Ray Farquharson
Encyclopedia
Ray Fletcher Farquharson (4 August 1897 – 1 June 1965) was a Canadian doctor, university professor, and medical researcher. Born in Claude, Ontario, he attended and taught at the University of Toronto
University of Toronto
The University of Toronto is a public research university in Toronto, Ontario, Canada, situated on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution of higher learning in Upper Canada...

 for most of his life, and was trained and employed at Toronto General Hospital
Toronto General Hospital
The Toronto General Hospital , is a part of the University Health Network, and a major teaching hospital in downtown Toronto, Ontario. It is located in the Discovery District, directly north of the Hospital for Sick Children, across Gerrard Street West, and east of Princess Margaret Hospital and...

. He served in the First and Second World Wars, receiving the Order of the British Empire
Order of the British Empire
The Most Excellent Order of the British Empire is an order of chivalry established on 4 June 1917 by George V of the United Kingdom. The Order comprises five classes in civil and military divisions...

 for his medical work during the latter. With co-researcher Arthur Squires, Farquharson was responsible for the discovery of the "Farquharson phenomenon", an important principle of endocrinology.

Farquharson was heavily involved in Canadian medical research and education. As a member of the National Research Council of Canada
National Research Council of Canada
The National Research Council is an agency of the Government of Canada which conducts scientific research and development.- History :...

, his "Farquharson Report" led to the establishment of the Medical Research Council of Canada, of which he was the first president. He received numerous honorary degrees from Canadian universities, and served on the first Board of Governors of York University
York University
York University is a public research university in Toronto, Ontario, Canada. It is Canada's third-largest university, Ontario's second-largest graduate school, and Canada's leading interdisciplinary university....

. He died in 1965, leaving a wife and two daughters. Farquharson was posthumously inducted into the Canadian Medical Hall of Fame
Canadian Medical Hall of Fame
The Canadian Medical Hall of Fame is a Canadian charitable organization, founded in 1994, that honours Canadians who have contributed to the understanding of disease and improving the health of people. It has a museum in London, Ontario, and has an annual induction ceremony.-2012:*Terry Fox*John...

 in 1998.

Early life and education

Farquharson was born in Claude, Ontario, in 1897 to Reverend William Farquharson, a Presbyterian minister, and Annie McDonald Coutts. His brother Charles also became a doctor, while another brother, Robert, was the managing editor for The Globe and Mail
The Globe and Mail
The Globe and Mail is a nationally distributed Canadian newspaper, based in Toronto and printed in six cities across the country. With a weekly readership of approximately 1 million, it is Canada's largest-circulation national newspaper and second-largest daily newspaper after the Toronto Star...

and an advisor at the Canadian Embassy to the United States. "Farquy", as he was nicknamed by friends, received his early education at Durham
Durham
Durham is a city in north east England. It is within the County Durham local government district, and is the county town of the larger ceremonial county...

 and graduated from Harbord Collegiate Institute
Harbord Collegiate Institute
Harbord Collegiate Institute is a public secondary school located in downtown Toronto, Canada. Specifically, the school is located in the Palmerston-Little Italy/The Annex neighbourhood, situated on the north side of Harbord Street, between Euclid Ave. and Manning St...

 in Toronto. He briefly attended the University of Toronto
University of Toronto
The University of Toronto is a public research university in Toronto, Ontario, Canada, situated on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution of higher learning in Upper Canada...

's medical school before enlisting in the Canadian Field Artillery
Royal Regiment of Canadian Artillery
The Royal Regiment of Canadian Artillery is the artillery personnel branch of the Canadian Forces .-History:...

