created an environment which stimulated the creativity of his research workers.
Janssen Pharmaceutica in China
In 1985, Janssen Pharmaceutica was the first Western pharmaceutical company to set up a pharmaceutical factory in the
People's Republic of ChinaThe People's Republic of China , commonly known as China, is the largest country in East Asia and the most populous in the world with over 1.3 billion people, approximately one-fifth of the world's population...
(
Xi'anXi'an , is the capital of the Shaanxi province in the People's Republic of China and a sub-provincial city...
). Already in 1983, Janssen had signed a cooperation contract to modernise products in an existing, but old, chemical factory in
HanzhongHanzhong is a municipality in the southwest corner of Shaanxi province, in central China. The population in 2006 was approximately 3.74 million, in a municipal territory of 27 246 square kilometres. -History:...
(in the province
Shaanxi' is a province in the Northwest China region of the People's Republic of China, and includes portions of the Loess Plateau on the middle reaches of the Yellow River as well as the Qinling Mountains across the southern part of the province.-Romanization and Name:By regular Hanyu Pinyin rules, if...
) and to produce the active compound of some Janssen products, such as
mebendazoleMebendazole or MBZ, marketed as Ovex, Vermox, Antiox, Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.-Mechanism:...
.
Paul AppermontPaul Appermont is a Belgian businessman. Together with Joos Horsten, he laid the foundation of Xi'an Janssen Pharmaceutical...
and
Joos HorstenJoos Horsten was a Belgian businessman. He founded Xian Janssen Pharmaceutical, the Sino-Belgian joint venture of Janssen Pharmaceutica, a Belgian pharmaceutical company.-Career:...
were responsible for the project.
In 1976 Paul Janssen had met the Lebanese-American doctor George Shafik Hatem (1912-1988) who was known in China under the name Ma Haide. Paul Janssen met with Ma Haide for three days in 1976, and decided to start a business in China right after the
Cultural RevolutionThe Great Proletarian Cultural Revolution was a period of widespread social and political upheaval in the People’s Republic of China between 1966 and 1976, resulting in nation-wide chaos and economic disarray.It was launched by Mao Zedong, the chairman of the Communist Party of China, on May 16,...
(1967-1976) and the opening to the west by
Deng XiaopingDeng Xiaoping was a prominent Chinese politician, statesman, theorist, and diplomat. As leader of the Communist Party of China, Deng became a reformer who led China towards market economics...
in 1978. The first factory was set up by
Joos HorstenJoos Horsten was a Belgian businessman. He founded Xian Janssen Pharmaceutical, the Sino-Belgian joint venture of Janssen Pharmaceutica, a Belgian pharmaceutical company.-Career:...
in Hanzhong, after which the second and larger factory followed in Xi'an.
Some drugs developed by Janssen Pharmaceutica
R-code |
Name |
Brandname |
Synthetized |
Marketed |
R5 |
ambucetamide Ambucetamide is an antispasmodic found to be particularly effective for the relief of menstrual pain. It was discovered in 1953 by Paul Janssen.-References:...
|
Neomeritine |
1953 |
1955 |
R79 |
isopropamide iodide |
Priamide-Janssen |
1954 |
1955 |
R253 |
diisopromineDiisopromine or disoprominum, usually as the hydrochloride salt, is a synthetic spasmolytic which neutralizes spastic conditions of the biliary tract and of the sphincter of Oddi. It was discovered at Janssen Pharmaceutica in 1955.-References:...
|
Bilagol |
1955 |
1956 |
R516 |
cinnarizineCinnarizine is an anti-histaminic drug which is mainly used for the control of vomiting due to motion sickness. It is marketed under the brand Stugeron or Stunarone. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955...
|
Stugeron |
1955 |
1958 |
R875 |
dextromoramideDextromoramide is a powerful opioid analgesic approximately three times more potent than morphine but shorter acting. It is subject to drug prohibition regimes, both internationally through UN treaties, and by the criminal law of individual states...
|
Palfium |
1955 |
1957 |
R1132 |
diphenoxylate Diphenoxylate is an opioid agonist used for the treatment of diarrhoea that acts by slowing intestinal contractions and peristalsis allowing the body to consolidate intestinal contents and prolong transit time, thus allowing the intestines to draw moisture out of them at a normal or higher rate...
