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Cramp



 
 
For the heraldic device, see cramp (heraldry); for the band, see The Cramps
The Cramps

The Cramps were an American garage punk band formed in 1976. Their line-up rotated much over their existence, with the husband and wife duo of lead singer Lux Interior and lead guitarist Poison Ivy as the only permanent members....


Cramps, (sometimes called charley horse
Charley horse

A charley horse is a popular North American colloquial term for a painful bruise of the quadriceps muscle of the anterior or lateral thigh that commonly results in a muscular hematoma and sometimes several weeks of pain and disability....
s in North America), are very unpleasant, often painful, sensations caused by contraction or over shortening of muscle
MUSCLE

MUSCLE is public domain, multiple sequence alignment software for protein and nucleotide sequences.MUSCLE is integrated into UGENE bioinformatics tool as a plugin....
s. Cramps can be caused by cold, overexertion or low calcium
Calcium

Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft grey alkaline earth metal, and is the fifth most abundant element by mass in the earth's Crust ....
 level in blood (especially for adolescents where they need calcium for both blood and bone maturing). Illness or poisoning can also cause cramps, particularly in the stomach
Stomach

In most mammals, the stomach is a hollow muscular organ of the gastrointestinal tract involved in the second phase of digestion, following mastication....
, which is referred to as colic
Colic

Colic is a form of pain in the abdomen which starts and stops abruptly....
 if it fits particular characteristics.

e are six basic causes of cramping: hyperflexion; hypoxia
Hypoxia (medical)

Hypoxia is a Pathology condition in which the body as a whole or a region of the body is deprived of adequate oxygen supply. Variations in arterial oxygen concentrations can be part of the normal physiology, for example, during strenuous physical exercise....
; exposure to large changes in temperature; dehydration; low blood salt
Salt

A salt, in chemistry, is defined as the product formed from the neutralisation reaction of acids and base . Salts are ionic compounds composed of cations and anions so that the product is electrically electric charge ....
; or low blood calcium
Calcium

Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft grey alkaline earth metal, and is the fifth most abundant element by mass in the earth's Crust ....
.






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For the heraldic device, see cramp (heraldry); for the band, see The Cramps
The Cramps

The Cramps were an American garage punk band formed in 1976. Their line-up rotated much over their existence, with the husband and wife duo of lead singer Lux Interior and lead guitarist Poison Ivy as the only permanent members....


Cramps, (sometimes called charley horse
Charley horse

A charley horse is a popular North American colloquial term for a painful bruise of the quadriceps muscle of the anterior or lateral thigh that commonly results in a muscular hematoma and sometimes several weeks of pain and disability....
s in North America), are very unpleasant, often painful, sensations caused by contraction or over shortening of muscle
MUSCLE

MUSCLE is public domain, multiple sequence alignment software for protein and nucleotide sequences.MUSCLE is integrated into UGENE bioinformatics tool as a plugin....
s. Cramps can be caused by cold, overexertion or low calcium
Calcium

Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft grey alkaline earth metal, and is the fifth most abundant element by mass in the earth's Crust ....
 level in blood (especially for adolescents where they need calcium for both blood and bone maturing). Illness or poisoning can also cause cramps, particularly in the stomach
Stomach

In most mammals, the stomach is a hollow muscular organ of the gastrointestinal tract involved in the second phase of digestion, following mastication....
, which is referred to as colic
Colic

Colic is a form of pain in the abdomen which starts and stops abruptly....
 if it fits particular characteristics.

Causes

There are six basic causes of cramping: hyperflexion; hypoxia
Hypoxia (medical)

Hypoxia is a Pathology condition in which the body as a whole or a region of the body is deprived of adequate oxygen supply. Variations in arterial oxygen concentrations can be part of the normal physiology, for example, during strenuous physical exercise....
; exposure to large changes in temperature; dehydration; low blood salt
Salt

A salt, in chemistry, is defined as the product formed from the neutralisation reaction of acids and base . Salts are ionic compounds composed of cations and anions so that the product is electrically electric charge ....
; or low blood calcium
Calcium

Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft grey alkaline earth metal, and is the fifth most abundant element by mass in the earth's Crust ....
. Muscle cramps may also be a symptom/complication of pregnancy, kidney disease, thyroid disease, hypokalemia
Hypokalemia

