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Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, is a benzimidazole
Benzimidazole

Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. The most prominent benzimidazole compound in nature is N-ribosyl-dimethylbenzimidazole, which serves as an axial ligand for cobalt in Cyanocobalamin....
 drug that is used to treat infestations by worm
Worm

A worm is a common name given to a diverse group of invertebrate animals that have a long, soft body and no legs. There are hundreds of thousands of species of worms, 2,700 of these are earthworms....
s including pinworm
Pinworm

The pinworm , also known as threadworm is a parasitic roundworm of the phylum Nematoda....
s, roundworms, tapeworms, hookworm
Hookworm

The hookworm is a parasitic worm nematode worm that lives in the small intestine of its host, which may be a mammal such as a dog, cat, or human....
s, and whipworm
Whipworm

The human whipworm , is a roundworm, which causes trichuriasis when it infects a human large intestine. The name whipworm refers to the shape of the worm; they look like whips with wider "handles" at the posterior end....
s.

ndazole causes slow immobilization and death of the worms by selectively and irreversibly blocking the uptake of glucose and other nutrients. It is a spindle poison
Spindle poison

These poisons disrupt cellular reproduction by affecting the protein threads which connect the centromere regions of chromosomes, known as spindles....
 that induces chromosome
Chromosome

A chromosome is an organized structure of DNA and protein that is found in Cell . A chromosome is a single piece of DNA that contains many genes, regulatory sequence and other genetic sequence....
 nondisjunction
Nondisjunction

Nondisjunction is the failure of chromosome pairs to separate properly during cell division. This could arise from a failure of homologous chromosomes to separate in meiosis I, or the failure of sister chromatids to separate during meiosis II or mitosis....
.

dosage is 100 mg per dose, two doses per day, for three days.






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Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, is a benzimidazole
Benzimidazole

Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. The most prominent benzimidazole compound in nature is N-ribosyl-dimethylbenzimidazole, which serves as an axial ligand for cobalt in Cyanocobalamin....
 drug that is used to treat infestations by worm
Worm

A worm is a common name given to a diverse group of invertebrate animals that have a long, soft body and no legs. There are hundreds of thousands of species of worms, 2,700 of these are earthworms....
s including pinworm
Pinworm

The pinworm , also known as threadworm is a parasitic roundworm of the phylum Nematoda....
s, roundworms, tapeworms, hookworm
Hookworm

The hookworm is a parasitic worm nematode worm that lives in the small intestine of its host, which may be a mammal such as a dog, cat, or human....
s, and whipworm
Whipworm

The human whipworm , is a roundworm, which causes trichuriasis when it infects a human large intestine. The name whipworm refers to the shape of the worm; they look like whips with wider "handles" at the posterior end....
s.

Mechanism

Mebendazole causes slow immobilization and death of the worms by selectively and irreversibly blocking the uptake of glucose and other nutrients. It is a spindle poison
Spindle poison

These poisons disrupt cellular reproduction by affecting the protein threads which connect the centromere regions of chromosomes, known as spindles....
 that induces chromosome
Chromosome

A chromosome is an organized structure of DNA and protein that is found in Cell . A chromosome is a single piece of DNA that contains many genes, regulatory sequence and other genetic sequence....
 nondisjunction
Nondisjunction

Nondisjunction is the failure of chromosome pairs to separate properly during cell division. This could arise from a failure of homologous chromosomes to separate in meiosis I, or the failure of sister chromatids to separate during meiosis II or mitosis....
.

Dosage

Oral dosage is 100 mg per dose, two doses per day, for three days. This regime is repeated two weeks later if the infection has not cleared up. The dosage may differ depending on which type of worm someone is infected with.

Drug interactions

Carbamazepine
Carbamazepine

Carbamazepine is an anticonvulsant and mood stabilizer drug used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat Attention-deficit hyperactivity disorder, ADHD, schizophrenia, phantom limb syndrome, paroxysmal extreme pain disorder, and trigeminal neuralgia....
 and lorazepam
Lorazepam

Lorazepam, initially marketed under the brand names Ativan and Temesta, is a benzodiazepine drug with short to medium duration of action....
 cause higher serum levels of mebendazole. Cimetidine
Cimetidine

Cimetidine is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach. It is largely used in the treatment of heartburn and peptic ulcers....
 raises serum mebendazole levels, increasing its effectiveness.

Stevens-Johnson syndrome
Stevens-Johnson syndrome

Stevens-Johnson syndrome is a life-threatening Medical_condition affecting the skin in which cell death causes the Epidermis to separate from the dermis....
 (toxic epidermal necrolysis) when Medendazole is combined with high doses of Metronidazole.

See also

  • Metronidazole
    Metronidazole

    Metronidazole is a nitroimidazole antibiotic medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobe bacterium and protozoa....
  • Janssen Pharmaceutica
    Janssen Pharmaceutica

    Janssen Pharmaceutica, is a pharmaceutical company based in Beerse, in the Campine region of the province of Antwerp , Belgium. The company was established in 1953 by Paul Janssen....


External links

  • (UK manufacturer's website)