NUMB (gene)
Encyclopedia
Protein numb homolog is a protein
that in humans is encoded by the NUMB gene
.
with Adaptor-related protein complex 2, alpha 1, Mdm2
, L1
, DPYSL2
, SIAH1
, P53
and LNX1
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the NUMB gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
NUMB (gene) has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Adaptor-related protein complex 2, alpha 1, Mdm2
Mdm2
Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain of the p53 tumor suppressor and an inhibitor of...
, L1
L1 (protein)
L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers....
, DPYSL2
DPYSL2
Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.-Interactions:DPYSL2 has been shown to interact with CRMP1, Adaptor-related protein complex 2, alpha 1 and NUMB.-Further reading:...
, SIAH1
SIAH1
E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene.-Interactions:SIAH1 has been shown to interact with PEG10, CACYBP, POU2AF1, RBBP8, BAG1, TRIB3, NUMB, KIF22, KHDRBS3, PEG3 and APC.-References:...
, P53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
and LNX1
LNX1
E3 ubiquitin-protein ligase LNX is an enzyme that in humans is encoded by the LNX1 gene.-Interactions:LNX1 has been shown to interact with NAGK, NUMB and PAFAH1B3.-Further reading:...
.