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Mange

 
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Mange



 
 
Mange (from Middle English
Middle English

Middle English is the name given by historical linguistics to the diverse forms of the English language spoken between the Norman conquest of England of 1066 and about 1470, when the #Chancery Standard, a form of London-based English, began to become widespread, a process aided by the introduction of the printing press into England by William...
 manjeue, from Old French
Old French

Old French was the Romance languages dialect continuum spoken in territories which span roughly the northern half of modern France and parts of modern Belgium and Switzerland from around 1000 to 1300....
 manjue, from mangier, meaning to eat) is a parasitic infestation of the skin
Skin

The skin is the outer covering of the body, also known as the epidermis. It is the largest organ of the integumentary system made up of multiple layers of epithelial biological tissue, and guards the underlying muscles, bones, ligaments and organ s....
 of animals. Common symptoms include hair
Hair

Hair is a protein filament that epidermal growth from hair follicle deep within the dermis. The fine, soft hair found on many nonhuman mammals is typically called fur; wool is the characteristically curly hair found on sheep and goats....
 loss, itching and inflammation
Inflammation

Inflammation is the complex biological response of Blood vessel tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue....
, all of which are caused by microscopic mites
MITES

MITES, or Minority Introduction to Engineering and Science, is a six-week summer program for rising high school seniors held at the Massachusetts Institute of Technology....
. Mange is most commonly found in dog
Dog

The dog is a domesticated subspecies of the Gray Wolf, a member of the Canidae family of the order Carnivora. The term is used for both feral and pet varieties....
s and other canines
Canidae

Canidae is the family of the dogs; a member of this family is called a canid. They include wolf, foxes, coyotes, and jackals. The Canidae family is divided into the "true dogs" of the tribe Canini and the "foxes" of the tribe Vulpini....
, but it can occur in other domestic and wild animal
Animal

Animals are a major group of multicellular, eukaryotic organisms of the Kingdom Animalia or Metazoa. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later on in their life....
s.

Similar skin infestations in human
Human

A human being, also human or man, is a member of a species of bipedalism primates in the family Hominidae . Mitochondrial DNA evidence indicates that modern humans originated in east Africa about 200,000 years ago....
s are not usually called mange but Demodicosis which may have a rosacea
Rosacea

Rosacea is a chronic condition characterized by facial erythema . Pimples are sometimes included as part of the definition.It is a common but often misunderstood condition that is estimated to affect over 45 million people worldwide....
-like appearance.

The mites embed themselves in the hair follicle
Hair follicle

A hair follicle is part of the skin that grows hair by packing old Cell s together. Attached to the follicle is a sebaceous gland, a tiny sebum-producing gland found everywhere except on the hands, lips and soles of the feet....
s or skin
Skin

The skin is the outer covering of the body, also known as the epidermis. It is the largest organ of the integumentary system made up of multiple layers of epithelial biological tissue, and guards the underlying muscles, bones, ligaments and organ s....
, depending on the type.






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Mange (from Middle English
Middle English

Middle English is the name given by historical linguistics to the diverse forms of the English language spoken between the Norman conquest of England of 1066 and about 1470, when the #Chancery Standard, a form of London-based English, began to become widespread, a process aided by the introduction of the printing press into England by William...
 manjeue, from Old French
Old French

Old French was the Romance languages dialect continuum spoken in territories which span roughly the northern half of modern France and parts of modern Belgium and Switzerland from around 1000 to 1300....
 manjue, from mangier, meaning to eat) is a parasitic infestation of the skin
Skin

The skin is the outer covering of the body, also known as the epidermis. It is the largest organ of the integumentary system made up of multiple layers of epithelial biological tissue, and guards the underlying muscles, bones, ligaments and organ s....
 of animals. Common symptoms include hair
Hair

Hair is a protein filament that epidermal growth from hair follicle deep within the dermis. The fine, soft hair found on many nonhuman mammals is typically called fur; wool is the characteristically curly hair found on sheep and goats....
 loss, itching and inflammation
Inflammation