 (67th Battery) in early 1918 as a gunner. Recalled from the war to complete his schooling, he graduated in 1922. He underwent post-graduate study in various fields from 1922 until 1927 while serving as an intern and resident at Toronto General Hospital
Toronto General Hospital
The Toronto General Hospital , is a part of the University Health Network, and a major teaching hospital in downtown Toronto, Ontario. It is located in the Discovery District, directly north of the Hospital for Sick Children, across Gerrard Street West, and east of Princess Margaret Hospital and...

 under Dr. Duncan Graham
Duncan Graham
Duncan Graham may refer to:* Duncan Archibald Graham , Canadian physician and academic* Duncan Graham , Canadian Member of Parliament for Ontario North, 1897–1900...

.

Farquharson then received research fellowships at Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital is a teaching hospital and biomedical research facility in the West End neighborhood of Boston, Massachusetts...

, where he worked with Joseph Aub and William Salter
William Salter
William Salter was an American Congregational minister, public orator, social activist and historian.Graduating from Andover Theological Seminary in 1843, Salter and his companions — the so-called "Iowa Band" — went West to Iowa when it was only a territory to organize congregations, build...

, and at Harvard University
Harvard University
Harvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...

 before becoming an assistant professor at the University of Toronto. He published papers discussing the excretion of calcium
Calcium
Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft gray alkaline earth metal, and is the fifth-most-abundant element by mass in the Earth's crust...

 in response to excessive acid in the body and "liver therapy" (the consumption of liver) as a treatment for spinal cord degeneration. In 1931 he married Christina Jane Fraser, with whom he had two daughters: Helen, who became a hematologist, and Catherine Jane.

Career

In addition to teaching at the University of Toronto, Farquharson established a private practice as a medical consultant, gaining a reputation as a "doctor's doctor". In 1934 he became the head of the therapeutics department at Toronto, and in 1947 was appointed to the Sir John and Lady Eaton Professor of Medicine chair. He continued to publish research findings on various topics, including anorexia nervosa
Anorexia nervosa
Anorexia nervosa is an eating disorder characterized by refusal to maintain a healthy body weight and an obsessive fear of gaining weight. Although commonly called "anorexia", that term on its own denotes any symptomatic loss of appetite and is not strictly accurate...

. Farquharson was a charter member of the Royal College of Physicians and Surgeons of Canada
Royal College of Physicians and Surgeons of Canada
The Royal College of Physicians and Surgeons of Canada ' , French: Collège royal des médecins et chirurgiens du Canada, is a national, private, nonprofit organization established in 1929 by a special Act of Parliament to oversee the medical education of specialists in Canada...

, which oversaw all Canadian postgraduate medical education; he served on its council from 1939 to 1943, and was the council's president from 1945 to 1947.

On 25 August 1943, Farquharson enlisted in the Royal Canadian Air Force
Royal Canadian Air Force
The history of the Royal Canadian Air Force begins in 1920, when the air force was created as the Canadian Air Force . In 1924 the CAF was renamed the Royal Canadian Air Force and granted royal sanction by King George V. The RCAF existed as an independent service until 1968...

 (RCAF) and was assigned to No. 1 Air Command. He was posted to the United Kingdom in 1944 and briefly returned to No. 1 Air Command before being released from service in November 1945 with the rank of wing commander
Wing Commander
Wing Commander may refer to:*Wing Commander , a military rank*Wing Commander , the Origin Systems computer game series and related franchise**Wing Commander , a collection of books set in the game universe...

. During the war, he chaired the Penicillin Committee of Canada, which regulated the distribution of penicillin
Penicillin
Penicillin is a group of antibiotics derived from Penicillium fungi. They include penicillin G, procaine penicillin, benzathine penicillin, and penicillin V....

 to the armed forces, and was a consultant to the RCAF's medical director. After V-E Day, he travelled to Belgium to supervise the administration of penicillin therapy. For his service in the war, Farquharson was appointed a Member of the Order of the British Empire in January 1946.

