4-HO-MPT
Encyclopedia
4-HO-MPT, or 4-hydroxy
-N-methyl-N-propyl
tryptamine
, is a lesser-known psychedelic drug
. It is the 4-hydroxyl
analog
of MPT. 4-HO-MPT was first synthesized by Alexander Shulgin
. In his book TiHKAL
(Tryptamines I Have Known and Loved), the minimum dosage is listed as 10-20 mg, and the duration listed as 4–6 hours. The book describes 4-HO-MPT as producing visual distortion, vertigo
, and slight insomnia
.
Anecdotal reports on this substance vary greatly in detail, including any combination of visual distortion, sedation, stimulation, and dissociated thoughts. Some users report taking very large amounts via multiple routes of ingestion and feeling nothing. There are many possible explanations for this phenomenon, including placebo, fast tolerance-building, cross-tolerance with other compounds, differences between the salt and the freebase, differences in bio-availability between routes of ingestion, and an uncertainty of what users are actually ingesting.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. Additionally, this chemical may be considered illegal in the United States due to the Federal Analog Act
. Extreme caution should be exercised by anyone planning on purchasing or ingesting this substance.
Hydroxyl
A hydroxyl is a chemical group containing an oxygen atom covalently bonded with a hydrogen atom. In inorganic chemistry, the hydroxyl group is known as the hydroxide ion, and scientists and reference works generally use these different terms though they refer to the same chemical structure in...
-N-methyl-N-propyl
Propyl
In organic chemistry, propyl is a three-carbon alkyl substituent with chemical formula -C3H7. It is the substituent form of the alkane propane...
tryptamine
Tryptamine
Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived...
, is a lesser-known psychedelic drug
Psychedelics, dissociatives and deliriants
This general group of pharmacological agents can be divided into three broad categories: psychedelics, dissociatives, and deliriants. These classes of psychoactive drugs have in common that they can cause subjective changes in perception, thought, emotion and consciousness...
. It is the 4-hydroxyl
Hydroxyl
A hydroxyl is a chemical group containing an oxygen atom covalently bonded with a hydrogen atom. In inorganic chemistry, the hydroxyl group is known as the hydroxide ion, and scientists and reference works generally use these different terms though they refer to the same chemical structure in...
analog
Analog (chemistry)
In chemistry, a structural analog , also known as chemical analog or simply analog, is a compound having a structure similar to that of another one, but differing from it in respect of a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced...
of MPT. 4-HO-MPT was first synthesized by Alexander Shulgin
Alexander Shulgin
Alexander "Sasha" Theodore Shulgin is an American pharmacologist, chemist, artist, and drug developer.Shulgin is credited with the popularization of MDMA, commonly known as ecstasy, in the late 1970s and early 1980s, especially for psychopharmaceutical use and the treatment of depression and...
. In his book TiHKAL
TiHKAL
TiHKAL: The Continuation is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines. A sequel to PiHKAL: A Chemical Love Story, TiHKAL is an acronym that stands for Tryptamines I Have Known and Loved.-Content:TiHKAL, much like its...
(Tryptamines I Have Known and Loved), the minimum dosage is listed as 10-20 mg, and the duration listed as 4–6 hours. The book describes 4-HO-MPT as producing visual distortion, vertigo
Vertigo (medical)
Vertigo is a type of dizziness, where there is a feeling of motion when one is stationary. The symptoms are due to a dysfunction of the vestibular system in the inner ear...
, and slight insomnia
Insomnia
Insomnia is most often defined by an individual's report of sleeping difficulties. While the term is sometimes used in sleep literature to describe a disorder demonstrated by polysomnographic evidence of disturbed sleep, insomnia is often defined as a positive response to either of two questions:...
.
Anecdotal reports on this substance vary greatly in detail, including any combination of visual distortion, sedation, stimulation, and dissociated thoughts. Some users report taking very large amounts via multiple routes of ingestion and feeling nothing. There are many possible explanations for this phenomenon, including placebo, fast tolerance-building, cross-tolerance with other compounds, differences between the salt and the freebase, differences in bio-availability between routes of ingestion, and an uncertainty of what users are actually ingesting.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MPT. Additionally, this chemical may be considered illegal in the United States due to the Federal Analog Act
Federal Analog Act
The Federal Analog Act, , is a controversial section of the United States Controlled Substances Act which allowed any chemical "substantially similar" to a controlled substance listed in Schedule I or II to be treated as if it were also listed in those schedules, but only if intended for human...
. Extreme caution should be exercised by anyone planning on purchasing or ingesting this substance.