L01AA Nitrogen mustard

Nitrogen mustard

The nitrogen mustards are cytotoxic chemotherapy agents similar to mustard gas. Although their common use is medicinal, in principle these compounds can also be deployed as chemical warfare agents. Nitrogen mustards are nonspecific DNA alkylating agents. Nitrogen mustard gas was stockpiled by...

 analogues

L01AA01 Cyclophosphamide

Cyclophosphamide

Cyclophosphamide , also known as cytophosphane, is a nitrogen mustard alkylating agent, from the oxazophorines group....

L01AA02 Chlorambucil

Chlorambucil

Chlorambucil is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia...

L01AA03 Melphalan

Melphalan

Melphalan hydrochloride is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents.An alkylating agent adds an alkyl group to DNA...

L01AA05 Chlormethine

L01AA06 Ifosfamide

Ifosfamide

Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.It is sometimes abbreviated "IFO".-Uses:It is given as a treatment for a variety of cancers, including:...

L01AA07 Trofosfamide

Trofosfamide

Trofosfamide is a nitrogen mustard alkylating agent.It is sometimes abbreviated "TRO"....

L01AA08 Prednimustine

Prednimustine

Prednimustine is a drug used in chemotherapy. It is the ester formed from two other drugs, prednisolone and chlorambucil.It can be associated with myoclonus....

L01AA09 Bendamustine

Bendamustine

Bendamustine is a nitrogen mustard used in the treatment of chronic lymphocytic leukemias and lymphomas. It belongs to the family of drugs called alkylating agents...

L01AB Alkyl sulfonates

L01AB01 Busulfan

Busulfan

Busulfan is a cancer drug, in use since 1959.Busulfan is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates...

L01AB02 Treosulfan

Treosulfan

Treosulfan is a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called alkylating agents.-External links:* entry in the public domain NCI Dictionary of Cancer Terms...

L01AB03 Mannosulfan

Mannosulfan

Mannosulfan is an alkylating agent used in the treatment of cancer....

L01AC Ethylene imines

L01AC01 Thiotepa

ThioTEPA

N,N'N'-triethylenethiophosphoramide is an alkylating agent used to treat cancer.ThioTEPA is an organophosphorus compound with the formula SP3. It is an analogue of N,N',N- triethylenephosphoramide . This molecule features tetrahedral phosphorus and is structurally akin to phosphate...

L01AC02 Triaziquone

Triaziquone

Triaziquone is a drug used in chemotherapy.It is an alkylating agent. It can react with DNA to form intrastrand crosslinks....

L01AC03 Carboquone

Carboquone

Carboquone is a drug used in chemotherapy....

L01AD Nitrosoureas

L01AD01 Carmustine

Carmustine

Carmustine or BCNU is a mustard gas-related β-chloro-nitrosourea compound used as an alkylating agent in chemotherapy...

L01AD02 Lomustine

Lomustine

Lomustine is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use...

L01AD03 Semustine

Semustine

Semustine is a drug used in chemotherapy.Structurally similar to Lomustine....

L01AD04 Streptozocin

L01AD05 Fotemustine

Fotemustine

Fotemustine is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma. A study has shown that fotemustine produces improved response rates and increased survival over dacarbazine in the treatment of disseminated cutaneous melanoma....

L01AD06 Nimustine

Nimustine

Nimustine is a nitrosourea alkylating agent....

L01AD07 Ranimustine

Ranimustine

Ranimustine is a nitrosourea alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia and polycythemia vera....

L01AX Other alkylating agents

L01AX01 Mitobronitol

Mitobronitol

Mitobronitol is a brominated analog of mannitol. It is an anticancer drug that is classified as an alkylating agent....

L01AX02 Pipobroman

Pipobroman

Pipobroman is an alkylating agent....

L01AX03 Temozolomide

Temozolomide

Temozolomide Temozolomide Temozolomide (brand names Temodar and Temodal is an oral alkylating agent which can be used for the treatment of Grade IV astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme as well as melanoma, a form of skin cancer...

L01AX04 Dacarbazine

Dacarbazine

Dacarbazine is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas.Dacarbazine is a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl...

