Mitochondrial ferritin
Encyclopedia
Mitochondrial ferritin is a ferroxidase
enzyme
that in humans is encoded by the FTMT gene
.
It is classified as a metal-binding protein which is located within the mitochondria
. After the protein is taken up by the mitochondria it can be processed into a mature protein and assemble functional ferritin
shells.
shows that the structure of mitochondrial ferritin is mainly alpha helical with a low prevalence of beta sheets.
Ferroxidase
Ferroxidase also known as Fe:oxygen oxidoreductase is an enzyme that catalyzes the oxidization of iron II to iron III:- Examples :Human genes encoding proteins with ferroxidase activity include:* CP – Ceruloplasmin* FTH1 – Ferritin heavy chain...
enzyme
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the FTMT gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
It is classified as a metal-binding protein which is located within the mitochondria
Mitochondrion
In cell biology, a mitochondrion is a membrane-enclosed organelle found in most eukaryotic cells. These organelles range from 0.5 to 1.0 micrometers in diameter...
. After the protein is taken up by the mitochondria it can be processed into a mature protein and assemble functional ferritin
Ferritin
Ferritin is a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion. The amount of ferritin stored reflects the amount of iron stored. The protein is produced by almost all living organisms, including bacteria, algae and higher plants, and animals...
shells.
Structure
Its structure was determined at 1.70 Å through the use of X-ray diffraction and contains 182 residues. It is 67% helical. The Ramachandran plotRamachandran plot
-Introduction and early history:A Ramachandran plot , originally developed in 1963 by G. N. Ramachandran C. Ramakrishnan and V...
shows that the structure of mitochondrial ferritin is mainly alpha helical with a low prevalence of beta sheets.