Sympathetic nervous system
Encyclopedia
The sympathetic nervous system (SNS) is one of the three parts of the autonomic nervous system
Autonomic nervous system
The autonomic nervous system is the part of the peripheral nervous system that acts as a control system functioning largely below the level of consciousness, and controls visceral functions. The ANS affects heart rate, digestion, respiration rate, salivation, perspiration, diameter of the pupils,...

, along with the enteric
Enteric nervous system
The enteric nervous system is a subdivision of the autonomic nervous system that directly controls the gastrointestinal system in vertebrates.It is derived from neural crest.-Function:...

 and parasympathetic
Parasympathetic nervous system
The parasympathetic nervous system is one of the two main divisions of the autonomic nervous system . The ANS is responsible for regulation of internal organs and glands, which occurs unconsciously...

 systems. Its general action is to mobilize the body's nervous system fight-or-flight response
Fight-or-flight response
The fight-or-flight response was first described by Walter Bradford Cannon....

. It is, however, constantly active at a basal level to maintain homeostasis
Homeostasis
Homeostasis is the property of a system that regulates its internal environment and tends to maintain a stable, constant condition of properties like temperature or pH...

.

Overview

Alongside the other two components of the autonomic nervous system
Autonomic nervous system
The autonomic nervous system is the part of the peripheral nervous system that acts as a control system functioning largely below the level of consciousness, and controls visceral functions. The ANS affects heart rate, digestion, respiration rate, salivation, perspiration, diameter of the pupils,...

, the sympathetic nervous system aids in the control of most of the body's internal organs. Stress
Stress (biology)
Stress is a term in psychology and biology, borrowed from physics and engineering and first used in the biological context in the 1930s, which has in more recent decades become commonly used in popular parlance...

—as in the flight-or-fight response—is thought to counteract the parasympathetic system
Parasympathetic nervous system
The parasympathetic nervous system is one of the two main divisions of the autonomic nervous system . The ANS is responsible for regulation of internal organs and glands, which occurs unconsciously...

, which generally works to promote maintenance of the body at rest. In truth, the functions of both the parasympathetic and sympathetic nervous systems are not so straightforward, but this is a useful rule of thumb.

There are two kinds of neurons involved in the transmission of any signal through the sympathetic system; pre- and post- ganglionic. The shorter preganglionic neurons originate from the thoracolumbar region of the spinal cord (levels T1 - L2, specifically) and travel to a ganglion, often one of the paravertebral ganglia
Paravertebral ganglia
Along the length of the sympathetic trunk are ganglia known as ganglia of sympathetic trunk or paravertebral ganglia. The ganglia are distinguished as cervical, thoracic, lumbar, and sacral and, except in the neck, they closely correspond in number to the vertebrae.-Arrangement:Only the cervical...

, where they synapse with a postganglionic neuron. From there, the long postganglionic neurons
Postganglionic fibers
In the autonomic nervous system, fibers from the ganglion to the effector organ are called postganglionic fibers.-Neurotransmitters:The neurotransmitters used for postganglionic fibers differ:...

 extend across most of the body.

At the synapses within the ganglia, preganglionic neurons release acetylcholine
Acetylcholine
The chemical compound acetylcholine is a neurotransmitter in both the peripheral nervous system and central nervous system in many organisms including humans...

, a neurotransmitter
Neurotransmitter
Neurotransmitters are endogenous chemicals that transmit signals from a neuron to a target cell across a synapse. Neurotransmitters are packaged into synaptic vesicles clustered beneath the membrane on the presynaptic side of a synapse, and are released into the synaptic cleft, where they bind to...

 that activates nicotinic acetylcholine receptors on postganglionic neurons. In response to this stimulus postganglionic neurons - with two important exceptions - release norepinephrine
Norepinephrine
Norepinephrine is the US name for noradrenaline , a catecholamine with multiple roles including as a hormone and a neurotransmitter...

, which activates adrenergic receptors on the peripheral target tissues. The activation of target tissue receptors causes the effects associated with the sympathetic system.

