Solabegron
Encyclopedia
Solabegron is a drug which acts as a selective agonist for the β3 adrenergic receptor
. It is being developed for the treatment of overactive bladder
and irritable bowel syndrome
.,, It has been shown to produce visceral analgesia by releasing somatostatin
from adipocytes. ,
Beta-3 adrenergic receptor
The beta-3 adrenergic receptor , also known as ADRB3, is an beta-adrenergic receptor, and also denotes the human gene encoding it.-Function:Actions of the β3 receptor include:*Enhancement of lipolysis in adipose tissue....
. It is being developed for the treatment of overactive bladder
Overactive bladder
Overactive bladder is a urological condition defined by a set of symptoms: urgency, with or without urge incontinence, usually with frequency and nocturia. Frequency is usually defined as urinating more than 8 times a day. The International Continence Society is responsible for this definition...
and irritable bowel syndrome
Irritable bowel syndrome
Irritable bowel syndrome is a diagnosis of exclusion. It is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause. In some cases, the symptoms are relieved by bowel movements...
.,, It has been shown to produce visceral analgesia by releasing somatostatin
Somatostatin
Somatostatin is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G-protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.Somatostatin...
from adipocytes. ,