CD20

	Email		Print
	Bookmark		Link

CD20

CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells.

Membrane-spanning 4-domains, subfamily A, member 1, also known as MS4A1, is a human gene

Gene

A gene is the basic unit of heredity in a living organism. All living things depend on genes. Genes hold the information to build and maintain their cell and pass genetic trait to offspring....
.

protein has no known natural ligand

Ligand

In chemistry, a ligand is either an atom, ion, or molecule that bonds to a central metal, generally involving formal donation of one or more of its electrons....
and its function is unclear. It is suspected that it acts as a calcium channel

Calcium channel

A Calcium channel is an ion channel which displays selective permeabiltiy to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels....
in the cell membrane

Cell membrane

The cell membrane is the interface between the cellular machinery inside the cell and the fluid outside.It is a semipermeable lipid bilayer found in all cell ....
.

is expressed on all stages of B cell development except the first and last; it is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells.

It is found on B-cell lymphomas, hairy cell leukemia

Hairy cell leukemia

Hairy cell leukemia is a mature B cell neoplasm. It is usually classified as a sub-type of chronic lymphoid leukemia for convenience. It is uncommon, representing about 2% of all leukemias, or less than a total of 2000 new cases diagnosed each year in North America and Western Europe combined....
, and B-cell chronic lymphocytic leukemia

Chronic lymphocytic leukemia

B-cell chronic lymphocytic leukemia , is a type of leukemia, or cancer of the white blood cells . CLL affects a particular lymphocyte, the B cell, which originates in the bone marrow, develops in the lymph nodes, and normally fights infection....
.

Discussion

Ask a question about 'CD20'

Start a new discussion about 'CD20'

Answer questions from other users

Full Discussion Forum

Encyclopedia

CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells.

Membrane-spanning 4-domains, subfamily A, member 1, also known as MS4A1, is a human gene

Gene

A gene is the basic unit of heredity in a living organism. All living things depend on genes. Genes hold the information to build and maintain their cell and pass genetic trait to offspring....
.

Function

The protein has no known natural ligand

Ligand

Calcium channel

Cell membrane

The cell membrane is the interface between the cellular machinery inside the cell and the fluid outside.It is a semipermeable lipid bilayer found in all cell ....
.

Expression

CD20 is expressed on all stages of B cell development except the first and last; it is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells.

It is found on B-cell lymphomas, hairy cell leukemia

Hairy cell leukemia

Chronic lymphocytic leukemia

Cancer stem cell

Cancer stem cells are cancer cells that possess characteristics associated with normal stem cell, specifically the ability to give rise to all cell types found in a particular cancer sample....
s.

Clinical significance

It is the target of the monoclonal antibodies

Monoclonal antibodies

Monoclonal antibodies are monospecific antibody that are identical because they are produced by one type of white blood cell that are all cloning of a single parent cell....
rituximab

Rituximab

Rituximab, sold under the trade names Rituxan and MabThera, is a Chimera monoclonal antibody against the protein CD20. Rituximab is used in the treatment of B cell non-Hodgkin's lymphoma, B-cell leukemias, and some autoimmune disorders....
, Ibritumomab tiuxetan

Ibritumomab tiuxetan

Ibritumomab tiuxetan, also sold under the trade name Zevalin, is a monoclonal antibody therapy radioimmunotherapy treatment for some forms of B cell non-Hodgkin's lymphoma, a myeloproliferative disorder of the lymphatic system....
, and tositumomab

Tositumomab

Tositumomab is a monoclonal antibody derived from immortalized mouse cells. It is a IgG2a anti-CD20 antibody and is covalently bound to Iodine-131....
, which are all active agents in the treatment of all B cell lymphoma

Lymphoma

Lymphoma is a type of cancer that originates in lymphocytes of the immune system. They often originate in lymph nodes, presenting as an enlargement of the node ....
s and leukemias. Additional antibody therapeutics under development (phase II or III clinical trials) include AME-133v (Applied Molecular Evolution), Ocrelizumab

Ocrelizumab

Ocrelizumab is a humanized anti CD20 monoclonal antibody. It targets mature B lymphocytes. As of May 2007 it is in clinical trials for rheumatoid arthritis, multiple sclerosis and lupus erythematosus....
(Roche), Ofatumumab

Ofatumumab

Ofatumumab is a human monoclonal antibody which appears to inhibit early-stage B lymphocyte activation. It is under development for treatment of certain B-cell cancers as well as rheumatoid arthritis ....
(Genmab

Genmab

Genmab A/S is a Denmark pharmaceutical company, founded in February 1999 and based in Copenhagen. Internationally, it operates through the subsidiaries Genmab BV in Utrecht , The Netherlands, Genmab Ltd in Stevenage, United Kingdom Genmab, Inc in Princeton, New Jersey, USA, and is publicly traded on the OMX OMX Nordic Excha...
), TRU-015 (Trubion

Trubion

Trubion is a publicly held biopharmaceutical company that is focused on creating a pipeline of protein-based therapeutic product candidates to treat autoimmune and inflammatory diseases and cancer....
) and IMMU-106 (Immunomedics).

FMC7 appears to be a conformational variant.

External links

representations of the shape are found and more detail

CD20

Function

Expression

Clinical significance

Further reading

External links