Transcription activator BRG1 also known as ATP-dependent helicase SMARCA4 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the SMARCA4 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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Function

The protein encoded by this gene is a member of the SWI/SNF

SWI/SNF

SWI/SNF is a yeast nucleosome remodeling complex composed of several proteins – products of the SWI and SNF genes as well as several other polypeptides...

 family of proteins and is similar to the brahma

SMARCA2

Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.-Interactions:SMARCA2 has been shown to interact with SS18, ACTL6A, SIN3A, POLR2A, Prohibitin, SMARCC1, CEBPB, SMARCB1 and ARID1B....

 protein of Drosophila. Members of this family have helicase

Helicase

Helicases are a class of enzymes vital to all living organisms. They are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating two annealed nucleic acid strands using energy derived from ATP hydrolysis.-Function:Many cellular processes Helicases are a...

 and ATPase

ATPase

ATPases are a class of enzymes that catalyze the decomposition of adenosine triphosphate into adenosine diphosphate and a free phosphate ion. This dephosphorylation reaction releases energy, which the enzyme harnesses to drive other chemical reactions that would not otherwise occur...

 activities and are thought to regulate transcription of certain genes by altering the chromatin

Chromatin

Chromatin is the combination of DNA and proteins that make up the contents of the nucleus of a cell. The primary functions of chromatin are; to package DNA into a smaller volume to fit in the cell, to strengthen the DNA to allow mitosis and meiosis and prevent DNA damage, and to control gene...

 structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1

BRCA1

BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...

, as well as regulate the expression of the tumorigenic protein CD44

CD44

The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene.- Tissue distribution and isoforms :...

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Clinical signficance

A high percent of inactivation of this gene has been found in human lung cancer cell lines.

Interactions

SMARCA4 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Beta-catenin

Beta-catenin

Beta-catenin is a protein that in humans is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo...

, SIN3A

SIN3A

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.-Interactions:SIN3A has been shown to interact with HDAC9, OGT, RBBP7, RBBP4, Host cell factor C1, MXD1, IKZF1, Nuclear receptor co-repressor 2, SAP130, KLF11, Methyl-CpG-binding domain protein 2, HDAC1,...

, Myc

Myc

Myc is a regulator gene that codes for a transcription factor. In the human genome, Myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on Enhancer Box sequences and recruiting histone acetyltransferases...

, CBX5

CBX5 (gene)

Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene.-Interactions:CBX5 has been shown to interact with HDAC9, Ku70, MIS12, Lamin B receptor, MBD1, TAF4, Histone deacetylase 5, TRIM28, HDAC4, CBX3, SMARCA4, DNMT3B, CHAF1A, CBX1 and SUV39H1....

, SMARCE1

SMARCE1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.-Interactions:...

, HSP90B1

HSP90B1

Heat shock protein 90kDa beta member 1 , known also as endoplasmin, gp96, grp94 and ERp99, is a chaperone protein that in humans is encoded by the HSP90B1 gene....

, STAT2

STAT2

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene.-Interactions:STAT2 has been shown to interact with MED14, CREB-binding protein, SMARCA4, STAT1, IFNAR2, IFNAR1 and ISGF3G.-Further reading:...

, CREB-binding protein, Glucocorticoid receptor

Glucocorticoid receptor

The glucocorticoid receptor also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind....

, FANCA

FANCA

Fanconi anemia, complementation group A, also known as FANCA, is a protein which in humans is encoded by the FANCA gene.- Function :...

, STK11

STK11

Serine/threonine kinase 11 also known as liver kinase B1 or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.-Expression:...

, BRCA1

BRCA1

BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...

, ACTL6A

ACTL6A

Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene.-Interactions:ACTL6A has been shown to interact with SMARCA2, Myc, Transformation/transcription domain-associated protein, RuvB-like 1 and SMARCA4.-Further reading:...

, POLR2A

POLR2A

DNA-directed RNA polymerase II subunit RPB1 is an enzyme that in humans is encoded by the POLR2A gene.-Interactions:POLR2A has been shown to interact with Transcription elongation regulator 1, CREB-binding protein, BRCA1, GTF2H4, TATA-binding protein, PCAF, GTF2F1, SUPT5H, Transcription Factor II...

, ING1

ING1

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.-Location on Chromosome 13:ING1 is located near the following genes on Chromosome 13*CARKD Carbohydrate Kinase Domain-Containing Protein...

, Cyclin E1

Cyclin E1

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.-Interactions:Cyclin E1 has been shown to interact with Retinoblastoma-like protein 2, Cdk1, CDC25A, Cyclin-dependent kinase 2, SMARCA4, CDKN1B, HERC5, CUL3 and P21....

, P53

P53

p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...

, Estrogen receptor alpha

Estrogen receptor alpha

Estrogen receptor alpha , also known as NR3A1 , is a nuclear receptor that is activated by the sex hormone estrogen...

, Prohibitin

Prohibitin

Prohibitin, also known as PHB, is a protein that in humans is encoded by the PHB gene.The Phb gene has also been described in animals, fungi, plants, and unicellular eukaryotes. Prohibitins are divided in two classes, termed Type-I and Type-II prohibitins, based on their similarity to yeast PHB1...

, SMARCC2

SMARCC2

SWI/SNF complex subunit SMARCC2 is a protein that in humans is encoded by the SMARCC2 gene.-Interactions:SMARCC2 has been shown to interact with BAZ1B and SMARCA4.-External links:...

, SMARCC1

SMARCC1

SWI/SNF complex subunit SMARCC1 is a protein that in humans is encoded by the SMARCC1 gene.-Interactions:SMARCC1 has been shown to interact with BAZ1B, SIN3A, SMARCA2, ING1, SMARCB1 and SMARCA4.-External links:...

, SMARCB1

SMARCB1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.-Interactions:...

, ARID1B

ARID1B

AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene.-Interactions:ARID1B has been shown to interact with SMARCA4 and SMARCA2.-Further reading:...

 and ARID1A

ARID1A

AT-rich interactive domain-containing protein 1A is a protein that in humans is encoded by the ARID1A gene.- Function :ARID1A is a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin...

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External links