Hypokalemia refers to the condition in which the concentration of potassium in the blood is low. The prefix hypo- means low . Kal refers to kalium, the Neo-Latin for potassium, and -emia means "in the blood."...
 or hypocalcemia (as conditions), restless legs syndrome
Restless legs syndrome

Restless legs syndrome is a condition that is characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations....
, varicose veins
Varicose veins

Varicose veins are veins that have become enlarged and twisted. Carl Arnold Ruge is credited with having first defined varicose veins as "any dilated, elongated and tortuous vein irrespective of size"....
, and multiple sclerosis
Multiple sclerosis

Multiple sclerosis is an autoimmune disease in which the immune system attacks the central nervous system, leading to demyelinating disease. Disease onset usually occurs in young adults, and it is more common in females....
.

Electrolyte
Electrolyte

An electrolyte is any substance containing free ions that behaves as an electrical conductor medium. Because they generally consist of ions in solution, electrolytes are also known as ionic solutions, but molten electrolytes and solid electrolytes are also possible....
 disturbance may cause cramping and tetany
Tetany (medical sign)

Tetany is a medical sign, the involuntary contraction of muscles, caused by diseases and other conditions that increase the action potential frequency....
 of muscles, particularly hypokalaemia (a low level of potassium
Potassium

Potassium is a chemical element. It has the symbol K , atomic number 19, and atomic mass 39.0983. Potassium was first isolated from potash, hence the name....
) and hypocalcaemia
Hypocalcaemia

In medicine, hypocalcemia is the presence of low blood plasma calcium levels in the blood, usually taken as less than 2.1 mmol/L or 9 mg/dl or an ionized calcium level of less than 1.1 mmol/L ....
 (a low level of calcium
Calcium in biology

Calcium plays a pivotal role in the physiology and biochemistry of organisms and the cell . It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization....
). This disturbance arises as the body loses large amounts of interstitial fluid
Interstitial fluid

Interstitial fluid is a solution which bathes and surrounds the cells of multicellular animals. It is the main component of the extracellular fluid, which also includes Blood plasma and transcellular fluid....
 through sweat. This interstitial fluid is composed mostly of water and table salt (NaCl). The loss of osmotically active particles outside muscle cells leads to a disturbance of the osmotic balance and swelling of muscle cells as these contain more osmotically active particles. This causes the calcium pump between the muscle lumen and sarcoplasmic reticulum to short circuit and the calcium ions remain bound to the troponin
Troponin

Troponin is a complex of three regulatory proteins that is integral to muscle contraction in skeletal muscle and cardiac muscle, but not smooth muscle....
 and the muscle contraction
Muscle contraction

Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may #Eccentric contraction, #Concentric contraction or #Isometric contraction....
 is continued. This may occur when the lactic acid
Lactic acid

Lactic acid , also known as milk acid, is a chemical compound that plays a role in several biochemistry processes. It was first isolated in 1780 by a Swedish chemist, Carl Wilhelm Scheele, and is a carboxylic acid with a chemical formula of C3H6O3....
 is high in the cells.

Iatrogenic causes


Statin
Statin

The statins are a class of drugs that lower cholesterol levels in people with or at risk of cardiovascular disease.They lower cholesterol by inhibiting the enzyme HMG-CoA reductase, which is the rate-limiting step enzyme of the mevalonate pathway of cholesterol synthesis....
s are known to cause myalgia
Myalgia

Myalgia means "muscle pain" and is a symptom of many diseases and disorders. The most common causes are overuse or over-stretching of a muscle or group of muscles....
 and cramps among other side effects. Additional factors increasing probability for these adverse side effects are physical exercise, age, female gender, history of cramps and hypothyroidism
Hypothyroidism

Hypothyroidism is the disease state in humans and in animals caused by insufficient production of thyroid hormone by the thyroid gland. Cretinism is a form of hypothyroidism found in infants....
. Up to 80% of athletes using statins suffer significant muscular adverse effects including cramps, the rate appears to be approximately 10-25% in typical population using statins. In some cases these adverse effects will disappear after switching to a different statin, however they should not be ignored if they persist as they can, in rare cases, develop into a more serious problem. Coenzyme Q10 supplementation can be helpful to avoid some statin related adverse effects but currently there is not enough evidence to prove effectiveness in avoiding myopathy or myalgia.

