Dobutamine

	Email		Print
	Bookmark		Link

Dobutamine

Dobutamine is a sympathomimetic drug

Drug

A drug, broadly speaking, is any chemical substance that, when absorbed into the body of a living organism, alters normal bodily function....
used in the treatment of heart failure and cardiogenic shock

Cardiogenic shock

Cardiogenic shock is based upon an inadequate circulation of blood due to primary failure of the ventricle s of the heart to function effectively....
. Its primary mechanism is direct stimulation of ß₁ receptors of the sympathetic nervous system

Sympathetic nervous system

The Sympathetic Nervous System is a branch of the autonomic nervous system along with the enteric nervous system and parasympathetic nervous system....
. It was developed by a laboratory led by Dr. Ronald Tuttle at Eli Lilly and Company

Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company and one of the world's largest corporations. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States....
.

tamine is used to treat acute but potentially reversible heart failure, such as cardiac surgery

Cardiac surgery

Cardiac surgery is surgery on the heart and/or great vessels performed by a cardiac surgeon. Frequently, it is done to treat complications of ischemic heart disease , correct congenital heart disease, or treat valvular heart disease created by various causes including endocarditis....
or cases of septic

Septic shock

Septic shock is a serious medicine condition caused by decreased tissue perfusion and oxygen delivery as a result of infection and sepsis, though the microbe may be systemic or localized to a particular site....
or cardiogenic shock, on the basis of its positive inotropic

Inotrope

An inotrope is an agent that alters the force or energy of muscular contractions. Negatively inotropic agents weaken the force of muscle contractions....
action.

Dobutamine can be used in cases of congestive heart failure to increase cardiac output.

Discussion

Ask a question about 'Dobutamine'

Start a new discussion about 'Dobutamine'

Answer questions from other users

Full Discussion Forum

Encyclopedia

Dobutamine is a sympathomimetic drug

Drug

Cardiogenic shock

Sympathetic nervous system

Eli Lilly and Company

Use

Dobutamine is used to treat acute but potentially reversible heart failure, such as cardiac surgery

Cardiac surgery

Septic shock

Inotrope

Total parenteral nutrition

Total parenteral nutrition , is the practice of feeding a person intravenously, bypassing the usual process of eating and digestion. The person receives nutritional formulas containing salts, glucose, amino acids, lipids and added vitamins....
is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility, which could be the result of either organic heart disease or cardiac surgical procedures. It is not useful in ischemic heart disease because it increases heart rate and thus increases myocardial oxygen demand.

Pharmacology

Dobutamine is a direct-acting agent whose primary activity results from stimulation of the ß₁-adrenoceptors of the heart, increasing contractility and cardiac output. Since it does not act on dopamine receptor

Dopamine receptor

Dopamine receptors are a class of metabotropic receptor G protein-coupled receptors that are prominent in the vertebrate central nervous system ....
s to induce the release of norepinephrine

Norepinephrine

Norepinephrine or noradrenaline is a catecholamine with dual roles as a hormone and a neurotransmitter.As a stress hormone, norepinephrine affects parts of the brain where attention and responding actions are controlled....
(another a₁ agonist), dobutamine is less prone to induce hypertension than is dopamine

Dopamine

Dopamine is a neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the human brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors ? D1, D2, D3, D4 and D5, and their variants....
. Arrhythmogenic and vasodilative effects are negligible.

Dobutamine is predominantly a ß₁-adrenergic agonist, with weak ß2 activity, and a₁ selective activity, although it is used clinically in cases of cardiogenic shock for its ß₁ inotropic effect in increasing heart contractility and cardiac output. Dobutamine is administered as a racemic

Racemic

In chemistry, a racemic mixture, or racemate, is one that has equal Amount of substance of left- and right-handed enantiomer of a Chirality molecule....
mixture consisting of both (+) and (-) isomer

Chirality (chemistry)

The term chiral is used to describe an object that is non-Superposition on its mirror image.Human hands are perhaps the most universally recognized example of chirality: The left hand is a non-superposable mirror image of the right hand; no matter how the two hands are oriented, it is impossible for all the major features of both hands...
s, and the (+) isomer is a potent ß₁ agonist while the (-) isomer is a a₁ agonist. Dobutamine also has mild ß₂ agonist activity.

Side effects

Primary side effects include those commonly seen for ß₁ active sympathomimetics, such as hypertension

Hypertension

Hypertension, also referred to as high blood pressure, HTN or HPN, is a medical condition in which the blood pressure is chronically elevated....
, angina

Angina

Angina pectoris, commonly known as angina, is severe chest pain due to ischemia of the myocardium, generally due to obstruction or spasm of the coronary circulation ....
, arrhythmia, and tachycardia

Tachycardia

The word tachycardia comes from the Greek words tachys and kardia .Tachycardia typically refers to a heartrate that exceeds the range of the normal resting heartrate, based upon age:...
.