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Infant Formula

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Infant formula



 
 
Infant formula is an artificial substitute for human breast milk
Breast milk

Breast milk refers to the milk produced by a mother to feed her baby. It provides the primary source of nutrition for newborns before they are able to eat and digest other foods; older infants and toddlers may continue to be breastfeeding....
, intended for infant
Infant

An infant or baby is the term used to refer to the young offspring of humans....
 consumption. The first preparations for the feeding of infants were produced commercially in 1867 by Justus von Liebig
Justus von Liebig

Justus von Liebig was a German chemist who made major contributions to agriculture and biology chemistry, and worked on the organization of organic chemistry....
. Today, most infant formulas are based on either cow milk or soy milk
Soy milk

Soy milk and sometimes referred to as soy drink/beverage is a beverage made from soybeans. A stable emulsion of oil, water and protein, it is produced by soaking dry soybeans, and grinding them with water....
. Some formulas, for infants with special dietary needs, are highly modified and may contain neither cow milk nor soy. An upswing in breastfeeding has been accompanied by a deferment in the average age of introduction of other foods (such as cow's milk), resulting in increased use of both breastfeeding and infant formula between the ages of 3-12 months.

A 2001 WHO report finds that infant formula prepared in accord with applicable Codex Alimentarius
Codex Alimentarius

The Codex Alimentarius is a collection of internationally recognized standards, codes of practice, guidelines and other recommendations relating to foods, food production and food safety....
 standards is a nutritionally adequate and safe complementary food and a suitable breast milk substitute
Milk substitute

A milk substitute is a liquid that replaces milk in a Diet or recipe. This overlaps with but is distinct from the group of milk-like liquids called "milks" because of their similarity to the liquid produced by mammary glands....
.






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Infant formula is an artificial substitute for human breast milk
Breast milk

Breast milk refers to the milk produced by a mother to feed her baby. It provides the primary source of nutrition for newborns before they are able to eat and digest other foods; older infants and toddlers may continue to be breastfeeding....
, intended for infant
Infant

An infant or baby is the term used to refer to the young offspring of humans....
 consumption. The first preparations for the feeding of infants were produced commercially in 1867 by Justus von Liebig
Justus von Liebig

Justus von Liebig was a German chemist who made major contributions to agriculture and biology chemistry, and worked on the organization of organic chemistry....
. Today, most infant formulas are based on either cow milk or soy milk
Soy milk

Soy milk and sometimes referred to as soy drink/beverage is a beverage made from soybeans. A stable emulsion of oil, water and protein, it is produced by soaking dry soybeans, and grinding them with water....
. Some formulas, for infants with special dietary needs, are highly modified and may contain neither cow milk nor soy. An upswing in breastfeeding has been accompanied by a deferment in the average age of introduction of other foods (such as cow's milk), resulting in increased use of both breastfeeding and infant formula between the ages of 3-12 months.

A 2001 WHO report finds that infant formula prepared in accord with applicable Codex Alimentarius
Codex Alimentarius

The Codex Alimentarius is a collection of internationally recognized standards, codes of practice, guidelines and other recommendations relating to foods, food production and food safety....
 standards is a nutritionally adequate and safe complementary food and a suitable breast milk substitute
Milk substitute

A milk substitute is a liquid that replaces milk in a Diet or recipe. This overlaps with but is distinct from the group of milk-like liquids called "milks" because of their similarity to the liquid produced by mammary glands....
. Nonetheless, with few exceptions the WHO report recommends exclusive breastfeeding
Breastfeeding

Breastfeeding is the feeding of an infant or young child with breast milk directly from human breasts rather than from a baby bottle or other container....
 for the first 6 months of life.

Infant formula is necessarily an imperfect approximation of breast milk because:
  • The exact chemical properties of breast milk are still unknown.
  • A mother's breast milk changes in response to the feeding habits of her baby and over time, thus adjusting to the infant's individual growth and development.
  • Breast milk includes a mother's antibodies that help the baby avoid or fight off infections and give his immature immune system the benefit of his mother's immune system that has many years of experience with the germs common in their environment.


History of formula


Early infant foods

Throughout history, mothers who could not (or chose not to) breastfeed their babies either employed the use of a wet nurse
Wet nurse

A wet nurse is a woman who breastfeeding a baby that is not her own. These children may be known as milk-siblings and in some cultures share a special relationship....
 or, less frequently, prepared food for their babies, a process known as "dry nursing." Baby food composition varied according to region and economic status. In Europe and America during the early 19th century, the prevalence of wet nursing began to decrease, while the practice of feeding babies mixtures based on animal milk rose in popularity.
Nestle Milk Poster
This trend was driven by cultural changes as well as increased sanitation measures, and it continued throughout the 19th and much of the 20th century, with a notable increase after Elijah Pratt invented and patented the India-rubber nipple in 1845. As early as 1846, scientists and nutritionists noted an increase in medical problems and infant mortality was associated with dry nursing. In an attempt to improve the quality of manufactured baby foods, in 1867, Justus von Liebig
Justus von Liebig

Justus von Liebig was a German chemist who made major contributions to agriculture and biology chemistry, and worked on the organization of organic chemistry....
 developed the world's first commercial infant formula, Liebig's Soluble Food for Babies. The success of this product quickly gave rise to competitors such as Mellin's Infant Food, Ridge's Food for Infants and Nestle's
Nestlé

Nestl? is a Multinational corporation packaged food company founded and headquartered in Vevey, Switzerland, and listed on the SWX Swiss Exchange with a turnover of over 87 billion Swiss francs....
 Milk.

