TGF beta receptor 2
Encyclopedia
Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene
.
It is a tumor suppressor gene
.
with Cyclin B2
, TGF beta receptor 1
, Transforming growth factor, beta 3
, AP2B1
, Endoglin
, Heat shock protein 90kDa alpha (cytosolic), member A1 and STRAP
.
and an N-terminal ectodomain. The ectodomain consists of a compact fold
containing nine beta-strands and a single helix
stabilised by a network of six intra strand disulphide bonds. The folding
topology includes a central five-stranded antiparallel
beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9).
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
It is a tumor suppressor gene
Tumor suppressor gene
A tumor suppressor gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.-Two-hit hypothesis:Unlike...
.
Interactions
TGF beta receptor 2 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Cyclin B2
Cyclin B2
G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.-Interactions:Cyclin B2 has been shown to interact with TGF beta receptor 2.-Further reading:...
, TGF beta receptor 1
TGF beta receptor 1
Transforming growth factor, beta receptor I is a TGF beta receptor. TGFBR1 is its human gene.-Interactions:...
, Transforming growth factor, beta 3
Transforming growth factor, beta 3
Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene.-Interactions:Transforming growth factor, beta 3 has been shown to interact with TGF beta receptor 2.-External links:* * -Further reading:...
, AP2B1
AP2B1
AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.-Interactions:AP2B1 has been shown to interact with TGF beta receptor 2, AP1M2, BUB1B, LDLRAP1 and Arrestin beta 2.-Further reading:...
, Endoglin
Endoglin
Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links....
, Heat shock protein 90kDa alpha (cytosolic), member A1 and STRAP
STRAP
Serine-threonine kinase receptor-associated protein is an enzyme that in humans is encoded by the STRAP gene.-Interactions:STRAP has been shown to interact with Mothers against decapentaplegic homolog 6, TGF beta receptor 2, Mothers against decapentaplegic homolog 7, TGF beta receptor 1, Mothers...
.
Domain architecture
TGF beta receptor 2 consists of a C-terminal protein kinase domainProtein kinase domain
The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation...
and an N-terminal ectodomain. The ectodomain consists of a compact fold
Protein folding
Protein folding is the process by which a protein structure assumes its functional shape or conformation. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil....
containing nine beta-strands and a single helix
Alpha helix
A common motif in the secondary structure of proteins, the alpha helix is a right-handed coiled or spiral conformation, in which every backbone N-H group donates a hydrogen bond to the backbone C=O group of the amino acid four residues earlier...
stabilised by a network of six intra strand disulphide bonds. The folding
Protein folding
Protein folding is the process by which a protein structure assumes its functional shape or conformation. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil....
topology includes a central five-stranded antiparallel
Antiparallel (biochemistry)
In biochemistry, two molecules are antiparallel if they run side-by-side in opposite directions or when both strands are complimentary to each other....
beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9).