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Succinyl coenzyme A synthetase

 

 
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Succinyl coenzyme A synthetase
 
 
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Succinyl coenzyme A synthetase (succinate thiokinase) catalyzes
Catalysis

Catalysis is the process in which the reaction rate of a chemical reaction is either increased or decreased by means of a chemical substance known as a catalyst....
 the formation of succinate and coenzyme-A, a 4-carbon metabolite
Metabolite

Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in normal growth, development, and reproduction....
, from succinyl-CoA
Succinyl-CoA

Succinyl-Coenzyme A, generally abbreviated as Succinyl-CoA or SucCoA is a combination of succinic acid and coenzyme A....
.

inyl-CoA synthetase catalyzes a reversible step in the citric acid cycle
Citric acid cycle

The citric acid cycle ? also known as the tricarboxylic acid cycle ; the Krebs cycle; or, more rarely, the Szent-Gy?rgyi-Krebs cycle) ? is a series of enzyme-catalysed chemical reactions of central importance in all living cell s that use oxygen as part of cellular respiration....
, which involves the substrate-level phosphorylation
Substrate-level phosphorylation

Substrate-level phosphorylation is a type of chemical reaction that results in the formation and creation of adenosine triphosphate by the direct transfer and donation of a phosphate group to adenosine diphosphate from a reactive intermediate....
 of GDP.

son et al. describe two isoforms of succinyl-CoA synthetase in mammal
Mammal

Mammals are a class of vertebrate animals whose name is derived from their distinctive feature, mammary glands, with which they feed their young....
s, one that specifically uses ATP
Adenosine triphosphate

This article is about the chemical used by cells as an energy carrier. For other uses, see ATP .Adenosine-5'-triphosphate is a multifunctional nucleotide, and plays an important role in cell biology as a coenzyme that is the "molecule unit of currency" of intracellular energy transfer....
 for synthesis, and one that utilizes GTP
Guanosine triphosphate

Guanosine-5'-triphosphate is a purine nucleotide. One role is as substrate for the synthesis of RNA during transcription . Its structure is similar to that of the guanine nucleoside, the only difference being that there are three phosphate groups attached to the 5' carbon....
.






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Succinyl coenzyme A synthetase (succinate thiokinase) catalyzes
Catalysis

Catalysis is the process in which the reaction rate of a chemical reaction is either increased or decreased by means of a chemical substance known as a catalyst....
 the formation of succinate and coenzyme-A, a 4-carbon metabolite
Metabolite

Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in normal growth, development, and reproduction....
, from succinyl-CoA
Succinyl-CoA

Succinyl-Coenzyme A, generally abbreviated as Succinyl-CoA or SucCoA is a combination of succinic acid and coenzyme A....
.

Reaction

Succinyl-CoA synthetase catalyzes a reversible step in the citric acid cycle
Citric acid cycle

The citric acid cycle ? also known as the tricarboxylic acid cycle ; the Krebs cycle; or, more rarely, the Szent-Gy?rgyi-Krebs cycle) ? is a series of enzyme-catalysed chemical reactions of central importance in all living cell s that use oxygen as part of cellular respiration....
, which involves the substrate-level phosphorylation
Substrate-level phosphorylation

Substrate-level phosphorylation is a type of chemical reaction that results in the formation and creation of adenosine triphosphate by the direct transfer and donation of a phosphate group to adenosine diphosphate from a reactive intermediate....
 of GDP.

Isoforms

Johnson et al. describe two isoforms of succinyl-CoA synthetase in mammal
Mammal

Mammals are a class of vertebrate animals whose name is derived from their distinctive feature, mammary glands, with which they feed their young....
s, one that specifically uses ATP
Adenosine triphosphate

This article is about the chemical used by cells as an energy carrier. For other uses, see ATP .Adenosine-5'-triphosphate is a multifunctional nucleotide, and plays an important role in cell biology as a coenzyme that is the "molecule unit of currency" of intracellular energy transfer....
 for synthesis, and one that utilizes GTP
Guanosine triphosphate

Guanosine-5'-triphosphate is a purine nucleotide. One role is as substrate for the synthesis of RNA during transcription . Its structure is similar to that of the guanine nucleoside, the only difference being that there are three phosphate groups attached to the 5' carbon....
.

- ADP-forming - - GDP-forming - ,

The GTP form is the one more commonly used in the human citric acid cycle.

Structure

The crystal structure of Succinyl-CoA synthetase alpha subunit (ATP-binding isoform) was determined by Joyce et al. to a resolution of 2.10 A, with PDB
Protein Data Bank

The Protein Data Bank is a repository for the 3-D structural data of large biological molecules, such as proteins and nucleic acids. . The data, typically obtained by X-ray crystallography or Protein NMR and submitted by biologists and biochemistry from around the world, are released into the public domain, and can be accessed at no charge...
 code 1CQJ. .

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