Raw milk formulas

As physicians became increasingly concerned about the quality of such foods, medical recommendations such as Thomas Morgan Rotch's "percentage method" (published in 1890) began to be distributed, and gained widespread popularity by 1907. These complex formulas recommended that parents mix cow's milk, water, cream, and sugar or honey in specific ratios to achieve the nutritional balance believed to approximate human milk reformulated in such a way as to accommodate the believed digestive capability of the infant.

At the dawn of the 20th century in the United States, most infants were breastfed, although many received some formula feeding as well. Home-made "percentage method" formulas were more commonly used than commercial formulas in both Europe and the United States. They were less expensive and were widely believed to be healthier. However, formula-fed babies exhibited more diet-associated medical problems, such as scurvy, rickets and bacterial infections than breastfed babies. By 1920, the incidence of scurvy and rickets in formula-fed babies had greatly decreased through the addition of orange juice and cod liver oil to home-made formulas. Bacterial infections associated with formula remained a problem more prevalent in the United States than in Europe, where milk was usually boiled prior to use in formulas.

Evaporated milk formulas

In the 1920s and 1930s, evaporated milk
Evaporated milk

Evaporated milk, also known as dehydrated milk, is a shelf stable food canned milk product with about 60% of the water removed from fresh milk. It differs from condensed milk, which contains added sugar....
 began to be widely commercially available at low prices, and several clinical studies suggested that babies fed evaporated milk formula thrive as well as breastfed babies (these findings are not supported by modern research.) These studies, accompanied by the affordable price of evaporated milk and the availability of the home icebox initiated a tremendous rise in the use of evaporated milk formulas. By the late 1930s, the use of evaporated milk formulas in the United States surpassed all commercial formulas, and by 1950 over half of all babies in the United States were reared on such formulas.

Commercial formulas

In parallel with the enormous shift (in industrialized nations) away from breastfeeding to home-made formulas, nutrition scientists continued to analyze human milk and attempt to make infant formulas that more closely matched its composition. Maltose and dextrins were believed nutritionally important, and in 1912, the Mead Johnson Company released a milk additive called Dextri-Maltose. This formula was made available to mothers only by physicians. In 1919, milkfats were replaced with a blend of animal and vegetable fats as part of the continued drive to closer simulate human milk. This formula was called SMA for "simulated milk adapted."

In the late 1920s, Alfred Bosworth released Similac (for "similar to lactation"), and Mead Johnson released Sobee. Several other formulas were released over the next few decades, but commercial formulas did not begin to seriously compete with evaporated milk formulas until the 1950s. The reformulation and concentration of Similac in 1951, and the introduction (by Mead Johnson) of Enfamil in 1959 were accompanied by marketing campaigns that provided inexpensive formula to hospitals and pediatricians. By the early 1960s, commercial formulas were more commonly used than evaporated milk formulas, which all but vanished in the 1970s. By the early 1970s, over 75% of babies in the United States were fed on formulas, almost entirely commercially produced.

When birth rates in industrial nations tapered off during the 1960s, infant formula companies heightened marketing campaigns in non-industrialized countries. Unfortunately, poor sanitation led to steeply increased mortality rates among infants fed formula prepared with contaminated (drinking) water. Organized protests, the most famous of which was the Nestlé boycott
Nestlé boycott

The Nestl? boycott is a boycott launched on July 4, 1977 in the United States against the Swiss based Nestl? corporation. It spread quickly throughout the United States, and expanded into Europe in the early 1980s....
 of 1977, called for an end to unethical marketing. This boycott is ongoing, as the current coordinators maintain that Nestlé engages in marketing practices which violate the International Code of Marketing of Breast-milk Substitutes
International Code of Marketing of Breast-milk Substitutes

The International Code of Marketing of Breast-milk Substitutes was developed in 1981 by the general assembly of the World Health Organization , in close consultation with member states and other concerned parties....
.

Store Brand (Generic) Infant formulas

Store brand infant formula was first introduced in the United States in 1997 by PBM Products. All infant formula brands adhere to Food and Drug Administration
Food and Drug Administration

The U.S. Food and Drug Administration is an Government agency of the United States Department of Health and Human Services and is responsible for regulating and supervising the safety of foods, dietary supplements, Medications, vaccines, Biopharmaceutical, blood transfusion, medical devices, Electromagnetic radiation-emitting devices, veteri...
 (FDA) guidelines.

The Mayo Clinic stated in a : “As with most consumer products, brand-name infant formulas cost more than generic brands. But that doesn't mean that brand-name [Similac, Nestle, Enfamil] formulas are better. Although manufacturers may vary somewhat in their formula recipes, the FDA requires that all formulas contain the same nutrient density.”

