Related to receptor tyrosine kinase
Encyclopedia
The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk.
encoding
mouse RYK was first identified in 1992.
Subsequently cDNA encoding
the RYK protein have been isolated from the following species.
family members, RYK is composed of three domains, an N-terminal domain, an extracellular
ligand
-binding domain, a transmembrane spanning domain and a C-terminal intracellular
domain. However, in contrast to other receptor tyrosine kinase
s the C-terminal domain of RYK is devoid of detectable kinase
activity.
History
The geneGene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
encoding
Genetic code
The genetic code is the set of rules by which information encoded in genetic material is translated into proteins by living cells....
mouse RYK was first identified in 1992.
Subsequently cDNA encoding
Genetic code
The genetic code is the set of rules by which information encoded in genetic material is translated into proteins by living cells....
the RYK protein have been isolated from the following species.
- ratRatRats are various medium-sized, long-tailed rodents of the superfamily Muroidea. "True rats" are members of the genus Rattus, the most important of which to humans are the black rat, Rattus rattus, and the brown rat, Rattus norvegicus...
- chickenChickenThe chicken is a domesticated fowl, a subspecies of the Red Junglefowl. As one of the most common and widespread domestic animals, and with a population of more than 24 billion in 2003, there are more chickens in the world than any other species of bird...
- HumanHumanHumans are the only living species in the Homo genus...
- Zebrafish
- DrosophilaDrosophila melanogasterDrosophila melanogaster is a species of Diptera, or the order of flies, in the family Drosophilidae. The species is known generally as the common fruit fly or vinegar fly. Starting from Charles W...
and - C. elegansCaenorhabditis elegansCaenorhabditis elegans is a free-living, transparent nematode , about 1 mm in length, which lives in temperate soil environments. Research into the molecular and developmental biology of C. elegans was begun in 1974 by Sydney Brenner and it has since been used extensively as a model...
Structure
In common with other receptor tyrosine kinaseReceptor tyrosine kinase
Receptor tyrosine kinases s are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins....
family members, RYK is composed of three domains, an N-terminal domain, an extracellular
Extracellular
In cell biology, molecular biology and related fields, the word extracellular means "outside the cell". This space is usually taken to be outside the plasma membranes, and occupied by fluid...
ligand
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In a narrower sense, it is a signal triggering molecule, binding to a site on a target protein.The binding occurs by intermolecular forces, such as ionic bonds, hydrogen...
-binding domain, a transmembrane spanning domain and a C-terminal intracellular
Intracellular
Not to be confused with intercellular, meaning "between cells".In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".It is used in contrast to extracellular...
domain. However, in contrast to other receptor tyrosine kinase
Receptor tyrosine kinase
Receptor tyrosine kinases s are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins....
s the C-terminal domain of RYK is devoid of detectable kinase
Kinase
In chemistry and biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation. Kinases are part of the larger family of phosphotransferases...
activity.