Inflammation is the complex biological response of Blood vessel tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue....
, all of which are caused by microscopic mites
MITES

MITES, or Minority Introduction to Engineering and Science, is a six-week summer program for rising high school seniors held at the Massachusetts Institute of Technology....
. Mange is most commonly found in dog
Dog

The dog is a domesticated subspecies of the Gray Wolf, a member of the Canidae family of the order Carnivora. The term is used for both feral and pet varieties....
s and other canines
Canidae

Canidae is the family of the dogs; a member of this family is called a canid. They include wolf, foxes, coyotes, and jackals. The Canidae family is divided into the "true dogs" of the tribe Canini and the "foxes" of the tribe Vulpini....
, but it can occur in other domestic and wild animal
Animal

Animals are a major group of multicellular, eukaryotic organisms of the Kingdom Animalia or Metazoa. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later on in their life....
s.

Similar skin infestations in human
Human

A human being, also human or man, is a member of a species of bipedalism primates in the family Hominidae . Mitochondrial DNA evidence indicates that modern humans originated in east Africa about 200,000 years ago....
s are not usually called mange but Demodicosis which may have a rosacea
Rosacea

Rosacea is a chronic condition characterized by facial erythema . Pimples are sometimes included as part of the definition.It is a common but often misunderstood condition that is estimated to affect over 45 million people worldwide....
-like appearance.

The mites embed themselves in the hair follicle
Hair follicle

A hair follicle is part of the skin that grows hair by packing old Cell s together. Attached to the follicle is a sebaceous gland, a tiny sebum-producing gland found everywhere except on the hands, lips and soles of the feet....
s or skin
Skin

The skin is the outer covering of the body, also known as the epidermis. It is the largest organ of the integumentary system made up of multiple layers of epithelial biological tissue, and guards the underlying muscles, bones, ligaments and organ s....
, depending on the type. Both detection and treatment can be difficult and generally require consultation with a veterinarian.

Two types of mites produce canine mange, and each type has characteristic symptoms.

Demodectic mange

Demodex Mite 1
Also called demodicosis or Red Mange, demodectic mange in dogs is caused by a sensitivity to and overpopulation of Demodex canis
Demodex mite

Demodex is a genus of tiny Parasite mites that live in or near hair follicles of mammals. About 65 species of Demodex mites are known; they are among the smallest of arthropods....
 as the animal's immune system is unable to keep the mites in check. This is a mite
Mite

Mites, along with ticks, belong to the subclass Acarina and the class Arachnida. Mites are among the most diverse and successful of all the invertebrate groups....
 that occurs naturally in the hair follicles of most dogs in low numbers around the face and other areas of the body. In most dogs, these mites never cause problems. However, in certain situations, such as an under-developed or impaired immune system
Immune system

An immune system is a collection of biological processes within an organism that protects against disease by identifying and killing pathogens and tumour cells....
, intense stress
Stress (medicine)

Stress is a biological term which refers to the consequences of the failure of a human or animal body to respond appropriately to emotional or body threats to the organism, whether actual or imagined....
, or malnutrition
Malnutrition

Malnutrition is a general term for a medical condition caused by an improper or inadequate diet and nutrition.According to the World Health Organization, hunger and malnutrition are the single gravest threats to the world's public health and malnutrition is by far the biggest contributor to child mortality, present in half of all cases....
, the mites can reproduce rapidly, causing symptoms in sensitive dogs that range from mild irritation and hair loss on a small patch of skin to severe and widespread inflammation, secondary infection, and—in rare cases—a life-threatening condition. Small patches of demodicosis often correct themselves over time as the dog's immune system matures, although treatment is usually recommended.

Minor cases of demodectic mange usually do not cause much itching but might cause pustules on the dog's skin, redness, scaling, hair loss, or any combination of these. It most commonly appears first on the face, around the eyes, or at the corners of the mouth, and on the forelimbs and paws.

