Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an
alkylatingAn alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group to DNA.The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring....
nitrosourea compoundNitrosourea is both the name of a molecule, and a class of compounds that include a nitroso group and a urea.-Examples:Examples include:* Carmustine* Lomustine* Semustine* Ethylnitrosourea * Streptozotocin...
used in
chemotherapyChemotherapy, in its most general sense, is the treatment of disease by chemicals especially by killing micro-organisms or cancerous cells. In popular usage, it refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a cytotoxic standardized treatment regimen...
. It is in the same family as
streptozotocinStreptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals...
. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).
Discussion
Ask a question about 'Lomustine' Start a new discussion about 'Lomustine' Answer questions from other users |
Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an
alkylatingAn alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group to DNA.The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring....
nitrosourea compoundNitrosourea is both the name of a molecule, and a class of compounds that include a nitroso group and a urea.-Examples:Examples include:* Carmustine* Lomustine* Semustine* Ethylnitrosourea * Streptozotocin...
used in
chemotherapyChemotherapy, in its most general sense, is the treatment of disease by chemicals especially by killing micro-organisms or cancerous cells. In popular usage, it refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a cytotoxic standardized treatment regimen...
. It is in the same family as
streptozotocinStreptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals...
. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).
External links