Private label
Private label

Private label Product or Service s are typically those manufactured or provided by one company for offer under another company's brand. Private label goods and services are available in a wide range of industries from food to cosmetics to web hosting....
 infant formulas have allowed the leading food and drug retailers to provide formula to customers that is labeled under the store brands of companies such as Wal-Mart
Wal-Mart

Wal-Mart Stores, Inc. is an American Public company that runs a chain of large, discount department stores. It is the world's largest public corporation by revenue, according to the 2008 Fortune Global 500....
, Target
Target Corporation

Target Corporation is an United States retailing company that was founded in Minneapolis, Minnesota in 1902 under the name of Dayton Dry Goods Company....
, Kroger
Kroger

File:KrogerGulfton1.JPGThe Kroger Co. is an United States Retailing supermarket chain and parent company, founded by Bernard Henry Kroger in 1883 in Cincinnati, Ohio....
, Loblaws
Loblaws

Loblaws is a supermarket chain with over 70 stores in Canada, headquartered in Brampton, Ontario, with stores across Ontario and Quebec. Loblaws is a division of Loblaw Companies Limited, Canada's largest food distributor....
, and Walgreens
Walgreens

The Walgreen Company , Doing business as Walgreens , is a leading pharmacy chain store, mail service, and Pharmacy Benefit Management, with specialty pharmacy operations in 49 states, the Washington, D.C....
.

Usage since 1970s

Since the early 1970s, industrial countries have witnessed a dramatic resurgence in breastfeeding among children from newborn to 6 months of age. However, this upswing in breastfeeding has been accompanied by a deferment in the average age of introduction of other foods (such as cow's milk), resulting in increased use of both breastfeeding and infant formula between the ages of 3-12 months.

Leading health organizations (e.g. US CDC, WHO
World Health Organization

The World Health Organization is a specialized agency of the United Nations that acts as a coordinating authority on international public health....
, US HHS
United States Department of Health and Human Services

The United States Department of Health and Human Services , is a United States Cabinet department of the United States government of the United States with the goal of protecting the health of all Americans and providing essential human services....
) are attempting to increase the prevalence of breastfeeding through public awareness campaigns. The goals of these programs vary by organization, with recommended breastfeeding ages ranging between birth and 24 months. Additionally, regulatory initiatives also encourage breastfeeding. For example, the International Code of Marketing of Breast-milk Substitutes
International Code of Marketing of Breast-milk Substitutes

The International Code of Marketing of Breast-milk Substitutes was developed in 1981 by the general assembly of the World Health Organization , in close consultation with member states and other concerned parties....
 requires infant formula companies to preface their product information with statements that breastfeeding is the best way of feeding babies and that a substitute should only be used after consultation with health professionals.

Choosing to use infant formula

Reasons for using infant formula include:
  • The mother's health: The mother is infected with HIV
    HIV

    Human immunodeficiency virus is a lentivirus that can lead to AIDS , a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections....
     or tuberculosis
    Tuberculosis

    Tuberculosis is a common and often deadly infectious disease caused by mycobacterium, mainly Mycobacterium tuberculosis . Tuberculosis usually attacks the lungs but can also affect the central nervous system, the lymphatic system, the circulatory system, the genitourinary system, the gastrointestinal system, bones, joints, and even the...
    . She is malnourished or has had certain kinds of breast surgery
    Breast surgery

    Breast surgery may refer to one of the following specific surgeries.*Breast reduction surgery*Augmentation mammoplasty*Mastectomy*Lumpectomy...
    . She is taking any kind of drug
    Drug

    A drug, broadly speaking, is any chemical substance that, when absorbed into the body of a living organism, alters normal bodily function....
     that could harm the baby, or drinks unsafe levels of alcohol. The mother is extremely ill.
  • The baby is unable to breastfeed: The child has a birth defect or inborn error of metabolism
    Inborn error of metabolism

    Inborn errors of metabolism comprise a large class of genetics diseases involving disorders of metabolism. The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances into others ....
     such as galactosemia
    Galactosemia

    Galactosemia is a rare genetics Metabolism Disease which affects an individual's ability to properly metabolize the sugar galactose.Galactosemia is somestimes confused with Lactose-Intolerance, but unlike lactose-intolerance, galactosemia is not something that someone can "grow out of." Once diagnosed, its there for the rest of the persons li...
     that makes breastfeeding difficult or impossible.
  • Absence of the mother: The child is adopted, orphan
    Orphan

    An orphan is a child whose natural parents are absent or dead. One legal definition used in the USA is someone bereft through "death or disappearance of, abandonment or desertion by, or separation or loss from, both parents"....
    ed, or in the sole custody
    Child custody

    Child custody and legal guardian are legal terms which are sometimes used to describe the legal and practical relationship between a parent and his or her child, such as the right of the parent to make decisions for the child, and the parent's duty to care for the child....
     of a man. The mother is separated from her child by being in prison
    Prison

    A prison, penitentiary, or correctional facility is a place in which individuals are physically confined or internment and usually deprived of a range of personal Freedom ....
     or a mental hospital
    Mental Hospital

