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Hyperuricosuria

 

 
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Hyperuricosuria
 
 
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Hyperuricosuria is a medical term referring to the presence of excessive amounts of uric acid
Uric acid

Uric acid is an organic compound of carbon, nitrogen, oxygen and hydrogen with the formula C5H4N4O3....
 in the urine
Urine

Urine is a liquid waste product of the body secreted by the kidneys by a process of filtration from blood called urination and excreted through the urethra....
. Notable direct causes of hyperuricosuria are dissolution of uric acid
Uric acid

Uric acid is an organic compound of carbon, nitrogen, oxygen and hydrogen with the formula C5H4N4O3....
 crystals in the kidney
Kidney

The kidneys are Organ that have numerous biological roles. Their primary role is to maintain the homeostasis balance of bodily fluids by filtering and secreting Metabolomics#Metabolitess and minerals from the blood and excreting them, along with water , as urine....
s or urinary bladder
Urinary bladder

In anatomy, the urinary bladder is a solid, muscle, and distensible organ that sits on the pelvic floor in mammals. It is the organ that collects urine excreted by the kidneys prior to disposal by urination....
, and hyperuricemia
Hyperuricemia

Hyperuricemia is a level of uric acid in the blood that is abnormally high. In humans, the upper end of the normal range is 360 ?mol/L for women and 400 ?mol/L for men....
. Notable indirect causes include uricosuric
Uricosuric

Uricosuric medications are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma....
 drugs, rapid breakdown of bodily tissues containing large quantities of DNA
DNA

Deoxyribonucleic acid is a nucleic acid that contains the genetics instructions used in the development and functioning of all known living organisms and some viruses....
 and RNA
RNA

Ribonucleic acid is a type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nucleobase, a ribose sugar, and a phosphate....
, and a diet high in purine
Purine

Purine is a heterocyclic compound aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature....
.

Drugs that may contribute to hyperuricosuria include allopurinol
Allopurinol

Allopurinol is a drug used primarily to treat hyperuricemia and its complications, including chronic gout....
 and uricase.

Hyperuricosuria may be a medical sign
Medical sign

A medical sign is an Objectivity indication of some medical fact or characteristic that may be detected by a physician during a physical examination of a patient....
 of:

lass="link1" onMouseover='showByLink("m1924680",this)' onMouseout='hide("m1924680")'href="http://www.absoluteastronomy.com/topics/Acute_%28medicine%29">Acute
Acute (medicine)

In medicine, an acute disease is a disease with either or both of:# a rapid onset;# a short course .This adjective is part of the definition of several diseases and is, therefore, incorporated in their name, for instance, severe acute respiratory syndrome, acute leukemia....
 hyperuricosuria is a common complication of tumor lysis syndrome.






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Hyperuricosuria is a medical term referring to the presence of excessive amounts of uric acid
Uric acid

Uric acid is an organic compound of carbon, nitrogen, oxygen and hydrogen with the formula C5H4N4O3....
 in the urine
Urine

Urine is a liquid waste product of the body secreted by the kidneys by a process of filtration from blood called urination and excreted through the urethra....
. Notable direct causes of hyperuricosuria are dissolution of uric acid
Uric acid

Uric acid is an organic compound of carbon, nitrogen, oxygen and hydrogen with the formula C5H4N4O3....
 crystals in the kidney
Kidney

The kidneys are Organ that have numerous biological roles. Their primary role is to maintain the homeostasis balance of bodily fluids by filtering and secreting Metabolomics#Metabolitess and minerals from the blood and excreting them, along with water , as urine....
s or urinary bladder
Urinary bladder

In anatomy, the urinary bladder is a solid, muscle, and distensible organ that sits on the pelvic floor in mammals. It is the organ that collects urine excreted by the kidneys prior to disposal by urination....
, and hyperuricemia
Hyperuricemia

Hyperuricemia is a level of uric acid in the blood that is abnormally high. In humans, the upper end of the normal range is 360 ?mol/L for women and 400 ?mol/L for men....
. Notable indirect causes include uricosuric
Uricosuric

Uricosuric medications are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma....
 drugs, rapid breakdown of bodily tissues containing large quantities of DNA
DNA

Deoxyribonucleic acid is a nucleic acid that contains the genetics instructions used in the development and functioning of all known living organisms and some viruses....
 and RNA
RNA

Ribonucleic acid is a type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nucleobase, a ribose sugar, and a phosphate....
, and a diet high in purine
Purine

Purine is a heterocyclic compound aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature....
.