The two exceptions mentioned above are postganglionic neurons innervating sweat glands—which release acetylcholine for the activation of muscarinic receptors - and the adrenal medulla. The adrenal medulla
Adrenal medulla
The adrenal medulla is part of the adrenal gland. It is located at the center of the gland, being surrounded by the adrenal cortex. It is the innermost part of the adrenal gland, consisting of cells that secrete epinephrine , norepinephrine , and a small amount of dopamine in response to...

 develops in tandem with the sympathetic nervous system, and acts as a modified sympathetic ganglion: synapses occur between pre- and post- ganglionic neurons within it, but the post ganglionic neurons do not leave the medulla; instead they directly release norepinephrine and epinephrine
Epinephrine
Epinephrine is a hormone and a neurotransmitter. It increases heart rate, constricts blood vessels, dilates air passages and participates in the fight-or-flight response of the sympathetic nervous system. In chemical terms, adrenaline is one of a group of monoamines called the catecholamines...

 into the blood.

Function

align="bottom" style="caption-side: bottom; font-weight: normal; font-style: italic; font-size: smaller;" | Examples of sympathetic system action on various organs.
Organ Effect
Eye Dilates pupil
Heart Increases rate and force of contraction
Lungs Dilates bronchioles
Blood Vessels Constricts
Sweat Glands Activates sweat secretion
Digestive tract Inhibits peristalsis
Kidney Increases renin secretion
Penis Promotes ejaculation


The sympathetic nervous system is responsible for up- and down-regulating many homeostatic mechanisms in living organisms. Fibers from the SNS innervate tissues in almost every organ system, providing at least some regulatory function to things as diverse as pupil
Pupil
The pupil is a hole located in the center of the iris of the eye that allows light to enter the retina. It appears black because most of the light entering the pupil is absorbed by the tissues inside the eye. In humans the pupil is round, but other species, such as some cats, have slit pupils. In...

 diameter, gut motility, and urinary
Urinary system
The urinary system is the organ system that produces, stores, and eliminates urine. In humans it includes two kidneys, two ureters, the bladder and the urethra.-Kidney:...

 output. It is perhaps best known for mediating the neuronal and hormonal stress response commonly known as the fight-or-flight response. This response is also known as sympatho-adrenal response of the body, as the preganglionic sympathetic fibers that end in the adrenal medulla (but also all other sympathetic fibers) secrete acetylcholine, which activates the great secretion of adrenaline (epinephrine) and to a lesser extent noradrenaline (norepinephrine) from it. Therefore, this response that acts primarily on the cardiovascular system is mediated directly via impulses transmitted through the sympathetic nervous system and indirectly via catecholamines secreted from the adrenal medulla.

Some evolutionary theorists suggest that the sympathetic nervous system operated in early organisms to maintain survival as the sympathetic nervous system is responsible for priming the body for action. One example of this priming is in the moments before waking, in which sympathetic outflow spontaneously increases in preparation for action.

Organization

Sympathetic nerves originate inside the vertebral column
Vertebral column
In human anatomy, the vertebral column is a column usually consisting of 24 articulating vertebrae, and 9 fused vertebrae in the sacrum and the coccyx. It is situated in the dorsal aspect of the torso, separated by intervertebral discs...

, toward the middle of the spinal cord in the intermediolateral cell column (or lateral horn
Lateral horn
In the thoracic region, the postero-lateral part of the anterior column projects lateralward as a triangular field, which is named the lateral column .-Nerve Cells in the Lateral Column:...

), beginning at the first thoracic segment of the spinal cord and are thought to extend to the second or third lumbar
Lumbar
In tetrapod anatomy, lumbar is an adjective that means of or pertaining to the abdominal segment of the torso, between the diaphragm and the sacrum ...

 segments. Because its cells begin in the thoracic and lumbar regions of the spinal cord, the SNS is said to have a thoracolumbar outflow. Axon
Axon
An axon is a long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neuron's cell body or soma....

s of these nerves leave the spinal cord through the anterior rootlet/root. They pass near the spinal (sensory) ganglion, where they enter the anterior rami of the spinal nerves. However, unlike somatic innervation, they quickly separate out through white rami connectors (so called from the shiny white sheaths of myelin
Myelin
Myelin is a dielectric material that forms a layer, the myelin sheath, usually around only the axon of a neuron. It is essential for the proper functioning of the nervous system. Myelin is an outgrowth of a type of glial cell. The production of the myelin sheath is called myelination...

 around each axon) that connect to either the paravertebral (which lie near the vertebral column) or prevertebral (which lie near the aortic bifurcation) ganglia
Ganglion
In anatomy, a ganglion is a biological tissue mass, most commonly a mass of nerve cell bodies. Cells found in a ganglion are called ganglion cells, though this term is also sometimes used to refer specifically to retinal ganglion cells....

 extending alongside the spinal column.

