B-cell prolymphocytic leukemia

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B-cell prolymphocytic leukemia

B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia

Leukemia

Leukemia is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation of blood Cell , usually white blood cells ....
. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.

It can involve deletions from chromosome 11 and chromosome 13.

It has been suggested that some cases may represent a variant of mantle cell lymphoma

Mantle cell lymphoma

Mantle cell lymphoma is one of the rarer of the Non-Hodgkin lymphoma , comprising about 6% of NHL cases. There are only about 15,000 patients presently in the U.S....
.

It has a relatively poor prognosis.

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Encyclopedia

B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia

Leukemia

Mantle cell lymphoma

Markers

A case has been described as CD20

CD20

CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells.Membrane-spanning 4-domains, subfamily A, member 1, also known as MS4A1, is a human gene....
+, CD22

CD22

CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases....
+, and CD5

CD5 (protein)

CD5 is a cluster of differentiation found on a subset of IgM secreting B cells called B-1 cells, and also on T cells. B1 B cells have limited diversity of their B_cell_receptor due to their lack of the enzyme Terminal_deoxynucleotidyl_transferase and are potentially self-reactive....
-.

It can also be CD5+.

Another case was described as CD45

CD45

In immunology, the CD45 antigen is a protein which was originally called leukocyte common antigen.The protein encoded by this gene is a member of the protein tyrosine phosphatase family....
+, CD19

CD19

CD19 , is a human protein encoded by the gene.CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells....
+, CD20

CD20

CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells.Membrane-spanning 4-domains, subfamily A, member 1, also known as MS4A1, is a human gene....
+, CD5

CD5

CD5 or CD-5 may be:* Child development-5, for five-year old children, a more developmentally appropriate acronym for kindergarten* CD5 molecule, type I transmembrane protein...
+, HLA-DR+, CD10-, CD23

CD23

CD23, also known as Fc epsilon RII, or FceRII, is the "low affinity" biochemistry for IgE, an antibody isotype involved in allergy and resistance to parasites and is important in regulation of IgE levels....
+/-, CD38

CD38

CD38 is a glycoprotein found on the surface of many immune cells , including CD4+, CD8+, B and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling....
+ and FMC7-.

Treatment

Splenic irradiation has been used in the treatment.