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Guanosine

 

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Guanosine



 
 
Guanosine is a nucleoside
Nucleoside

Nucleosides are glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar. Examples of these include






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Guanosine is a nucleoside
Nucleoside

Nucleosides are glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar. Examples of these include cytidine, uridine, adenosine, guanosine, thymidine and inosine....
 comprising guanine
Guanine

Guanine is one of the five main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, thymine, and uracil. In DNA, guanine is paired with cytosine....
 attached to a ribose
Ribose

Ribose, primarily occurring as D-ribose, is an organic compound that occurs widely in nature. It is an aldopentose, that is a monosaccharide containing five carbon atoms that, in its acyclic form, has an aldehyde functional group at one end....
 (ribofuranose
Ribofuranose

Ribofuranose is the biochemical name for the 5-carbon sugar commonly known as ribose when having the furan ring structure....
) ring via a ß-N9-glycosidic bond
Glycosidic bond

In chemistry, a glycosidic bond is a certain type of functional group that joins a carbohydrate molecule to another, which may be another carbohydrate....
.

Guanosine can be phosphorylated to become GMP (guanosine monophosphate
Guanosine monophosphate

Guanosine monophosphate, also known as 5'-guanidylic acid or guanylic acid and abbreviated GMP, is a nucleotide that is found in RNA....
), cGMP (cyclic guanosine monophosphate
Cyclic guanosine monophosphate

Cyclic guanosine monophosphate is a cyclic nucleotide derived from guanosine triphosphate . cGMP acts as a second messenger much like cyclic AMP, most notably by activating intracellular protein kinases in response to the binding of cell membrane-impermeable peptide hormones to the external cell surface....
), GDP (guanosine diphosphate
Guanosine diphosphate

Guanosine diphosphate, abbreviated GDP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleoside guanosine. GDP consists of the pyrophosphate Functional group, the pentose sugar ribose, and the nucleobase guanine....
) and GTP (guanosine triphosphate
Guanosine triphosphate

Guanosine-5'-triphosphate is a purine nucleotide. One role is as substrate for the synthesis of RNA during transcription . Its structure is similar to that of the guanine nucleoside, the only difference being that there are three phosphate groups attached to the 5' carbon....
).

When guanine
Guanine

Guanine is one of the five main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, thymine, and uracil. In DNA, guanine is paired with cytosine....
 is attached to a deoxyribose
Deoxyribose

Deoxyribose, also known as D-Deoxyribose and 2-deoxyribose, is an aldopentose — a monosaccharide containing five carbon atoms, and including an aldehyde functional group in its linear structure....
 ring, it is known as a deoxyguanosine
Deoxyguanosine

Deoxyguanosine is a Compound and a nucleoside. It is like guanosine, but with one oxygen atom removed at the 2' position of the ribose sugar . If a phosphate group is attached at the 5' position, it becomes Deoxyguanosine monophosphate....
.

Guanosine's structure bears similarities to that of the antiviral drug aciclovir
Aciclovir

Aciclovir or acyclovir , chemical name acycloguanosine, is a guanosine nucleic acid analogues antiviral drug, marketed under trade names such as Cyclovir, Herpex, Acivir, Zovirax and Zovir ....
, often used in HIV/AIDS treatment.

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