L01BA Folic acid

Folic acid

Folic acid and folate , as well as pteroyl-L-glutamic acid, pteroyl-L-glutamate, and pteroylmonoglutamic acid are forms of the water-soluble vitamin B9...

 analogues

L01BA01 Methotrexate

Methotrexate

Methotrexate , abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate...

L01BA03 Raltitrexed

Raltitrexed

Raltitrexed is an antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca.-Mechanism of action:...

L01BA04 Pemetrexed

Pemetrexed

Pemetrexed is a chemotherapy drug manufactured and marketed by Eli Lilly and Company. Its indications are the treatment of Pleural Mesothelioma as well as non-small cell lung cancer.-History:...

L01BA05 Pralatrexate

L01BB Purine

Purine

A purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature....

 analogues

L01BB02 Mercaptopurine

Mercaptopurine

Mercaptopurine is an immunosuppressive drug.It is a thiopurine.-Uses:...

L01BB03 Tioguanine

Tioguanine

Tioguanine , formerly thioguanine , is a drug that is used in the treatment of cancer.It belongs to the family of drugs called antimetabolites...

L01BB04 Cladribine

Cladribine

Cladribine is a drug used to treat hairy cell leukemia and multiple sclerosis. Its chemical name is 2-chlorodeoxyadenosine ....

L01BB05 Fludarabine

Fludarabine

Fludarabine or fludarabine phosphate is a chemotherapy drug used in the treatment of hematological malignancies. It has been unofficially and casually referred to as "AIDS in a bottle" amongst healthcare professionals due to its significant immunosuppresive activity.-Indications:Fludarabine is...

L01BB06 Clofarabine

Clofarabine

Clofarabine is a purine nucleoside antimetabolite marketed in the U.S. and Canada as Clolar. In Europe and Australia/New Zealand the product is marketed under the name Evoltra. It is FDA-approved for treating a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia in...

L01BB07 Nelarabine

L01BC Pyrimidine

Pyrimidine

Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring...

 analogues

L01BC01 Cytarabine

Cytarabine

Cytarabine, or cytosine arabinoside, is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia and non-Hodgkin lymphoma. It is also known as Ara-C...

L01BC02 Fluorouracil

Fluorouracil

Fluorouracil is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites...

L01BC03 Tegafur

Tegafur

Tegafur is a chemotherapeutic fluorouracil prodrug used in the treatment of cancers. It is a component of the combination drug tegafur-uracil. When metabolized, it becomes 5-fluorouracil....

L01BC04 Carmofur

Carmofur

Carmofur or HCFU is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.-Colorectal Cancer:...

L01BC05 Gemcitabine

L01BC06 Capecitabine

L01BC07 Azacitidine

L01BC08 Decitabine

L01BC52 Fluorouracil, combinations

L01BC53 Tegafur, combinations

L01CA Vinca

Vinca

Vinca is a genus of six species in the family Apocynaceae, native to Europe, northwest Africa and southwest Asia. The English name periwinkle is shared with the related genus Catharanthus .-Description:Vinca plants are subshrubs or herbaceous, and have slender trailing stems 1–2 m long...

 alkaloids and analogues

L01CA01 Vinblastine

Vinblastine

Vinblastine is an antimicrotubule drug used to treat certain kinds of cancer, including Hodgkin's lymphoma, non-small cell lung cancer, breast cancer, head and neck cancer, and testicular cancer. It is also used to treat Langerhan cell histiocytosis....

L01CA02 Vincristine

Vincristine

Vincristine , formally known as leurocristine, sometimes abbreviated "VCR", is a vinca alkaloid from the Catharanthus roseus , formerly Vinca rosea and hence its name. It is a mitotic inhibitor, and is used in cancer chemotherapy.-Mechanism:Tubulin is a structural protein that polymerizes to...

L01CA03 Vindesine

Vindesine

Vindesine is an anti-mitotic vinca alkaloid used in chemotherapy. It is used to treat many different types of cancer, including leukaemia, lymphoma, melanoma, breast cancer, and lung cancer....