Dogmangeeee
In the more severe form, hair loss can occur in patches all over the body and might be accompanied by crusting, pain, enlarged lymph nodes, and deep skin infections.

Demodectic mange is not generally contagious to people, other animals, or even other dogs (except from mother to pup). However, the mite is zoonotic, and, upon infesting a human, will generally live in the hair follicles of the eyelashes and eyebrows. These mites thrive only on very specific hosts (dogs) and transmission usually occurs only from the mother to nursing puppies during the first few days after birth. The transmission of these mites from mother to pup is normal (which is why the mites are normal inhabitants of the dog's skin), but some individuals are sensitive to the mites, which can lead to the development of demodectic mange.

Some breeds appear to have an increased risk of mild cases as young dogs, including the Afghan Hound
Afghan Hound

The Afghan Hound is a very old sighthound dog dog breed. Distinguished by its thick, fine, silky coat and its tail with a ring curl at the end, the breed acquired its unique features in the cold mountains of Afghanistan, where it was originally used to hunt hares, and gazelles by coursing them....
, American Staffordshire Terrier
American Staffordshire Terrier

The American Staffordshire terrier is a dog breed of dog. The breed is a second cousin of the American Pit Bull Terrier. Early bulldog?terrier crosses were brought to the US by British and Irish settlers, especially after the American Civil War, where they were mainly used as fighting dogs, but also as hunting dogs, farm dogs, and guard dogs....
, Boston Terrier
Boston Terrier

The Boston Terrier is a dog breed of dog of the Terrier dog Dog type, originating in the United States of America....
, Boxer
Boxer (dog)

Developed in Germany, the Boxer is a dog breed of stocky, medium-sized, short-haired dog. The coat is smooth and fawn or brindled, with or without white markings....
, Chihuahua
Chihuahua (dog)

akcgroup = Toy| akcstd = http://www.akc.org/breeds/chihuahua/index.cfm| ankcgroup = Group 1 | ankcstd = http://www.ankc.aust.com/chihsmth.html Smooth Stds]]...
, Shar Pei
Shar Pei

The Shar Pei or Chinese Shar-Pei is a dog breed of dog known for its distinctive features of deep wrinkles and a blue-black tongue. The breed derives from China....
, Collie
Collie

A collie is a distinctive type of herding dog, ultimately originating in Great Britain, especially in the upland areas of the north and west....
, Dalmatian
Dalmatian (dog)

The Dalmatian is a dog breed originating from Dalmatia, a historical region of Croatia. It is noted for its white coat with either black or liver spots....
, Doberman Pinscher
Dobermann

The Doberman Pinscher or Doberman is a dog breed of domestic dog. Doberman Pinschers are among the most common of pet breeds, and the breed is well known as an intelligent, alert, and loyal companion dog....
, Bulldog
Bulldog

A Bulldog, colloquially known as the British Bulldog, is a type of dog which traces its ancestry to England....
, English Bull Terrier, Miniature Bull Terrier, German Shepherd Dog
German Shepherd Dog

The German Shepherd Dog , is a breed of large-sized dog that originates from Germany. German Shepherds are a fairly new breed of dog, with their origins only dating back to 1899....
, Great Dane
Great Dane

The Great Dane, Danish Hound, Deutsche Dogge, Boarhound, or German Mastiff is a dog breed of domestic dog known for its giant size and gentle personality....
, Old English Sheepdog
Old English Sheepdog

The Old English Sheepdog is a large dog breed of dog which was developed in England from very old herding dog dog type of dog. The Old English Sheepdog has very long coat covering the face and eyes....
, American Pit Bull Terrier
American Pit Bull Terrier

The American Pit Bull Terrier is a Dog breed of dog....
, West Highland White Terrier
West Highland White Terrier

West Highland White Terriers, commonly known as Westies, are a dog breed of dog known for their distinctive white coat. This breed is commonly recognised through its use as a mascot for Black & White , and on the packaging of Cesar brand dog food....
, Rat Terrier
Rat Terrier

The Rat Terrier is an United States dog breed with a rich and varied background as an all-around farm dog. Traditionally more of a type than a breed they share much ancestry with the tough little mixed breed dogs known as 'feist s.' Several private associations have maintained Rat Terriers registries for some decades, but more recently there...
, and Pug
Pug

The Pug is a small dog breed of dog with a wrinkly, short muzzled face . The word "pug" may have come from the Old English pugg or "puge", which were affectionate terms for a playful little devil or monkey....
. There is strong evidence that a predilection for juvenile demodectic mange is inherited, and those suffering from this form should not be bred.

