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Enteric nervous system
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The enteric nervous system (ENS) is a subdivision of the Peripheral Nervous System, that directly controls the gastrointestinal system.
It is derived from neural crest.
s capable of autonomous functions such as the coordination of reflexes, although it receives considerable innervation from the autonomic nervous system and thus is often considered a part of it.
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Encyclopedia
The enteric nervous system (ENS) is a subdivision of the Peripheral Nervous System, that directly controls the gastrointestinal system.
It is derived from neural crest.
Function
It is capable of autonomous functions such as the coordination of reflexes, although it receives considerable innervation from the autonomic nervous system and thus is often considered a part of it. Its study is the focus of neurogastroenterology.
It can be damaged by ischemia.
Transplantation has been described as a theoretical possibility.
Anatomy
It has as many as one hundred million neurons, one thousandth of the number of neurons in the brain, and considerably more than the number of neurons in the spinal cord. The enteric nervous system is embedded in the lining of the gastrointestinal system.
The neurons of the ENS are collected into two types of ganglia: myenteric (Auerbach's) and submucosal (Meissner's) plexuses. Myenteric plexuses are located between the inner and outer layers of the muscularis externa, while submucosal plexuses are located in the submucosa.
Complexity
The enteric nervous system has been described as a "second brain". There are several reasons for this. The enteric nervous system can operate autonomously. It normally communicates with the CNS through the parasympathetic (eg, via the vagus nerve) and sympathetic (eg, via the prevertebral ganglia) nervous systems. However, vertebrate studies show that when the vagus nerve is severed, the enteric nervous system continues to function.
In vertebrates the enteric nervous system includes efferent neurons, afferent neurons, and interneurons, all of which make the enteric nervous system capable of carrying reflexes and acting as an integrating center in the absence of CNS input. The sensory neurons report on mechanical and chemical conditions. Through intestinal muscles, the motor neurons control peristalsis and churning of intestinal contents. Other neurons control the secretion of enzymes. The enteric nervous system also makes use of more than 30 neurotransmitters, most of which are identical to the ones found in CNS, such as acetylcholine, dopamine, and serotonin. The enteric nervous system has the capacity to alter its response depending on such factors as bulk and nutrient composition. In addition, ENS contains support cells which are similar to astroglia of the brain and a diffusion barrier around the capillaries surrounding ganglia which is similar to the blood-brain barrier of cerebral blood vessels.
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