L01CA04 Vinorelbine

Vinorelbine

Vinorelbine is an anti-mitotic chemotherapy drug that is given as a treatment for some types of cancer, including breast cancer and non-small cell lung cancer.-Pharmacology:...

L01CA05 Vinflunine

Vinflunine

Vinflunine is a novel fluorinated Vinca alkaloid undergoing research for the treatment of bladder cancer. It was originally discovered by the team of the Professor Jean-Claude Jacquesy , developed by Laboratoires Pierre Fabre and was licensed to Bristol-Myers Squibb for development in certain...

L01CB Podophyllotoxin

Podophyllotoxin

Podophyllotoxin , otherwise known as podofilox, is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. Under the trade name Condylox, a topical gel, it is used on the skin to treat external genital warts, caused by some types of the human papillomavirus...

 derivatives

L01CB01 Etoposide

Etoposide

Etoposide phosphate is an anti-cancer agent. It is known in the laboratory as a topoisomerase poison. Etoposide is often incorrectly referred to as a topoisomerase inhibitor in order to avoid using the term "poison" in a clinical setting...

L01CB02 Teniposide

Teniposide

Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia . It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body....

L01CD Taxane

Taxane

The taxanes are diterpenes produced by the plants of the genus Taxus . As their name suggests, they were first derived from natural sources, but some have been synthesized artificially. Taxanes include paclitaxel and docetaxel . Paclitaxel was originally derived from the Pacific yew tree.Taxanes...

s

L01CD01 Paclitaxel

Paclitaxel

Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a U.S. National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol...

L01CD02 Docetaxel

L01CD03 Paclitaxel poliglumex

L01DB Anthracycline

Anthracycline

Anthracyclines are a class of drugs used in cancer chemotherapy derived from Streptomyces bacterium Streptomyces peucetius var...

s and related substances

L01DB01 Doxorubicin

Doxorubicin

Doxorubicin INN is a drug used in cancer chemotherapy. It is an anthracycline antibiotic, closely related to the natural product daunomycin, and like all anthracyclines, it works by intercalating DNA....

L01DB02 Daunorubicin

Daunorubicin

Daunorubicin or daunomycin is chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. It is most commonly used to treat specific types of leukaemia...

L01DB03 Epirubicin

Epirubicin

Epirubicin is an anthracycline drug used for chemotherapy. It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere....

L01DB04 Aclarubicin

Aclarubicin

Aclarubicin is an anthracycline drug that is used in the treatment of cancer....

L01DB05 Zorubicin

Zorubicin

Zorubicin is an anthracycline....

L01DB06 Idarubicin

Idarubicin

Idarubicin or 4-demethoxydaunorubicin is an anthracycline antileukemic drug. It inserts itself into DNA and prevents DNA from unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular...

L01DB07 Mitoxantrone

Mitoxantrone

Mitoxantrone is an anthracenedione antineoplastic agent.-Uses:It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma...

L01DB08 Pirarubicin

Pirarubicin

Pirarubicin is an anthracycline drug....

L01DB09 Valrubicin

Valrubicin

Valrubicin is a chemotherapy drug used to treat bladder cancer. Valrubicin is a semisynthetic analog of the anthracycline doxorubicin, and is administered by infusion directly into the bladder.It was originally launched as Valstar in the U.S...

L01DB10 Amrubicin

Amrubicin

Amrubicin is an anthracycline used in the treatment of lung cancer. It is marketed in Japan since 2002 by Sumitomo Pharmaceuticals under the brand name Calsed....

L01DB11 Pixantrone

Pixantrone

Pixantrone is an experimental antineoplastic drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue. It acts as a topoisomerase II poison and intercalating agent...

L01DC Other cytotoxic antibiotics

L01DC01 Bleomycin

Bleomycin

Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. Bleomycin refers to a family of structurally related compounds. When used as an anticancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2. It works by causing breaks in DNA...

L01DC02 Plicamycin

Plicamycin

Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It is an RNA synthesis inhibitor...

L01DC03 Mitomycin

Mitomycin

The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. One of these compounds, mitomycin C, finds use as a chemotherapeutic agent by virtue of its antitumour antibiotic activity. It is given intravenously to treat...