Demodectic mange also occurs in other domestic and wild animals. The mites are specific to their hosts, and each mammal species is host to one or two unique species of Demodex mites. There are two types of demodectic mange in cats. Demodex cati causes follicular mange, similar to that seen in dogs, though it is much less common. Demodex gatoi is a more superficial form of mange, causes an itchy skin condition, and is contagious amongst cats.

Treatment

Minor, localized cases are often treated with medicated shampoo
Shampoo

Shampoo is a hair care product used for the removal of sebum, dirt, skin particles, dandruff, environmental pollutants and other contaminant particles that gradually build up in hair....
s and not treated with agents aimed at killing mites as these infestations often resolve within several weeks in young dogs.

Demodectic mange with secondary infection is treated with antibiotic
Antibiotic

In common usage, an antibiotic is a substance or compound that kills or inhibits the growth of bacteria. Antibiotics belong to the group of antimicrobial compounds used to treat infections caused by microorganisms, including fungus and protozoa....
s and medicated shampoos as well as parasiticidal agents. Amitraz
Amitraz

Amitraz is an antiparasitic drug. Product names include Aazdieno, Acarac, Aludex, Amitraze, Avartin, Baam, Edrizan, Maitac, Mitac, Mitaban, Triatox, Triatix, Vapcozin Taktic, Triazid, Topline, Tudy, Ectodex, Garial, Danicut, Ovidrex, Acadrex, Bumetran, and Ovasyn....
 is a parasiticidal rinse that is licensed for use in many countries for treating canine demodicosis. It is applied weekly or biweekly, for several weeks, until no mites can be detected by skin scrapings.

Demodectic mange in dogs can also be managed with ivermectin
Ivermectin

Ivermectin is a broad-spectrum antiparasitic medication.It is sold under brand names Stromectol in the United States, Mectizan in Canada by Merck & Co....
s, although there are few countries which license these drugs, which are given by mouth, daily, for this use. Ivermectin is used most frequently; collie
Collie

A collie is a distinctive type of herding dog, ultimately originating in Great Britain, especially in the upland areas of the north and west....
-like herding breeds often do not tolerate this drug due to a defect in the blood-brain barrier
Blood-brain barrier

The blood-brain barrier is a metabolic or cellular structure in the central nervous system that restricts the passage of various chemical substances and microscopic objects between the bloodstream and the neural tissue itself, while still allowing the passage of substances essential to metabolism function ....
, though not all of them have this defect. Other avermectin drugs that can be used include doramectin
Doramectin

Treatment and control of internal parasitosis , ticks and mange . Its spectrum includes: Haemonchus spp., Ostertagia spp., Trichostrongylus spp, Cooperia spp., Oesophagostomum spp., Dyctiocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, among many other internal and external parasites....
 and milbemycin.

Cats with Demodex gatoi must be treated with weekly or bi-weekly sulfurated lime rinses. Demodex cati is treated similarly to canine demodicosis.