|
Reasec |
1956 |
1960 |
R1625 |
haloperidolHaloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines....
|
Haldol |
1958 |
1959 |
R2498 |
trifluperidolTrifluperidol is a drug which is a butyrophenone derivative. It has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects. It is used in the...
|
Triperidol |
1959 |
1961 |
R3345 |
pipamperonePipamperone is an antipsychotic drug used in the treatment of schizophrenia. Pipamperone is known to the general public under the marketed brand name Dipiperon. It was discovered at Janssen Pharmaceutica in 1960.-References:...
|
Dipiperon |
1960 |
1961 |
R3365 |
piritramide Piritramide is a synthetic opioid analgesic with a potency 0.65 to 0.75 times that of morphine. A common starting dose is 15 mg IV, equivalent to 10 mg of morphine hydrochloride. Piritramide is commonly used for the treatment of postoperative pain...
|
Dipidolor |
1960 |
1967 |
R4263 |
fentanylFentanyl — brand names include Actiq, Duragesic, Fentora, Onsolis, Sublimaze and Instanyl — is a synthetic primary μ-opioid agonist commonly used to treat chronic breakthrough pain and is commonly used pre-procedures...
|
Fentanyl |
1960 |
1963 |
R4584 |
benperidolBenperidol is a drug which is a highly potent butyrophenone derivative. It is in fact the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 ....
|
Frenactyl |
1961 |
1965 |
R4749 |
droperidol Droperidol is an antidopaminergic drug used as an antiemetic and antipsychotic. Droperidol is also often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment.-History and use:...
|
Dehydrobenzperidol |
1961 |
1963 |
R4845 |
bezitramide Bezitramide is a narcotic analgesic. Bezitramide itself is a prodrug which is readily hydrolyzed in the gastrointestinal tract to its main metabolite, despropionyl-bezitramide. Bezitramide was discovered at Janssen Pharmaceutica in 1961...
|
Burgodin |
1961 |
1971 |
R6218 |
fluspirileneFluspirilene is a diphenylbutylpiperidine antipsychotic drug, used for the treatment of schizophrenia. It is administered intramuscularly. It was discovered at Janssen Pharmaceutica in 1963.-References:...
|
Imap |
1963 |
1971 |
R6238 |
pimozidePimozide is an antipsychotic drug. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine . On a weight basis it is even more potent than haloperidol. It also has special neurologic indications for Tourette syndrome and resistant tics...
|
Orap |
1963 |
1970 |
R7904 |
lidoflazineLidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at Janssen Pharmaceutica in 1964.-Solubility at room temperature:Extracted from -References:...
|
Clinium |
1964 |
1969 |
R11333 |
bromperidolBromperidol is a drug which is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia...
|
Impromen |
1966 |
1981 |
R12564 |
levamisole Levamisole is an antibiotic belonging to a class of synthetic imidazothiazole derivatives. It was discovered at Janssen Pharmaceutica in 1966.Ergamisol was withdrawn from the U.S...
|
Ergamisol |
1966 |
1969 |
R13672 |
haloperidol decanoateHaloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines....
|
Haldol decanoas |
1967 |
1981 |
R14889 |
miconazole nitrate |
Daktarin |
1967 |
1971 |
R14950 |
flunarizineFlunarizine is a drug classified as a calcium channel blocker. Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and...
|
Sibelium |
1967 |
1977 |
R15889 |
lorcainideLorcainide is a class 1c antiarrhythmic agent. It was discovered at Janssen Pharmaceutica in 1968.-References:* Kesteloot H, Stroobandt R., Clinical experience with lorcainide , a new anti-arrhythmic drug, Arch Int Pharmacodyn Ther...
|
Remivox |
1968 |
1983 |
R16341 |
penfluridolPenfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects...
|
Semap |
1968 |
1973 |
R16470 |
dexetimideDexetimide is a piperidine anticholinergic. It is a muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Dexetimide was discovered at Janssen Pharmaceutica in 1968.-References:...
