Sesquiterpene lactone
Encyclopedia
Sesquiterpene lactones are a class of chemical compounds; they are sesquiterpenoids (built from three isoprene
Isoprene
Isoprene , or 2-methyl-1,3-butadiene, is a common organic compound with the formula CH2=CCH=CH2. Under standard conditions it is a colorless liquid...

 units) and contain a lactone
Lactone
In chemistry, a lactone is a cyclic ester which can be seen as the condensation product of an alcohol group -OH and a carboxylic acid group -COOH in the same molecule...

 ring, hence the name.

They are found in many plants and can cause allergic reactions and toxicity if overdosed, particularly in grazing livestock. In moderate amounts, the chemical can work with vernolic acid and other compounds in plants to reduce inflammation.

Some plants containing these compounds are:
  • Laurus nobilis
  • Chrysanthemum
    Chrysanthemum
    Chrysanthemums, often called mums or chrysanths, are of the genus constituting approximately 30 species of perennial flowering plants in the family Asteraceae which is native to Asia and northeastern Europe.-Etymology:...

  • Pyrethrum
    Pyrethrum
    Pyrethrum refers to several Old World plants of the genus Chrysanthemum which are cultivated as ornamentals for their showy flower heads. Pyrethrum is also the name of a natural insecticide made from the dried flower heads of C. cinerariifolium and C...

  • Ragweed
    Ragweed
    Ragweeds are flowering plants in the genus Ambrosia in the sunflower family Asteraceae. Common names include bitterweeds and bloodweeds....

  • Sneezeweed
    Sneezeweed
    There are several plants referred to as sneezeweed:*Achillea ptarmica in the Asteraceae family*Various species of Helenium in the Asteraceae family...

  • Ironweed
    Vernonia
    Vernonia is a genus of about 1000 species of forbs and shrubs in the family Asteraceae. Some species are known as Ironweed. Some species are edible and of economic value. They are known for having intense purple flowers. The genus is named for English botanist William Vernon. There are numerous...

  • Sagebrush
    Sagebrush
    Sagebrush is a common name of a number of shrubby plant species in the genus Artemisia native to western North America;Or, the sagebrush steppe ecoregion, having one or more kinds of sagebrush, bunchgrasses and others;...

  • Wormwood
  • Mugwort
  • Boneset
  • Poverty weed
  • Marsh elder
  • Cocklebur
    Cocklebur
    Cockleburs are a genus of flowering plants in the family Asteraceae, native to the Americas and eastern Asia.-Growth:They are coarse, herbaceous annual plants growing to 19.69-47.24 in tall. The leaves are spirally arranged, with a deeply toothed margin. Some species, notably X...

  • Burdock
    Burdock
    Burdock is any of a group of biennial thistles in the genus Arctium, family Asteraceae. Native to the Old World, several species have been widely introduced worldwide....

  • Chamomile
    Chamomile
    Chamomile or camomile is a common name for several daisy-like plants of the family Asteraceae. These plants are best known for their ability to be made into an infusion which is commonly used to help with sleep and is often served with either honey or lemon. Because chamomile can cause uterine...

  • Feverfew
    Feverfew
    Feverfew is a traditional medicinal herb which is found in many old gardens, and is also occasionally grown for ornament. The plant grows into a small bush up to around high, with citrus-scented leaves and is covered by flowers reminiscent of daisies...

  • Artichoke
    Artichoke
    -Plants:* Globe artichoke, a partially edible perennial thistle originating in southern Europe around the Mediterranean* Jerusalem artichoke, a species of sunflower with an edible tuber...

  • Gailladrin
  • Parthenium
    Parthenium
    Parthenium is a genus of flowering plants in the aster family, Asteraceae. The name is derived from either the Greek word παρθένος , meaning "virgin," or παρθένιον , an ancient name for a plant. Members of the genus are commonly known as feverfew. Notable species include Guayule and P...

  • Sunflower
    Sunflower
    Sunflower is an annual plant native to the Americas. It possesses a large inflorescence . The sunflower got its name from its huge, fiery blooms, whose shape and image is often used to depict the sun. The sunflower has a rough, hairy stem, broad, coarsely toothed, rough leaves and circular heads...

  • Lettuce
    Lettuce
    Lettuce is a temperate annual or biennial plant of the daisy family Asteraceae. It is most often grown as a leaf vegetable. It is eaten either raw, notably in salads, sandwiches, hamburgers, tacos, and many other dishes, or cooked, as in Chinese cuisine in which the stem becomes just as important...

  • Spinach
    Spinach
    Spinach is an edible flowering plant in the family of Amaranthaceae. It is native to central and southwestern Asia. It is an annual plant , which grows to a height of up to 30 cm. Spinach may survive over winter in temperate regions...

  • Yellow star thistle
  • Ginkgo biloba


Artemisinin
Artemisinin
Artemisinin , also known as Qinghaosu , and its derivatives are a group of drugs that possess the most rapid action of all current drugs against falciparum malaria. Treatments containing an artemisinin derivative are now standard treatment worldwide for falciparum malaria...

, a new, highly-effective anti-malaria
Malaria
Malaria is a mosquito-borne infectious disease of humans and other animals caused by eukaryotic protists of the genus Plasmodium. The disease results from the multiplication of Plasmodium parasites within red blood cells, causing symptoms that typically include fever and headache, in severe cases...

l compound, is a sesquiterpene lactone found in Chinese wormwood. Lactucin
Lactucin
Lactucin is a bitter substance that forms a white crystalline solid and belongs to the group of sesquiterpene lactones. It is found in some varieties of lettuce and is an ingredient of lactucarium. It has been shown to have analgesic and sedative properties....

, desoxylactucin, lactucopicrin
Lactucopicrin
Lactucopicrin is a bitter substance that has a sedative and analgesic effect, acting on the central nervous system. It is a sesquiterpene lactone, and is a component of lactucarium, derived from the plant Lactuca virosa , as well as being found in some related plants such as Cichorium intybus...

, lactucin-15-oxalaat, lactucopicrin-15-oxalaat are some of the most prominent and well determinable sesquiterpene lactones found e.g. in lettuce
Lettuce
Lettuce is a temperate annual or biennial plant of the daisy family Asteraceae. It is most often grown as a leaf vegetable. It is eaten either raw, notably in salads, sandwiches, hamburgers, tacos, and many other dishes, or cooked, as in Chinese cuisine in which the stem becomes just as important...

 and spinach
Spinach
Spinach is an edible flowering plant in the family of Amaranthaceae. It is native to central and southwestern Asia. It is an annual plant , which grows to a height of up to 30 cm. Spinach may survive over winter in temperate regions...

, giving most of the bitter taste in these crops.
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