Small nucleolar RNA SNORD79
Encyclopedia
snoRNA U79 is a non-coding RNA
(ncRNA) molecule which functions in the modification of other small nuclear RNA
s (snRNAs). This type of modifiying RNA is usually located in the nucleolus
of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA
(snoRNA) and also often referred to as a guide RNA.
U79 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation
of substrate RNAs.
snoRNA U79 is found in intron
7 of the gas5 gene in humans and is also present in mice U79 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA
(rRNA) residue A3809.
Non-coding RNA
A non-coding RNA is a functional RNA molecule that is not translated into a protein. Less-frequently used synonyms are non-protein-coding RNA , non-messenger RNA and functional RNA . The term small RNA is often used for short bacterial ncRNAs...
(ncRNA) molecule which functions in the modification of other small nuclear RNA
Small nuclear RNA
Small nuclear ribonucleic acid is a class of small RNA molecules that are found within the nucleus of eukaryotic cells. They are transcribed by RNA polymerase II or RNA polymerase III and are involved in a variety of important processes such as RNA splicing , regulation of transcription factors ...
s (snRNAs). This type of modifiying RNA is usually located in the nucleolus
Nucleolus
The nucleolus is a non-membrane bound structure composed of proteins and nucleic acids found within the nucleus. Ribosomal RNA is transcribed and assembled within the nucleolus...
of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA
SnoRNA
Small nucleolar RNAs are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs...
(snoRNA) and also often referred to as a guide RNA.
U79 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation
Methylation
In the chemical sciences, methylation denotes the addition of a methyl group to a substrate or the substitution of an atom or group by a methyl group. Methylation is a form of alkylation with, to be specific, a methyl group, rather than a larger carbon chain, replacing a hydrogen atom...
of substrate RNAs.
snoRNA U79 is found in intron
Intron
An intron is any nucleotide sequence within a gene that is removed by RNA splicing to generate the final mature RNA product of a gene. The term intron refers to both the DNA sequence within a gene, and the corresponding sequence in RNA transcripts. Sequences that are joined together in the final...
7 of the gas5 gene in humans and is also present in mice U79 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA
Ribosomal RNA
Ribosomal ribonucleic acid is the RNA component of the ribosome, the enzyme that is the site of protein synthesis in all living cells. Ribosomal RNA provides a mechanism for decoding mRNA into amino acids and interacts with tRNAs during translation by providing peptidyl transferase activity...
(rRNA) residue A3809.