To reach target organs and glands, the axons must travel long distances in the body, and, to accomplish this, many axons relay their message to a second cell through synaptic transmission. The ends of the axons link across a space, the synapse
Synapse
In the nervous system, a synapse is a structure that permits a neuron to pass an electrical or chemical signal to another cell...

, to the dendrites of the second cell. The first cell (the presynaptic cell) sends a neurotransmitter
Neurotransmitter
Neurotransmitters are endogenous chemicals that transmit signals from a neuron to a target cell across a synapse. Neurotransmitters are packaged into synaptic vesicles clustered beneath the membrane on the presynaptic side of a synapse, and are released into the synaptic cleft, where they bind to...

 across the synaptic cleft where it activates the second cell (the postsynaptic cell). The message is then carried to the final destination.

Presynaptic nerves' axons terminate in either the paravertebral ganglia
Paravertebral ganglia
Along the length of the sympathetic trunk are ganglia known as ganglia of sympathetic trunk or paravertebral ganglia. The ganglia are distinguished as cervical, thoracic, lumbar, and sacral and, except in the neck, they closely correspond in number to the vertebrae.-Arrangement:Only the cervical...

 or prevertebral ganglia. This can occur through one of four methods:

1. The nerve enters the paravertebral ganglion at the level of its originating spinal nerve, and then ascends to a more superior paravertebral ganglion, where it synapses with the postsynaptic cell.

2. The nerve enters the paravertebral ganglion at the level of its originating spinal nerve and synapses with the postsynaptic cell at that level.

3. The nerve enters the paravertebral ganglion at the level of its originating spinal nerve, and then descends to a more inferior paravertebral ganglion, where it synapses with the postsynaptic cell.

4. The nerve enters the paravertebral ganglion at the level of its originating spinal nerve and then descends to a prevertebral ganglion, where it synapses with the postsynaptic cell.

The postsynaptic cell then goes on to innervate the targeted end effector (i.e. gland, smooth muscle, etc.). Because paravertebral and prevertebral ganglia are relatively close to the spinal cord, presynaptic neurons are generally much shorter than their postsynaptic counterparts, which must extend throughout the body to reach their destinations.

A notable exception to the routes mentioned above is the sympathetic innervation of the suprarenal (adrenal) glands. In this case, presynaptic neurons pass through paraverterbral ganglia, on through prevertebral ganglia and then synapse directly with suprarenal tissue. This tissue consists of cells that have pseudo-neuron like qualities in that when activated by the presynaptic neuron, they will release their neurotransmitter (epinephrine) directly into the blood stream.

In the SNS and other components of the peripheral nervous system, these synapses are made at sites called ganglia. The cell that sends its fiber is called a preganglionic cell, while the cell whose fiber leaves the ganglion is called a postganglionic cell. As mentioned previously, the preganglionic cells of the SNS are located between the first thoracic segment and third lumbar segments of the spinal cord. Postganglionic cells have their cell bodies in the ganglia and send their axons to target organs or glands.

The ganglia include not just the sympathetic trunks but also the cervical ganglia (superior
Superior cervical ganglion
The superior cervical ganglion , the largest of the cervical ganglia, is placed opposite the second and third cervical vertebræ. It contains neurons that supply sympathetic innervation to the face....

, middle
Middle cervical ganglion
The middle cervical ganglion is the smallest of the three cervical ganglia, and is occasionally absent.It is placed opposite the sixth cervical vertebra, usually in front of, or close to, the inferior thyroid artery....

 and inferior
Inferior cervical ganglion
The inferior cervical ganglion is situated between the base of the transverse process of the last cervical vertebra and the neck of the first rib, on the medial side of the costocervical artery....

), which sends sympathetic nerve fibers to the head and thorax organs, and the celiac and mesenteric ganglia
Mesenteric ganglion
Mesenteric ganglion can refer to:* inferior mesenteric ganglion* superior mesenteric ganglion...

 (which send sympathetic fibers to the gut).

