Fenbendazole
Encyclopedia
Fenbendazole is a broad spectrum benzimidazole
anthelmintic
used against gastrointestinal parasites including roundworms, hookworm
s, whipworm
s, the taenia species of tapeworms, pinworm
s, aelurostrongylus, paragonimiasis
, strongyles and strongyloides and can be administered to sheep, cattle
, horse
s, fish
, dog
s, cat
s, rabbits and seal
s. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together.
Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The in laboratory animals exceeds 10 g/kg when administered orally.
Benzimidazole
Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. The most prominent benzimidazole compound in nature is N-ribosyl-dimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. Benzimidazole, in...
anthelmintic
Anthelmintic
Anthelmintics or antihelminthics are drugs that expel parasitic worms from the body, by either stunning or killing them. They may also be called vermifuges or vermicides .-Pharmaceutical classes:...
used against gastrointestinal parasites including roundworms, hookworm
Hookworm
The hookworm is a parasitic nematode that lives in the small intestine of its host, which may be a mammal such as a dog, cat, or human. Two species of hookworms commonly infect humans, Ancylostoma duodenale and Necator americanus. A. duodenale predominates in the Middle East, North Africa, India...
s, whipworm
Whipworm
The human tapworm is a roundworm, which causes trichuriasis when it infects a human large intestine. The name whipworm refers to the shape of the worm; they look like whips with wider "handles" at the posterior end.-Life cycle:The female T. trichiura produces 2,000–10,000 single celled eggs per day...
s, the taenia species of tapeworms, pinworm
Pinworm
The pinworm , also known as threadworm or seatworm, is a nematode and a common human intestinal parasite, especially in children...
s, aelurostrongylus, paragonimiasis
Paragonimiasis
Paragonimiasis is a food-borne parasitic infection caused by the lung fluke, most commonly Paragonimus westermani. It infects an estimated 22 million people worldwide. It is particularly common in East Asia. More than 30 species of trematodes of the genus Paragonimus have been reported which...
, strongyles and strongyloides and can be administered to sheep, cattle
Cattle
Cattle are the most common type of large domesticated ungulates. They are a prominent modern member of the subfamily Bovinae, are the most widespread species of the genus Bos, and are most commonly classified collectively as Bos primigenius...
, horse
Horse
The horse is one of two extant subspecies of Equus ferus, or the wild horse. It is a single-hooved mammal belonging to the taxonomic family Equidae. The horse has evolved over the past 45 to 55 million years from a small multi-toed creature into the large, single-toed animal of today...
s, fish
Fish
Fish are a paraphyletic group of organisms that consist of all gill-bearing aquatic vertebrate animals that lack limbs with digits. Included in this definition are the living hagfish, lampreys, and cartilaginous and bony fish, as well as various extinct related groups...
, dog
Dog
The domestic dog is a domesticated form of the gray wolf, a member of the Canidae family of the order Carnivora. The term is used for both feral and pet varieties. The dog may have been the first animal to be domesticated, and has been the most widely kept working, hunting, and companion animal in...
s, cat
Cat
The cat , also known as the domestic cat or housecat to distinguish it from other felids and felines, is a small, usually furry, domesticated, carnivorous mammal that is valued by humans for its companionship and for its ability to hunt vermin and household pests...
s, rabbits and seal
Pinniped
Pinnipeds or fin-footed mammals are a widely distributed and diverse group of semiaquatic marine mammals comprising the families Odobenidae , Otariidae , and Phocidae .-Overview: Pinnipeds are typically sleek-bodied and barrel-shaped...
s. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together.
Toxicity
Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis and distal villi sloughing. Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The in laboratory animals exceeds 10 g/kg when administered orally.