Franz Nissl

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Franz Nissl

Franz Nissl (September 9, 1860 – August 11, 1919) was a German

Germany

Germany , officially the Federal Republic of Germany , is a country in Central Europe. It is bordered to the north by the North Sea, Denmark, and the Baltic Sea; to the east by Poland and the Czech Republic; to the south by Austria and Switzerland; and to the west by France, Luxembourg, Belgium, and the Netherlands....
neuropathologist.

Life
Born in Frankenthal

Frankenthal

Frankenthal is a city in southwestern Germany, in the state of Rhineland-Palatinate....
, Rhenish Palatinate, he did his medical studies in Munich where he became interested in the pathology of cortical

Cerebral cortex

The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness....
neurons.

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Encyclopedia

Franz Nissl (September 9, 1860 – August 11, 1919) was a German

Germany

Life

Born in Frankenthal

Frankenthal

Cerebral cortex

The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness....
neurons. He is best known for developing a histological stain which allowed for selective visualization of neuron

Neuron

Neurons are responsive cell in the nervous system that process and transmit information by electrochemical Signal . They are the core components of the brain, the vertebrate spinal cord, the invertebrate ventral nerve cord, and the peripheral nerves....
al cell bodies

Soma (biology)

The soma, or cyton or perikaryon, is the bulbous end of a neuron, containing the cell nucleus. The word soma is Greek language, meaning "body"; the soma of a neuron is often called the "Cell body"....
throughout the brain, ushering a new era in neurocytology and neuropathology. He also did important work in psychiatry correlating changes in glial cells, blood vessels, and brain tissue in general with mental illness. He also worked with and was friends with Alois Alzheimer

Alois Alzheimer

Aloysius "Alois" Alzheimer, was a Germany psychiatrist and neuropathologist and a colleague of Emil Kraepelin. Alzheimer is credited with the first published case of "presenile dementia", which Kraepelin would later identify as Alzheimer's disease....
. Toward the end of his life he studied the nature of the connections between the cerebral cortex

Cerebral cortex

The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness....
and the thalamus

Thalamus

The thalamus is a pair and symmetric part of the brain. It constitutes the main part of the diencephalon....
.

Named histology concepts

The Nissl method uses basic aniline

Aniline

Aniline, phenylamine or aminobenzene is an organic compound with the Chemical formula C6H7N. It is the simplest and one of the most important aromatic amines, being used as a precursor to more complex chemicals....
to stain RNA

RNA

Ribonucleic acid is a type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nucleobase, a ribose sugar, and a phosphate....
blue, and is used to highlight important structural features of neurons. The Nissl substance (rough endoplasmic reticulum) appears dark blue due to the staining of ribosomal RNA, giving the cytoplasm a mottled appearance. Individual granules of extranuclear RNA are named Nissl granules (ribosomes). DNA present in the nucleus

Cell nucleus

In cell biology, the nucleus , also sometimes referred to as the "control center", is a membrane-enclosed organelle found in all eukaryote cell ....
stains a similar color.

Franz Nissl

Life

Named histology concepts

See also

External links