The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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Function

The Na⁺/H⁺ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride

Amiloride

Amiloride is a potassium-sparing diuretic, first approved for use in 1967 , used in the management of hypertension and congestive heart failure. Amiloride was also tested as treatment of cystic fibrosis, but it was revealed inefficient in vivo due to it's short time of action, therefore...

 and activated by a variety of signals including growth factor

Growth factor

A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes....

s, mitogen

Mitogen

A mitogen is a chemical substance that encourages a cell to commence cell division, triggering mitosis. A mitogen is usually some form of a protein.Mitogenesis is the induction of mitosis, typically via a mitogen....

s, neurotransmitter

Neurotransmitter

Neurotransmitters are endogenous chemicals that transmit signals from a neuron to a target cell across a synapse. Neurotransmitters are packaged into synaptic vesicles clustered beneath the membrane on the presynaptic side of a synapse, and are released into the synaptic cleft, where they bind to...

s, tumor promoter

Tumor promotion

Tumor promotion is a process in which existing tumors are stimulated to grow. It is the second phase in tumor development. Tumor promoters are not able to cause tumors to form.-External links:* entry in the public domain NCI Dictionary of Cancer Terms...

s, and others.

Interactions

Sodium-hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II

Carbonic anhydrase II

Carbonic anhydrase II , is one of fourteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide...

 and CHP

CHP (gene)

Calcium binding protein P22, also known as CHP, is a human gene.-Interactions:CHP has been shown to interact with Sodium-hydrogen antiporter 1 and Sodium-hydrogen antiporter 3.-Further reading:...

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Further reading