Small nucleolar RNA SNORD47
Encyclopedia
SNORD47 is a non-coding RNA
(ncRNA) molecule which functions in the modification of other small nuclear RNA
s (snRNAs). This type of modifiying RNA is usually located in the nucleolus
of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA
(snoRNA) and also often referred to as a guide RNA.
snoRNA U57 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation
of substrate RNAs.
This snoRNA was originally cloned from HeLa
cells and expression verified by northern blotting
. It is predicted to guide 2'O-ribose methylation of ribosomal RNA
(rRNA) 28S at residue C3866. The mouse orthologue was also cloned
This snoRNA is encoded in the introns of the same genes as other C/D bx snoRNAs U44, U74, U75, U76, U77, U78, U79, U80 and U81..
Non-coding RNA
A non-coding RNA is a functional RNA molecule that is not translated into a protein. Less-frequently used synonyms are non-protein-coding RNA , non-messenger RNA and functional RNA . The term small RNA is often used for short bacterial ncRNAs...
(ncRNA) molecule which functions in the modification of other small nuclear RNA
Small nuclear RNA
Small nuclear ribonucleic acid is a class of small RNA molecules that are found within the nucleus of eukaryotic cells. They are transcribed by RNA polymerase II or RNA polymerase III and are involved in a variety of important processes such as RNA splicing , regulation of transcription factors ...
s (snRNAs). This type of modifiying RNA is usually located in the nucleolus
Nucleolus
The nucleolus is a non-membrane bound structure composed of proteins and nucleic acids found within the nucleus. Ribosomal RNA is transcribed and assembled within the nucleolus...
of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA
SnoRNA
Small nucleolar RNAs are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs...
(snoRNA) and also often referred to as a guide RNA.
snoRNA U57 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation
Methylation
In the chemical sciences, methylation denotes the addition of a methyl group to a substrate or the substitution of an atom or group by a methyl group. Methylation is a form of alkylation with, to be specific, a methyl group, rather than a larger carbon chain, replacing a hydrogen atom...
of substrate RNAs.
This snoRNA was originally cloned from HeLa
HeLa
A HeLa cell is a cell type in an immortal cell line used in scientific research. It is the oldest and most commonly used human cell line. The line was derived from cervical cancer cells taken on February 8, 1951 from Henrietta Lacks, a patient who eventually died of her cancer on October 4, 1951...
cells and expression verified by northern blotting
. It is predicted to guide 2'O-ribose methylation of ribosomal RNA
Ribosomal RNA
Ribosomal ribonucleic acid is the RNA component of the ribosome, the enzyme that is the site of protein synthesis in all living cells. Ribosomal RNA provides a mechanism for decoding mRNA into amino acids and interacts with tRNAs during translation by providing peptidyl transferase activity...
(rRNA) 28S at residue C3866. The mouse orthologue was also cloned
This snoRNA is encoded in the introns of the same genes as other C/D bx snoRNAs U44, U74, U75, U76, U77, U78, U79, U80 and U81..