    Mental hospital may mean:*A Psychiatric hospital* A List of hospitals in Nepal named Mental Hospital...
    . The mother has left the child in the care of another person for an extended period of time, such as while traveling or working abroad. The mother has abandoned the child.
  • Family pressures: Family members, such as mother's husband or boyfriend encourage use of infant formula.
  • Lack of education: The mother believes that her breast milk is of low quality or in low supply, or that breastfeeding will decrease her energy, health, or attractiveness. The mother is not trained sufficiently to breastfeed without pain and to produce enough milk.
  • Financial pressures: Maternity leave is unpaid, insufficient, or lacking. The mother's employment interferes with breastfeeding.
  • Societal structure: Breastfeeding is difficult or forbidden at the mother's job, school, place of worship or while commuting. The mother feels infant formula is socially preferable.
  • Personal beliefs: The mother feels that breasts are too sexual for a baby or feels uncomfortable breastfeeding around other people. Nursing by a relative or paid wet-nurse is socially unsupported, believed to be unhygienic, or too expensive. Also, the mother does not want to breastfeed or prefers to use both breast milk and infant formula.
  • Dietary concerns: The contents of breastmilk are influenced by the dietary habits of the mother. If the mother consumes a food that contains an allergen breastfeeding may, for a brief period after consumption, provoke an allergic reaction in the infant.


Nutritional content

Besides breast milk, infant formula is the only other milk product which the medical
Medicine

Medicine is the art and science of healing. It encompasses a range of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
 community considers nutritionally acceptable for infants under the age of one year. Although cow's milk is the basis of almost all infant formula, plain cow's milk is unsuited for infants because of its high protein
Protein

Proteins are organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid Residue ....
 and electrolyte
Electrolyte

An electrolyte is any substance containing free ions that behaves as an electrical conductor medium. Because they generally consist of ions in solution, electrolytes are also known as ionic solutions, but molten electrolytes and solid electrolytes are also possible....
 (salt) content which may put a strain on an infant's immature kidney
Kidney

The kidneys are Organ that have numerous biological roles. Their primary role is to maintain the homeostasis balance of bodily fluids by filtering and secreting Metabolomics#Metabolitess and minerals from the blood and excreting them, along with water , as urine....
s. The infant intestine is not properly equipped to digest non-human milk and this may often result in diarrhea, intestinal bleeding and malnutrition. Evaporated milk, although perhaps easier to digest due to the processing of the protein, is still nutritionally inadequate. To reduce the negative effect on the infants digestive system, cows milk used for formula undergoes processing in order to be made into infant formula. This includes steps in order to make protein more easily digestible and alter the whey
Whey

Whey or milk plasma is the liquid remaining after milk has been curdled and strained; it is a by-product of the manufacture of cheese or casein and has several commercial uses....
-to-casein
Casein

Casein is the predominant phosphoprotein that accounts for nearly 80% of proteins in cow milk and cheese. Milk-clotting proteases act on the soluble portion of the caseins, K-Casein, thus originating an unstable micelle state that results in clot formation....
 protein balance to a ratio closer to human milk, the addition of several essential ingredients (often called "fortification", see below), the partial or total replacement of dairy fat with fats of vegetable or marine origin, etc.

Most of the world's supply of infant formula is produced in the United States
United States

The United States of America is a Federal government constitutional republic comprising U.S. state and a federal district. The country is situated mostly in central North America, where its Contiguous United States and Washington, D.C., the Capital districts and territories, lie between the Pacific Ocean and Atlantic Oceans, Borders of the U...
. The nutrient content is regulated by the American Food and Drug Administration
Food and Drug Administration

The U.S. Food and Drug Administration is an Government agency of the United States Department of Health and Human Services and is responsible for regulating and supervising the safety of foods, dietary supplements, Medications, vaccines, Biopharmaceutical, blood transfusion, medical devices, Electromagnetic radiation-emitting devices, veteri...
 (FDA) based on recommendations by the American Academy of Pediatrics
American Academy of Pediatrics

The American Academy of Pediatrics was founded in 1930 and now has 60,000 primary care pediatricians, pediatric medical subspecialists and pediatric surgical specialists as members....
 Committee on Nutrition. The following must be included in all formulas produced in the U.S.:

  • Protein
    Protein

    Proteins are organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid Residue ....
  • Fat
    Fat

    Fats consist of a wide group of compounds that are generally soluble in organic solvents and largely insoluble in water. Chemistry, fats are generally ester of glycerol and fatty acids....
  • Linoleic acid
    Linoleic acid

    Linoleic acid is an unsaturated omega-6 fatty acid. It is a colorless liquid. In physiological literature, it is called 18:2. Chemically, linoleic acid is a carboxylic acid with an 18-carbon chain and two cis double bonds; the first double bond is located at the sixth carbon from the omega end....
  • Vitamin
    Vitamin

    A vitamin is an organic compound required as a nutrient in tiny amounts by an organism. A compound is called a vitamin when it cannot be biosynthesis in sufficient quantities by an organism, and must be obtained from the diet....
    s: A
    Vitamin A

    Vitamin A, a bi-polar molecule formed with bi-polar covalent bonds between carbon and hydrogen, is linked to a family of similarly shaped molecules, the retinoids, which complete the remainder of the vitamin sequence....
    , C
    Vitamin C

    Vitamin C or ascorbic acid is an essential nutrient for humans, a large number of simian species, a small number of other mammalian species , a few species of birds, and some fish....
    , D
    Vitamin D