L01DC04 Ixabepilone

Ixabepilone

Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug.It is produced by Sorangium cellulosum.-Pharmacology:It acts to stabilize microtubules....

L01XA Platinum

Platinum

Platinum is a chemical element with the chemical symbol Pt and an atomic number of 78. Its name is derived from the Spanish term platina del Pinto, which is literally translated into "little silver of the Pinto River." It is a dense, malleable, ductile, precious, gray-white transition metal...

 compounds

L01XA01 Cisplatin

Cisplatin

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas , lymphomas, and germ cell tumors...

L01XA02 Carboplatin

Carboplatin

Carboplatin, or cis-Diammineplatinum is a chemotherapy drug used against some forms of cancer...

L01XA03 Oxaliplatin

Oxaliplatin

Oxaliplatin is a coordination complex that is used in cancer chemotherapy. These platinum-based drugs are usually classified as alkylating agents, although they are not actually alkylating groups ....

L01XA04 Satraplatin

Satraplatin

Satraplatin is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration...

L01XA05 Polyplatillen

L01XC Monoclonal antibodies

Monoclonal antibodies

Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell....

L01XC01 Edrecolomab

Edrecolomab

Edrecolomab is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM , which is expressed on epithelial tissues and on various carcinomas....

L01XC02 Rituximab

Rituximab

Rituximab, sold under the trade names Rituxan and MabThera, is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells...

L01XC03 Trastuzumab

Trastuzumab

Trastuzumab is a monoclonal antibody that interferes with the HER2/neu receptor.The HER receptors are proteins that are embedded in the cell membrane and communicate molecular signals from outside the cell to inside the cell, and turn genes on and off...

L01XC04 Alemtuzumab

Alemtuzumab

Alemtuzumab is a monoclonal antibody used in the treatment of chronic lymphocytic leukemia , cutaneous T-cell lymphoma and T-cell lymphoma...

L01XC05 Gemtuzumab

L01XC06 Cetuximab

Cetuximab

Cetuximab is a chimeric monoclonal antibody, an epidermal growth factor receptor inhibitor, given by intravenous infusion for treatment of metastatic colorectal cancer and head and neck cancer.- Distribution :Cetuximab is manufactured and distributed in North America by ImClone and Bristol-Myers...

L01XC07 Bevacizumab

Bevacizumab

Bevacizumab is a drug that blocks angiogenesis, the growth of new blood vessels. It is commonly used to treat various cancers, including colorectal, lung, breast, kidney, and glioblastomas....

L01XC08 Panitumumab

Panitumumab

Panitumumab , formerly ABX-EGF, is a fully human monoclonal antibody specific to the epidermal growth factor receptor ....

L01XC09 Catumaxomab

Catumaxomab

Catumaxomab is a rat-mouse hybrid monoclonal antibody which is used to treat malignant ascites, a condition occurring in patients with metastasizing cancer. It binds to antigens CD3 and EpCAM. It is in clinical trials in the United States currently and is used in Europe...

L01XC10 Ofatumumab

Ofatumumab

Ofatumumab is a human monoclonal antibody which appears to inhibit early-stage B lymphocyte activation...

L01XC11 Ipilimumab

Ipilimumab

Ipilimumab , marketed as Yervoy, is a drug used for the treatment of melanoma, a type of skin cancer. It is a U.S...

L01XC12 Brentuximab vedotin

Brentuximab vedotin

Brentuximab vedotin is an antibody-drug conjugate approved to treat anaplastic large cell lymphoma and Hodgkin lymphoma. The U.S...

L01XD Sensitizers used in photodynamic

Photodynamic therapy

Photodynamic therapy is used clinically to treat a wide range of medical conditions, including malignant cancers, and is recognised as a treatment strategy which is both minimally invasive and minimally toxic...

/radiation

Radiation therapy

Radiation therapy , radiation oncology, or radiotherapy , sometimes abbreviated to XRT or DXT, is the medical use of ionizing radiation, generally as part of cancer treatment to control malignant cells.Radiation therapy is commonly applied to the cancerous tumor because of its ability to control...

 therapy

L01XD01 Porfimer sodium

Porfimer sodium

Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer....

