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Ferroxidase also known as
Fe(II):oxygen oxidoreductase is an
enzymeEnzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that catalyzes the
oxidization of iron II to iron III:
- 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2H2O
Examples
Human genes encoding proteins with ferroxidase activity include:
- CP
Ceruloplasmin is a ferroxidase enzyme that in humans is encoded by the CP gene.Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948...
– Ceruloplasmin
- FTH1
Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene.- Function :This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains...
– Ferritin heavy chain
- FTMT
Mitochondrial ferritin is a ferroxidase enzyme that in humans is encoded by the FTMT gene.It is classified as a metal-binding protein which is located within the mitochondria...
– Ferritin, mitochondrial