|
Tremblex |
1968 |
1972 |
R16659 |
etomidateEtomidate is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia and for sedation for short procedures such as reduction of dislocated joints and cardioversion...
|
Hypnomidate |
1964 |
1977 |
R17635 |
mebendazole Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.-Mechanism:...
|
Vermox |
1968 |
1972 |
R18553 |
loperamideLoperamide, a synthetic piperidine derivative, is a drug effective against diarrhea resulting from gastroenteritis or inflammatory bowel disease. In most countries it is available generically and under brand names such as Lopex, Imodium, Dimor and Pepto Diarrhea Control...
|
Imodium |
1969 |
1973 |
R33800 |
sufentanil citrate Sufentanil is a powerful synthetic opioid analgesic drug, approximately 5 to 10 times more potent than its analog, Fentanyl. Sufentanil is marketed for use by specialist centres under different trade names, such as Sufenta and Sufentil...
|
Sufenta |
1974 |
1979 |
R33812 |
domperidoneDomperidone is an antidopaminergic drug, developed by Janssen Pharmaceutica, and used orally, rectally or intravenously, generally to suppress nausea and vomiting. It has also been used to stimulate lactation.- Gastrointestinal problems :There is some evidence that domperidone has antiemetic...
|
Motilium |
1974 |
1978 |
R35443 |
oxatomideOxatomide is a piperazine antihistamine. It was discovered at Janssen Pharmaceutica in 1975....
|
Tinset |
1975 |
1981 |
R39209 |
alfentanil Alfentanil is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around 1/10 the potency of fentanyl and around 1/3 of the duration of action, but with an onset of effects 4x faster than fentanyl...
|
Rapifen |
1976 |
1983 |
R41400 |
ketoconazoleKetoconazole is a synthetic antifungal drug used to prevent and treat skin and fungal infections, especially in immunocompromised patients such as those with AIDS...
|
Nizoral |
1976 |
1981 |
R43512 |
astemizoleAstemizole is a second generation antihistamine drug which has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977.-Metabolism:It is metabolized by CYP3A4....
|
Hismanal |
1977 |
1983 |
R46541 |
bromperidol decanoateBromperidol is a drug which is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia...
|
Impromen decanoas |
1978 |
1984 |
R49945 |
ketanserin tartrate Ketanserin is drug with affinity for multiple GPCR receptors. Initially it was believed to be a highly selective antagonist for serotonin 5-HT2A receptors, however this not true. Ketanserin only has weak selectivity for 5-HT2A receptors over 5-HT2C receptors...
|
Sufrexal |
1980 |
1987 |
R50547 |
levocabastine Levocabastine is a selective second-generation H1-receptor antagonist which was discovered at Janssen Pharmaceutica in 1979. It is used for allergic conjunctivitis....
|
Livostin |
1979 |
1989 |
R51211 |
itraconazoleItraconazole , invented in 1984, is a triazole antifungal agent that is prescribed to patients with fungal infections...
|
Sporanox |
1980 |
1986 |
R51619 |
cisaprideCisapride is a parasympathomimetic and gastroprokinetic agent that acts as a serotonin 5-HT 4 receptor agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It is sold under the trade names Prepulsid and Propulsid...
|
Prepulsid |
1980 |
1989 |
R64766 |
risperidoneRisperidone is an atypical antipsychotic used to treat schizophrenia , the mixed and manic states associated with bipolar disorder, and irritability in children with autism...
|
Risperdal |
1984 |
1993 |
Janssen Pharmaceutica has developed and brought to the market about 70 new active substances (
NCEA new chemical entity is, according to the U.S. Food and Drug Administration, a drug that contains no active moiety that has been approved by FDA in any other application submitted under section 505 of the Federal Food, Drug, and Cosmetic Act."An active moiety is a molecule or ion, excluding...
), of which the most well-known are (name may differ):
- Imodium (against diarrhoea. Active substance: loperamide
Loperamide, a synthetic piperidine derivative, is a drug effective against diarrhea resulting from gastroenteritis or inflammatory bowel disease. In most countries it is available generically and under brand names such as Lopex, Imodium, Dimor and Pepto Diarrhea Control...