L01XD03 Methyl aminolevulinate

Methyl aminolevulinate

Methyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX used in photodynamic therapy. It is marketed as Metvix....

L01XD04 Aminolevulinic acid

L01XD05 Temoporfin

Temoporfin

Temoporfin is a photosensitizer used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck....

L01XD06 Efaproxiral

Efaproxiral

Efaproxiral is an analog of the cholesterol drug bezafibrate developed as a radio sensitizer. It is used to increase the efficacy of certain chemotherapy drugs which have reduced efficacy against hypoxic tumours, and can thus be made more effective by increasing oxygenation of the tumour tissues...

L01XE Protein kinase inhibitors

L01XE01 Imatinib

Imatinib

Imatinib is a drug used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec or Glivec as its mesylate salt, imatinib mesilate . It is used in treating chronic myelogenous leukemia , gastrointestinal stromal tumors and some other diseases...

L01XE02 Gefitinib

Gefitinib

Gefitinib INN , trade name Iressa, is a drug used in the treatment of certain types of cancer, particularly those with mutated and overactive EGFR. Gefitinib is an EGFR inhibitor, like erlotinib, which interrupts signaling through the epidermal growth factor receptor in target cells...

L01XE03 Erlotinib

Erlotinib

Erlotinib hydrochloride is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor . It is marketed in the United States by Genentech and OSI...

L01XE04 Sunitinib

Sunitinib

Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase inhibitor that was approved by the FDA for the treatment of renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor on January 26, 2006...

L01XE05 Sorafenib

Sorafenib

Sorafenib , is a drug approved for the treatment of primary kidney cancer and advanced primary liver cancer ....

L01XE06 Dasatinib

Dasatinib

Dasatinib, previously known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel. Dasatinib is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia after imatinib treatment...

L01XE07 Lapatinib

Lapatinib

Lapatinib , used in the form of lapatinib ditosylate, is an orally active drug for breast cancer and other solid tumours. It is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway. It is used in combination therapy for HER2-positive breast cancer...

L01XE08 Nilotinib

Nilotinib

Nilotinib , in the form of the hydrochloride monohydrate salt, is a tyrosine kinase inhibitor approved for the treatment of chronic myelogenous leukemia.-Uses:...

L01XE09 Temsirolimus

Temsirolimus

Temsirolimus is an intravenous drug for the treatment of renal cell carcinoma , developed by Wyeth Pharmaceuticals and approved by the U.S. Food and Drug Administration in late May 2007, and was also approved by the European Medicines Agency on November 2007...

L01XE10 Everolimus

Everolimus

Everolimus is the 40-O- derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor....

L01XE11 Pazopanib

Pazopanib

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. It has been approved for renal cell carcinoma by the U.S. Food and Drug Administration. Pazopanib may also be...

L01XE12 Vandetanib

Vandetanib

Vandetanib , also known as ZD6474, is an antagonist of the vascular endothelial growth factor receptor and the epidermal growth factor receptor ....

L01XE13 Afatinib

QL01XE90 Masitinib

QL01XE91 Toceranib

Toceranib

Toceranib is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. Together with masitinib , Toceranib is the only dog-specific anti-cancer drug approved by the U.S. Food and Drug Administration. It is marketed as Palladia as its...

L01XX Other antineoplastic agents

L01XX01 Amsacrine

Amsacrine

Amsacrine is an antineoplastic agent.It has been used in acute lymphoblastic leukemia.-Mechanism:Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions...

L01XX02 Asparaginase

Asparaginase

Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid. Asparaginases are naturally occurring enzymes expressed and produced by microorganisms. Different types of asparaginases can be used for different industrial and pharmaceutical purposes. The most common use of...

L01XX03 Altretamine

Altretamine

Altretamine is an antineoplastic agent. It was approved by the FDA in 1990.-Uses:It is used to treat refractory ovarian cancer.It is not considered a first-line treatment, but it can be useful as salvage therapy...

L01XX05 Hydroxycarbamide

L01XX07 Lonidamine

Lonidamine

Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the...

