Indinavir

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Indinavir

Indinavir (IDV; trade name Crixivan, manufactured by Merck

Merck & Co.

Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the USA and Canada, is one of the largest pharmaceutical companies in the world....
) is a protease inhibitor

Protease inhibitor (pharmacology)

Protease inhibitors are a class of medications used to treat or prevent infection by viruses, including HIV and Hepatitis C. PIs prevents viral replication by inhibiting the activity of HIV-1 protease, an enzyme used by the viruses to cleave nascent proteins for final assembly of new virons....
used as a component of highly active antiretroviral therapy

Antiretroviral drug

Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. When several such drugs, typically three or four, are taken in combination, the approach is known as highly active antiretroviral therapy, or HAART....
(HAART) to treat HIV

HIV

Human immunodeficiency virus is a lentivirus that can lead to AIDS , a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections....
infection and AIDS

AIDS

Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the HIV ....
.

Food and Drug Administration

Food and Drug Administration

The U.S. Food and Drug Administration is an Government agency of the United States Department of Health and Human Services and is responsible for regulating and supervising the safety of foods, dietary supplements, Medications, vaccines, Biopharmaceutical, blood transfusion, medical devices, Electromagnetic radiation-emitting devices, veteri...
(FDA) approved indinavir March 13, 1996, making it the eighth approved antiretroviral. Indinavir was much more powerful than any prior antiretroviral drug; using it with dual NRTIs set the standard for treatment of HIV/AIDS and raised the bar on design and introduction of subsequent antiretroviral drugs.

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Encyclopedia

Indinavir (IDV; trade name Crixivan, manufactured by Merck

Merck & Co.

Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the USA and Canada, is one of the largest pharmaceutical companies in the world....
) is a protease inhibitor

Protease inhibitor (pharmacology)

Antiretroviral drug

HIV

AIDS

Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the HIV ....
.

History

The Food and Drug Administration

Food and Drug Administration

Lopinavir

Lopinavir is an Antiretroviral drug of the Protease inhibitor class. It is marketed by Abbott Laboratories as Kaletra and Aluvia , both of which represent a Fixed dose combination with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV/AIDS....
or atazanavir

Atazanavir

Atazanavir, marketted under the trade name Reyataz by Bristol-Myers Squibb, is an antiretroviral drug of the Protease inhibitor class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus ....
.

Administration

Unfortunately, indinavir wears off quickly after dosing and therefore requires dosing very precisely every eight hours in order to thwart HIV from forming drug resistant mutations including resistances to other protease inhibitors. It has restrictions on what sorts of food may be eaten concurrently.

Side effects

Side effects include

Kidney stone
Kidney stone

Kidney stones, also called renal Calculus , are solid concretions of dissolved dietary mineral in urine; calculi typically form inside the kidneys or bladder....
s
Metabolic abnormalities including hyperlipidemia
Hyperlipidemia

Hyperlipidemia, hyperlipoproteinemia or dyslipidemia is the presence of raised or abnormal levels of lipids and/or lipoproteins in the blood....
(cholesterol
Cholesterol

Cholesterol is a lipidic, waxy alcohol found in the cell membranes and transported in the blood plasma of all animals. It is an essential component of mammalian cell membranes where it is required to establish proper membrane permeability and membrane fluidity....
or triglyceride
Triglyceride

is a glyceride in which the glycerol is esterified with three fatty acids. It is the main constituent of vegetable oil and animal fats....
elevations)
alterations in body shape known as lipodystrophy
Lipodystrophy

Lipodystrophy is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. A more specific term, lipoatrophy is used when describing the loss of fat from one area ....