SMARCB1
Encyclopedia
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein
that in humans is encoded by the SMARCB1 gene
.
with PPP1R15A
, XPO1
, Myc
, SMARCE1
, CREB-binding protein, Cyclin-dependent kinase 8
, BRCA1
, PPP1CB
, PPP1CA
, BAZ1B
, PPP1CC
, SS18
, POLR2A
, SMARCA2
, P53
, SMARCC1
, SMARCA4
and ARID1A
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SMARCB1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
SMARCB1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with PPP1R15A
PPP1R15A
Protein phosphatase 1 regulatory subunit 15A is an enzyme that in humans is encoded by the PPP1R15A gene.-Interactions:PPP1R15A has been shown to interact with PPP1CB, PPP1CA, PPP1CC, SMARCB1, LYN, TSN, BAG1 and MLL.-Further reading:...
, XPO1
XPO1
Exportin-1 is a protein that in humans is encoded by the XPO1 gene.-Interactions:XPO1 has been shown to interact with NMD3, CIITA, RANBP3, Nucleoporin 62, Ran, RANBP1, APC, SMARCB1 and CDKN1B.-Further reading:...
, Myc
Myc
Myc is a regulator gene that codes for a transcription factor. In the human genome, Myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on Enhancer Box sequences and recruiting histone acetyltransferases...
, SMARCE1
SMARCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.-Interactions:...
, CREB-binding protein, Cyclin-dependent kinase 8
Cyclin-dependent kinase 8
Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.-Interactions:Cyclin-dependent kinase 8 has been shown to interact with MED16, MED26, MED17, MED14, CREB binding protein, MED1, MED6, MED24, CCNC, POLR2A, MED21, SMARCB1, MED12 and CRSP3....
, BRCA1
BRCA1
BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...
, PPP1CB
PPP1CB
Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.-Interactions:PPP1CB has been shown to interact with PPP1R15A, Nucleolin, SMARCB1 and PPP1R9B.-Further reading:...
, PPP1CA
PPP1CA
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.-Interactions:...
, BAZ1B
BAZ1B
Tyrosine-protein kinase BAZ1B is an enzyme that in humans is encoded by the BAZ1B gene.-Animal models:Model organisms have been used in the study of BAZ1B function...
, PPP1CC
PPP1CC
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.-Interactions:PPP1CC has been shown to interact with PPP1R15A, SMARCB1, TLX1 and PPP1R9B.-Further reading:...
, SS18
SS18
Protein SSXT is a protein that in humans is encoded by the SS18 gene.-Interactions:SS18 has been shown to interact with MLLT10, EP300, SMARCB1 and SMARCA2.-Further reading:...
, POLR2A
POLR2A
DNA-directed RNA polymerase II subunit RPB1 is an enzyme that in humans is encoded by the POLR2A gene.-Interactions:POLR2A has been shown to interact with Transcription elongation regulator 1, CREB-binding protein, BRCA1, GTF2H4, TATA-binding protein, PCAF, GTF2F1, SUPT5H, Transcription Factor II...
, SMARCA2
SMARCA2
Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.-Interactions:SMARCA2 has been shown to interact with SS18, ACTL6A, SIN3A, POLR2A, Prohibitin, SMARCC1, CEBPB, SMARCB1 and ARID1B....
, P53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
, SMARCC1
SMARCC1
SWI/SNF complex subunit SMARCC1 is a protein that in humans is encoded by the SMARCC1 gene.-Interactions:SMARCC1 has been shown to interact with BAZ1B, SIN3A, SMARCA2, ING1, SMARCB1 and SMARCA4.-External links:...
, SMARCA4
SMARCA4
Transcription activator BRG1 also known as ATP-dependent helicase SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.- Function :...
and ARID1A
ARID1A
AT-rich interactive domain-containing protein 1A is a protein that in humans is encoded by the ARID1A gene.- Function :ARID1A is a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin...
.