    Vitamin D is a group of fat-soluble prohormones, the two major forms of which are vitamin D2 and vitamin D3 . The term vitamin D also refers to metabolites and other analogues of these substances....
    , E
    Vitamin E

    Vitamin E is the collective name for a set of 8 related a-, ?-, ?-, and d-tocopherols and the corresponding four tocotrienols, which are fat-soluble vitamins with antioxidant properties....
    , K
    Vitamin K

    Vitamin K denotes a group of lipophilic, hydrophobic vitamins that are needed for the posttranslational modification of certain proteins, mostly required for blood coagulation....
    , thiamin (B1), riboflavin
    Riboflavin

    Riboflavin , also known as vitamin B2, is an easily absorbed micronutrient with a key role in maintaining health in humans and animals....
     (B2), B6
    Vitamin B6

    Vitamin B6 is a water-soluble vitamin and is part of the vitamin B complex group. Pyridoxal phosphate is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination, deamination, and decarboxylation....
    , B12
    Vitamin B12

    Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood....
  • Niacin
    Niacin

    Niacin, also known as vitamin B3, is a water-soluble vitamin which prevents the Nutrition disorder pellagra. It is an organic compound with the chemical formula C6H5NO2....
  • Folic acid
    Folic acid

    Folic acid and Folate are forms of the water-soluble B vitamins. Vitamin B9 is essential to numerous bodily functions ranging from nucleotide synthesis to the remethylation of homocysteine....
  • Pantothenic acid
    Pantothenic acid

    Pantothenic acid, also called vitamin B5 , is a water-soluble vitamin required to sustain life . Pantothenic acid is needed to form coenzyme-A , and is critical in the metabolism and synthesis of carbohydrates, proteins, and fats....
  • Calcium
    Calcium

    Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft grey alkaline earth metal, and is the fifth most abundant element by mass in the earth's Crust ....
  • Metals: magnesium
    Magnesium

    Magnesium is a chemical element with the symbol Mg, atomic number 12, atomic weight 24.3050 and common oxidation number +2.Magnesium, an alkaline earth metal, is the ninth most abundance of the chemical elements in the universe by mass....
    , iron
    Iron

    Iron is a chemical element with the symbol Fe and atomic number 26. Iron is a Group 8 element and period 4 element. Iron is lustrous and silvery in color....
    , zinc
    Zinc

    Zinc is a metallic chemical element with the symbol Zn and atomic number 30. It is a first-row transition metal of the group 12 element of the periodic table....
    , manganese
    Manganese

    Manganese is a chemical element, designated by the symbol Mn. It has the atomic number 25. It is found as a Oxidation state in nature , and in many minerals....
    , copper
    Copper

    Copper is a chemical element with the symbol Cu and atomic number 29.It is a ductile metal with very high thermal and electrical conductivity....
  • Phosphorus
    Phosphorus

    Phosphorus is the chemical element that has the symbol P and atomic number 15. The name comes from the and . A Valency nonmetal of the nitrogen group, phosphorus is commonly found in inorganic phosphate minerals....
  • Iodine
    Iodine

    Iodine , is a chemical element that has the symbol I and atomic number 53. Naturally-occurring iodine is a single isotope with 74 neutrons....
  • Sodium chloride
    Sodium chloride

    Sodium chloride, also known as common salt, table salt, or halite, is a chemical compound with the chemical formula SodiumChlorine....
  • Potassium chloride
    Potassium chloride

    The chemical compound potassium chloride is a metal halide Salt composed of potassium and chlorine. In its pure state it is odorless. It has a white or colorless vitreous crystal, with a crystal structure that cleaves easily in three directions....


In addition, formulas not made with cow's milk must include biotin
Biotin

Biotin, also known as vitamin H or B7, has the chemical formula C10H16N2O3S , is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring....
, choline
Choline

Choline is an organic compound, classified as a water-soluble essential nutrient and usually grouped within the Vitamin B complex. This natural amine is found in the lipids that make up cell membranes and in the neurotransmitter acetylcholine....
, and inositol
Inositol

Inositol, , is a carbocyclic polyol that plays an important role as the structural basis for a number of secondary messengers in Eukaryote cell s, including inositol phosphates, phosphatidylinositol and phosphatidylinositol phosphate lipids....
.

Hypoallergenic formulas reduce the likelihood of certain medical complications in babies with specific health problems. Baby formula can be synthesized from raw amino acids. This kind of formula is sometimes referred to as elemental infant formula or as medical food because of its specialized nature. While quite expensive, such formula is hypoallergenic
Hypoallergenic

Hypoallergenic is a term coined by advertisers and first used in a cosmetics campaign in 1953. It is used to describe items that cause or are claimed to cause fewer allergy reactions....
 and is sometimes used for babies with severe allergies to cow's milk and soy. Some commercial brands are Neocate and Peptamen. Being purely synthetic monomeric amino acids, it is also quite foul-tasting to adults, and it is not uncommon for infants to reject elemental formulas after having been established on a sweeter tasting, non-elemental formula.

