Carbazochrome is an antihemorrhagic.

With troxerutin

Troxerutin

Troxerutin is a flavonol, a type of flavonoid. It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the japanese pagoda tree.It is used as a vasoprotective....

, it has been investigated for use in the treatment of hemorrhoids.

Indications

Capillary and parenchymal hemorrhage (trauma, tonsillectomy

Tonsillectomy

A tonsillectomy is a 3,000-year-old surgical procedure in which the tonsils are removed from either side of the throat. The procedure is performed in response to cases of repeated occurrence of acute tonsillitis or adenoiditis, obstructive sleep apnea, nasal airway obstruction, snoring, or...

, during surgery), intestinal bleeding

Bleeding

Bleeding, technically known as hemorrhaging or haemorrhaging is the loss of blood or blood escape from the circulatory system...

, thrombocytopenic purpura

Thrombocytopenic purpura

Thrombocytopenic purpura are purpura associated with a reduction in circulating blood platelets which can result from a variety of causes.- Types :...

.

Mechanism of action

Carbazochrome, an oxidation product of adrenaline, that interacts with α-adrenoreceptors on surface of platelets, which are coupled to Gq protein and initiate PLC

Phospholipase C

Phosphoinositide phospholipase C is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. In general, this enzyme is denoted as Phospholipase C, although three other families of phospholipase C enzymes have been identified in bacteria and in...

 IP3/DAG pathway to increase intracellular free calcium concentration with subsequent actions:

• Activates PLA2 and induce arachidonic acid pathway to synthese endoperoxides (TxA2, thromboxane A2
  Thromboxane A2
  Thromboxane A2 is a thromboxane. It is produced by activated platelets and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation. This is achieved by mediating expression of the glycoprotein complex GP IIb/IIIa in the cell membrane of...
  
  )
• Calcium binds to calmodulin
  Calmodulin
  Calmodulin is a calcium-binding protein expressed in all eukaryotic cells...
  
   which then binds and activates myosin light-chain kinase
  Myosin light-chain kinase
  Myosin light-chain kinase also known as MYLK or MLCK is a serine/threonine-specific protein kinase that phosphorylates the regulatory light chain of myosin II.- Isoforms :Four different MLCK isoforms exist:* MYLK – smooth muscle...
  
  , that will enable the myosin crossbridge to bind to the actin filament and allow contraction to begin. This will change platelet’s shape and induce release of serotonin
  Serotonin
  Serotonin or 5-hydroxytryptamine is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans...
  
  , ADP
  Adenosine triphosphate
  Adenosine-5'-triphosphate is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism...
  
  , vWF
  Von Willebrand factor
  von Willebrand factor is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome...
  
   (Von Willebrand factor), PAF
  Platelet-activating factor
  Platelet-activating factor, also known as a PAF, PAF-acether or AGEPC is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation and degranulation, inflammation, and anaphylaxis...
  
  (Platelet-activating factor) to promote further aggregation and adhesion.