POLR2A
Encyclopedia
DNA-directed RNA polymerase II subunit RPB1 is an enzyme
that in humans is encoded by the POLR2A gene
.
with Transcription elongation regulator 1
, CREB-binding protein, BRCA1
, GTF2H4
, TATA-binding protein, PCAF
, GTF2F1
, SUPT5H
, Transcription Factor II B
, POLR2H
, POLR2L
, MED26
, Cyclin-dependent kinase 8
, ZNF74
, TCEA1
, SMYD3
, CTDP1
, POLR2C
, PQBP1
, SMARCA2
, SND1
, MED21
, SMARCB1
, POLR2E
, SMARCA4
and TAF11
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the POLR2A gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
POLR2A has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Transcription elongation regulator 1
Transcription elongation regulator 1
Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.- Function :This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing...
, CREB-binding protein, BRCA1
BRCA1
BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...
, GTF2H4
GTF2H4
General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.-Interactions:GTF2H4 has been shown to interact with MED21, GTF2F1, TATA binding protein, XPB, POLR2A and Transcription Factor II B....
, TATA-binding protein, PCAF
PCAF
P300/CBP-associated factor , also known as K acetyltransferase 2B , is a human gene and trancriptional coactivator associated with p53.-Structure:...
, GTF2F1
GTF2F1
General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.-Interactions:GTF2F1 has been shown to interact with TAF1, HNRPU, GTF2H4, CTDP1, TATA binding protein, POLR2A, MED21, TAF11, Serum response factor and Transcription Factor II B.-Further reading:...
, SUPT5H
SUPT5H
Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.-Interactions:SUPT5H has been shown to interact with Cyclin-dependent kinase 7, PIN1, CDK9, HTATSF1, POLR2A, PRMT1 and Protein arginine methyltransferase 5....
, Transcription Factor II B
Transcription Factor II B
Transcription factor II B is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is encoded by the gene....
, POLR2H
POLR2H
DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the POLR2H gene.-Interactions:POLR2H has been shown to interact with POLR2C, POLR2G, POLR2A, POLR2B and POLR2E.-Further reading:...
, POLR2L
POLR2L
DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the POLR2L gene.-Interactions:POLR2L has been shown to interact with POLR2C, POLR2A, POLR2B and POLR2E.-Further reading:...
, MED26
MED26
Mediator of RNA polymerase II transcription subunit 26 is an enzyme that in humans is encoded by the MED26 gene.-Interactions:MED26 has been shown to interact with MED8, Cyclin-dependent kinase 8, POLR2A, MED12 and MED28.-Further reading:...
, Cyclin-dependent kinase 8
Cyclin-dependent kinase 8
Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.-Interactions:Cyclin-dependent kinase 8 has been shown to interact with MED16, MED26, MED17, MED14, CREB binding protein, MED1, MED6, MED24, CCNC, POLR2A, MED21, SMARCB1, MED12 and CRSP3....
, ZNF74
ZNF74
Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene....
, TCEA1
TCEA1
Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.-Interactions:TCEA1 has been shown to interact with GTF2H1 and POLR2A.-Further reading:...
, SMYD3
SMYD3
SET and MYND domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.-Interactions:SMYD3 has been shown to interact with Heat shock protein 90kDa alpha , member A1 and POLR2A.-Further reading:...
, CTDP1
CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.-Interactions:CTDP1 has been shown to interact with WD repeat-containing protein 77, GTF2F1 and POLR2A.-Further reading:...
, POLR2C
POLR2C
DNA-directed RNA polymerase II subunit RPB3 is an enzyme that in humans is encoded by the POLR2C gene.-Interactions:POLR2C has been shown to interact with TAF15, POLR2F, POLR2G, POLR2H, POLR2J, POLR2K, POLR2L, ATF4, CCHCR1, POLR2A, POLR2B, POLR2E and Myogenin.-Further reading:...
, PQBP1
PQBP1
Polyglutamine-binding protein 1 is a protein that in humans is encoded by the PQBP1 gene.It can be associated with Renpenning's syndrome.-Interactions:PQBP1 has been shown to interact with WBP11, POU3F2, POLR2A and TXNL4A.-Further reading:...
, SMARCA2
SMARCA2
Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.-Interactions:SMARCA2 has been shown to interact with SS18, ACTL6A, SIN3A, POLR2A, Prohibitin, SMARCC1, CEBPB, SMARCB1 and ARID1B....
, SND1
SND1
Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 is a protein that in humans is encoded by the SND1 gene...
, MED21
MED21
Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.-Interactions:MED21 has been shown to interact with Cyclin-dependent kinase 8, BRCA1, GTF2H4, MED6, POLR2A and GTF2F1.-Further reading:...
, SMARCB1
SMARCB1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.-Interactions:...
, POLR2E
POLR2E
DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.-Interactions:POLR2E has been shown to interact with TAF15, POLR2C, POLR2G, POLR2H, POLR2A, POLR2B, POLR2L and GTF2F2....
, SMARCA4
SMARCA4
Transcription activator BRG1 also known as ATP-dependent helicase SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.- Function :...
and TAF11
TAF11
Transcription initiation factor TFIID subunit 11 is a protein that in humans is encoded by the TAF11 gene.-Interactions:TAF11 has been shown to interact with TAF15, TAF13, TATA binding protein, GTF2F1, POLR2A and Transcription Factor II B....
.