ATC code B02
Encyclopedia
B02AA Amino acidAmino acidAmino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...
s
- B02AA01 Aminocaproic acidAminocaproic acidAminocaproic acid is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis...
- B02AA02 Tranexamic acidTranexamic acidTranexamic acid is a drug used to treat or prevent excessive blood loss during surgery and in certain other conditions...
- B02AA03 Aminomethylbenzoic acidAminomethylbenzoic acidAminomethylbenzoic acid is an antifibrinolytic....
B02AB Proteinase inhibitors
- B02AB01 AprotininAprotininThe drug aprotinin , is the bovine version of the small protein basic pancreatic trypsin inhibitor, or BPTI, which inhibits trypsin and related proteolytic enzymes. Under the trade name Trasylol, aprotinin was used as a medication administered by injection to reduce bleeding during complex surgery,...
- B02AB02 Alfa1 antitrypsin
- B02AB03 C1-inhibitorC1-inhibitorC1-inhibitor is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation. C1-inhibitor is an acute-phase protein that circulates in blood at levels of around 0.25 g/L. The levels rise ~2-fold during...
- B02AB04 CamostatCamostatCamostat is a serine protease inhibitor....
B02BC Local hemostatics
- B02BC01 Absorbable gelatin spongeAbsorbable gelatin spongeAbsorbable gelatin sponge is an antihemorrhagic.It is sometimes soaked with buprenorphine....
- B02BC02 Oxidized celluloseOxidized celluloseOxidized cellulose is a water insoluble derivative of cellulose. It can be produced from cellulose by the action of an oxidizing agent, such as chlorine, hydrogen peroxide, peracetic acid, chlorine dioxide, nitrogen dioxide, persulfates, permanganate, dichromate-sulfuric acid, hypochlorous acid,...
- B02BC03 Tetragalacturonic acid hydroxymethylesterTetragalacturonic acid hydroxymethylesterTetragalacturonic acid hydroxymethylester is an antihemorrhagic....
- B02BC05 AdrenaloneAdrenaloneAdrenalone is an adrenergic agent used as a topical vasoconstrictor and hemostatic. It is the ketone form of epinephrine....
- B02BC06 ThrombinThrombinThrombin is a "trypsin-like" serine protease protein that in humans is encoded by the F2 gene. Prothrombin is proteolytically cleaved to form thrombin in the first step of the coagulation cascade, which ultimately results in the stemming of blood loss...
- B02BC07 CollagenCollagenCollagen is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content...
- B02BC08 Calcium alginateCalcium alginateCalcium alginate is a water-insoluble, gelatinous, cream coloured substance that can be created through the addition of aqueous calcium chloride to aqueous sodium alginate. Adding artificial flavours and colours creates a more tasty edible slime...
- B02BC09 EpinephrineEpinephrineEpinephrine is a hormone and a neurotransmitter. It increases heart rate, constricts blood vessels, dilates air passages and participates in the fight-or-flight response of the sympathetic nervous system. In chemical terms, adrenaline is one of a group of monoamines called the catecholamines...
- B02BC10 FibrinogenFibrinogenFibrinogen is a soluble plasma glycoprotein, synthesised by the liver, that is converted by thrombin into fibrin during blood coagulation. This is achieved through processes in the coagulation cascade that activate the zymogen prothrombin to the serine protease thrombin, which is responsible for...
, human - B02BC30 Combinations
B02BD Blood coagulation factors
- B02BD01 Coagulation factor IXFactor IXFactor IX is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to...
, II, VIIFactor VIIFactor VII is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. A recombinant form of human factor VIIa has U.S. Food and Drug Administration approval for uncontrolled bleeding in hemophilia patients...
and XFactor XFactor X, also known by the eponym Stuart-Prower factor or as prothrombinase, is an enzyme of the coagulation cascade. It is a serine endopeptidase .-Physiology:...
in combination - B02BD02 Coagulation factor VIIIFactor VIIIFactor VIII is an essential blood clotting factor also known as anti-hemophilic factor . In humans, Factor VIII is encoded by the F8 gene...
- B02BD03 Factor VIII inhibitor bypassing activity
- B02BD04 Coagulation factor IX
- B02BD05 Coagulation factor VII
- B02BD06 Von Willebrand factorVon Willebrand factorvon Willebrand factor is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome...
and coagulation factor VIII in combination - B02BD07 Coagulation factor XIIIFactor XIIIFactor XIII or fibrin stabilizing factor is an enzyme of the blood coagulation system that crosslinks fibrin.- Function :Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier B subunits...
- B02BD08 Eptacog alfa (activated)
- B02BD09 Nonacog alfa
- B02BD30 ThrombinThrombinThrombin is a "trypsin-like" serine protease protein that in humans is encoded by the F2 gene. Prothrombin is proteolytically cleaved to form thrombin in the first step of the coagulation cascade, which ultimately results in the stemming of blood loss...
B02BX Other systemic hemostatics
- B02BX01 Etamsylate
- B02BX02 CarbazochromeCarbazochromeCarbazochrome is an antihemorrhagic.With troxerutin, it has been investigated for use in the treatment of hemorrhoids.-Indications:Capillary and parenchymal hemorrhage , intestinal bleeding, thrombocytopenic purpura....
- B02BX03 BatroxobinBatroxobinBatroxobin is a serine protease derived from the venom of Bothrops atrox. Its molecular weight is approximately 43,000 g/mol−1.This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A-chain of fibrinogen, releasing fibrinopeptide A and leading to the clot formation through...
- B02BX04 RomiplostimRomiplostimRomiplostim is a fusion protein analog of thrombopoietin, a hormone that regulates platelet production. The drug was developed by Amgen and is marketed under the trade name Nplate through a restricted usage program called NEXUS...
- B02BX05 EltrombopagEltrombopagEltrombopag is a medication that has been developed for conditions that lead to thrombocytopenia . It is a small molecule agonist of the c-mpl receptor, which is the physiological target of the hormone thrombopoietin...