Farquharson was the director of medicine for Toronto veterans' hospitals from 1945 to 1947, and at the same time served as president of the Royal College of Physicians and Surgeons of Canada. From 1947 until his retirement in 1960, he was the Physician-in-Chief of the Toronto General Hospital. His well-known patients included Canadian politician George A. Drew, who he advised to resign as head of the Progressive Conservative Party of Canada
Progressive Conservative Party of Canada
The Progressive Conservative Party of Canada was a Canadian political party with a centre-right stance on economic issues and, after the 1970s, a centrist stance on social issues....

 and Leader of the Opposition
Leader of the Opposition (Canada)
The Leader of Her Majesty's Loyal Opposition , or simply the Leader of the Opposition is the leader of Canada's Official Opposition, the party with the most seats in the House of Commons that is not a member of the government...

 following a near-fatal attack of meningitis
Meningitis
Meningitis is inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation may be caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs...

; Drew did so, and was succeeded as party leader by John Diefenbaker
John Diefenbaker
John George Diefenbaker, PC, CH, QC was the 13th Prime Minister of Canada, serving from June 21, 1957, to April 22, 1963...

, who later became Prime Minister of Canada
Prime Minister of Canada
The Prime Minister of Canada is the primary minister of the Crown, chairman of the Cabinet, and thus head of government for Canada, charged with advising the Canadian monarch or viceroy on the exercise of the executive powers vested in them by the constitution...

. Farquharson established clinical teaching programs at Women's College Hospital and Sunnybrook Hospital, and expanded those already in place at St. Michael's and Toronto Western. He also appointed the first full-time clinical investigators to the Toronto medical school faculty and increased total faculty numbers from 40 to over 100. He became a Fellow of the American College of Physicians
American College of Physicians
The American College of Physicians is a national organization of doctors of internal medicine —physicians who specialize in the prevention, detection, and treatment of illnesses in adults. With 130,000 members, ACP is the largest medical-specialty organization and second-largest physician group in...

 in 1947 and of the Royal College of Physicians
Royal College of Physicians
The Royal College of Physicians of London was founded in 1518 as the College of Physicians by royal charter of King Henry VIII in 1518 - the first medical institution in England to receive a royal charter...

 in 1950. He was appointed a member of the Bacteriological Warfare Review Committee, established in 1950 by the Defence Research Board (of which he was a member) and chaired by Dr. Charles Best
Charles Best
Charles Herbert Best, CC, CH, CBE, MD, FRS, FRSC, FRCP was a medical scientist and one of the co-discoverers of insulin.-Biography:...

. For his service to the nation, he was awarded the Queen's Coronation Medal in 1953.

Through his research in endocrinology
Endocrinology
Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions called hormones, the integration of developmental events such as proliferation, growth, and differentiation and the coordination of...

 with colleague Arthur Squires, Farquharson discovered what is now known as the "Farquharson Phenomenon": the introduction of continuous exogenous
Exogenous
Exogenous refers to an action or object coming from outside a system. It is the opposite of endogenous, something generated from within the system....

 hormone doses suppresses the natural production of that hormone in the patient and causes temporary atrophy in the producing organ. This phenomenon became one of the basic principles of endocrinology and a key factor in the etiology of hormonal abnormalities. Farquharson also made significant contributions related to anemia
Anemia
Anemia is a decrease in number of red blood cells or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin...

 and pigment metabolism
Secondary metabolism
Secondary metabolism is a term for pathways and small molecule products of metabolism that are not absolutely required for the survival of the organism. Examples of the products include antibiotics and pigments. To distinguish non-secondary metabolism, the term basic metabolism is sometimes used...

. He was the first Canadian doctor to publicize Sheehan's syndrome
Sheehan's syndrome
Sheehan syndrome, also known as Simmonds' syndrome or postpartum hypopituitarism or postpartum pituitary necrosis, is hypopituitarism , caused by necrosis due to blood loss and hypovolemic shock during and after childbirth...

, and the first North American to report on Simmond's disease. As an educator and researcher, he an early promoter of laboratory testing in the evaluation of illness; he was known for advocating both this and understanding of potential psychological issues in his medical teaching.