Variations

Infant formula is available in powder, liquid concentrate and ready-to-feed forms, which are prepared by the caregiver or parent in small batches and fed to the infant, usually with either a baby bottle
Baby bottle

A baby bottle is a bottle with a teat to drinking directly from. It is typically used when a mother does not breastfeed, or if someone can not drink from a cup, for feeding oneself or being fed....
 or cup. It is very important to measure powders or concentrates accurately to achieve the intended final product. It is advisable that all equipment that comes into contact with the infant formula be cleaned and sterilized before each use. Proper refrigeration
Refrigeration

Refrigeration is the process of removing heat from an enclosed space, or from a substance, and moving it to a place where it is unobjectionable....
 is essential for any infant formula which is prepared in advance.

Controversy and science

The use of infant formula has come under scrutiny. Health authorities recommend breastfeeding for newborns through 12 months of age, and some through 24 months due to the infant's need for Omega 3, a nutrient that is ordinarily found in breast milk but not in formula. Today, however, DHA ( docosahexaenoic acid)
Docosahexaenoic acid

Docosahexaenoic acid is an omega-3 fatty acid essential fatty acid. In chemical structure, DHA is a carboxylic acid with a 22-carbon chain and hexa Cis-trans isomerism double bonds; the first double bond is located at the third carbon from the omega end....
 Omega-3 and ARA ( arachidonic acid)
Arachidonic acid

Arachidonic acid is an omega-6 fatty acid 20:4.It is the counterpart to the saturated arachidic acid found in peanut oil, ...
 are found in over 97% of U.S. infant formulas. Studies have found infants in developed countries who consume formula are at increased risk for acute otitis media
Otitis media

Otitis media is inflammation of the middle ear, or middle ear infection .Otitis media occurs in the area between the ear drum and the inner ear, including a duct known as the Eustachian tube....
, non-specific gastroenteritis
Gastroenteritis

Gastroenteritis is inflammation of the gastrointestinal tract, involving both the stomach and the small intestine and resulting in acute diarrhea....
, severe lower respiratory tract infections, atopic dermatitis
Dermatitis

Dermatitis is a blanket term meaning any "inflammation of the skin" . There are several different types of dermatitis. The different kinds usually have in common an allergic reaction to specific allergens....
, asthma
Asthma

Asthma is a common chronic obstructive pulmonary disease, in which the Lung constrict, become inflammation, and are lined with excessive amounts of thickened mucus, often in response to one or more triggers....
, obesity
Obesity

Obesity is a condition in which excess body fat has accumulated to an extent that health may be negatively affected. It is commonly defined as a body mass index of 30 kg/m2 or higher....
, type 1 and 2 diabetes, sudden infant death syndrome
Sudden infant death syndrome

Sudden infant death syndrome is a syndrome marked by the symptoms of sudden and unexplained death of an apparently healthy infant aged one month to one year....
 (SIDS), eczema
Eczema

Eczema is a form of dermatitis, or inflammation of the epidermis. The term eczema is broadly applied to a range of persistent skin conditions....
, necrotizing enterocolitis
Necrotizing enterocolitis

Necrotizing enterocolitis is a medical condition primarily seen in premature birth infants, where portions of the bowel undergo necrosis ....
 and autism when compared to infants who are breastfed.

Although some early studies have found an association between infant formular and lower cognitive development, other studies have found no correlation. However recently more questions have arisen. It has been discovered that iron supplementation in baby formula is linked to lowered I.Q. and other neurodevelopmental delays.

Melamine contamination

On November 25, 2008, an Associated Press article entitled, "FDA finds traces of melamine in US infant formula," explains infant formula made by the main three firms has tested positive for melamine contamination. These three main firms are responsible for 90% of infant formula in the US, "Abbott Laboratories, Nestle and Mead Johnson."

The MSDS for Melamine (CAS NO 108-78-1; C3-H6-N6) records the acute oral toxicity (LD50) at 3161 mg/kg (3161 ppm) for a rat. The highest levels previously reported in China reached approximately 2500 ppm. The article mentioned above indicated that the US testing found 10,000 times less than the China levels or 0.25 ppm.

Health Canada conducted a separate test and also detected traces of melamine in infant formula available in Canada
Canada

Canada is a country occupying most of northern North America, extending from the Atlantic Ocean in the east to the Pacific Ocean in the west and northward into the Arctic Ocean....
. The melamine levels were well below Health Canada's safety limits, although some public health advocates are critical of the industry and regulators for allowing any residues of a potentially dangerous substance in food for infants.

Health officials have been on alert for the chemical since the discovery this year of a massive case of melamine poisoning in China, where milk was deliberately adulterated with the chemical, leading to illnesses in more than 50,000 children, including cases of acute kidney failure. In China, large quantities of melamine were deliberately added to watered-down milk to give it the appearance of having adequate protein levels.

