L1 (protein)
Encyclopedia
L1, also known as L1CAM, is a transmembrane protein
; it is a neuronal cell adhesion molecule
, member of the L1 protein family
, of 200-220 kDa, and involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers.
L1CAM has also been designated CD171 (cluster of differentiation
171).
with NUMB
.
Transmembrane protein
A transmembrane protein is a protein that goes from one side of a membrane through to the other side of the membrane. Many TPs function as gateways or "loading docks" to deny or permit the transport of specific substances across the biological membrane, to get into the cell, or out of the cell as...
; it is a neuronal cell adhesion molecule
Cell adhesion molecule
Cell Adhesion Molecules are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix in the process called cell adhesion....
, member of the L1 protein family
L1 family
The L1 family is a family of cell adhesion molecules that includes four different L1-like proteins. They are members of the immunoglobulin superfamily . The members of the L1-family in humans are called L1 or L1cam, CHL1 , Neurofascin and NrCAM . L1 family members are found on neurons, ...
, of 200-220 kDa, and involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers.
L1CAM has also been designated CD171 (cluster of differentiation
Cluster of differentiation
The cluster of differentiation is a protocol used for the identification and investigation of cell surface molecules present on white blood cells, providing targets for immunophenotyping of cells...
171).
Interactions
L1 (protein) has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NUMB
NUMB (gene)
Protein numb homolog is a protein that in humans is encoded by the NUMB gene.-Interactions:NUMB has been shown to interact with Adaptor-related protein complex 2, alpha 1, Mdm2, L1, DPYSL2, SIAH1, P53 and LNX1.-Further reading:...
.