)
- Motilium (against flatulence — and bowel impairments. Active substance: domperidone
Domperidone is an antidopaminergic drug, developed by Janssen Pharmaceutica, and used orally, rectally or intravenously, generally to suppress nausea and vomiting. It has also been used to stimulate lactation.- Gastrointestinal problems :There is some evidence that domperidone has antiemetic...
)
- Reminyl (against Alzheimer's disease
Alzheimer's disease , also called Alzheimer disease, Senile Dementia of the Alzheimer Type or simply Alzheimer's, is the most common form of dementia. This incurable, degenerative, and terminal disease was first described by German psychiatrist and neuropathologist Alois Alzheimer in 1906 and was...
(dementia). Active substance: galantamineGalantamine or galanthamine is a chemical used for the treatment of mild to moderate Alzheimer’s disease and various memory impairments...
)
- Daktarin (against fungal infections. Active substance: miconazole
Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, and commonly applied topically or mucus membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes...
)
- Nizoral (against dandruff
Dandruff is the excessive shedding of dead skin cells from the scalp. Dandruff can also be caused by frequent exposure to extreme heat and cold. As it is normal for skin cells to die and flake off, a small amount of flaking is normal and in fact quite common...
, Active substance: ketoconazoleKetoconazole is a synthetic antifungal drug used to prevent and treat skin and fungal infections, especially in immunocompromised patients such as those with AIDS...
)
- Durogesic
Duragesic and Durogesic are trade names of fentanyl transdermal therapeutic systems, and are used for relief of moderate to severe pain. Since Duragesic/Durogesic release Fentanyl, a potent opioid, slowly through the skin, one patch may provide 72 hours of pain relief...
(fentanylpatch for pain suppression. Active substance: fentanylFentanyl — brand names include Actiq, Duragesic, Fentora, Onsolis, Sublimaze and Instanyl — is a synthetic primary μ-opioid agonist commonly used to treat chronic breakthrough pain and is commonly used pre-procedures...
)
- Vermox (against worms. Active substance: mebendazole
Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.-Mechanism:...
)
- Risperdal (antipsychotic, against mental illness such as schizophrenia. Active substance: risperidone
Risperidone is an atypical antipsychotic used to treat schizophrenia , the mixed and manic states associated with bipolar disorder, and irritability in children with autism...
)
Five drugs of Janssen Pharmaceutica, in the course of time, were put on the WHO Model List of Essential Medicines:
- Haldol (haloperidol
Haloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines....
)
- Ergamisol (levamisole
Levamisole is an antibiotic belonging to a class of synthetic imidazothiazole derivatives. It was discovered at Janssen Pharmaceutica in 1966.Ergamisol was withdrawn from the U.S...
)
- Daktarin (miconazole
Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, and commonly applied topically or mucus membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes...
)
- Vermox (mebendazole
Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.-Mechanism:...
)
- Nizoral (ketoconazole
Ketoconazole is a synthetic antifungal drug used to prevent and treat skin and fungal infections, especially in immunocompromised patients such as those with AIDS...
) (on the WHO list until 2005)
R207910R207910 is an experimental diarylquinoline anti-tuberculosis drug, which was discovered by Koen Andries and his team at Janssen Pharmaceutica...
is an experimental diarylquinoline anti-tuberculosis drug, discovered by
Koen AndriesKoen Andries is a Belgian scientist working at Janssen Pharmaceutica and professor at the University of Antwerp. In 2005 he and his team published a discovery about a new di-Aryl-Quinoline-based drug which promises a shorter and simpler treatment for Tuberculosis .-Career:He graduated as a...
and his team, which promises a shorter and simpler
treatmentActive tuberculosis will kill about two of every three people affected if left untreated. Treated tuberculosis has a mortality rate of less than 5%....
for
TuberculosisTuberculosis is a common and often deadly infectious disease caused by mycobacteria...
(TB).
