Sceletium tortuosum
Encyclopedia
Sceletium tortuosum is a succulent herb commonly found in South Africa
South Africa
The Republic of South Africa is a country in southern Africa. Located at the southern tip of Africa, it is divided into nine provinces, with of coastline on the Atlantic and Indian oceans...

, which is also known as Kanna, Channa, Kougoed (Kauwgoed,/ 'kougoed', prepared from 'fermenting' Sceletium tortuosum) - which literally means, 'chew(able) things/goodies' or 'something to chew'. The plant has been used by South African pastoralists and hunter-gatherer
Hunter-gatherer
A hunter-gatherer or forage society is one in which most or all food is obtained from wild plants and animals, in contrast to agricultural societies which rely mainly on domesticated species. Hunting and gathering was the ancestral subsistence mode of Homo, and all modern humans were...

s as a mood-altering substance from prehistoric times. The first known written account of the plant's use was in 1662 by Jan van Riebeeck
Jan van Riebeeck
Johan Anthoniszoon "Jan" van Riebeeck was a Dutch colonial administrator and founder of Cape Town.-Biography:...

. The traditionally prepared dried sceletium was often chewed and the saliva
Saliva
Saliva , referred to in various contexts as spit, spittle, drivel, drool, or slobber, is the watery substance produced in the mouths of humans and most other animals. Saliva is a component of oral fluid. In mammals, saliva is produced in and secreted from the three pairs of major salivary glands,...

 swallowed, but it has also been made into gel caps, teas and tincture
Tincture
A tincture is an alcoholic extract or solution of a non-volatile substance . To qualify as a tincture, the alcoholic extract is to have an ethanol percentage of at least 40-60%...

s. It has also been used as a snuff
Snuff
Snuff is a product made from ground or pulverised tobacco leaves. It is an example of smokeless tobacco. It originated in the Americas and was in common use in Europe by the 17th century...

 and smoked.

Effects

Sceletium elevates mood
Mood (psychology)
A mood is a relatively long lasting emotional state. Moods differ from emotions in that they are less specific, less intense, and less likely to be triggered by a particular stimulus or event....

 and decreases anxiety
Anxiety
Anxiety is a psychological and physiological state characterized by somatic, emotional, cognitive, and behavioral components. The root meaning of the word anxiety is 'to vex or trouble'; in either presence or absence of psychological stress, anxiety can create feelings of fear, worry, uneasiness,...

, stress and tension. It has also been used as an appetite suppressant by shepherds walking long distances in arid areas. In intoxicating doses it can cause euphoria
Euphoria
Euphoria is an emotional and mental state defined as a sense of great elation and well being.Euphoria may also refer to:* Euphoria , a genus of scarab beetles* Euphoria, a genus name previously used for the longan and other trees...

, initially with stimulation and later with sedation
Sedation
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure...

. Users also report increased personal insight, interpersonal ease and a meditative, grounded feeling without any perceptual dulling. Having such properties Sceletium is classified as an empathogen type herb. Others have noted enhanced tactile and sexual response, as well as vivid dream inducing properties. High doses produce distinct inebriation and stimulation often followed by sedation. The plant is not hallucinogenic, contrary to some literature on the subject, and no adverse effects have been documented. Kanna is considered a potentiator (enhancer of effects) for other psychoactive herbal material, such as cannabis.

Growing

Canna is best planted in spring/summer and harvested early October. It can be used as a herbal smoke, pill or one can chew the leaves to feel it's effects. You can harvest it regardless of whether or not the flowers themselves have appeared yet. [REF: alicecorrigan+msn+com]

Pharmacology

S. tortuosum can cause significant mood-elevation and anxiolytic (anti-anxiety) action. In doses as low as 50 mg users have reported improvements in mood, decreased anxiety, relaxation and a sense of well-being. At higher dosages near 100 mg, kanna acts as a calming euphoriant and empathogen.

The alkaloids contained in S. tortuosum believed to possess psychoactivity include: mesembrine, mesembrenone, mesembrenol and tortuosamine. Mesembrine
Mesembrine
Mesembrine is an alkaloid present in Sceletium tortuosum. Mesembrine acts as a serotonin reuptake inhibitor. Mesembrine may contribute to the antidepressant effects of kanna....

 is a major alkaloid present in Sceletium tortuosum, which is claimed by a US patent to be a potent serotonin reuptake inhibitor with stronger antidepressant effects than imipramine
Imipramine
Imipramine , also known as melipramine, is an antidepressant medication, a tricyclic antidepressant of the dibenzazepine group...

.

Sceletium tortuosum contains about 1–1.5% total alkaloids. There is about 0.3% mesembrine in the leaves and 0.86% in the stems of the plant.

Interactions

Little is known about the interactions of S. tortuosum, although it should not be combined with SSRIs, MAOIs, or cardiac medications. Headaches in conjunction with alcohol have been noted with kanna use. Some reports suggest a synergy
Synergy
Synergy may be defined as two or more things functioning together to produce a result not independently obtainable.The term synergy comes from the Greek word from , , meaning "working together".-Definitions and usages:...

 with cannabis
Cannabis
Cannabis is a genus of flowering plants that includes three putative species, Cannabis sativa, Cannabis indica, and Cannabis ruderalis. These three taxa are indigenous to Central Asia, and South Asia. Cannabis has long been used for fibre , for seed and seed oils, for medicinal purposes, and as a...

.
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