Risks increased

In studies, formula-feeding is associated with increased likelihood of the following conditions in infants: Digestive/gastrointestinal issues
  • Appendicitis
    Appendicitis

    Appendicitis is a condition characterized by inflammation of the Vermiform appendix. It is a medical emergency. All cases require removal of the inflamed appendix, either by laparotomy or laparoscopy....
  • Constipation
    Constipation

    Constipation, costiveness, or irregularity, is a condition of the digestive system in which a person experiences hard feces that are difficult to expel....
     and Anal fissure
    Anal fissure

    An anal fissure is an unnatural crack or tear in the skin of the anal canal. Anal fissures may be noticed by bright red anal bleeding on the toilet paper, sometimes in the toilet....
    s
  • Diarrhea
    Diarrhea

    In medicine, diarrhea, also spelled diarrhoea , is characterized by frequent loose or liquid bowel movements. The spelling of "diarrhea" is an appropriation of the Greek "diarrhoia" meaning "a flowing through." ....
  • Esophogeal and Gastrid Lesions
  • Gastroenteritis
    Gastroenteritis

    Gastroenteritis is inflammation of the gastrointestinal tract, involving both the stomach and the small intestine and resulting in acute diarrhea....
  • Gastroesophogeal Reflux
  • Necrotizing Enterocolitis
    Necrotizing enterocolitis

    Necrotizing enterocolitis is a medical condition primarily seen in premature birth infants, where portions of the bowel undergo necrosis ....
  • Salmonellosis
    Salmonellosis

    Salmonellosis is an infection with Salmonella bacteria. Most persons infected with salmonella develop diarrhea, fever, vomiting, and abdominal pain; 12 to 72 hours after infection....
  • Ulcerative Colitis
    Ulcerative colitis

    Ulcerative colitis is a form of inflammatory bowel disease . Ulcerative colitis is a form of colitis, a disease of the intestine, specifically the large intestine or colon , that includes characteristic Peptic ulcer, or open sores, in the colon....


Respiratory issues
  • Allergies
  • Asthma
    Asthma

    Asthma is a common chronic obstructive pulmonary disease, in which the Lung constrict, become inflammation, and are lined with excessive amounts of thickened mucus, often in response to one or more triggers....
  • Respiratory Infections
  • Respiratory Syncytial Virus
  • Wheezing


Autoimmune disorders
  • Autoimmune Thyroid Disease
  • Celiac Disease
  • Crohn's Disease
    Crohn's disease

    Crohn's disease is an inflammatory disease which may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms....
  • Diabetes Mellitus
    Diabetes mellitus

    Diabetes mellitus , often referred to simply as diabetes , is a syndrome of disordered metabolism, usually due to a combination of genetic disorder and environmental causes, resulting in abnormally high blood sugar levels ....
  • Juvenile Rheumatoid Arthritis
  • Multiple Sclerosis
    Multiple sclerosis

    Multiple sclerosis is an autoimmune disease in which the immune system attacks the central nervous system, leading to demyelinating disease. Disease onset usually occurs in young adults, and it is more common in females....


Other infectious diseases
  • Candidiasis
    Candidiasis

    Candidiasis, commonly called yeast infection or thrush, is a fungal infection of any of the Candida species, of which Candida albicans is the most common....
  • Ear Infection
  • Haemophilus influenzae
    Haemophilus influenzae

    Haemophilus influenzae, formerly called Pfeiffer's bacillus or Bacillus influenzae, is a non-motile Gram-negative coccobacillus first described in 1892 by Richard Friedrich Johannes Pfeiffer during an influenza pandemic....
  • Streptococcus pneumoniae
    Streptococcus pneumoniae

    Streptococcus pneumoniae, or pneumococcus, is a Gram-positive, Hemolysis diplococcus aerotolerant anaerobe and a member of the genus Streptococcus....
  • Tonsillitis
    Tonsillitis

    Tonsillitis is an infection of the tonsils and will often, but not necessarily, cause a sore throat and fever....
  • Urinary Tract Infections


Cardiovascular issues
  • High Blood Pressure
  • High Cholesterol


Mental/Psychological issues
  • Delayed Speech and Language Development
  • Lower IQ
  • Schizophrenia
    Schizophrenia

    Schizophrenia , from the Ancient Greek Root schizein and phren, phren- is a psychiatry diagnosis that describes a mental disorder characterized by abnormalities in the perception or expression of reality....


Other issues
  • Anemia
    Anemia

    Anemia or an?mia/anaemia is defined as a qualitative or quantitative deficiency of hemoglobin, a protein found inside red blood cells ....
     and Iron Deficiency
    Iron deficiency

    Iron deficiency may refer to:*Iron deficiency *Iron deficiency ...
  • Cancer
    Cancer

    Cancer is a class of diseases in which a group of cell display uncontrolled growth , invasion , and sometimes metastasis . These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, do not invade or metastasize....
  • Cryptorchidism
    Cryptorchidism

    Cryptorchidism is the absence of one or both testes from the scrotum. This usually represents failure of the testis to move, or "descend," during fetal development from an abdomen position, through the inguinal canal, into the ipsilateral scrotum....
  • Eczema
    Eczema

    Eczema is a form of dermatitis, or inflammation of the epidermis. The term eczema is broadly applied to a range of persistent skin conditions....
  • Inguinal Hernia
    Inguinal hernia

    Inguinal hernias are protrusions of abdominal cavity contents through the inguinal canal. They are very common and their repair is one of the most frequently performed surgery operations....
  • Lower Visual Acuity
  • Lower Bone Mass
  • Morbidity and Mortality
    Infant mortality

    Infant mortality is defined as the number of deaths of infants per 1000 live births. The most common cause of infant mortality worldwide has traditionally been dehydration from diarrhea....
  • Obesity
    Obesity