Treatment

Muscle cramps can be treated by applying a soft massage on the cramped muscle, stretching your hands up above you and breathing in deeply through the mouth, stretching the muscle and applying heat or cold. Heat improves superficial blood circulation and makes muscles more flexible, so some people find heat to be soothing for muscle cramps. Application of excessive heat or cold to sore muscles may bring on cramps. Pounding on a cramped muscle can increase soreness. Trying to put weight on a cramp too soon can cause another cramp, or even a temporary loss of ability to use that muscle.

  • In the case of inadequate oxygenation, excess lactic acid, produced by anaerobic respiration
    Anaerobic respiration

    Anaerobic respiration is the process of generating energy through cellular respiration , without the use of oxygen....
    , builds up and stresses the muscle. In addition to the methods described above, cramps from poor oxygenation can be improved by rapid deep breathing.


  • Cramps from lack of water and/or salt can be treated by drinking water and/or increasing salt intake, respectively.


There is no scientific evidence to support the widely held claim by the sports nutrition industry that intake of specially composed electrolyte drinks has any advantage over intake of plain table salt (via drink or food) and water to counter these electrolyte disturbances and muscle cramps in people with a well-functioning renal system.

Eating foods high in potassium
Potassium

Potassium is a chemical element. It has the symbol K , atomic number 19, and atomic mass 39.0983. Potassium was first isolated from potash, hence the name....
 can help prevent muscle cramps.

In the case of cramps caused by varicose veins, treatment of the affected veins with sclerotherapy, endovenous laser or surgery usually provides relief.

Quinine
Quinine

Quinine is a natural white crystalline alkaloid having antipyretic , antimalarial drug, analgesic , and anti-inflammatory properties and a bitter taste....
 has been prescribed for the treatment of leg cramps. However, because of the drug's risks, the United States FDA has declared it should not be used to prevent or treat leg cramps.

Specific types of cramps


Smooth muscle cramps

Smooth muscle
Smooth muscle

Smooth muscle is a type of non-striated muscle, found within the tunica media layer of large and small arteries and veins, the urinary bladder, uterus, male and female reproductive tracts, gastrointestinal tract, respiratory tract, the ciliary muscle, and iris of the eye....
 contractions lie at the heart of the cramping (or colic
Colic

Colic is a form of pain in the abdomen which starts and stops abruptly....
ky) pain of internal organs. These include the intestine
Intestine

In anatomy, the intestine is the segment of the Gastrointestinal tract extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine....
, uterus
Uterus

The uterus is a major female hormone-responsive reproductive sex organ of most mammals, including humans. It is within the uterus that the fetus develops during gestation....
, ureter (in kidney stone
Kidney stone

Kidney stones, also called renal Calculus , are solid concretions of dissolved dietary mineral in urine; calculi typically form inside the kidneys or bladder....
 pain), and various others.

Menstrual cramps
Menstruation
Menstrual cycle

The menstrual cycle is a recurring cycle of physiology changes that occurs in reproductive-age females. Overt menstruation occurs primarily in humans and close evolutionary relatives such as chimpanzees....
 is also highly likely to cause cramps of varying severity in the abdomen
Abdomen

In vertebrates such as mammals the abdomen constitutes the part of the body between the thorax and pelvis. The region enclosed by the abdomen is termed the abdominal cavity....
 that may radiate to the lower back and thighs. Menstrual cramps can be treated with ibuprofen
Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug originally marketed as Brufen, and since then under various other trademarks , most notably Nurofen, Advil and Motrin....
, acetaminophen
Paracetamol

Paracetamol or acetaminophen is a widely used over-the-counter drug analgesic and antipyretic . It is commonly used for the relief of fever, headaches, and other minor aches and pains, and is a major ingredient in numerous common cold and Influenza remedies....
 (paracetamol
Paracetamol

Paracetamol or acetaminophen is a widely used over-the-counter drug analgesic and antipyretic . It is commonly used for the relief of fever, headaches, and other minor aches and pains, and is a major ingredient in numerous common cold and Influenza remedies....
), stretching exercises, or the application of heat through such means as warm baths or heating pads. Menstrual cramps that do not respond to self-treatment can be a symptom of endometriosis
Endometriosis

Endometriosis is a medical condition in women in which endometrial cells are deposited in areas outside the uterine cavity. The uterine cavity is lined by endometrial cells, which are under the influence of female hormones....
 or other health problems.