L01XX08 Pentostatin

Pentostatin

Pentostatin is an anticancer chemotherapeutic drug.-Mechanism:It is classified as a purine analog, which is a type of antimetabolite....

L01XX09 Miltefosine

Miltefosine

Miltefosine is a phospholipid drug.Originally developed as an antineoplastic , it is finding use as an antiprotozoal drug...

L01XX10 Masoprocol

Masoprocol

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.Also called nordihydroguaiaretic acid, NDGA, and actinex....

L01XX11 Estramustine

Estramustine

Estramustine is a chemotherapy agent used to treat prostate cancer. It is a derivative of estrogen with a nitrogen mustard-carbamate ester moiety that makes it a alkylating antineoplastic agent similar to mechlorethamine, with estrogen-induced specificity.Estramustine is marketed in the United...

L01XX14 Tretinoin

Tretinoin

Tretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel...

L01XX16 Mitoguazone

Mitoguazone

Mitoguazone is a drug used in chemotherapy....

L01XX17 Topotecan

Topotecan

Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase I inhibitor. It is the water-soluble derivative of camptothecin...

L01XX18 Tiazofurine

L01XX19 Irinotecan

Irinotecan

Irinotecan is a drug used for the treatment of cancer.Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin....

L01XX22 Alitretinoin

Alitretinoin

Alitretinoin, or 9-cis-retinoic acid, is an antineoplastic agent developed by Ligand Pharmaceuticals. It is a first generation retinoid. Ligand gained Food and Drug Administration approval for alitretinoin in February 1999.-Kaposi’s sarcoma:...

L01XX23 Mitotane

Mitotane

Mitotane, or o,p'-DDD, is an antineoplastic medication used in the treatment of adrenocortical carcinoma. It is an isomer of DDD and is a derivative of DDT...

L01XX24 Pegaspargase

Pegaspargase

Pegaspargase is a modified enzyme used as an antineoplastic agent. It is a form of L-asparaginase which has undergone PEGylation.It is used in the treatment of acute lymphoblastic leukemia....

L01XX25 Bexarotene

Bexarotene

Bexarotene is an oral antineoplastic agent indicated by the FDA for cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.-Mechanism:...

L01XX27 Arsenic trioxide

Arsenic trioxide

Arsenic trioxide is the inorganic compound with the formula As2O3. This commercially important oxide of arsenic is the main precursor to other arsenic compounds, including organoarsenic compounds. Approximately 50,000 tonnes are produced annually...

L01XX29 Denileukin diftitox

Denileukin diftitox

Denileukin diftitox is an antineoplastic agent, an engineered protein combining Interleukin-2 and Diphtheria toxin. This can bind to Interleukin-2 receptors and introduce the diphtheria toxin into cells that express those receptors, killing the cells...

L01XX32 Bortezomib

Bortezomib

Bortezomib is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma...

L01XX33 Celecoxib

Celecoxib

Celecoxib INN is a sulfa non-steroidal anti-inflammatory drug and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial...

L01XX35 Anagrelide

Anagrelide

Anagrelide is a drug used for the treatment of essential thrombocytosis , or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. -Mechanism:...

L01XX36 Oblimersen

Oblimersen

Oblimersen is an antisense oligodeoxyribonucleotide being studied as a possible treatment for several types of cancer, including chronic lymphocytic leukemia, B-cell lymphoma, and breast cancer...

L01XX37 Sitimagene ceradenovec

L01XX38 Vorinostat

Vorinostat

Vorinostat or suberoylanilide hydroxamic acid is a member of a larger class of compounds that inhibit histone deacetylases...

L01XX39 Romidepsin

Romidepsin

Romidepsin , codenamed FK228 and FR901228, is an anticancer agent undergoing clinical trials as a treatment for cutaneous T-cell lymphoma , peripheral T-cell lymphoma, and a variety of other cancers...

L01XX40 Omacetaxine mepesuccinate

L01XX41 Eribulin

Eribulin

Eribulin is an anticancer drug marketed by Eisai Co. under the trade name Halaven. Eribulin mesylate was approved by the U.S. Food and Drug Administration on November 15, 2010, to treat patients with metastatic breast cancer who have received at least two prior chemotherapy regimens for late-stage...