Farquharson became a member of the National Research Council of Canada
National Research Council of Canada
The National Research Council is an agency of the Government of Canada which conducts scientific research and development.- History :...

 in 1951, and in 1957 was named the director of the Division of Medical Research. In 1958, he chaired a Privy Council
Privy council
A privy council is a body that advises the head of state of a nation, typically, but not always, in the context of a monarchic government. The word "privy" means "private" or "secret"; thus, a privy council was originally a committee of the monarch's closest advisors to give confidential advice on...

 Committee tasked with producing a report on the state of medical research in Canada; this charge was in response to a 1957 report by the Association of Canadian Medical Colleges to the Prime Minister, which suggested that medical research in Canada was underfunded. Farquharson concluded that government support for research was inadequate both because it failed to specifically address medical research as a separate discipline and because it was financially insufficient. His "Farquharson Report" led to the formation of the Medical Research Council of Canada in 1960, over which he presided until his death. As president, Farquharson advocated for progressive medical education taught by practicing physicians and for research as continuing education for doctors. He was also able to increase the organization's budget for awards and grants from C$4 million in 1963 to $9 million by 1965.

Farquharson became the Regent of the American College of Physicians after having spent three years as the Ontario representative. He joined the first Board of Governors of York University
York University
York University is a public research university in Toronto, Ontario, Canada. It is Canada's third-largest university, Ontario's second-largest graduate school, and Canada's leading interdisciplinary university....

 in 1959, and was a member of the University of Toronto Senate in the same year. He was named a Fellow of the Royal Society of Canada in 1960. He was also a member of a number of medical organizations in both Canada and the US, and chairman or board member for some 20 medical research groups.

Retirement and legacy

In 1960, having reached the University of Toronto's compulsory retirement age, Farquharson left the university and the hospital. In recognition of his work for Toronto General Hospital, the Clinical Investigation Unit was named after him in 1961. Farquharson won the National Heart Foundation
Heart and Stroke Foundation of Canada
The Heart and Stroke Foundation of Canada is a registered Canadian charity. The foundation's purpose is centered around educating individuals about the prevention and management of heart disease and stroke, and to fund medical research regarding the causes of these conditions...

's Award of Merit in 1960, followed by the Pharmaceutical Manufacturers' Association of Canada Health Research Foundation's Medal of Honour in 1964 "for his clinical assessment of antibiotics [and] service as a leading medical educator", becoming one of only 18 people to ever receive this award. He was featured on the cover of Modern Medicine in November 1963. Farquharson was granted honorary degrees by a number of Canadian universities: the University of British Columbia
University of British Columbia
The University of British Columbia is a public research university. UBC’s two main campuses are situated in Vancouver and in Kelowna in the Okanagan Valley...

 in 1949, the University of Saskatchewan
University of Saskatchewan
The University of Saskatchewan is a Canadian public research university, founded in 1907, and located on the east side of the South Saskatchewan River in Saskatoon, Saskatchewan, Canada. An "Act to establish and incorporate a University for the Province of Saskatchewan" was passed by the...

 in 1957, Laval University in 1959, Queen's University
Queen's University
Queen's University, , is a public research university located in Kingston, Ontario, Canada. Founded on 16 October 1841, the university pre-dates the founding of Canada by 26 years. Queen's holds more more than of land throughout Ontario as well as Herstmonceux Castle in East Sussex, England...

 in 1960, the University of Alberta
University of Alberta
The University of Alberta is a public research university located in Edmonton, Alberta, Canada. Founded in 1908 by Alexander Cameron Rutherford, the first premier of Alberta and Henry Marshall Tory, its first president, it is widely recognized as one of the best universities in Canada...

 in 1960, the University of Toronto in 1962, and the University of Montreal in 1965. He was named an honorary member of the Ontario Medical Association. He was also appointed a Knight of the Military and Hospitaller Order of St Lazarus of Jerusalem and an Honorary Fellow of the Royal Society of Medicine
Royal Society of Medicine
The Royal Society of Medicine is a British charitable organisation whose main purpose is as a provider of medical education, running over 350 meetings and conferences each year.- History and overview :...

 in London
London
London is the capital city of :England and the :United Kingdom, the largest metropolitan area in the United Kingdom, and the largest urban zone in the European Union by most measures. Located on the River Thames, London has been a major settlement for two millennia, its history going back to its...