Business
- Revenue:
- 2001: 1568 M euro
- 2002: 1674
- 2003: 1876
- 2004: 1934
- 2005: 2104
- Profit:
- 2001: 285 M euro
- 2002: 282
- 2003: 355
- 2004: 433
- 2005: 346
- Employment in Belgium
- 1955: 190
- 1960: 350
- 1965: 465
- 1970: 807
- 1975: 1378
- 1980: 1734
- 1985: 2322
- 1990: 2914
- 1995: 3245
- 2000: 4036
- 2001: 3954
- 2002: 4234
- 2003: 4386
- 2004: 4343
- 2005: 4715
- 2007: 4723
See also
- Ajit Shetty
Ajit, Baron Shetty is an Indian-Belgian businessman, who was born in Bangalore, India. He is Chairman of the Board of Directors and Managing Director of Janssen Pharmaceutica, a pharmaceutical company and subsidiary of Johnson & Johnson, with its headquarters in Beerse, Belgium...
- Didier de Chaffoy de Courcelles
Didier R.G.G. de Chaffoy de Courcelles is a Belgian scientist and businessman. He is Senior Vice President, Drug Discovery Europe, of Johnson & Johnson Pharmaceutical Research & Development , a division of Janssen Pharmaceutica .-Education:Didier de Chaffoy de Courcelles went to highschool at the...
- Paul Stoffels
Paul Stoffels is a Belgian MD, who studied Medicine at the University of Hasselt and the University of Antwerp . In addition he studied Infectious Diseases and Tropical Medicine at the Prince Leopold Institute of Tropical Medicine in Antwerp, Belgium...
- Staf Van Reet
Staf Van Reet is a Belgian scientist and businessman. Currently he is Managing Director of the biotech company Viziphar Biosciences BVBA, and member of the Board of Directors of Janssen Pharmaceutica and the VIB. He was succeeded as Chairman of FlandersBio by Johan Cardoen.-Education:He obtained a...
- Koen Andries
Koen Andries is a Belgian scientist working at Janssen Pharmaceutica and professor at the University of Antwerp. In 2005 he and his team published a discovery about a new di-Aryl-Quinoline-based drug which promises a shorter and simpler treatment for Tuberculosis .-Career:He graduated as a...
- Jan Schuurkes
Jan A. J. Schuurkes is a Dutch biologist and gastrointestinal researcher.-Education:He graduated as a biochemist at the Catholic University of Nijmegen...
- Tibotec
Tibotec is a pharmaceutical company with a focus on research and development for the treatment of infectious diseases such as HIV , and Hepatitis C...
- Virco
Virco is a biotech company located in Mechelen, Belgium. It provides a quantitative phenotype prediction for HIV resistance testing. The prediction is achieved by performing a search in a database of genotype-phenotype pairs and matching the mutations in the database with those of the sample of the...
- Rega Institute for Medical Research
The Rega Institute for Medical Research is a Belgian scientific establishment that is part of the Catholic University of Leuven in central Belgium...
- Janssen-Cilag
Janssen-Cilag is a subsidiary of the Johnson & Johnson pharmaceutical company. The company was founded in the early 1990s by a merger between Janssen Pharmaceutica and Cilag....
- Ortho-McNeil Pharmaceutical
The company was formed from the merger of Ortho Pharmaceutical and McNeil Pharmaceutical in 1993. Both of these pharmaceutical companies are pioneers and leaders in areas such as pain management, acid reflux disease, and infectious diseases...
- Drug development
Drug development is a blanket term used to define the entire process of bringing a new drug or device to the Market. It includes Drug discovery / product development, pre-clinical research and Clinical trials...
- Nanovid microscopy
Nanovid microscopy, from “nanometer video-enhanced microscopy”, is a microscopic technique aimed at visualizing colloidal gold particles of 20-40 nm diameter as dynamic markers at the light microscopic level...
- FlandersBio
FlandersBio is a non-profit organization which represents the cluster of Flemish life sciences in Belgium. The members of FlandersBio are organizations involved with Research and Development, and production in life sciences, or organizations and companies servicing Flemish life sciences...
- Joan Daemen
Joan Daemen is a Belgian cryptographer and one of the designers of Rijndael, the Advanced Encryption Standard , together with Vincent Rijmen. He has also designed or co-designed the MMB, Square, SHARK, NOEKEON, 3-Way, and BaseKing block ciphers.In 1988, Daemen graduated in electro-mechanical...
External links