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Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard
Nitrogen mustard

The nitrogen mustards are cytotoxic chemotherapy agents similar to mustard gas. Although their common use is medicinal, in principle these compounds may also be used for chemical warfare purposes....
 alkylating agent
Alkylating antineoplastic agent

An alkylating antineoplastic agent is an alkylating agent that attaches an alkyl group to DNA.Since cancer cells generally proliferate unrestrictively more than healthy cells do, cancer cells are more sensitive to DNA damage - such as being alkylated....
 used in the treatment of cancer
Cancer

Cancer is a class of diseases in which a group of cell display uncontrolled growth , invasion , and sometimes metastasis . These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, do not invade or metastasize....
.

It is sometimes abbreviated "IFO".








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Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard
Nitrogen mustard

The nitrogen mustards are cytotoxic chemotherapy agents similar to mustard gas. Although their common use is medicinal, in principle these compounds may also be used for chemical warfare purposes....
 alkylating agent
Alkylating antineoplastic agent

An alkylating antineoplastic agent is an alkylating agent that attaches an alkyl group to DNA.Since cancer cells generally proliferate unrestrictively more than healthy cells do, cancer cells are more sensitive to DNA damage - such as being alkylated....
 used in the treatment of cancer
Cancer

Cancer is a class of diseases in which a group of cell display uncontrolled growth , invasion , and sometimes metastasis . These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, do not invade or metastasize....
.

It is sometimes abbreviated "IFO".

Uses

It is given as a treatment for a variety of cancer
Cancer

Cancer is a class of diseases in which a group of cell display uncontrolled growth , invasion , and sometimes metastasis . These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, do not invade or metastasize....
s, including:

  • Testicular cancer
    Testicular cancer

    Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.In the United States, between 7,500 and 8,000 diagnoses of testicular cancer are made each year....
  • Breast cancer
    Breast cancer

    Breast cancer is a cancer that starts in the Cell of the breast in women and men. Worldwide, breast cancer is the second most common type of cancer after lung cancer and the fifth most common cause of cancer death....
  • Lymphoma
    Lymphoma

    Lymphoma is a type of cancer that originates in lymphocytes of the immune system. They often originate in lymph nodes, presenting as an enlargement of the node ....
     (Hodgkin's and Non-Hodgkin's)
  • Soft tissue sarcoma
    Soft tissue sarcoma

    A soft tissue sarcoma is a form of sarcoma that develops in connective tissue., though the term is sometimes applied to elements of the soft tissue that are not currently considered connective tissue....
  • Osteogenic sarcoma
  • Lung cancer
    Lung cancer

    Lung cancer is a disease of uncontrolled cell growth in tissue of the lung. This growth may lead to metastasis, which is the invasion of adjacent tissue and infiltration beyond the lungs....
  • Cervical cancer
    Cervical cancer

    Cervical cancer is malignant cancer of the cervix uteri or cervical area. It may present with vaginal bleeding but symptoms may be absent until the cancer is in its advanced stages....
  • Ovarian cancer
    Ovarian cancer

    Ovarian cancer is a malignant tumor arising from an ovary. Although ovarian cancer is known to occur in many species, the majority of the medical literature and the focus of this article is on ovarian cancer in humans....
  • Bone cancer


Administration

It is a white powder
Powder (substance)

A powder is a dry, bulk solid composed of a large number of very fine particles that may flow freely when shaken or tilted. Powders are a special sub-class of granular materials, although the terms powder and granular are sometimes used to distinguish separate classes of material....
 which, when prepared for use in chemotherapy
Chemotherapy

Chemotherapy, in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer....
 becomes a clear, colorless fluid
Fluid

A fluid is defined as a substance that continually deforms under an applied shear stress. All liquids and all gases are fluids. Fluids are a subset of the Phase and include liquids, gas, Plasma physics and, to some extent, plasticity ....
. The delivery is intravenous.

Ifosfamide is often used in conjunction with Mesna
Mesna

Mesna is an adjuvant used in cancer chemotherapy involving cyclophosphamide and ifosfamide. It is marketed by Baxter International as Uromitexan and Mesnex....
 to avoid internal bleeding
Internal bleeding

Internal bleeding is bleeding occurring inside the body. It can be a serious medical emergency depending on where it occurs , and can potentially cause death and cardiac arrest if proper medical treatment is not received quickly....
 in the patient, in particular hemorrhagic cystitis.

External links

  • (Professional)