Sarcoptic mange

Canine Scabies Mite
Also known as canine scabies
Scabies

Scabies is a contagious Parasitism skin infection characterized by superficial burrows, intense pruritus and secondary infection. It is etiology by the mite Sarcoptes scabiei....
, sarcoptic mange is a highly contagious infestation of Sarcoptes scabiei canis, a burrowing mite
Mite

Mites, along with ticks, belong to the subclass Acarina and the class Arachnida. Mites are among the most diverse and successful of all the invertebrate groups....
. The canine sarcoptic mite can also infest humans and cats, pigs, horses, sheep and various other species. These mites dig into and through the skin, causing intense itching and crusting that can quickly become infected
Infection

An infection is the detrimental colonization of a host organism by a foreign species. In an infection, the infecting organism seeks to utilize the host resources to multiply ....
. Hair loss and crusting frequently appear first on elbows and ears. Skin damage can occur from the dog's intense scratching and biting and secondary skin infection is common. Dogs with chronic sarcoptic mange are often in poor condition.

Treatment

Affected dogs need to be isolated from other dogs and their bedding, and places they have occupied must be thoroughly cleaned. Other dogs in contact with a diagnosed case should be evaluated and treated.

There are a number of parasiticidal treatments useful in treating canine scabies. Sulfurated lime rinses applied weekly or bi-weekly are effective. Selamectin
Selamectin

Selamectin is the active ingredient in the prescription drug Revolution Pet Medicine , a topical insecticide and antihelminthic used on dogs and cats....
 is licensed for treatment by veterinary prescription in several countries; it is applied as a drip-on directly to the skin. Unlicensed, but frequently used, ivermectin
Ivermectin

Ivermectin is a broad-spectrum antiparasitic medication.It is sold under brand names Stromectol in the United States, Mectizan in Canada by Merck & Co....
, given by mouth for two to four weekly treatments; this drug is not safe to use on some collie-like herding dog
Herding dog

A herding dog, is also known as a stock dog, is a Dog type of pastoral dog that either has been trained in herding or belongs to dog breeds developed for herding....
s, however. Other avermectin drugs are also effective, but none is licensed for use on dogs.

Diagnosis

Veterinarian
Veterinarian

A veterinarian or a veterinary surgeon , often shortened to vet, is a physician for animals and a practitioner of veterinary medicine....
s usually attempt diagnosis with skin scrapings from multiple areas, which are then examined under a microscope
Microscope

A microscope is an Laboratory equipment for viewing objects that are too small to be seen by the naked or unaided eye. The science of investigating small objects using such an instrument is called microscopy....
 for mites. Sarcoptes, because they may be present in relatively low numbers, and because they are often removed by dogs chewing at themselves, may be difficult to demonstrate. As a result, diagnosis in Sarcoptic mange is often based on symptoms rather than actual confirmation of the presence of mites. A common and simple way of determining if a dog has mange is if it displays what is called a "Pedal-Pinna reflex
ReFLEX

ReFLEX is a wireless protocol developed by Motorola which is used for two-way paging.The Motorola PageWriter released in 1996 was one of the first devices to use the ReFLEX network protocol....
", which is when the dog moves one of its hind legs in a scratching motion as the ear is being manipulated and scratched gently by the examiner; because the mites proliferate on the ear margins in nearly all cases at some point, this method works over 95% of the time. It is helpful in cases where all symptoms of mange are present but no mites are observed with a microscope. In some countries, a serologic test is available that may be useful in diagnosis.

For demodectic mange, properly performed deep skin scrapings generally allow the veterinarian to identify the microscopic mites. However because the mite is a normal inhabitant of the dog's skin, the presence of the mites does not conclusively mean the dog suffers from demodex. Rather abnormally high numbers of the mite are more useful. In breeds such as the West Highland White Terrier
West Highland White Terrier

West Highland White Terriers, commonly known as Westies, are a dog breed of dog known for their distinctive white coat. This breed is commonly recognised through its use as a mascot for Black & White , and on the packaging of Cesar brand dog food....
, relatively minor skin irritation which would otherwise be considered allergy should be carefully scraped because of the predilection of these dogs to demodectic mange. Skin scrapings may be used to follow the progress of treatment in demodectic mange.

See also

  • Cheyletiellosis
    Cheyletiellosis

    Cheyletiellosis is a mild dermatitis caused by mites of the genus Cheyletiella. It is also known as walking dandruff due to skin scales being carried by the mites....