.

Farquharson died on 1 June 1965 at Ottawa Civic Hospital at age 68 after suffering a heart attack. He had been in Ottawa
Ottawa
Ottawa is the capital of Canada, the second largest city in the Province of Ontario, and the fourth largest city in the country. The city is located on the south bank of the Ottawa River in the eastern portion of Southern Ontario...

 to attend a meeting of the Medical Research Council. The University of Toronto held a memorial service commemorating his contributions to the school and the medical community.
The Farquharson Life Sciences Building, the first science building at York University, was renamed in honour of Farquharson. A biography of Farquharson was planned, but was never completed. The Ray F. Farquharson Memorial Lecture was established in his memory; the first such lecture was delivered by John Eager Howard
John Eager Howard
John Eager Howard was an American soldier and politician from Maryland. He was elected as governor of the state in 1789, and served three one-year terms. He also was elected to the Continental Congress, Congress of the United States and the US Senate. He was born in and died in Baltimore County...

 of Johns Hopkins University
Johns Hopkins University
The Johns Hopkins University, commonly referred to as Johns Hopkins, JHU, or simply Hopkins, is a private research university based in Baltimore, Maryland, United States...

 in 1968 on the topic of calcium metabolism
Calcium metabolism
Calcium metabolism or calcium homeostasis is the mechanism by which the body maintains adequate calcium levels. Derangements of this mechanism lead to hypercalcemia or hypocalcemia, both of which can have important consequences for health....

. He was posthumously inducted into the Canadian Medical Hall of Fame
Canadian Medical Hall of Fame
The Canadian Medical Hall of Fame is a Canadian charitable organization, founded in 1994, that honours Canadians who have contributed to the understanding of disease and improving the health of people. It has a museum in London, Ontario, and has an annual induction ceremony.-2012:*Terry Fox*John...

 in 1998 alongside such notable figures as Tommy Douglas
Tommy Douglas
Thomas Clement "Tommy" Douglas, was a Scottish-born Baptist minister who became a prominent Canadian social democratic politician...

, Norman Bethune
Norman Bethune
Henry Norman Bethune was a Canadian physician and medical innovator. Bethune is best known for his service in war time medical units during the Spanish Civil War and with the Communist Eighth Route Army during the Second Sino-Japanese War...

 and Roberta Bondar
Roberta Bondar
Roberta Bondar,is OC, O.Ont, FRCP, FRSC is Canada's first female astronaut and the first neurologist in space. Following more than a decade as NASA's head of space medicine, Bondar became a consultant and speaker in the business, scientific and medical communities.-Education:Roberta Bondar had...

.

Farquharson was credited by Professor William Goldberg of McMaster University
McMaster University
McMaster University is a public research university whose main campus is located in Hamilton, Ontario, Canada. The main campus is located on of land in the residential neighbourhood of Westdale, adjacent to Hamilton's Royal Botanical Gardens...

 with "attack[ing] racism as part of [his] clinical teaching" because he suggested patient race should only be mentioned if relevant to their diagnosis; he is also credited with combating anti-Semitism
Anti-Semitism
Antisemitism is suspicion of, hatred toward, or discrimination against Jews for reasons connected to their Jewish heritage. According to a 2005 U.S...

. He is considered one of the "Fathers of Canadian Medicine" in both medical research and education. According to one memorial, "no Canadian since Sir William Osler
William Osler
Sir William Osler, 1st Baronet was a physician. He was one of the "Big Four" founding professors at Johns Hopkins Hospital as the first Professor of Medicine and founder of the Medical Service there. Sir William Osler, 1st Baronet (July 12, 1849 – December 29, 1919) was a physician. He was...

has left as great an imprint upon the practice of Medicine."
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