Skeletal muscle cramps

Skeletal muscle
Skeletal muscle

They generally contract voluntarily , although they can contract involuntarily through Reflex action. The whole muscle is wrapped in a special type of connective tissue, epimysium....
s are muscles that can be voluntarily controlled. Of the skeletal muscles, those which cramp the most often are the calves
Calf muscle

The calf or gastroc-soleus is a pair of muscles—the gastrocnemius muscle and soleus muscle—at the back of the lower human leg....
, thighs, and arches of the foot
Arches of the foot

The arches of the foot are formed by the tarsus and metatarsal bones, and strengthened by ligaments and tendons, allow the foot to support the weight of the body in the erect posture with the least weight....
. These cramps are seemingly associated with strenuous activity and can be intensely painful.

Nocturnal leg cramps
Nocturnal leg cramps are involuntary muscle contractions that occur in the calves
Calf muscle

The calf or gastroc-soleus is a pair of muscles—the gastrocnemius muscle and soleus muscle—at the back of the lower human leg....
, soles of the feet
Foot

The foot is an anatomical structure found in many animals. It is the terminal portion of a limb which bears weight and allows locomotion. In many animals with feet, the foot is a separate organ at the terminal part of the leg made up of one or more segments or bones, generally including claws or nails....
, or other muscles in the body during the night or (less commonly) while resting. Only a few fibers of a muscle may be activated. The duration of nocturnal leg cramps is highly variable with cramps sometimes only lasting a few seconds and other times several minutes. Soreness in the muscles may remain for some time after the cramp ends. These cramps are more common in older people but may happen to anyone. They can happen quite frequently in teenagers and in some people while they are exercising at night. Nocturnal leg cramps can be very painful, especially if the person is dehydrated. Usually, putting some pressure on the affected leg by walking some distance will make the cramp go away.

The precise cause of these cramps is unclear. Potential contributing factors are believed to include dehydration
Dehydration

Dehydration is the removal of water from an object. In Physiology terms, it entails a relative deficiency of water molecules in relation to other dissolved solutes....
, low levels of certain minerals (magnesium
Magnesium

Magnesium is a chemical element with the symbol Mg, atomic number 12, atomic weight 24.3050 and common oxidation number +2.Magnesium, an alkaline earth metal, is the ninth most abundance of the chemical elements in the universe by mass....
, potassium
Potassium

Potassium is a chemical element. It has the symbol K , atomic number 19, and atomic mass 39.0983. Potassium was first isolated from potash, hence the name....
, calcium
Calcium

Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft grey alkaline earth metal, and is the fifth most abundant element by mass in the earth's Crust ....
, and sodium
Sodium

Sodium is an element which has the symbol Na , atomic number 11, atomic mass 23 amu , and a common oxidation number +1. Sodium is a soft, silvery white, highly reactive element and is a member of the alkali metals within "group 1" ....
), and the reduced blood flow through the muscles attendant in prolonged sitting or lying down. Less common causes include more serious conditions or the use of drugs.

Nocturnal leg cramps may be relieved by stretching the affected leg straight out and pointing the toes upward. People report that quickly standing up and walking a few steps may also shorten the duration of a cramp.

Nocturnal leg cramps (almost exclusively calf cramps) are considered to be 'normal' during the late stages of pregnancy. They can however vary in intensity from mild to incredibly painful. Also, the standard R.I.C.E.
RICE (medicine)

RICE is a treatment method for soft tissue injury which is an acronym for Rest, Ice, Physical compression and Elevation . When used appropriately, recovery time is usually shortened and discomfort minimized....
 treatment may be used.

See also

  • Trigger point
    Trigger point

    Trigger points are described as hyperirritable spots in skeletal muscle that are associated with palpable Nodule in Wiktionary:taut bands of muscle fibers....
    s
  • Side stitch
    Side stitch

    When exercise, a side stitch is an intense stabbing pain under the lower edge of the ribcage. It is also referred to as exercise related transient abdominal pain ....
  • Delayed onset muscle soreness
    Delayed onset muscle soreness

    Delayed onset muscle soreness , also sometimes called muscle fever, is the pain or discomfort often felt 24 to 72 hours after exercising and subsides generally within 2 to 3 days....


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