Information transmission

Messages travel through the SNS in a bidirectional flow. Efferent
Efferent
Efferent is an anatomical term with the following meanings:*Conveying away from a center, for example the efferent arterioles conveying blood away from the Bowman's capsule in the kidney. Opposite to afferent....

 messages can trigger changes in different parts of the body simultaneously. For example, the sympathetic nervous system can accelerate heart rate
Heart rate
Heart rate is the number of heartbeats per unit of time, typically expressed as beats per minute . Heart rate can vary as the body's need to absorb oxygen and excrete carbon dioxide changes, such as during exercise or sleep....

; widen bronchial passages; decrease motility
Motility
Motility is a biological term which refers to the ability to move spontaneously and actively, consuming energy in the process. Most animals are motile but the term applies to single-celled and simple multicellular organisms, as well as to some mechanisms of fluid flow in multicellular organs, in...

 (movement) of the large intestine
Large intestine
The large intestine is the third-to-last part of the digestive system — — in vertebrate animals. Its function is to absorb water from the remaining indigestible food matter, and then to pass useless waste material from the body...

; constrict blood vessels; increase peristalsis
Peristalsis
Peristalsis is a radially symmetrical contraction and relaxation of muscles which propagates in a wave down the muscular tube, in an anterograde fashion. In humans, peristalsis is found in the contraction of smooth muscles to propel contents through the digestive tract. Earthworms use a similar...

 in the esophagus
Esophagus
The esophagus is an organ in vertebrates which consists of a muscular tube through which food passes from the pharynx to the stomach. During swallowing, food passes from the mouth through the pharynx into the esophagus and travels via peristalsis to the stomach...

; cause pupillary dilation, piloerection (goose bumps
Goose bumps
Goose bumps, also called goose flesh, goose pimples, chill bumps, chicken skin, funky spots, Dasler Bumps, chicken bumps or the medical term cutis anserina, are the bumps on a person's skin at the base of body hairs which may involuntarily develop when a person is cold or experiences strong...

) and perspiration (sweating
Sweating
Perspiration is the production of a fluid consisting primarily of water as well as various dissolved solids , that is excreted by the sweat glands in the skin of mammals...

); and raise blood pressure
Blood pressure
Blood pressure is the pressure exerted by circulating blood upon the walls of blood vessels, and is one of the principal vital signs. When used without further specification, "blood pressure" usually refers to the arterial pressure of the systemic circulation. During each heartbeat, BP varies...

. Afferent
Afferent
Afferent is an anatomical term with the following meanings:*Conveying towards a center, for example the afferent arterioles conveying blood towards the Bowman's capsule in the Kidney. Opposite to Efferent.*Something that so conducts, see Afferent nerve fiber...

 messages carry sensations such as heat, cold, or pain.

The first synapse (in the sympathetic chain) is mediated by nicotinic receptors physiologically activated by acetylcholine, and the target synapse is mediated by adrenergic receptors physiologically activated by either noradrenaline (norepinephrine) or adrenaline (epinephrine
Epinephrine
Epinephrine is a hormone and a neurotransmitter. It increases heart rate, constricts blood vessels, dilates air passages and participates in the fight-or-flight response of the sympathetic nervous system. In chemical terms, adrenaline is one of a group of monoamines called the catecholamines...

). An exception is with sweat glands, which receive sympathetic innervation but have muscarinic acetylcholine receptors, which are normally characteristic of Parasympathetic nervous system. Another exception is with certain deep muscle blood vessels, which dilate (rather than constrict) with an increase in sympathetic tone. This is because of the presence of more beta2 receptors (rather than alpha1, which are frequently found on other vessels).

Sympathicotonia

Sympathicotonia is a stimulated condition of the sympathetic nervous system, marked by vascular spasm, elevated blood pressure
Hypertension
Hypertension or high blood pressure is a cardiac chronic medical condition in which the systemic arterial blood pressure is elevated. What that means is that the heart is having to work harder than it should to pump the blood around the body. Blood pressure involves two measurements, systolic and...

, and goose bumps
Goose bumps
Goose bumps, also called goose flesh, goose pimples, chill bumps, chicken skin, funky spots, Dasler Bumps, chicken bumps or the medical term cutis anserina, are the bumps on a person's skin at the base of body hairs which may involuntarily develop when a person is cold or experiences strong...

.
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