The
thromboxane receptor (
TP) is a protein on the surface of
cellThe cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of an organism that is classified as living, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos...
s in the
endotheliumThe endothelium is the thin layer of cells that line the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. Endothelial cells line the entire circulatory system, from the heart to the smallest capillary...
of blood vessels and in the
placentaThe placenta is an organ unique to mammals that connects the developing fetus to the uterine wall. The placenta supplies the fetus with oxygen and food, and allows fetal waste to be disposed of via the maternal kidneys...
which interacts with the
eicosanoidIn biochemistry, eicosanoids are signaling molecules made by oxygenation of twenty-carbon essential fatty acids, .They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system....
lipid
thromboxaneThromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2.Thromboxane is named for its role in clot formation .-Production:...
. It is a G-protein coupled receptors coupled to the
G proteinG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.G proteins are so called because they function as "molecular switches," alternating between an inactive guanosine diphosphate and active guanosine triphosphate bound state,...
GqGq protein or Gq/11 is a heterotrimeric G protein subunit that activates phospholipase C . PLC in turn hydrolyzes Phosphatidylinositol 4,5-bisphosphate...
.
The
geneA gene is the basic unit of heredity in a living organism. All living things depend on genes. Genes hold the information to build and maintain their cells and pass genetic traits to offspring...
responsible for the thromboxane receptor,
TBXA2R is found on chromosome 19 and spans 15 kilobases. Thromboxane is a potent stimulator for
plateletPlatelets, or thrombocytes , are small, irregularly-shaped anuclear cells , 2-3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average lifespan of a platelet is between 8 and 12 days...
aggregation and clot formation and also plays a role in vascular tone.
Discussion
Ask a question about 'Thromboxane receptor' Start a new discussion about 'Thromboxane receptor' Answer questions from other users |
The
thromboxane receptor (
TP) is a protein on the surface of
cellThe cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of an organism that is classified as living, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos...
s in the
endotheliumThe endothelium is the thin layer of cells that line the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. Endothelial cells line the entire circulatory system, from the heart to the smallest capillary...
of blood vessels and in the
placentaThe placenta is an organ unique to mammals that connects the developing fetus to the uterine wall. The placenta supplies the fetus with oxygen and food, and allows fetal waste to be disposed of via the maternal kidneys...
which interacts with the
eicosanoidIn biochemistry, eicosanoids are signaling molecules made by oxygenation of twenty-carbon essential fatty acids, .They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system....
lipid
thromboxaneThromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2.Thromboxane is named for its role in clot formation .-Production:...
. It is a G-protein coupled receptors coupled to the
G proteinG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.G proteins are so called because they function as "molecular switches," alternating between an inactive guanosine diphosphate and active guanosine triphosphate bound state,...
GqGq protein or Gq/11 is a heterotrimeric G protein subunit that activates phospholipase C . PLC in turn hydrolyzes Phosphatidylinositol 4,5-bisphosphate...
.
Gene
The
geneA gene is the basic unit of heredity in a living organism. All living things depend on genes. Genes hold the information to build and maintain their cells and pass genetic traits to offspring...
responsible for the thromboxane receptor,
TBXA2R is found on chromosome 19 and spans 15 kilobases. Thromboxane is a potent stimulator for
plateletPlatelets, or thrombocytes , are small, irregularly-shaped anuclear cells , 2-3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average lifespan of a platelet is between 8 and 12 days...
aggregation and clot formation and also plays a role in vascular tone. The thromboxane receptor is a member of the family of
G protein-coupled receptorG protein-coupled receptors , also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors , comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal...
s. Mutation of the receptor can lead to a bleeding disorder.
Further reading