Proteomic Code
Encyclopedia
The Proteomic Code is a set of rules by which information in genetic
material is transferred into the physicochemical properties of amino acid
s and determines how individual amino acids interact with each other during folding
and in specific protein–protein interactions. The Proteomic Code is part of the redundant Genetic Code
. The 25 years old history of this concept is reviewed from the first suggestion in 1981 by Mekler and Biro through the hypothesis of a Common Periodic Table of Codons and Nucleic acids in 2003 and the recent conceptualization of partial complementary coding of interacting amino acids as well as the theory of the nucleic acid assisted protein folding.
However, the idea of complementary coding as source for protein–protein interactions, which forms the basis for the Proteomic Code Hypothesis, has been shown to be false, as no compelling evidence yet exists that antisense-like domains play any role in the folding or conformation of proteins.
Genetics
Genetics , a discipline of biology, is the science of genes, heredity, and variation in living organisms....
material is transferred into the physicochemical properties of amino acid
Amino acid
Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...
s and determines how individual amino acids interact with each other during folding
Protein folding
Protein folding is the process by which a protein structure assumes its functional shape or conformation. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil....
and in specific protein–protein interactions. The Proteomic Code is part of the redundant Genetic Code
Genetic code
The genetic code is the set of rules by which information encoded in genetic material is translated into proteins by living cells....
. The 25 years old history of this concept is reviewed from the first suggestion in 1981 by Mekler and Biro through the hypothesis of a Common Periodic Table of Codons and Nucleic acids in 2003 and the recent conceptualization of partial complementary coding of interacting amino acids as well as the theory of the nucleic acid assisted protein folding.
However, the idea of complementary coding as source for protein–protein interactions, which forms the basis for the Proteomic Code Hypothesis, has been shown to be false, as no compelling evidence yet exists that antisense-like domains play any role in the folding or conformation of proteins.