    Obesity is a condition in which excess body fat has accumulated to an extent that health may be negatively affected. It is commonly defined as a body mass index of 30 kg/m2 or higher....
  • Sudden Infant Death Syndrome (SIDS
    Sudden infant death syndrome

    Sudden infant death syndrome is a syndrome marked by the symptoms of sudden and unexplained death of an apparently healthy infant aged one month to one year....
    )


Risks decreased

Infectious diseases transmitted from the breastfeeder

  • HIV
    HIV

    Human immunodeficiency virus is a lentivirus that can lead to AIDS , a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections....
     infection
  • CMV
    CMV

    CMV is a three-letter abbreviation with multiple meanings, as described below:* Cauliflower mosaic virus, although more commonly abbreviated as CaMV...
     infection, with potentially dangerous consequences in pre-term babies
  • HTLV-1 infection
  • HTLV-2 infection
  • Tuberculosis
    Tuberculosis

    Tuberculosis is a common and often deadly infectious disease caused by mycobacterium, mainly Mycobacterium tuberculosis . Tuberculosis usually attacks the lungs but can also affect the central nervous system, the lymphatic system, the circulatory system, the genitourinary system, the gastrointestinal system, bones, joints, and even the...
     in the context of tuberculosis mastitis
  • Herpes simplex
    Herpes simplex

    Herpes simplex is a viral disease caused by Herpes simplex viruses; both herpes simplex virus 1 and herpes simplex virus 2 cause herpes simplex....
     when lesions are present on the breasts
  • Chickenpox
    Chickenpox

    Chickenpox or chicken pox is a highly contagious illness caused by primary infection with varicella zoster virus . It generally begins with a vesicular skin rash appearing in two or three waves, mainly on the body and head rather than the hands and becoming itchy raw pockmarks, small open sores which heal mostly without scarring....
     in the newborn, when the disease manifested in the mother within a few days of birth


Environmental contaminants

  • Exposure to polybrominated diphenyl ethers (PBDEs)
  • Exposure to polychlorinated biphenyls


Malnutrition

  • Iron deficiency
  • Vitamin deficiencies
  • Inadequate nutrition during transition to solid foods


Manufacturers

Major infant formula manufacturers include:
  • Mead Johnson: owned by Bristol-Myers Squibb
    Bristol-Myers Squibb

    Bristol-Myers Squibb , colloquially referred to as BMS, is a pharmaceutical corporation, formed by a 1989 merger between pharmaceutical companies Bristol-Myers Company, founded in 1887 by William McLaren Bristol and John Ripley Myers in Clinton, NY , and E.R....
    , makes Enfamil
  • Nestlé
    Nestlé

    Nestl? is a Multinational corporation packaged food company founded and headquartered in Vevey, Switzerland, and listed on the SWX Swiss Exchange with a turnover of over 87 billion Swiss francs....
    : the largest producer of formula in the world, makes Good Start
  • Abbott Laboratories
    Abbott Laboratories

    Abbott Laboratories is a diversified Pharmacology health care company. It has 68,000 employees and operates in 130 countries. The corporate headquarters are in Abbott Park, Illinois, located near North Chicago, Illinois....
    : makes Similac, Isomil, and Alimentum
  • Wyeth
    Wyeth

    Wyeth, formerly known as American Home Products , is one of the largest pharmaceutical company in the world. The company is based in Madison, New Jersey....
     Nutrition: Market leader in the Philippines


S-26 Gold, Promil Gold, Progress Gold, S-26, Promil, Promil Kid, Bonna, Bonamil, Bonakid 1+, Bonakid 3+, Nursoy,Parent's Choice/Bright Beginnings

  • Gerber Products Company
    Gerber Products Company

    Gerber Products Company is a purveyor of baby food and baby products. The company was founded in 1927 in Fremont, Michigan by Daniel Frank Gerber, owner of the Fremont Canning Company producing canned fruits and vegetables....
  • Earth's Best owned by Hain Celestial


  • Danone recently acquired Royal Numico, Dumex, Milupa


Sales and advertising

In the Phillipines annual sales amount to some US$469 million annually. And US$88 million is spent on advertising the product.

See also

  • Child development
    Child development

    Child development stages describe theoretical milestones of child development. Many stage models of development have been proposed, used as working concepts and in some cases asserted as nativism theories....
  • Baby food
    Baby food

    Baby food is any food, other than breastmilk or infant formula, that is given specifically to infants, roughly between the ages of four months to two years....
  • Baby bottle
    Baby bottle

    A baby bottle is a bottle with a teat to drinking directly from. It is typically used when a mother does not breastfeed, or if someone can not drink from a cup, for feeding oneself or being fed....
  • Breastfeeding
    Breastfeeding

    Breastfeeding is the feeding of an infant or young child with breast milk directly from human breasts rather than from a baby bottle or other container....
  • Breast milk
    Breast milk

    Breast milk refers to the milk produced by a mother to feed her baby. It provides the primary source of nutrition for newborns before they are able to eat and digest other foods; older infants and toddlers may continue to be breastfeeding....


External links

  • Infant Formula: Second Best but Good Enough
  • Center for Food Safety and Applied Nutrition/Food and Drug Administration