Drugs that may contribute to hyperuricosuria include allopurinol
Allopurinol

Allopurinol is a drug used primarily to treat hyperuricemia and its complications, including chronic gout....
 and uricase.

Hyperuricosuria may be a medical sign
Medical sign

A medical sign is an Objectivity indication of some medical fact or characteristic that may be detected by a physician during a physical examination of a patient....
 of:
  • Gout
    Gout

    Gout is a crystal deposition disease hallmarked by elevated levels of uric acid in the Circulatory system. In this condition, crystals of monosodium urate or uric acid are deposited on the articular cartilage of joints, tendons and surrounding tissues....
     (very common)
  • Kidney stones of uric acid (uric acid nephrolithiasis)
  • Acute uric acid nephropathy
    Acute uric acid nephropathy

    Acute uric acid nephropathy is a rapidly worsening kidney function that is caused by high levels of uric acid in the urine ....
  • Acute renal failure
    Acute renal failure

    Acute renal failure , also known as acute kidney failure or acute kidney injury, is a rapid loss of renal function due to damage to the kidneys, resulting in retention of nitrogenous and non-nitrogenous waste products that are normally excreted by the kidney....
  • Tumor lysis syndrome
    Tumor lysis syndrome

    In medicine , tumor lysis syndrome is a group of metabolism complications that can occur after treatment of cancer, usually lymphomas and leukemias, and sometimes even without treatment....
  • Fanconi syndrome
    Fanconi syndrome

    Fanconi Syndrome is a disorder in which the Nephron#Proximal_tubule function of the kidney is impaired, resulting in decreased reabsorption of electrolytes and nutrients back into the bloodstream....
  • Dent's disease
    Dent's disease

    Dent's disease is a rare X-linked recessive inherited condition that affects the kidney. It is one cause of Fanconi syndrome, and is characterized by tubular proteinuria, hypercalciuria, calcium nephrolithiasis, nephrocalcinosis and chronic renal failure....
     (very rare)


Acute vs chronic

Acute
Acute (medicine)

In medicine, an acute disease is a disease with either or both of:# a rapid onset;# a short course .This adjective is part of the definition of several diseases and is, therefore, incorporated in their name, for instance, severe acute respiratory syndrome, acute leukemia....
 hyperuricosuria is a common complication of tumor lysis syndrome. This syndrome appears not to contribute to gout and to uric acid nephrolithiasis, which is evidence that these two conditions have chronic, not acute, causes.

Chronic
Chronic (medicine)

In medicine, a chronic disease is a disease that is long-lasting or recurrent. The term chronic describes the Course of the disease, or its rate of onset and development....
 hyperuricosuria is associated with gout and uric acid nephrolithiasis. However, both conditions can occur in the absence of hyperuricosuria. Treatment of gout with uricosuric drugs can lead to uric acid nephrolithiasis.

Treatment

If neither hyperuricemia
Hyperuricemia

Hyperuricemia is a level of uric acid in the blood that is abnormally high. In humans, the upper end of the normal range is 360 ?mol/L for women and 400 ?mol/L for men....
 nor gout is present, then the risk of uric acid nephrolithiasis can be reduced by the use of antiuricosuric drugs. Alternatively, making the urine pH more alkaline is protective.

See also

  • Uricosuria
    Uricosuria

    Uricosuria can refer to:*Hyperuricosuria, an abnormally high level of uric acid in the urine*Hypouricosuria, an abnormally low level of uric acid in the urine...
     (disambiguation)