Alchornea castaneifolia
Encyclopedia
Alchornea castaneifolia (Iporuru, Iporoni, Iporuro, Ipururo, Ipurosa, Macochihua, Niando, Pajaro; syn. Hermesia castaneifolia Humb. & Bonpl. ex Willd.) is a medicinal plant native to Amazon Rainforest
Amazon Rainforest
The Amazon Rainforest , also known in English as Amazonia or the Amazon Jungle, is a moist broadleaf forest that covers most of the Amazon Basin of South America...

 vegetation
Vegetation
Vegetation is a general term for the plant life of a region; it refers to the ground cover provided by plants. It is a general term, without specific reference to particular taxa, life forms, structure, spatial extent, or any other specific botanical or geographic characteristics. It is broader...

 in Brazil
Brazil
Brazil , officially the Federative Republic of Brazil , is the largest country in South America. It is the world's fifth largest country, both by geographical area and by population with over 192 million people...

.

Traditional medicine

For centuries the ndigenous peoples of the Amazon have used the bark and leaves of iporuru (Alchornea castaneifolia) for many different purposes and prepared it in many different ways. The Alchornea castaneifolia plant commonly is used with other plants during shamanistic training and, sometimes is an ingredient in ayahuasca
Ayahuasca
Ayahuasca is any of various psychoactive infusions or decoctions prepared from the Banisteriopsis spp. vine, usually mixed with the leaves of dimethyltryptamine-containing species of shrubs from the Psychotria genus...

 (a hallucinogenic, multi-herb decoction used by South American shamans). Throughout the Amazon
Amazon Basin
The Amazon Basin is the part of South America drained by the Amazon River and its tributaries that drains an area of about , or roughly 40 percent of South America. The basin is located in the countries of Bolivia, Brazil, Colombia, Ecuador, Guyana, Peru, and Venezuela...

 the bark or leaves of iporuro are tincture
Tincture
A tincture is an alcoholic extract or solution of a non-volatile substance . To qualify as a tincture, the alcoholic extract is to have an ethanol percentage of at least 40-60%...

d (generally with the local rum
Rum
Rum is a distilled alcoholic beverage made from sugarcane by-products such as molasses, or directly from sugarcane juice, by a process of fermentation and distillation. The distillate, a clear liquid, is then usually aged in oak barrels...

, called aguardiente) as a local remedy for rheumatism, arthritis
Arthritis
Arthritis is a form of joint disorder that involves inflammation of one or more joints....

, colds, and muscle pains. Iporuro (Alchornea castaneifolia) is well known to the indigenous peoples of Peru
Peru
Peru , officially the Republic of Peru , is a country in western South America. It is bordered on the north by Ecuador and Colombia, on the east by Brazil, on the southeast by Bolivia, on the south by Chile, and on the west by the Pacific Ocean....

 for relieving the symptoms of osteoarthritis
Osteoarthritis
Osteoarthritis also known as degenerative arthritis or degenerative joint disease, is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion...

, and in aiding flexibility and range of motion. The Candochi-Shapra and the Shipibo Indian tribes use both the bark and roots of iporuro for treating rheumatism
Rheumatism
Rheumatism or rheumatic disorder is a non-specific term for medical problems affecting the joints and connective tissue. The study of, and therapeutic interventions in, such disorders is called rheumatology.-Terminology:...

. To prevent diarrhea
Diarrhea
Diarrhea , also spelled diarrhoea, is the condition of having three or more loose or liquid bowel movements per day. It is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause dehydration and...

, members of the Tikuna tribe take 1 tbsp. of Alchornea castaneifolia bark decoction before meals. The pain-relieving properties of iporuru appear in topical treatments; crushed leaves are rubbed on painful joints and are beaten into a paste to apply to painful stingray
Stingray
The stingrays are a group of rays, which are cartilaginous fishes related to sharks. They are classified in the suborder Myliobatoidei of the order Myliobatiformes, and consist of eight families: Hexatrygonidae , Plesiobatidae , Urolophidae , Urotrygonidae , Dasyatidae , Potamotrygonidae The...

 wounds.

"Little research has been done to catalog completely the phytochemical
Phytochemical
Phytochemicals are biologically active chemical compounds that occur naturally in plants . Phytochemicals are the molecules responsible for the color and organoleptic properties . For example, the deep purple color of blueberries and the smell of garlic...

s in iporuru. Initial screening has revealed it to contain steroid
Steroid
A steroid is a type of organic compound that contains a characteristic arrangement of four cycloalkane rings that are joined to each other. Examples of steroids include the dietary fat cholesterol, the sex hormones estradiol and testosterone, and the anti-inflammatory drug dexamethasone.The core...

s, saponin
Saponin
Saponins are a class of chemical compounds, one of many secondary metabolites found in natural sources, with saponins found in particular abundance in various plant species...

s, phenols
Natural phenol
Natural phenols, bioavailable phenols, plant phenolics, low molecular weight phenols or phenoloids are a class of natural products. They are small molecules containing one or more phenolic group. These molecules are smaller in size than polyphenols, containing less than 12 phenolic groups...

, flavonols, flavones, tannin
Tannin
A tannin is an astringent, bitter plant polyphenolic compound that binds to and precipitates proteins and various other organic compounds including amino acids and alkaloids.The term tannin refers to the use of...

s, xanthonoid
Xanthonoid
A xanthonoid is a chemical natural phenolic compound formed from the xanthone backbone. Many members of the Clusiaceae contain xanthonoids.Xanthonoid biosynthesis in cell cultures of Hypericum androsaemum involves the presence of a benzophenone synthase condensing a molecule of benzoyl-CoA with...

s, and alkaloids. The anti-inflammatory
Anti-inflammatory
Anti-inflammatory refers to the property of a substance or treatment that reduces inflammation. Anti-inflammatory drugs make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which affect the central nervous system....

 properties of iporuru are attributed to a group of alkaloids, including one called alchorneine, which are found in the bark of iporuru as well as several other species of Alchornea
Alchornea
Alchornea is a plant genus of the family Euphorbiaceae. It comprises 70 tropical species.-Synonyms:*Bleekeria Miq.*Bossera Leandri*Caelebogyne J.Sm.*Cladodes Lour.*Hermesia Humb. & Bonpl....

."

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