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Selamectin
 
 
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Selamectin is the active ingredient in the prescription drug Revolution
Revolution Pet Medicine

Revolution is a topical, once-monthly pet medication manufactured by Pfizer, that prevents heartworms, fleas, ear mites, sarcoptic mange , and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats....
 (manufactured by Pfizer Canada
Pfizer

Pfizer Incorporated is a major pharmaceutical company, ranking number one in sales in the world. The company is based in New York City, and its research headquarters is in Groton, Connecticut....
 .), a topical
Topical

In medicine, a topical medication is applied to body surface area such as the skin or mucous membranes, for example the vagina, anus, pharynx, eyes and ears....
 insecticide
Insecticide

An insecticide is a pesticide used against insects in all developmental forms. They include ovicides and larvicides used against the Egg and larvae of insects respectively....
 and antihelminthic used on dogs and cats. It controls outbreaks of flea
Flea

Flea is the common name for insects of the order Siphonaptera which are wingless insects whose mouthparts are adapted for piercing skin and sucking blood....
s, heartworm
Heartworm

Heartworm is a Parasitism roundworm that is spread from host to host through the bites of mosquitoes. The heartworm is a type of Filariasis , a small thread-like worm....
, hookworm
Hookworm

The hookworm is a parasitic worm nematode worm that lives in the small intestine of its host, which may be a mammal such as a dog, cat, or human....
s, roundworms, and ear mite
Ear mite

Ear mites are mites that live in the ears of animals. The most commonly seen species is Otodectes cynotis....
s. Selamectin is not approved for human use.

mectin disables parasites by replacing glutamate in their muscle
MUSCLE

MUSCLE is public domain, multiple sequence alignment software for protein and nucleotide sequences.MUSCLE is integrated into UGENE bioinformatics tool as a plugin....
 synapses; glutamate is the amino acid
Amino acid

In chemistry, an amino acid is a molecule containing both amine and carboxyl functional groups. These molecules are particularly important in biochemistry, where this term refers to alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent....
 which normally interacts with the receptors
Receptor (biochemistry)

In biochemistry, a receptor is a protein molecule, embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling molecule may attach....
 that open chloride channels into the muscle.






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Selamectin is the active ingredient in the prescription drug Revolution
Revolution Pet Medicine

Revolution is a topical, once-monthly pet medication manufactured by Pfizer, that prevents heartworms, fleas, ear mites, sarcoptic mange , and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats....
 (manufactured by Pfizer Canada
Pfizer

Pfizer Incorporated is a major pharmaceutical company, ranking number one in sales in the world. The company is based in New York City, and its research headquarters is in Groton, Connecticut....
 .), a topical
Topical

In medicine, a topical medication is applied to body surface area such as the skin or mucous membranes, for example the vagina, anus, pharynx, eyes and ears....
 insecticide
Insecticide

An insecticide is a pesticide used against insects in all developmental forms. They include ovicides and larvicides used against the Egg and larvae of insects respectively....
 and antihelminthic used on dogs and cats. It controls outbreaks of flea
Flea

Flea is the common name for insects of the order Siphonaptera which are wingless insects whose mouthparts are adapted for piercing skin and sucking blood....
s, heartworm
Heartworm

Heartworm is a Parasitism roundworm that is spread from host to host through the bites of mosquitoes. The heartworm is a type of Filariasis , a small thread-like worm....
, hookworm
Hookworm

The hookworm is a parasitic worm nematode worm that lives in the small intestine of its host, which may be a mammal such as a dog, cat, or human....
s, roundworms, and ear mite
Ear mite

Ear mites are mites that live in the ears of animals. The most commonly seen species is Otodectes cynotis....
s. Selamectin is not approved for human use.

How it works

Selamectin disables parasites by replacing glutamate in their muscle
MUSCLE

MUSCLE is public domain, multiple sequence alignment software for protein and nucleotide sequences.MUSCLE is integrated into UGENE bioinformatics tool as a plugin....
 synapses; glutamate is the amino acid
Amino acid

In chemistry, an amino acid is a molecule containing both amine and carboxyl functional groups. These molecules are particularly important in biochemistry, where this term refers to alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent....
 which normally interacts with the receptors
Receptor (biochemistry)

In biochemistry, a receptor is a protein molecule, embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling molecule may attach....
 that open chloride channels into the muscle. Selamectin interferes with this process; it activates the chloride current without desensitization, allowing chloride ions to enter the nerve cells
Neuron

Neurons are responsive cell in the nervous system that process and transmit information by electrochemical Signal . They are the core components of the brain, the vertebrate spinal cord, the invertebrate ventral nerve cord, and the peripheral nerves....
 and causing neuromuscular paralysis
Paralysis

Paralysis is the complete loss of muscle function for one or more muscle groups. Paralysis can cause loss of feeling or loss of mobility in the affected area....
, impaired muscular contraction, and eventual death.

Selamectin fights both internal and surface parasitic infection
Infection

An infection is the detrimental colonization of a host organism by a foreign species. In an infection, the infecting organism seeks to utilize the host resources to multiply ....
. Absorbed into the body through the skin and hair follicles, it travels through the bloodstream, intestines, and sebaceous glands; parasites ingest the drug when they feed on the animal's blood.

A 2003 report by E. Pipano in the Israel Journal of Veterinary Medicine describes the testing of Selamectin for safety and effectiveness, and the positive results .

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